Logothetis, N.K.: Single units and conscious vision. Philosophical Transactions of the Royal Society of London Series B-Biological Sciences 353, 1801-1818 (1998) Abstract.

Traditional explanations of multistable visual phenomena (e.g. ambiguous figures, perceptual rivalry) suggest that the basis for spontaneous reversals in perception lies in antagonistic connectivity within the visual system. In this review, we suggest an alternative, albeit speculative, explanation for visual multistability – that spontaneous alternations reflect responses to active, programmed events initiated by brain areas that integrate sensory and non-sensory information to coordinate a diversity of behaviors. Much evidence suggests that perceptual reversals are themselves more closely related to the expression (...) of a behavior than to passive sensory responses: (1) they are initiated spontaneously, often voluntarily, and are influenced by subjective variables such as attention and mood; (2) the alternation process is greatly facilitated with practice and compromised by lesions in non-visual cortical areas; (3) the alternation process has temporal dynamics similar to those of spontaneously initiated behaviors; (4) functional imaging reveals that brain areas associated with a variety of cognitive behaviors are specifically activated when vision becomes unstable. In this scheme, reorganizations of activity throughout the visual cortex, concurrent with perceptual reversals, are initiated by higher, largely non-sensory brain centers. Such direct intervention in the processing of the sensory input by brain structures associated with planning and motor programming might serve an important role in perceptual organization, particularly in aspects related to selective attention. (shrink)

Correspondence should be addressed to David A. Leopold [email protected] the viewing of certain patterns, widely known as ambiguous or puzzle figures, perception lapses into a sequence of spontaneous alternations, switching every few seconds between two or more visual interpretations of the stimulus. Although their nature and origin remain topics of debate, these stochastic switches are generally thought to be the automatic and inevitable consequence of viewing a pattern without a unique solution. We report here that in humans such perceptual alternations (...) can be slowed, and even brought to a standstill, if the visual stimulus is periodically removed from view. We also show, with a visual illusion, that this stabilizing effect hinges on perceptual disappearance rather than on actual removal of the stimulus. These findings indicate that uninterrupted subjective perception of an ambiguous pattern is required for the initiation of the brain-state changes underlying multistable vision.Visual perception involves coordination between sensory sampling of the world and active interpretation of the sensory data. Human perception of objects and scenes is normally stable and robust, but it falters when one is presented with patterns that are inherently ambiguous or contradictory. Under such conditions, vision lapses into a chain of continually alternating percepts, whereby a viable visual interpretation dominates for a few seconds and is then replaced by a rival interpretation. This multistable vision, or 'multistability', is thought to result from destabilization of fundamental visual mechanisms, and has offered valuable insights into how sensory patterns are actively organized and interpreted in the brain1, 2. Despite a great deal of recent research and interest in multistable perception, however, its neurophysiological underpinnings remain poorly understood. Physiological studies have suggested that disambiguation of ambiguous patterns. (shrink)

Background: Continuous viewing of ambiguous patterns is characterized by wavering perception that alternates between two or more equally valid visual solutions. However, when such patterns are viewed intermittently, either by repetitive presentation or by periodic closing of the eyes, perception can become locked or "frozen" in one configuration for several minutes at a time. One aspect of this stabilization is the possible existence of a perceptual memory that persists during periods in which the ambiguous stimulus is absent. Here, we use (...) a novel paradgim of temporally interleaved ambiguous stimuli to explore the nature of this memory, with particular regard to its potential impact on perceptual organization. Results: We found that the persistence of a perceptual configuration was robust to interposed visual patterns and, further, that at least three ambiguous patterns, when interleaved in time, could undergo parallel, stable time courses. Then, using an interleaved presentation paradigm, we established that the occasional reversal in one pattern could be coupled with that of its interleaved counterpart, and that this coupling was a function of the structural similarity between the patterns. Conclusions: We postulate that the stabilization observed with repetitive presentation of ambiguous patterns can be at least partially accounted for by processes that retain a recent perceptual interpretation, and we speculate that such memory may be important in natural vision. We further propose tha the interleaved paradigm introduced here may be of great value to gauge aspects of stimulus similarity that appeal to particular mechanisms of perceptual organization. (shrink)

Understanding how activity in the brain leads to a subjective percept is of great interest to philosophers and neuroscientists alike. In the last years, neurophysiological experiments have approached this problem directly by measuring neural signals in animals as they experience well-defined visual percepts. Stimuli in these studies are often inherently ambiguous, and thus rely upon the subjective report, generally from trained monkeys, to provide a measure of perception. By correlating activity levels in the brain to this report, one can speculate (...) on the role of individual neurons and groups of neurons in the formation and maintenance of a particular percept. However, in order to draw valid conclusions from such experiments, it is critical that the responses accurately and reliably reflect what is perceived. For this reason, a number of behavioural paradigms have been developed to control and evaluate the truthfulness of responses from behaving animals. Here we describe several approaches to optimizing the reliability of a monkey's perceptual report, and argue that their combination provides an invaluable approach in the study of subjective visual perception. (shrink)

Moutoussis, K., A. Maier, S. Zeki and N. K. Logothetis: Seeing invisible motion: responses of area V5 neurons in the awake-behaving macaque. Soc. for Neurosci. Abstr. 390.11, 1.

Asif A. Ghazanfar,1,3,* Hjalmar K. Turesson,1,3 statistical pattern recognition [16, 17] and psychophys- Joost X. Maier,1 Ralph van Dinther,2 ics [13, 18–23] have suggested that formants are signif- Roy D. Patterson,2 and Nikos K. Logothetis1 icant contributors to these indexical cues. It is likely, 1Max Planck Institute for Biological Cybernetics then, that detecting formants could have provided 72076 Tuebingen ancestral primates with indexical cues necessary for Germany navigating the complex social interactions that are the 2Centre for the Neural Basis (...) of Hearing essence of primate societies. One important indexical Department of Physiology cue is body size. Formant cues related to body size University of Cambridge could be used by monkeys to determine the sex (in sex- CB2 3EG Cambridge ually dimorphic species), degree of potential threat (e.g., United Kingdom whether a competitor is larger or smaller), and/or age of an individual, as such cues do for human listeners [13, 18, 20, 21]. Summary Formants are the result of acoustic filtering by the supralaryngeal vocal tract—the nasal and oral cavities Vocal-tract resonances (or formants) are acoustic sigabove the vocal folds. During vocal production, pulses natures in the voice and are related to the shape and of air generated by the rapid movement of the vocal length of the vocal tract. Formants play an important folds produce an acoustic signal. The frequency of these role in human communication, helping us not only to pulses—the glottal-pulse rate—determines the fundadistinguish several different speech sounds [1], but mental frequency of the signal, which in turn is perceived also to extract important information related to the as pitch. As the signal passes through the supralaryngphysical characteristics of the speaker, so-called ineal vocal tract, it excites resonances, resulting in the dexical cues. How did formants come to play such an enhancement of particular frequency bands; these are important role in human vocal communication? One the formants.. (shrink)

Traditional explanations of multistable visual phenomena (e.g. ambiguous figures, perceptual rivalry) suggest that the basis for spontaneous reversals in perception lies in antagonistic connectivity within the visual system. In this review, we suggest an alternative, albeit speculative. explanation for visual multistability - that spontaneous alternations reflect responses to active, programmed events initiated by brain areas that integrate sensory and non-sensory information to coordinate a diversity of behaviors. Much evidence suggests that perceptual reversals are themselves more closely related to the expression (...) of a behavior than to passive sensory responses: (1) they are initiated spontaneously, often voluntarily, and are influenced by subjective variables such as attention and mood; (2) the alternation process is greatly facilitated with practice and compromised by lesions in non- visual cortical areas; (3) the alternation process has temporal dynamics similar to those of spontaneously initiated behaviors; (4) functional imaging reveals that brain areas associated with a variety of cognitive behaviors are specifically activated when vision becomes unstable. In this scheme, reorganizations of activity throughout the visual cortex, concurrent with perceptual reversals, are initiated by higher, largely non- sensory brain centers. Such direct intervention In the processing of the sensory input by brain structures associated with planning and motor programming might serve an important role in perceptual organization, particularly in aspects related to selective attention. (shrink)

t. 1. Hē kyriarchia tou Aristotelismou -- t. 2. Hē epikratēsē tēs neōterikēs philosophias.

Despite considerable evidence that neural activity in monkeys reflects various aspects of face perception, relatively little is known about monkeys’ face processing abilities. Two characteristics of face processing observed in humans are a subordinate-level entry point, here, the default recognition of faces at the subordinate, rather than basic, level of categorization, and holistic effects, i.e. perception of facial displays as an integrated whole. The present study used an adaptation paradigm to test whether untrained rhesus macaques (Macaca mulatta) display these hallmarks (...) of face processing. In experiments 1 and 2, macaques showed greater rebound from adaptation to conspecific faces than to other animals at the individual or subordinate level. In experiment 3, exchanging only the bottom half of a monkey face produced greater rebound in aligned than in misaligned composites, indicating that for normal, aligned faces, the new bottom half may have influenced the perception of the whole face. Scan path analysis supported this assertion: during rebound, fixation to the unchanged eye region was renewed, but only for aligned stimuli. These experiments show that macaques naturally display the distinguishing characteristics of face processing seen in humans and provide the first clear demonstration that holistic information guides scan paths for conspecific faces. (shrink)

manganese (Mn2+) enhanced MRI (MEMRI) to study neuronal connectivity in vivo opens the possibility to these studies. However, several drawbacks exist that challenge its applicability. High Mn2+ concentrations produce cytotoxic effects that can perturb the circuits under study. In the other hand, the MR signal is..

In-vivo phenotyping of genetically engineered mouse models for amyotrophic lateral sclerosis is established by combining BT-MRI and CASL G. Vanhoutte1, E. Storkebaum2, P. Carmeliet2, A. Van der Linden1.

We report and compare the performance of different learning algorithms based on data from cortical recordings. The task is to predict the orientation of visual stimuli from the activity of a population of simultaneously recorded neurons. We compare several ways of improving the coding of the input (i.e., the spike data) as well as of the output (i.e., the orientation), and report the results obtained using different kernel algorithms.

c Ralph Mason -- 199. A New Frontier for Proton MRI: Quantitative Tissue Oximetry g f e d c Ralph P. Mason -- 200. S-GalTM, a Novel 1H MRI Reporter for b-Galactosidase g f e d c John Chen -- 201. Myeloperoxidase-mediated activation of paramagnetic imaging g f e d.

The relationship between brain activity and conscious visual experience is central to our understanding of the neural mechanisms underlying perception. Binocular rivalry, where monocular stimuli compete for perceptual dominance, has been previously used to dissociate the constant stimulus from the varying percept. We report here fMRI results from humans experiencing binocular rivalry under a dichoptic stimulation paradigm that consisted of two drifting random dot patterns with different motion coherence. Each pattern had also a different color, which both enhanced rivalry and (...) was used for reporting which of the two patterns was visible at each time. As the perception of the subjects alternated between coherent motion and motion noise, we examined the effect that these alternations had on the strength of the MR signal throughout the brain. Our results demonstrate that motion perception is able to modulate the activity of several of the visual areas which are known to be involved in motion processing. More specifically, in addition to area V5 which showed the strongest modulation, a higher activity during the perception of motion than during the perception of noise was also clearly observed in areas V3A and LOC, and less so in area V3. In previous studies, these areas had been selectively activated by motion stimuli but whether their activity reflects motion perception or not remained unclear; here we show that they are involved in motion perception as well. The present findings therefore suggest a lack of a clear distinction between ?processing? versus ?perceptual? areas in the brain, but rather that the areas involved in the processing of a specific visual attribute are also part of the neuronal network that is collectively responsible for its perceptual representation. (shrink)

Human-Computer Interaction and games set a new domain in understanding people’s motivations in gaming, behavioral implications of game play, game adaptation to player preferences and needs for increased engaging experiences in the context of HCI serious games. When the latter relate with people’s health status, they can become a part of their daily life as assistive health status monitoring/enhancement systems. Co-designing HCI-SGs can be seen as a combination of art and science that involves a meticulous collaborative process. The design elements (...) in assistive HCI-SGs for Parkinson’s Disease patients, in particular, are explored in the present work. Within this context, the Game-Based Learning design framework is adopted here and its main game-design parameters are explored for the Exergames, Dietarygames, Emotional games, Handwriting games, and Voice games design, drawn from the PD-related i-PROGNOSIS Personalized Game Suite holistic approach. Two main data sources were involved in the study. In particular, the first one includes qualitative data from semi-structured interviews, involving 10 PD patients and four clinicians in the co-creation process of the game design, whereas the second one relates with data from an online questionnaire addressed by 104 participants spanning the whole related spectrum, i.e., PD patients, physicians, software/game developers. Linear regression analysis was employed to identify an adapted GBL framework with the most significant game-design parameters, which efficiently predict the transferability of the PGS beneficial effect to real-life, addressing functional PD symptoms. The findings of this work can assist HCI-SG designers for designing PD-related HCI-SGs, as the most significant game-design factors were identified, in terms of adding value to the role of HCI-SGs in increasing PD patients’ quality of life, optimizing the interaction with personalized HCI-SGs and, hence, fostering a collaborative human-computer symbiosis. (shrink)

Nikos K. Logothetis University of Manchester, Manchester, UK In binocular rivalry, the visual percept alternates stochastically between two dichoptically presented stimuli. It is established that both processes related to the eye of origin and binocular, stimulus-related processes account for these fluctuations in conscious perception. Here we studied how their relative contributions vary over time. We applied brief disruptions to rivalry displays, concurrent with an optional eye swap, at varying time intervals after one stimulus became visible (dominant). We found (...) that early in a dominance phase the dominant eye determined the percept by stabilizing its own contribution (regardless of the stimulus), with an additional yet weaker stabilizing contribution of the stimulus (regardless of the eye). Their stabilizing contributions declined in parallel with time so that late in a dominance phase the stimulus (and in some cases also the eye-based) contribution turned negative, favoring a perceptual (or ocular) switch. Our findings show that depending on the time, first processes related to the eye of origin and then those related to the stimulus can have a greater net influence on the stability of the conscious percept. Their co-varying change may be due to feedback from image- to eyeof-origin representations. (shrink)

Our political thinking is driven, far more than philosophers recognize, by a concern for social equality and, more specifically, a concern to avoid relations of inferiority. Niko Kolodny argues that, in order to make sense of the most familiar ideas in our political thought and discourse - the justification of the state, democracy, and rule of law, as well as objections to paternalism and corruption - we cannot merely appeal to freedom (as libertarians like Nozick do) or to distributive fairness (...) (as liberals like Rawls do). We must, instead, appeal directly to claims against inferiority, that no one stands above or below. (shrink)

Often our reason for doing something is an "instrumental reason": that doing that is a means to doing something else that we have reason to do. What principles govern this "instrumental transmission" of reasons from ends to means? Negatively, I argue against principles often invoked in the literature, which focus on necessary or sufficient means. Positively, I propose a principle, "General Transmission," which answers to two intuitive desiderata: that reason transmits to means that are "probabilizing" and "nonsuperfluous" with respect to (...) the relevant end. I then apply General Transmission to the debate over "detachment": whether "wide-scope" reason for a material conditional or disjunction implies "narrow-scope" reason for the consequent or disjuncts. (shrink)

My subject is what I will call the “Myth of Formal Coherence.” In its normative telling, the Myth is that there are “requirements of formal coherence as such,” which demand just that our beliefs and intentions be formally coherent.1 Some examples are.

Quel rapport entretenait Marx avec la culture, l'histoire et la philosophie de la Grèce antique? Pourquoi le jeune Marx s'était-il intéressé à la pensée d'Epicure? Que représentait pour lui la philosophie enseignée par le fondateur de l'École du Jardin? A part l'aspect purement philosophique du rapport de l'auteur du Capital à la Grèce antique, on se donnera également pour tâche de mettre en perspective la contribution que les notions marxiennes de classe, de lutte des classes et d'exploitation peuvent apporter à (...) une compréhension féconde de l'histoire des formations sociales grecques, en partant de l'oeuvre majeure de l'historien britannique G. E. M. de Ste Croix. (shrink)

In this paper we will try to find resemblances of the operation of human consciousness with systems with the intention to simulate it mathematically. Also we will try to do the same for the non-conscious operations and try to synthesize the human mind in form of system with subsystems.

In this paper I argue that Mill’s ‘Doctrine of Philosophical Necessity’ regarding the human will and action cannot apply on all cases, and that the human mind has potentially the capacity to create freely a will or action that, no matter what kind of knowledge we possess, cannot be predicted. More precisely, I argue against Mill’s attempt of conjunction between the freedom of the will and the ‘Doctrine of Philosophical Necessity’ while I attempt a comparison with the relevant Kantian approach. (...) I then claim that a will cannot be free and be predicted at the same time, as both the elements of freedom and unpredictability of the will are founded on the very process of its formulation as an outcome of genuine creativity. I, thus, attempt to propose a more substantially free view of free will and action than the ones presented by the prominent conceptions. (shrink)

It is argued that standard music notation pictures Aristotle’s time (time, as Aristotle conceived of it) in a number of important respects, which concern its micro-structure. It is then argued that this allows us to see some features of Aristotle’s time more clearly. Most importantly, Aristotelian instants can be pictured by bar-lines. This allows us to see as how radically devoid of any content Aristotelian instants should be interpreted. Thus, attention to music notation may show why Aristotle was not a (...) presentist. (shrink)

Normativity involves two kinds of relation. On the one hand, there is the relation of being a reason for. This is a relation between a fact and an attitude. On the other hand, there are relations specified by requirements of rationality. These are relations among a person's attitudes, viewed in abstraction from the reasons for them. I ask how the normativity of rationality—the sense in which we ‘ought’ to comply with requirements of rationality—is related to the normativity of reasons—the sense (...) in which we ‘ought’ to have the attitudes what we have conclusive reason to have. The normativity of rationality is not straightforwardly that of reasons, I argue; there are no reasons to comply with rational requirements in general. First, this would lead to ‘bootstrapping’, because, contrary to the claims of John Broome, not all rational requirements have ‘wide scope’. Second, it is unclear what such reasons to be rational might be. Finally, we typically do not, and in many cases could not, treat rational requirements as reasons. Instead, I suggest, rationality is only apparently normative, and the normativity that it appears to have is that of reasons. According to this ‘Transparency Account’, rational requirements govern our responses to our beliefs about reasons. The normative ‘pressure’ that we feel, when rational requirements apply to us, derives from these beliefs: from the reasons that, as it seems to us, we have. (shrink)

Comment le jeune Hegel définit-il la notion du positif, ainsi que le concept de positivité? Pour quelles raisons insiste-t-il tellement sur la critique du judaïsme et du christianisme dans ses écrits des années 1790-1800, en se fondant sur une conception novatrice de la positivité? Ce livre essaie de mettre en perspective à travers la lecture de certains textes, que la positivité est pour le jeune Hegel, la perte de la part de l'être humain de la maîtrise de sa propre vie, (...) la privation de l'autonomie du sujet au profit de l'autonomisation du monde des objets, aussi bien que l'asservissement des personnes à des lois et à des forces, lesquelles leur sont étrangères et hostiles. Ainsi cet ouvrage propose de comprendre la positivité, tantôt comme l'extension des rapports mutilés entre l'être humain, le monde et la nature, tantôt comme le prodrome du concept de l'aliénation. (shrink)