Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

There is a large literature in empirical psychology studying what psychologists call 'subjective well-being'. Only limited attention has been given to these results by philosophers who study what we call 'well-being'. In this paper, I assess the relevance of the empirical results to one philosophical theory of well-being, the desire satisfaction theory. According to the desire satisfaction theory, an individual's well-being is enhanced when her desires are satisfied. The empirical results, however, show that many of our desires are disappointed in (...) the sense that the satisfaction of those desires does not make us any happier. So I develop an argument against the desire theory of well-being on the basis of these empirical results. I then provide a defense of the desire theory based on a careful examination of the measures of subjective well-being used by psychologists. I conclude that the empirical results do not threaten the desire theory of well-being. (shrink)

A succinct, neurobiological explanation of the pathways that 'wake up the brain' from deep anesthesia, sleep and brain injury.

Our century has witnessed violence on an unprecedented scale, in wars that have torn deep into the fabric of national and international life. And as we can see in the recent strife in Bosnia, genocide in Rwanda, and the ongoing struggle to control nuclear weaponry, ancient enmities continue to threaten the lives of masses of human beings. As never before, the question is urgent and practical: How can nations--or ethnic groups, or races--after long, bitter struggles, learn to live side by (...) side in peace? In An Ethic for Enemies, Donald W. Shriver, Jr., President Emeritus of Union Theological Seminary, argues that the solution lies in our capacity to forgive. Taking forgiveness out of its traditional exclusive association with personal religion and morality, Shriver urges us to recognize its importance in the secular political arena. The heart of the book examines three powerful and moving cases from recent American history--our postwar dealings with Germany, with Japan, and our continuing domestic problem with race relations--cases in which acts of forgiveness have had important political consequences. Shriver traces how postwar Germany, in its struggle to break with its political past, progressed from denial of a Nazi past, to a formal acknowledgement of the crimes of Nazi Germany, to providing material compensation for survivors of the Holocaust. He also examines the efforts of Japan and the United States, over time and across boundaries of race and culture, to forgive the wrongs committed by both peoples during the Pacific War. And finally he offers a fascinating discussion of the role of forgiveness in the American civil rights movement. He shows, for instance, that even Malcolm X recognized the need to move from contempt for the integrationist ideal to a more conciliatory, repentant stance toward Civil Rights leaders. Malcolm came to see that only through forgiveness could the separate voices of the African-American movement work together to achieve their goals. If mutual forgiveness was a radical thought in 1964, Shriver reminds us that it has yet to be realized in 1994. "We are a long way from ceasing to hold the sins of the ancestors against their living children," he writes. Yet in this poignant volume, we discover how, by forgiving, enemies can progress and have progressed toward peace. A timely antidote to today's political conflicts, An Ethic for Enemies challenges to us to confront the hatreds that cripple society and threaten to destroy the global village. (shrink)

Applying the rules and systems of mathematics and logic to instance ontology, this work argues for the validity and problem-solving capacities of instance ontology, and associates it with a version of the realist position which is named by the author as moderate realism.

The most popular and convincing arguments for the claim that vegetarianism is morally obligatory focus on the extensive, unnecessary harm done to animals and to the environment by raising animals industrially in confinement conditions (factory farming). I outline the strongest versions of these arguments. I grant that it follows from their central premises that purchasing and consuming factoryfarmed meat is immoral. The arguments fail, however, to establish that strict vegetarianism is obligatory because they falsely assume that eating vegetables is the (...) only alternative to eating factory-farmed meat that avoids the harms of factory farming. I show that these arguments not only fail to establish that strict vegetarianism is morally obligatory, but that the very premises of the arguments imply that eating some (non-factory-farmed) meat rather than only vegetables is morally obligatory. Therefore, if the central premises of these usual arguments are true, then strict vegetarianism is immoral. (shrink)

Cognitive neuroscientists have anticipated the union of neural and behavioral science with ethics (Gazzaniga 2005). The identification of an ethical rule—the dictum that we should treat others in the manner in which we would like to be treated—apparently widespread among human societies suggests a dependence on fundamental human brain mechanisms. Now, studies of neural and molecular mechanisms that underlie the feeling of fear suggest how this form of ethical behavior is produced. Counterintuitively, a new theory presented here states that it (...) is actually a loss of social information that leads to sharing others' fears with our own, thus allowing us to treat others as we would like to be treated. Adding to that hypothetical mechanism is the well-studied predilection toward affiliative behaviors. Thus, even as Chomsky hypothesizes that humans are predisposed to utter grammatical sentences, we propose that humans are 'wired for reciprocity'. However, these two neural forces supporting ethical behavior do not explain individual or collective violence. At any given moment, the ability to produce behavior that obeys this ethical rule is proposed to depend on a balance between mechanisms for prosocial and antisocial behaviors. That balance results not only from genetic influences on temperament but also from environmental effects particularly during critical neonatal and pubertal periods. (shrink)

Whitehead's magnum opus is as important as it is difficult. It is the only work in which his metaphysical ideas are stated systematically and completely, and his metaphysics are the heart of his philosophical system as a whole.

An adaptive preference is a preference that is regimented in response to an agent’s set of feasible options. The fabled fox in the sour grapes story undergoes an adaptive preference change. I consider adaptive preferences more broadly, to include adaptive preference formation as well. I argue that many adaptive preferences that other philosophers have cast out as irrational sour-grapes-like preferences are actually fully rational preferences worthy of pursuit. I offer a means of distinguishing rational and worthy adaptive preferences from irrational (...) and unworthy ones. The distinction is based on the agent’s own appraisal of the adaptive preference. (shrink)

Institutional corruption is a normative concept of growing importance that embodies the systemic dependencies and informal practices that distort an institution’s societal mission. An extensive range of studies and lawsuits already documents strategies by which pharmaceutical companies hide, ignore, or misrepresent evidence about new drugs; distort the medical literature; and misrepresent products to prescribing physicians. We focus on the consequences for patients: millions of adverse reactions. After defining institutional corruption, we focus on evidence that it lies behind the epidemic of (...) harms and the paucity of benefits. (shrink)

There is almost no theoretical discussion of non‐human animal well‐being in the philosophical literature on well‐being. To begin to rectify this, I develop a desire satisfaction theory of well‐being for animals. I contrast this theory with my desire theory of well‐being for humans, according to which a human benefits from satisfying desires for which she can offer reasons. I consider objections. The most important are (1) Eden Lin's claim that the correct theory of well‐being cannot vary across different welfare subjects (...) and (2) his objection against theories of human well‐being that require exercising a sophisticated capacity such as reason giving. (shrink)

Over the past 35 years, patients have suffered from a largely hidden epidemic of side effects from drugs that usually have few offsetting benefits. The pharmaceutical industry has corrupted the practice of medicine through its influence over what drugs are developed, how they are tested, and how medical knowledge is created. Since 1906, heavy commercial influence has compromised congressional legislation to protect the public from unsafe drugs. The authorization of user fees in 1992 has turned drug companies into the FDA's (...) prime clients, deepening the regulatory and cultural capture of the agency. Industry has demanded shorter average review times and, with less time to thoroughly review evidence, increased hospitalizations and deaths have resulted. Meeting the needs of the drug companies has taken priority over meeting the needs of patients. Unless this corruption of regulatory intent is reversed, the situation will continue to deteriorate. We offer practical suggestions including: separating the funding of clinical trials from their conduct, analysis, and publication; independent FDA leadership; full public funding for all FDA activities; measures to discourage R&D on drugs with few, if any, new clinical benefits; and the creation of a National Drug Safety Board. (shrink)

Here Donald Livingston traces this distinction through all of Hume's writings and reveals its relevance for contemporary discussion.

One version of the desire satisfaction theory of well-being (i.e., welfare, or what is good for one) holds that only the satisfaction of one's present desires for present states of affairs can affect one's well-being. So if I desire fame today and become famous tomorrow, my well-being is positively affected onlyif tomorrow, when I am famous, I still desire to be famous. Call this the present desire satisfaction theory of well-being. I argue, contrary to this theory, that the satisfaction of (...) past desires that are no longer held does indeed affect one's well-being. The satisfaction of past desires is good for one in that the present satisfaction of past desires positively affects one's past well-being. I argue for this view in stages, starting with the recognition that many of our desires are satisfied not at an instant but over an interval of time, and that it is during this interval of time that our well-being is positively affected. Once we get our foot in the door with some temporal thickness to desire satisfaction and the associated well-being, I argue, the door must open more widely to allow for greater temporal distance between present desire satisfaction and past well-being. I defend my thesis that present satisfaction of past desires increases one's past welfare against objections, including the claim that it involves backward causation and Velleman's claim that the view is highly counterintuitive whether or not it involves backward causation. I argue that some of the objections rely on hedonistic intuitions, intuitions that most desire satisfaction theories of welfare aim to correct. Once properly understood and applied, my counterintuitive and controversial thesis is really quite innocuous. (shrink)

Immanuel Kant was a German philosopher. He is a central figure of modern philosophy, and set the terms by which all subsequent thinkers have had to grapple. He argued that human perception structures natural laws, and that reason is the source of morality. His thought continues to hold a major influence in contemporary thought, especially in fields such as metaphysics, epistemology, ethics, political philosophy, and aesthetics.

In a well-known paper, Bernard Williams argues that an immortal life would not be worth living, for it would necessarily become boring. I examine the implications for the boredom thesis of three human traits that have received insufficient attention in the literature on Williams’ paper. First, human memory decays, so humans would be entertained and driven by things that they experienced long before but had forgotten. Second, even if memory does not decay to the extent necessary to ward off boredom, (...) once-satisfied desires often return after a sufficient period of time. Eternity would always contain sufficient time for our desires to rejuvenate. Third, even if too many of our desires were satisfied but not yet rejuvenated, we can expect that human ingenuity would continue to invent new pursuits, pastimes, careers, and ways of life that would prevent us from becoming bored as we moved from one to another. Finally, I consider and respond to several objections, including the claims that as much variety as I propose to be put into an eternal life is inconsistent with having one character throughout one’s life and that the sort of character change and memory decay I postulate is inconsistent with personal identity. (shrink)

Although human well-being is a topic of much contemporary philosophical discussion, there has been comparatively little theoretical discussion in philosophy of (nonhuman) animal well-being. Animal welfare science is a well-established scientific discipline that studies animal well-being from an empirical standpoint. This article examines parts of this literature that may be relevant to philosophical treatments of animal well-being and to other philosophical issues. First, I explain the dominant conceptions of well-being in animal welfare science and survey some debates in that literature (...) surrounding these competing conceptions. Second, I explain the empirical methods used to measure animal well-being. Third, I argue for the philosophical relevance of the research in animal welfare science and outline some philosophical issues concerning animal welfare and its science that I claim are worthy of attention by philosophers. (shrink)

It is widely accepted by philosophers of well‐being that the shape or narrative structure of a life is a significant determinant of its overall welfare value. Most arguments for this thesis posit agent‐independent value in certain life shapes. The desire theory of well‐being, I argue, has all of the resources needed to account for the value that many philosophers have identified in lives with certain shapes. The theory denies that there is any agent‐independent value in shapes and, indeed, allows that (...) there can be both agent‐dependent value and agent‐dependent disvalue in the shapes commonly claimed to hold agent‐independent value. (shrink)

Donald Shriver argues that recognition of morally negative events in American history is essential to the health of our society. The failure to acknowledge and repent of these events skews the relations of many Americans to one another and breeds ongoing hostility. Focusing on the wrongs suffered by African Americans and Native Americans, Shriver examines the challenges associated with the call for collective repentance: What can it mean to morally master a past whose victims are dead and whose sufferings (...) cannot be alleviated? What are the measures that lend substance to language and action expressing repentance? In answering these questions Shriver creates a compelling vision of the collective repentance and apology that must precede real progress in relations between the races in this country. (shrink)

This paper is about two seemingly inconsistent theories of well-being and how to reconcile them. The first theory is perfectionism, the view that the good of a human is determined by human nature. The second theory is preferentism, the view that the good of a human lies in the satisfaction of her preferences. I begin by sketching the theories and then developing an objection against each from the standpoint of the other. I then develop a version of each theory that (...) is meant to address the objection from the other theory. It turns out that these modified perfectionist and preferentist theories are mutually supporting and co-extensive. They can be combined into a new theory, perfectionist preferentism, which is an independently plausible theory of well-being. (shrink)

A common and convincing argument for the moral requirement of veganism is based on the widespread, severe, and unnecessary harm done to animals, the environment, and humans by the practices of animal agriculture. If this harm footprint argument succeeds in showing that producing and consuming animal products is morally impermissible, then parallel harm footprint arguments show that a vast array of modern practices are impermissible. On this first horn of the dilemma, by engaging in these practices, vegans are living immorally (...) by their own lights. This first horn can be avoided by assuming that morality requires not minimizing harm, but only keeping the harm of our actions within some budget. On the second horn, however, we recognize that there are many ways of keeping our harm footprints within budget other than through our dietary choices. On the second horn of the vegan's dilemma, therefore, veganism is not a moral requirement. (shrink)

Hugh LaFollette, Jeff McMahan, and David DeGrazia endorse the most popular and convincing argument for the strict regulation of firearms in the U.S. The argument is based on the extensive, preventable harm caused by firearms. DeGrazia offers another compelling argument based on the rights of those threatened by firearms. My thesis is a conditional: if these usual arguments for gun control succeed, then alcoholic beverages should be controlled much more strictly than they are, possibly to the point of prohibition. The (...) argument for this thesis involves developing a careful analogy between firearms and alcohol and defending the analogy against objections. (shrink)

We adjudicate a recent dispute concerning the desire theory of well-being. Stock counterexamples to the desire theory include “quirky” desires that seem irrelevant to well-being, such as the desire to count blades of grass. Bruckner claims that such desires are relevant to well-being, provided that the desirer can characterize the object in such a way that makes it clear to others what attracts the desirer to it. Lin claims that merely being attracted to the object of one’s desire should be (...) sufficient for it to be relevant to one’s well-being. The capacity to characterize the desire as Bruckner requires does no work in the explanation of the welfare-relevance of the desire, Lin claims, especially since Lin’s account and Bruckner’s account are extensionally equivalent. In response, we provide a conceptual analysis of desire based on conceptual role semantics. Our analysis shows the plausibility of and motivation for Bruckner’s account. As well, it shows that the extensional equivalence of the accounts is no accident, but due to what it is to have a desire. Lin has not succeeded in providing an alternative to Bruckner’s account, but merely reformulated it, though in an illuminating way that supports Bruckner’s original case. (shrink)

Hugh LaFollette, Jeff McMahan, and David DeGrazia endorse the most popular and convincing argument for the strict regulation of firearms in the U.S. The argument is based on the extensive, preventable harm caused by firearms. DeGrazia offers another compelling argument based on the rights of those threatened by firearms. My thesis is a conditional: if these usual arguments for gun control succeed, then alcoholic beverages should be controlled much more strictly than they are, possibly to the point of prohibition. The (...) argument for this thesis involves developing a careful analogy between firearms and alcohol and defending the analogy against objections. (shrink)

In the continuing discussion and debate over the development of letter-forms in fifth-century Athens, the official casualty lists from the public cemetery have played little part. One of them, however, the so-called ‘Koroneia’ epigram and related fragments , has been used in the argument by H. B. Mattingly, who has assigned it to Delion and claims its tailed rho for the 420s. But, the epigraphical argument aside, it seems to me that in so doing he has ignored two important characteristics (...) of the lists—characteristics that are not apparent from these fragments by themselves but that can be seen from all the inscriptions of this class taken as a group. No summary of our knowledge of these lists has been written for almost 50 years, during which time the number known has almost doubled. In this paper I should like to outline the present state of our knowledge and to give some impressions of them gained from examining all known fragments and preparing them for publication. I wish to stress that these impressions were formed slowly, with no parti pris, no idea of their being used in any debate over letter-forms, but merely with the purpose of understanding as much as possible about the lists as a group. (shrink)