Standing on the Shoulders of Darwin and Mendel: Early Views of Inheritance explores early theories about the mechanisms of inheritance. Beginning with Charles Darwin's now rejected Gemmule hypothesis, the book documents the reception of Gregor Mendel's work on peas and follows the work of early 20th century scholars. The research of Francis Galton, a cousin of Darwin, and the friction it caused between these two are a part of longer story of the development of genetics and an understanding (...) of how offspring inherit the characteristics of their parents. Bateson, Garrod, de Vries, Tschermak and others are all characters in a scientific story of discovery, acrimony, cooperation and revelation. (shrink)

Eugenics can be defined as the use of science applied to the qualitative and quantitative improvement of the human genome. The subject was initiated by Francis Galton with considerable support from Charles Darwin in the latter half of the 19th century. Its scope has increased enormously since the recent revolution in molecular genetics. Genetic files can be easily obtained for individuals either antenatally or at birth; somatic gene therapy has been introduced for some rare inborn errors of metabolism; (...) and gene manipulation of human germ-line cells will no doubt occur in the near future to generate organs for transplantation. The past history of eugenics has been appalling, with gross abuses in the USA between 1931 and 1945 when compulsory sterilization was practised; and in Germany between 1933 and 1945 when mass extermination and compulsory sterilization were performed. To prevent such abuses in the future statutory bodies, such as a genetics commission, should be established to provide guidance and rules of conduct for use of the new information and technologies as applied to the human genome. (shrink)

With the recent developments in the Human Genome Mapping Project and the new technologies that are developing from it there is a renewal of concern about eugenic applications. Francis Galton (b1822, d1911), who developed the subject of eugenics, suggested that the ancient Greeks had contributed very little to social theories of eugenics. In fact the Greeks had a profound interest in methods of supplying their city states with the finest possible progeny. This paper therefore reviews the works of (...) Plato (The Republic and Politics) and Aristotle (The Politics and The Athenian Constitution) which have a direct bearing on eugenic techniques and relates them to methods used in the present century. (shrink)

A prevalent narrative locates the discovery of the statistical phenomenon of regression to the mean in the work of Francis Galton. It is claimed that after 1885, Galton came to explain the fact that offspring deviated less from the mean value of the population than their parents did as a population-level statistical phenomenon and not as the result of the processes of inheritance. Arguing against this claim, we show that Galton did not explain regression towards mediocrity (...) statistically, and did not give up on his ideas regarding an inheritance process that caused offspring to revert to the mean. While the common narrative focuses almost exclusively on Galton’s statistics, our arguments emphasize the anthropological and biological questions that Galton addressed. Galton used regression towards mediocrity to support the claim that some biological types were more stable than others and hence were resistant to evolutionary change. This view had implications concerning both natural selection and eugenics. The statistical explanation attributed to Galton appeared later, during the biometrician-mutationist debate in the early 1900s. It was in the context of this debate and specifically by the biometricians, that the development of the statistical explanation was originally attributed to Galton. (shrink)

Elsewhere I have argued that the most significant threat to scientific realism arises from what I call the problem of unconceived alternatives: the repeated failure of past scientists and scientific communities to even conceive of alternatives to extant scientific theories, even when such alternatives were both (1) well-confirmed by the evidence available at the time and (2) sufficiently scientifically serious as to be actually embraced in the course of further investigation. In this paper I explore Francis Galton’s development (...) and defense of his “stirp” theory of inheritance and conclude that this particular historical example offers impressive support for the challenge posed by the problem of unconceived alternatives while simultaneously showing how we can make that challenge deeper and sharper. (shrink)

Fletcher, Laadan Sir Francis Galton was Charles Darwin's cousin. He was born in Birmingham, and educated at King Edward's School before studying medicine at King's College, London and also graduating from Trinity College, Cambridge. Two years later he travelled in North Africa and in 1850, in hitherto unexplored regions of South Africa; and, in 1855, published a very successful book giving an account of his experiences. He was probably inspired by the celebrated travels of his cousin.

Galton greeted Darwin's theory of pangenesis with enthusiasm, and tried to test the assumption that the hereditary particles circulate in the blood by transfusion experiments on rabbits. The failure of these experiments led him to reject this assumption, and in the 1870s he developed an alternative theory of heredity, which incorporated those parts of Darwin's theory that did not involve the transportation of hereditary particles throughout the system. He supposed that the fertilized ovum contains a large number of hereditary (...) elements, which he collectively called the "stirp," a few of which are patent, developing into particular cell types, while the rest remain latent; the latent elements can be transmitted to the next generation, while the patent elements, with rare exceptions, cannot since they have developed into cells. The problem with this theory is that it does not explain the similarity between parent and child unless there is a high correlation between latent and patent elements. Galton probably came to realize this problem during his subsequent statistical work on heredity, and he quietly dropped the idea that patent elements are not transmitted in Natural Inheritance (1889). Galton thought that brothers and sisters had identical stirps, and he attributed differences between them to variability in the choice of patent elements from the stirp, that is to say to developmental variability. He attributed the likeness of monozygotic twins to the similarity of their developmental environment. Galton's twin method was to track the life history changes of twins to see whether twins who were similar at birth diverged in dissimilar environments or whether twins who were dissimilar at birth converged in similar environments. It is quite different from the modern twin method of comparing the similarities between monozygotic and dizygotic twins, on the assumption that monozygotic twins are genetically identical whereas dizygotic twins are not. It has been argued that Galton foreshadowed Weismann's theory of the continuity of the germ-plasm, but this is only true in a weak sense. They both believed that the inheritance of acquired characters was either rare or impossible, but Galton did not forestall the essential part of Weismann's theory, that the germ-plasm of the zygote is doubled, with one part being reserved for the formation of the germ-cells. (shrink)

Because Francis Galton (1822-1911) was a well-connected gentleman scientist with substantial private means, the importance of the role he played in the professionalization of the Victorian life-sciences has been considered anomalous. In contrast to the X-clubbers, he did not seem to have any personal need for the reforms his Darwinist colleagues were advocating. Nor for making common cause with individuals haling from social strata clearly inferior to his own. However, in this paper I argue that Galton quite (...) realistically discerned in the reforming endeavors of the 1860s, and beyond, the potential for considerably enhancing his own reputation and standing within both the scientific community and the broader Victorian culture. In addition, his professionalizing aspirations, and those of his reformist allies, were fully concordant with the interests, ambitions and perceived opportunities of his elite social group during the Victorian period. Professionalization appealed to gentlemen of Galton's status and financial security as much as it did to the likes of Thomas Huxley and John Tyndall, primarily because it promised to confer on the whole scientific enterprise an unprecedented level of social prestige. (shrink)

Sir Francis Galton writes: “Those who find a difficulty in understanding how a feebly felt mental action can vanquish a strong desire, will find the difficulty vanish if they consent to assume a physiological and not a psychical standpoint. The gain is as great as viewing the planetary system after the fashion of Copernicus, instead of that of Ptolemy. There is nothing contrary to experience in supposing that conflicting physiological actions may be perceived with a distinctness quite disproportionate (...) to their real efficacy. We may compare the conflict between faintly perceived activities of one kind and clearly perceived activities of another kind, to that between troops dressed in a uniform scarcely distinguishable from the background with others clad in staring scarlet. We must be content to admit that our consciousness has a very inexact cognisance of the physiological battles in our brain, and that the mystery why apparently weak motives of one class should invariably get the better of apparently strong motives of another class, lies wholly in the word ‘apparently’. In short, that the appearances of their relative strength are deceptive”. (shrink)

In 1865 Francis Galton published ‘Hereditary Talent and Character’, an elaborate attempt to prove the heritability of intelligence on the basis of pedigree data. It was the start of Galton's lifelong commitment to investigating the statistical patterns and physiological mechanisms of hereditary transmission. Most existing attempts to explain Galton's fascination for heredity have argued that he was driven by a commitment to conservative political ideologies to seek means of naturalizing human inequality. However, this paper shows that (...) another factor of at least equal importance has been overlooked by Galton scholars: his determination during the 1860s to be accepted among the ranks of the Darwinian inner circle. By hitching his career to the fortunes of what looked likely to emerge as a new scientific elite, Galton felt that he could bypass the typically slow and uncertain route to achieving scientific distinction. For this essentially strategic reason, between 1860 and 1865 he drifted away from a set of existing scientific concerns that were failing to deliver the approbation that he desired. Earnestly seeking to ingratiate himself with the Darwinian lobby, he then toyed with a variety of potential research projects relevant to Darwinian evolution. Yet Galton consistently failed to stimulate the enthusiasm of the Darwinians. Finally, however, after several months of ruminating, in 1864 he settled on a study of eminent pedigrees as a subject that was both germane and highly useful to the Darwinian enterprise. Galton's willingness to shift the direction of his scientific career during the 1860s underscores the importance of examining the micro‐politics of scientific careers in addition to their broader social and political context. This account also emphasizes the limitations of class‐based explanations even when considering scientists whose work seems so manifestly indicative of ideological motivation. (shrink)