Results for 'Brendan Clarke'

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  1. Causation in medicine.Brendan Clarke - 2011 - In Wenceslao J. González (ed.), Conceptual Revolutions: from Cognitive Science to Medicine. Oleiros (La Coruña): Netbiblo.
    In this paper, I offer one example of conceptual change. Specifically, I contend that the discovery that viruses could cause cancer represents an excellent example of branch jumping, one of Thagard’s nine forms of conceptual change. Prior to about 1960, cancer was generally regarded as a degenerative, chronic, non-infectious disease. Cancer causation was therefore usually held to be a gradual process of accumulating cellular damage, caused by relatively non-specific component causes, acting over long periods of time. Viral infections, on the (...)
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  2. Mechanisms and the Evidence Hierarchy.Brendan Clarke, Donald Gillies, Phyllis Illari, Federica Russo & Jon Williamson - 2014 - Topoi 33 (2):339-360.
    Evidence-based medicine (EBM) makes use of explicit procedures for grading evidence for causal claims. Normally, these procedures categorise evidence of correlation produced by statistical trials as better evidence for a causal claim than evidence of mechanisms produced by other methods. We argue, in contrast, that evidence of mechanisms needs to be viewed as complementary to, rather than inferior to, evidence of correlation. In this paper we first set out the case for treating evidence of mechanisms alongside evidence of correlation in (...)
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  3.  84
    The Evidence that Evidence-based Medicine Omits.Brendan Clarke, Donald Gillies, Phyllis Illari, Federica Russo & Jon Williamson - unknown
    According to current hierarchies of evidence for EBM, evidence of correlation is always more important than evidence of mechanisms when evaluating and establishing causal claims. We argue that evidence of mechanisms needs to be treated alongside evidence of correlation. This is for three reasons. First, correlation is always a fallible indicator of causation, subject in particular to the problem of confounding; evidence of mechanisms can in some cases be more important than evidence of correlation when assessing a causal claim. Second, (...)
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  4. Modelling mechanisms with causal cycles.Brendan Clarke, Bert Leuridan & Jon Williamson - 2014 - Synthese 191 (8):1-31.
    Mechanistic philosophy of science views a large part of scientific activity as engaged in modelling mechanisms. While science textbooks tend to offer qualitative models of mechanisms, there is increasing demand for models from which one can draw quantitative predictions and explanations. Casini et al. (Theoria 26(1):5–33, 2011) put forward the Recursive Bayesian Networks (RBN) formalism as well suited to this end. The RBN formalism is an extension of the standard Bayesian net formalism, an extension that allows for modelling the hierarchical (...)
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  5. Causality in medicine with particular reference to the viral causation of cancers.Brendan Clarke - 2011 - Dissertation, University College London
    In this thesis, I give a metascientific account of causality in medicine. I begin with two historical cases of causal discovery. These are the discovery of the causation of Burkitt’s lymphoma by the Epstein-Barr virus, and of the various viral causes suggested for cervical cancer. These historical cases then support a philosophical discussion of causality in medicine. This begins with an introduction to the Russo- Williamson thesis (RWT), and discussion of a range of counter-arguments against it. Despite these, I argue (...)
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  6. Causation and melanoma classification.Brendan Clarke - 2011 - Theoretical Medicine and Bioethics 32 (1):19-32.
    In this article, I begin by giving a brief history of melanoma causation. I then discuss the current manner in which malignant melanoma is classified. In general, these systems of classification do not take account of the manner of tumour causation. Instead, they are based on phenomenological features of the tumour, such as size, spread, and morphology. I go on to suggest that misclassification of melanoma is a major problem in clinical practice. I therefore outline an alternative means of classifying (...)
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  7.  82
    Evaluating evidence of mechanisms in medicine.Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael P. Kelly, Charles Norell, Federica Russo, Beth Shaw & Jon Williamson - 2018 - Dordrecht, Netherlands: Springer. Edited by Brendan Clarke, Phyllis Illari, Michael P. Kelly, Charles Norell, Federica Russo, Beth Shaw, Christian Wallmann, Michael Wilde & Jon Williamson.
    The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.
  8.  24
    Response to Open Peer Commentaries on “A Radical Approach to Ebola: Saving Humans and Other Animals”.Carolyn P. Neuhaus, Brendan Clarke, Phyllis Illari, Charles H. Norell & Sarah J. L. Edwards - 2019 - American Journal of Bioethics 19 (1):W8-W9.
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  9. Discovery in medicine.Brendan Clarke - 2016 - In Miriam Solomon, Jeremy R. Simon & Harold Kincaid (eds.), The Routledge Companion to Philosophy of Medicine. Routledge.
     
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  10.  15
    Mapping the methodologies of Burkitt lymphoma.Brendan Clarke - 2014 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 48:210-217.
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  11.  17
    Sampling philosophy of medicine: Philippe Huneman, Gérard Lambert and Marc Silberstein : Classification, disease and evidence: new essays in the philosophy of medicine. Dordrecht, Heidelberg, New York, London: Springer, 2015, 232pp, $129 HB.Brendan Clarke - 2015 - Metascience 25 (1):87-90.
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  12.  21
    Learning to Expect: Predicting Sounds During Movement Is Related to Sensorimotor Association During Listening.Jed D. Burgess, Brendan P. Major, Claire McNeel, Gillian M. Clark, Jarrad A. G. Lum & Peter G. Enticott - 2019 - Frontiers in Human Neuroscience 13.
  13.  40
    A Radical Approach to Ebola: Saving Humans and Other Animals.Sarah J. L. Edwards, Charles H. Norell, Phyllis Illari, Brendan Clarke & Carolyn P. Neuhaus - 2018 - American Journal of Bioethics 18 (10):35-42.
    As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...)
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  14.  25
    Making sense of failure. [REVIEW]Brendan Clarke - 2014 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 48:122-125.
    Essay review of C. Timmermann A history of lung cancer: The recalcitrant disease (Palgrave Macmillan, Basingstoke (2014)) and C. Timmermann, E. Toon (Eds.), Cancer patients, cancer pathways: historical and social perspectives (Palgrave Macmillan, Basingstoke (2012)).
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  15.  21
    First page preview.Jonathan Bain, Timothy Bays, Katherine A. Brading, Stephen G. Brush, Murray Clarke, Sharyn Clough, Jonathan Cohen, Giancarlo Ghirardi, Brendan S. Gillon & Robert G. Hudson - 2004 - International Studies in the Philosophy of Science 18 (2-3).
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  16. Metabolic theories of Whipple disease.Oscar Morice, Mathew Elameer, Mina Arsanious, Helen Stephens, Eleanor Soutter, Thomas Hughes & Brendan Clarke - manuscript
    Whipple disease is a rare, infectious, disease first described from a single case by Whipple in 1907. As well as characterising the clinical and pathological features of the condition, Whipple made two suggestions regarding its aetiology. These were either than the disease was caused by an infectious agent, or that it was of metabolic origin. As the disease is now thought to be caused by infection with the bacterium Tropheryma whipplei, historical reviews of the history of the disease typically mention (...)
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  17.  16
    The God Who Is Beauty: Beauty as a Divine Name in Thomas Aquinas and Dionysius the Areopagite. By Brendan Thomas Sammon. Pp. ix, 391, Cambridge, James Clarke, 2014, $44.00. [REVIEW]Patrick Madigan - 2016 - Heythrop Journal 57 (2):371-372.
  18. Whatever next? Predictive brains, situated agents, and the future of cognitive science.Andy Clark - 2013 - Behavioral and Brain Sciences 36 (3):181-204.
    Brains, it has recently been argued, are essentially prediction machines. They are bundles of cells that support perception and action by constantly attempting to match incoming sensory inputs with top-down expectations or predictions. This is achieved using a hierarchical generative model that aims to minimize prediction error within a bidirectional cascade of cortical processing. Such accounts offer a unifying model of perception and action, illuminate the functional role of attention, and may neatly capture the special contribution of cortical processing to (...)
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  19. Mindware: An Introduction to the Philosophy of Cognitive Science.Andy Clark - 2001 - New York: Oxford University Press.
    Mindware: An Introduction to the Philosophy of Cognitive Science invites readers to join in up-to-the-minute conceptual discussions of the fundamental issues, problems, and opportunities in cognitive science. Written by one of the most renowned scholars in the field, this vivid and engaging introductory text relates the story of the search for a cognitive scientific understanding of mind. This search is presented as a no-holds-barred journey from early work in artificial intelligence, through connectionist (artificial neural network) counter-visions, and on to neuroscience, (...)
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  20. What is the Benacerraf Problem?Justin Clarke-Doane - 2017 - In Fabrice Pataut Jody Azzouni, Paul Benacerraf Justin Clarke-Doane, Jacques Dubucs Sébastien Gandon, Brice Halimi Jon Perez Laraudogoitia, Mary Leng Ana Leon-Mejia, Antonio Leon-Sanchez Marco Panza, Fabrice Pataut Philippe de Rouilhan & Andrea Sereni Stuart Shapiro (eds.), New Perspectives on the Philosophy of Paul Benacerraf: Truth, Objects, Infinity (Fabrice Pataut, Editor). Springer.
    In "Mathematical Truth", Paul Benacerraf articulated an epistemological problem for mathematical realism. His formulation of the problem relied on a causal theory of knowledge which is now widely rejected. But it is generally agreed that Benacerraf was onto a genuine problem for mathematical realism nevertheless. Hartry Field describes it as the problem of explaining the reliability of our mathematical beliefs, realistically construed. In this paper, I argue that the Benacerraf Problem cannot be made out. There simply is no intelligible problem (...)
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  21. Morality and Mathematics.Justin Clarke-Doane - 2020 - Oxford, England: Oxford University Press.
    To what extent are the subjects of our thoughts and talk real? This is the question of realism. In this book, Justin Clarke-Doane explores arguments for and against moral realism and mathematical realism, how they interact, and what they can tell us about areas of philosophical interest more generally. He argues that, contrary to widespread belief, our mathematical beliefs have no better claim to being self-evident or provable than our moral beliefs. Nor do our mathematical beliefs have better claim (...)
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  22. Moral psychology as accountability.Brendan Dill & Stephen Darwall - 2014 - In Justin D'Arms & Daniel Jacobson (eds.), Moral Psychology and Human Agency: Philosophical Essays on the Science of Ethics. Oxford University Press UK. pp. 40-83.
    Recent work in moral philosophy has emphasized the foundational role played by interpersonal accountability in the analysis of moral concepts such as moral right and wrong, moral obligation and duty, blameworthiness, and moral responsibility (Darwall 2006; 2013a; 2013b). Extending this framework to the field of moral psychology, we hypothesize that our moral attitudes, emotions, and motives are also best understood as based in accountability. Drawing on a large body of empirical evidence, we argue that the implicit aim of the central (...)
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  23.  3
    Do Good Games Make Good People?Brendan P. Shea - 2013-08-26 - In Kevin S. Decker (ed.), Ender's Game and Philosophy. Wiley. pp. 89–98.
    Ender Wiggin spends much of Ender's Game playing games of one sort or another. These range from simple role‐playing games with his siblings (“buggers and astronauts”), to battleroom contests, to the strange free play Giant's Drink video game in which he must kill a giant and confront his deepest fears. This chapter examines the role that games play in Ender's development as both a military commander and as a human being. It considers a number of interrelated questions: What is a (...)
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  24. Some reflections on the relationship between religion and science, especially evolution.Brendan Sweetman - 2022 - In Joel C. Sagut & Alfredo P. Co (eds.), Faith and reason in the Catholic intellectual tradition. España, Manila, Philippines: University of Santo Tomas Publishing House.
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  25. Anomalous experience and delusional thinking: The logic of explanations.Brendan A. Maher - 1988 - In T. F. Oltmanns & B. A. Maher (eds.), Delusional Beliefs. John Wiley. pp. 15–33.
     
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  26. Mindware: An Introduction to the Philosophy of Cognitive Science.Andy Clark - 2001 - New York: Oxford University Press USA.
    Ranging across both standard philosophical territory and the landscape of cutting-edge cognitive science, Mindware: An Introduction to the Philosophy of Cognitive Science, Second Edition, is a vivid and engaging introduction to key issues, research, and opportunities in the field.Starting with the vision of mindware as software and debates between realists, instrumentalists, and eliminativists, Andy Clark takes students on a no-holds-barred journey through connectionism, dynamical systems, and real-world robotics before moving on to the frontiers of cognitive technologies, enactivism, predictive coding, and (...)
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  27.  8
    Resolving the evolutionary paradox of consciousness.Brendan P. Zietsch - forthcoming - Phenomenology and the Cognitive Sciences:1-19.
    Evolutionary fitness threats and rewards are associated with subjectively unpleasant and pleasant sensations, respectively. Initially, these correlations appear explainable via adaptation by natural selection. But here I analyse the major metaphysical perspectives on consciousness – physicalism, dualism, and panpsychism – and conclude that none help to understand the adaptive-seeming correlations via adaptation. I also argue that a recently proposed explanation, the phenomenal powers view, has major problems that mean it cannot explain the adaptive-seeming correlations via adaptation either. So the mystery (...)
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  28.  27
    Moral imagination: Facilitating prosocial decision-making through scene imagery and theory of mind.Brendan Gaesser, Kerri Keeler & Liane Young - 2018 - Cognition 171 (C):180-193.
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  29. On an argument for the impossibility of moral responsibility.Randolph Clarke - 2005 - Midwest Studies in Philosophy 29 (1):13-24.
    Galen Strawson has published several versions of an argument to the effect that moral responsibility is impossible, whether determinism is true or not. Few philosophers have been persuaded by the argument, which Strawson remarks is often dismissed “as wrong, or irrelevant, or fatuous, or too rapid, or an expression of metaphysical megalomania.” I offer here a two-part explanation of why Strawson’s argument has impressed so few. First, as he usually states it, the argument is lacking at least one key premise. (...)
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  30. Definite Descriptions and Semantic Pluralism.Brendan Murday - 2014 - Philosophical Papers 43 (2):255-284.
    We pose two arguments for the view that sentences containing definite descriptions semantically express multiple propositions: a general proposition as Russell suggested, and a singular proposition featuring the individual who uniquely satisfies the description at the world-time of utterance. One argument mirrors David Kaplan's arguments that indexicals express singular propositions through a context-sensitive character. The second argument mirrors Kent Bach's and Stephen Neale's arguments for pluralist views about terms putatively triggering conventional implicatures, appositive, and nonrestrictive relative clauses. After presenting these (...)
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  31.  6
    The Invisible Threshold: Two Plays by Gabriel Marcel.Brendan Sweetman, Maria Traub & Geoffrey Karabin (eds.) - 2019 - South Bend, Indiana: St. Augustine's Press.
    The plays in this new volume were written early in Marcel’s career, and were published together under the title Le Seuil invisible (The Invisible Threshold) in 1913. The first play, Grace, explores the theme of religious conversion. The drama depicts a crisis between characters of genuine depth and sincerity, who are struggling with different interpretations of shared experiences. Similar themes are addressed but developed differently in the second play, The Sandcastle. This drama explores the confrontation between one’s beliefs and their (...)
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  32. Reason to Feel Guilty.Randolph Clarke & Piers Rawling - 2022 - In Andreas Carlsson (ed.), Self-Blame and Moral Responsibility. New York, USA: Cambridge University Press. pp. 217-36.
    Let F be a fact in virtue of which an agent, S, is blameworthy for performing an act of A-ing. We advance a slightly qualified version of the following thesis: -/- (Reason) F is (at some time) a reason for S to feel guilty (to some extent) for A-ing. -/- Leaving implicit the qualification concerning extent, we claim as well: -/- (Desert) S's having this reason suffices for S’s deserving to feel guilty for A-ing. -/- We also advance a third (...)
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  33.  13
    Episodic mindreading: Mentalizing guided by scene construction of imagined and remembered events.Brendan Gaesser - 2020 - Cognition 203 (C):104325.
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  34.  10
    Burt uses a fallacious motte-and-bailey argument to dispute the value of genetics for social science.Brendan P. Zietsch, Abdel Abdellaoui & Karin J. H. Verweij - 2023 - Behavioral and Brain Sciences 46:e231.
    Burt's argument relies on a motte-and-bailey fallacy. Burt aims to argue against the value of genetics for social science; instead she argues against certain interpretations of a specific kind of genetics tool, polygenic scores (PGSs). The limitations, previously identified by behavioural geneticists including ourselves, do not negate the value of PGSs, let alone genetics in general, for social science.
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  35. Are Credences Different From Beliefs?Roger Clarke & Julia Staffel - forthcoming - In Ernest Sosa, Matthias Steup, John Turri & Blake Roeber (eds.), Contemporary Debates in Epistemology, 3rd edition. Wiley-Blackwell.
    This is a three-part exchange on the relationship between belief and credence. It begins with an opening essay by Roger Clarke that argues for the claim that the notion of credence generalizes the notion of belief. Julia Staffel argues in her reply that we need to distinguish between mental states and models representing them, and that this helps us explain what it could mean that belief is a special case of credence. Roger Clarke's final essay reflects on the (...)
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  36.  11
    An invitation to applied category theory: seven sketches in compositionality.Brendan Fong - 2019 - New York, NY: Cambridge University Press. Edited by David I. Spivak.
    Category theory reveals commonalities between structures of all sorts. This book shows its potential in science, engineering, and beyond.
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  37.  20
    Natural language semantics: formation and valuation.Brendan S. Gillon - 2019 - Cambridge, Massachussetts: The MIT Press.
    This textbook, which is completely self-contained and can be read by anyone with a secondary school education, is the result of the author's material prepared over the past 15 years of teaching introductory natural language semantics to graduate and undergraduate students at McGill University. The intended audience comprises undergraduate and graduate students in linguistics as well as those in philosophy, computer science and psychology with an interest in natural language semantics. The aim of the textbook is to teach the fundamentals (...)
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  38.  3
    Adam Smith and the invisible hand of God.Brendan Long - 2022 - New York: Routledge, Taylor & Francis Group.
    This book contributes to the 'new view' reading of Adam Smith, providing a historically and contextually rich interpretation of Smith's thought. Smith built a moral philosophy on the foundations of a natural theology of human sociality. Examination of his life, relationship with David Hume, and use of divine names shows that he retained a progressive form of Christian theism. The book interrogates the metaphor of the 'invisible hand' and highlights the importance of the religious dimension of Adam Smith's thought for (...)
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  39.  4
    Walter Benjamin and political theology.Brendan P. Moran & Paula Schwebel (eds.) - 2024 - London: Bloomsbury Academic.
    Tracing Walter Benjamin's convergences with, and divergences from, influential German theorist Carl Schmitt, this edited collection places his thinking in the context of broader 20th century political philosophy of his time, and examines the question of whether Benjamin presents the possibility for a distinctive political theology, mapping the coordinates of this question without collapsing the tensions internal to Benjamin's thought. This volume brings together a host of multifaceted contributions that explore why Benjamin has been a fertile source for thinking about (...)
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  40.  52
    Omissions: Agency, Metaphysics, and Responsibility.Randolph K. Clarke - 2014 - New York, NY: Oxford University Press.
    Philosophical theories of agency have focused primarily on actions and activities. But, besides acting, we often omit to do or refrain from doing certain things. How is this aspect of our agency to be conceived? This book offers a comprehensive account of omitting and refraining, addressing issues ranging from the nature of agency and moral responsibility to the metaphysics of absences and causation. Topics addressed include the role of intention in intentional omission, the connection between negligence and omission, the distinction (...)
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  41.  6
    Delusions as the Product of Normal Cognitions.Brendan A. Maher - 1988 - In T. F. Oltmanns & B. A. Maher (eds.), Delusional Beliefs. John Wiley. pp. 333-6.
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  42.  64
    Philosophy in Classical India: The Proper Work of Reason.Brendan S. Gillon - 2003 - Mind 112 (448):707-711.
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  43. Skilled activity and the causal theory of action.Randolph Clarke - 2010 - Philosophy and Phenomenological Research 80 (3):523-550.
    Skilled activity, such as shaving or dancing, differs in important ways from many of the stock examples that are employed by action theorists. Some critics of the causal theory of action contend that such a view founders on the problem of skilled activity. This paper examines how a causal theory can be extended to the case of skilled activity and defends the account from its critics.
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  44. Ethical Explorations: Moral Dilemmas in a Universe of Possibilities.Brendan Shea - 2023 - Rochester, MN: Thoughtful Noodle Books.
    "Ethical Explorations: Moral Dilemmas in a Universe of Possibilities" by Brendan Shea is an open access textbook that provides a comprehensive study of ethical philosophy. Shea makes it his task to chart the sprawling landscape of moral thought from ancient times to the present, employing a straightforward, easily accessible style. -/- In the book, each chapter addresses a distinct ethical theory. Shea discusses everything from Plato's allegorical Cave to contemporary issues in bioethics. The text features relatable narratives, clear explanations (...)
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  45. The Tenuous Harmony of Imagination, Vision, and Critique.Brendan Hogan - 2019 - In Randall Auxier, Eli Kramer & Krzysztof Piotr Skowroński (eds.), Rorty and Beyond. Lanham, Maryland: Lexington Books.
  46.  51
    Emily Grosholz and Herbert Breger, editors. The Growth of Mathematical Knowledge.Brendan P. Larvor - 2002 - Philosophia Mathematica 10 (1):93-96.
  47.  11
    The God who is beauty: beauty as a divine name in Thomas Aquinas and Dionysius the Areopagite.Brendan Thomas Sammon - 2013 - Eugene, Oregon: Pickwick Publications.
    When in the sixth century Dionysius the Areopagite declared beauty to be a name for God, he gave birth to something that had long been gestating in the womb of philosophical and theological thought. In doing so, Dionysius makes one of his most pivotal contributions to Christian theological discourse. It is a contribution that is enthusiastically received by the schoolmen of the Middle Ages, and it comes to permeate the thought of scholasticism in a multitude of ways. But perhaps nowhere (...)
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  48.  5
    Philosophical thinking and the religious context: essays in honor of Santiago Sia.Brendan Sweetman (ed.) - 2013 - New York: Bloomsbury Academic.
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  49.  73
    The soul of Nietzsche's Beyond good and evil.Maudemarie Clark & David Dudrick - 2012 - New York: Cambridge University Press. Edited by David Dudrick.
    This book presents a provocative new interpretation of what is arguably Nietzsche's most important and most difficult work, Beyond Good and Evil.
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  50. Promises as Proposals in Joint Practical Deliberation.Brendan Kenessey - 2020 - Noûs 54 (1):204-232.
    This paper argues that promises are proposals in joint practical deliberation, the activity of deciding together what to do. More precisely: to promise to ϕ is to propose (in a particular way) to decide together with your addressee(s) that you will ϕ. I defend this deliberative theory by showing that the activity of joint practical deliberation naturally gives rise to a speech act with exactly the same properties as promises. A certain kind of proposal to make a joint decision regarding (...)
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