An altered lipidome in tumors may affect not only tumor cells themselves but also their microenvironment. In this study, a lipidomics screen reveals increased amounts of phosphatidylser-ine (PS), particularly ether-PS (ePS), in murine mammary tumors compared with normal tissue. PS was produced by phosphatidylserine synthase 1 (PTDSS1), and depletion of Ptdss1 from tumor cells in mice reduced ePS levels accompanied by stunted tumor growth and decreased tumor-associated macrophage (TAM) abundance. Ptdss1-deficient tumor cells exposed less PS during apoptosis, which was recognized (...) by the PS receptor MERTK. Mammary tumors in macrophage-specific Mertk-/- mice showed similarly suppressed growth and reduced TAM infiltration. Transcriptomic profiles of TAMs from Ptdss1-knockdown tumors and Mertk-/- TAMs revealed that macrophage proliferation was reduced when the Ptdss1/Mertk pathway was targeted. Moreover, PTDSS1 expression correlated positively with TAM abundance but negatively with breast carcinoma patient survival. PTDSS1 thus may be a target to modify tumor-promoting inflammation. Significance: This study shows that inhibiting the production of ether-phosphatidylserine by targeting phosphatidylserine syn-thase PTDSS1 limits tumor-associated macrophage expansion and breast tumor growth. (shrink)

The aim of the article is to characterize the early Neolithic settlement region of Targowisko in SE Poland. It is located on the northern edge of the Western Carpathians, 30 km east of Krakow. It functioned during the development of the entire Linear Pottery culture (IRK) and the subsequent Malice culture (MC), in the period from 5300 to 4500 BC. The focus was on the cultural transformation at the turn of the 6th to the 5th millennium BC. Cases of decisive (...) cultural change (e. g. forms and ornamentation of ceramics, dwellings construction, directions of the supply of stone materials, the organization of inhabited space) and cases of continuity (elements of ceramics technology and flint production, continuation of settlement processes and subsistence strategy) were recorded. Cultural change is best represented by the symbolic realm and continuity in the utilitarian realm. These processes were projected onto a reconstructed, dynamic picture of environmental changes recorded in the palynological and geochemical material. Impulses from various cultural environments contributed to the formation of the MC, which proves its heterogeneous character and the complicated course of its genesis. (shrink)

There has been considerable progress in investigating collective actions in the last decades. However, the real progress is different from what many scholars take it to be. It lies in the fact that there is by now a wealth of different approaches from a variety of fields. Each approach has carved out fruitful mechanisms for explaining collective action, but is also faced with limitations. Given that situation, we submit that the next step in investigating collective action is to acknowledge the (...) plurality of approaches and bring them into dialogue. With this aim in mind, the present article discusses the strengths and weaknesses of some of the to our mind most relevant approaches to collective action in current debates. We begin with the collective intentionality framework, the team reasoning approach, and social identity theory. Then, we move to ecological social psychology, participatory sense-making, and, through the lenses of those frameworks, dynamical systems theory. Finally, we discuss practice theory. Against this background, we provide a proposal for a synthesis of the successful explanatory mechanisms as they have been carved out by the different research programs. The suggestion is, roughly, to understand collective action as dynamical interaction of a self-organizing system with its environment, shaped by a process of collective sense-making. (shrink)

In 1939 and 1940 the Reich Office for Teaching Films (Reichsstelle fur den Unterrichtsfilm [RfdU]), the film organization of the National Socialist German government, published three educational films on the early development of the chicken embryo. They were the result of Ludwig Graper's (1882-1937) experimental investigations of the embryology of birds. In the course of his research, the German embryologist continuously made, used, and reused film material for epistemic and educational purposes. The history of the production of these films is (...) an early example of the ways in which film was introduced into the experimental life sciences. Graper's films were experimental in three ways: as recordings of his experiments, as part of his experimental system, and as a new way to secure funding for his work. (shrink)

The concept of an evidential conditional If A then C that can be defined by the conjunction of A>C and ¬C>¬A, where > is a conditional of the kind introduced by Stalnaker and Lewis, has recently been studied in a series of papers by Vincenzo Crupi and Andrea Iacona. In this paper I argue that Crupi and Iacona’s central idea that contraposition captures the idea of evidential support cannot be maintained. I give examples showing that contraposition is neither necessary nor (...) sufficient for a conditional’s antecedent supporting its consequent. Crupi and Iacona’s alternative account of evidential conditionals that is based on a probabilistic measure of evidential support cannot add to the credentials of their modal account, because both the theoretical role of contraposition and the resulting logic are different in this account. (shrink)

The Mexican axolotl is one of the most important models in contemporary regeneration research and regenerative medicine. This is the result of the long history of the species as an experimental and laboratory bred animal. One of many research questions investigated in the axolotl is regeneration. The species’ astonishing ability to regenerate tissues and entire body parts already became apparent shortly after the first 34 living axolotls had been brought from Mexico to Europe in 1864. In the context of their (...) unclear status as larvae or adults and the mysterious transformation of some animals into an adult form, the Paris zoologist Auguste Duméril cut off the gills of several individuals in an attempt to artificially induce the metamorphosis. This produced the first reports on the animals’ regenerative powers and led to sporadic but continuous investigations. But it remained just one of the many phenomena studied in axolotls. Only at the beginning of the 20th century, regeneration became a more prominent aspect in the experimental investigations of axolotls. In experimental embryology, regeneration in axolotls was used in three different ways: it was studied as a phenomenon in its own right: more importantly, it served as a macroscopic model for normal development and, together with other techniques like grafting, became a technical object in the experimental systems of embryologists. In my paper, I will look into how the axolotl became an experimental animal in regeneration research, the role of practices and infrastructures in this process and the ways in which regeneration in the axolotl oscillated between epistemic thing and technical object. (shrink)

Ever since Savage represented acts by reference to their consequences, it has remained unclear how this conceptual move and its implications for evaluating acts may be reconciled with what is treated as people's acts in everyday talk and in our societies' legal practices. The present contribution, first, comments on applied and theoretical debates to emphasize the systematic relevance of Savage's move. It then focuses on the purportedly causal element in the term "consequence." A simple case shows how the idea that (...) choices are causally connected to their consequences meets with problems. Possible consequentialist reactions are discussed. (shrink)

We analyze selected iterated conditionals in the framework of conditional random quantities. We point out that it is instructive to examine Lewis's triviality result, which shows the conditions a conditional must satisfy for its probability to be the conditional probability. In our approach, however, we avoid triviality because the import-export principle is invalid. We then analyze an example of reasoning under partial knowledge where, given a conditional if A then Cas information, the probability of A should intuitively increase. We explain (...) this intuition by making some implicit background information explicit. We consider several iterated conditionals, which allow us to formalize different kinds of latent information. We verify that for these iterated conditionals the prevision is greater than or equal to the probability of A. We also investigate the lower and upper bounds of the Affirmation of the Consequent inference. We conclude our study with some remarks on the supposed "independence" of two conditionals, and we interpret this property as uncorrelation between two random quantities. 2020 Elsevier Inc. All rights reserved. (shrink)

This article develops an ecological framework for understanding collective action. This is contrasted with approaches familiar from the collective intentionality debate, which treat individuals as fundamental units of collective action. Instead, we turn to social ecological psychology and dynamical systems theory and argue that they provide a promising framework for understanding collectives as the central unit in collective action. However, we submit that these approaches do not yet appreciate enough the relevance of social identities for collective action. To analyze this (...) aspect, we build on key insights from social identity theory and synthesize it with embodied and ecological accounts of perception and action. This results in the proposal of two new types of affordances. For an individual who enacts her "embodied social identity" of being a member of a particular collective, there can be what we call embodied social identity affordances. Moreover, when several individuals dynamically interact with each other against the background of their embodied social identities, this might lead to the emergence of a collective, which we understand as a dynamically constituted and ecologically situated perception-action system consisting of several individuals enacting relevant embodied social identity affordances. Building on previous work in social ecological psychology, we suggest that there can be genuine collective affordances, that is, affordances whose subject is not an individual, but a collective. (shrink)

The most discussed and mysterious column within the Babylonian astronomy is column phi. It is closely connected to the lunar velocity and to the duration of the Saros. This paper presents new ideas for the development and interpretation of column phi. It combines the excellent Goal-Year method (for the prediction of Lunar Six time intervals) with old ideas and practices from the "schematic astronomy". Inspired by the old "TU11" rule for prediction of times of lunar eclipses, it proposes that column (...) phi, in a similar way, used the sum of the Lunar Four to predict times of lunar eclipses as well as the duration of one, 6, and 12 months by means of what usually is called "R-S" schemes. It also explains fully the structure and development of such schemes, a fact that strongly supports the new interpretation of column phi. (shrink)

The aim of the work is to examine the relationship between the concepts of “immanence” and “politics” in the works of Hegel and Deleuze. Both Hegel and Deleuze are thinkers of immanence and they explicitly think this concept in relation to the problem of political practice. As I show, they attempt to “ground” politics in immanence. The purpose of this work is to prove that there exists an inherent paradox in the undertaking to “ground” politics in immanence. Both philosophers are (...) confronted with a paradox that emerges from this “grounding”. The paradox appears in the form of natural violence. Both authors fail to contain this violence through arguments. In order to show this, I examine the relationship between two further concepts: history and the state. I compare Hegel’s and Deleuze’s formulations of world-history and universal history, tracing the analogies and differences in how they think the relationship of the state to history. Based on the conclusions I then focus on the relationship of politics to immanence. The paradox of natural violence, I show, emerges from the relationship of the state at the “end of history”. (shrink)

The reply concentrates on advancing again my third thesis, which has not directly been taken up by Breyer and Kliemt. The thesis says that both criticisms against the Rule of Rescue - the irrationality objection, which Breyer and Kliemt try to defend, and the objection that the Rule is discriminatory, which they do not defend - are the results of insufficient action-theoretical reflection. I argue that Breyer's and Kliemt's objection to the Rule, unstable as it is in their comment, is (...) not even clearly identifiable if they do not take a stance towards the central question: Do they want to -and, if so, can they consistently -incorporate people's interest in taking account of the attributability of an outcome to a decision maker into their utility concept? (shrink)

Global supervenience of beliefs about physical states of affairs on such states has strongly counter-intuitive consequences about what beliefs we can nomologically hold. Tfcs is an argument against a global supervenience of all mental properties on physical 0 n es, and, since that is implied by strong supervenience, also against that as the preferred materialist thesis.

The paper attempts to reconcile two very different approaches to the concept of causation. In the original form, it is the opposition found in Laplace between his doctrine of constant and variable causes on the one hand and his mechanistic determinism on the other. This tension was described clearly only by Maxwell who stressed the contrast between the statistical and the dynamical method (calling the latter also the historical or strictly kinetic method). A similar dichotomy surfaces in the work of (...) Wesley Salmon who distinguished statistical from aleatory causation. Acknowledging that we seem to have conflicting intuitions about causality and explanation, I argue that assigning probabilistic laws a fundamental role in scientific explanation does not conflict with the assumption of Laplacian determinism. This is due to the fact that in most systems of interest, we confront a complex interaction of multiple causal factors and an extreme sensitivity to small variations of initial conditions. (shrink)