Plasmodium falciparum is the most deadly human malarial parasite, responsible for an estimated 207 million cases of disease and 627,000 deaths in 2012. Recent studies reveal that the parasite actively regulates a large fraction of its genes throughout its replicative cycle inside human red blood cells and that epigenetics plays an important role in this precise gene regulation. Here, we discuss recent advances in our understanding of three aspects of epigenetic regulation in P. falciparum: changes in histone modifications, nucleosome occupancy (...) and the three‐dimensional genome structure. We compare these three aspects of the P. falciparum epigenome to those of other eukaryotes, and show that large‐scale compartmentalization is particularly important in determining histone decomposition and gene regulation in P. falciparum. We conclude by presenting a gene regulation model for P. falciparum that combines the described epigenetic factors, and by discussing the implications of this model for the future of malaria research. (shrink)

John Stuart Mill (1806 1873) was one of Britain's greatest philosophers and radical politicians, whose views had a profound influence on thinking on liberty, social policy and gender relations. William Stafford's accessible study outlines Mill's reputation from his lifetime to the present, together with a discussion of the major areas of his moral and political thought.

This fascinating book examines what sixteen radical and conservative, famous and notorious British women wrote about their sex in the 1790s. It offers the most comprehensive survey of what they thought about their fellow women with regard to love, sexual desire and marriage; their domestic roles and their engagement in the 'public' sphere; and issues of gender and female abilities including sensibility and genius. How contemporary reviewers divided women writers into 'unsex'd' and 'proper' is investigated, as is the issue of (...) whether they attempted to exclude women from certain kinds of writing. The book reveals the depth of female complaint but contends that women did not passively submit. Conservative and radicals alike sought to extend their sphere of activity, to reform men, challenge gender stereotypes and propose that a woman should be a self for herself and her God rather than for her husband. (shrink)

Clear, concise and authoritative, Professor Stafford summarises and discusses five key works of one of England's greatest nineteenth-century thinkers: Mill's autobiography, Considerations on representative government, On liberty, The subjection of women and utilitarianism. Every year students of a variety of disciplines, political thought, history, literature, must rapidly acquire a basic understanding of some of Mill's principal ideas, their historical importance and continuing significance. This original work will be an invaluable companion.

Sir Roderick Murchison's Humboldtian belief in a close linkage between the sciences of geology and physical geography finds its best illustration in his prediction of the three-dimensional structure of Africa in 1852 from explorers' reports, fossil discoveries, and a theory of crustal uplift and fracturing elaborated by the Cambridge mathematician William Hopkins. From this remarkably accurate hypothesis and other theories which he had developed concerning the occurrence of coal and gold, Murchison concluded that exploitable deposits of economic minerals which (...) might justify the foundation of a series of new British colonies could be systematically discovered around the continent's elevated rim. As the simultaneous President of the Royal Geographical Society and Director-General of the British Geological Survey, Murchison subsequently organized the dispatch of numerous scientific exploring expeditions to test his theory and reconnoitre commercial opportunities in Africa. While widening the frontier of British science, he thus schooled the imperial government in the belief that science could serve the drive for national expansion. His views on the physical, biological, and cultural conservatism of Africa also provided scientific justification for Victorian schemes of improvement, and his promotional activities helped set the stage for the British annexations in the continent during its fin de siècle partition by the European powers. (shrink)

ABSTRACT Attention is usually drawn to the negative relationship between Richard Hooker and his Puritan opponents. Such concerns dominate the polemical landscape of the late 16th and 17th centuries. However, the extent to which later Puritans appear to converge on Hooker’s epistemology and overall attitude to the place of reason, Scripture and sacrament is often overlooked. This paper consider some key affirmations from Richard Baxter, John Owen and Hooker’s contemporary William Perkins. The paper concludes that in more settled times (...) substantive agreement might have been found on issues that during the reigns of Elizabeth and James I were profoundly divisive including the question of ministry orders. (shrink)

Propounds a moderate view of animal rights, in 17 essays reprinted from various publications. Among the authors are Jane Goodall, Steve Siegel, and Tim Stafford. No index. Annotation copyrighted by Book News, Inc., Portland, OR.

Barbara Stafford is at the forefront of a growing movement that calls for the humanities to confront the brain’s material realities. In Echo Objects she argues that humanists should seize upon the exciting neuroscientific discoveries that are illuminating the underpinnings of cultural objects. In turn, she contends, brain scientists could enrich their investigations of mental activity by incorporating phenomenological considerations—particularly the intricate ways that images focus intentional behavior and allow us to feel thought. This, then, is a book for (...) both sides of the aisle, a stunningly broad exploration of how complex images—or patterns that compress space and time—make visible the invisible ordering of human consciousness. Stafford demonstrates, for example, how the compound formats of emblems, symbols, collage, and electronic media reveal the brain’s grappling to construct mental objects that are redoubled by prior associations. On the other hand, she compellingly shows that findings in evolutionary biology and the neurosciences are providing profound opportunities for understanding aesthetic conundrums as old and deep-seated as the human urge to imitate, the mapping of inner space, and the role of narrative and nonnarrative representation. As precise in her discussions of firing neurons as she is about the coordinating dynamics of image making, Stafford locates these major transdisciplinary issues at the intersection of art, science, philosophy, and technology. Ultimately, she makes an impassioned plea for a common purpose—for the acknowledgement that, at the most basic level, these separate projects belong to a single investigation. (shrink)

In his book SEXUAL DESIRE, Roger Scruton wrongly maintains that human sexual experience is essential intentional. His thesis depends on his highly revisionary definition of 'sexual desire', the artificial nature of which I expose and criticise. He admits that homosexual desire is capable of the same kind of intentionality as heterosexual desire, and is therefore not intrinsically obscene or perverted, but he advances reasons why homosexuality is morally different from heterosexuality and is therefore an object of disapproval. His arguments presuppose (...) 'an impassable moral divide' between the sexes, and are, on his own admission, not very cogent. Since he allows that homosexual desire is a natural and spontaneous phenomenon and also proposes that moral education should guide us towards a state in which our sexuality is entirely integrated within a life of personal affection and responsibility, consistency requires that he adopt a sexual ideology which does not discriminate against homosexuality. For homosexuals are unlikely to achieve the 'sexual integrity' which Scruton advocates (and which I endorse) if they are constantly encouraged to disparage their own sexual nature and if social institutions make no positive provision for them. (shrink)

Philosophy has often been represented by its detractors, and even sometimes by its practitioners, as a subject which, unlike the natural sciences, exhibits a degree of progress far from commensurate with its long history. Many of the questions entertained by the ancients are still very much alive: answers proffered are put forward very tentatively, seldom meet with universal acceptance, and frequently give rise to controversy even more prolific than that which they were intended to lay low.

In The Emergent Self, William Hasker joins one of the most heated debates in contemporary analytic philosophy, that over the nature of mind.

Toward theory a homuncular of believing For years and years, philosophers took thoughts and beliefs to be modifications of incorporeal Cartesian egos. ...

Research programs in empirical psychology over the past few decades have led scholars to posit implicit biases. This is due to the development of innovative behavioural measures that have revealed aspects of our cognitions which may not be identified on self-report measures requiring individuals to reflect on and report their attitudes and beliefs. But what does it mean to characterise such biases as implicit? Can we satisfactorily articulate the grounds for identifying them as bias? And crucially, what sorts of cognitions (...) are in fact being measured; what mental states or processes underpin such behavioural responses? In this paper, we outline some of the philosophical and empirical issues engaged when attempting to address these three questions. Our aim is to provide a constructive taxonomy of the issues, and how they interrelate. As we will see, any view about what implicit bias is may depend on a range of prior theoretical choices. (shrink)

J Martin Stafford; A Rejoinder to Professor Edgley, Journal of Philosophy of Education, Volume 15, Issue 2, 30 May 2006, Pages 171–174, https://doi.org/10.1111/.

J Martin Stafford; In Defence of Sensualism: a reply to M. J. Newby, Journal of Philosophy of Education, Volume 23, Issue 1, 30 May 2006, Pages 123–128, https:/.

J Martin Stafford; John Wilson, Prophet of the Sane Society, Journal of Philosophy of Education, Volume 13, Issue 1, 30 May 2006, Pages 169–186, https://doi.org.

J Martin Stafford; Marxism, Neutrality and Education, Journal of Philosophy of Education, Volume 15, Issue 2, 30 May 2006, Pages 161–166, https://doi.org/10.111.

J Martin Stafford; Public Schools, Private Privilege and Common Sense, Journal of Philosophy of Education, Volume 19, Issue 1, 30 May 2006, Pages 137–141, https.

This is merely a non-commercial limited reprint of two previously published essays. No ISBN. It includes 'Hutcheson, Hume and the Ontology of Morals' (1985) and 'Hume, Spencer and the Standard of Morals' (1983). It was superseded in 1995 by the author's collected ESSAYS ON SEXUALITY AND ETHICS - ISBN 095125944X, which includes these two plus eight other articles.

Descartes has often been called the 'father of modern philosophy'. His attempts to find foundations for knowledge, and to reconcile the existence of the soul with the emerging science of his time, are among the most influential and widely studied in the history of philosophy. This is a classic and challenging introduction to Descartes by one of the most distinguished modern philosophers. Bernard Williams not only analyzes Descartes' project of founding knowledge on certainty, but uncovers the philosophical motives for his (...) search. With acute insight, he demonstrates how Descartes' _Meditations _are not merely a description but the very enactment of philosophical thought and discovery. Williams covers all of the key areas of Descartes' thought, including God, the will, the possibility of knowledge, and the mind and its place in nature. He also makes profound contributions to the theory of knowledge, metaphysics and philosophy generally. With a new foreword by John Cottingham. (shrink)

For this 1897 publication, the American philosopher William James brought together ten essays, some of which were originally talks given to Ivy League societies. Accessible to a broader audience, these non-technical essays illustrate the author's pragmatic approach to belief and morality, arguing for faith and action in spite of uncertainty. James thought his audiences suffered 'paralysis of their native capacity for faith' while awaiting scientific grounds for belief. His response consisted in an attitude of 'radical empiricism', which deals practically (...) rather than ideologically with real-world phenomena. When facing a 'momentous' decision about belief, he says, we both can and must choose the best hypothesis. The first four essays apply this principle to religious faith, and the rest explore the pragmatic approach to such topics as determinism, ethics and individual achievement. James developed his ideas further in The Varieties of Religious Experience and Pragmatism, both of which are reissued in this series. (shrink)

The Gifford Lectures were established in 1885 at the universities of St Andrews, Glasgow, Aberdeen and Edinburgh to promote the discussion of 'Natural Theology in the widest sense of the term - in other words, the knowledge of God', and some of the world's most influential thinkers have delivered them. The 1901–2 lectures given in Edinburgh by American philosopher William James are considered by many to be the greatest in the series. The lectures were published in book form in (...) 1902 and have been reprinted many times. James, who was educated in the United States and Europe, and spent much of his career teaching philosophy at Harvard, was very influential in the development of modern psychology, and in these twenty lectures he explores the personal experience of religion. Some of the topics include religion and neurology, 'the sick soul', saintliness, and mysticism. (shrink)

This small book is very large: it contains the living universe. It is a privilege to be asked to write this preface, and a delight to do so. That is because I recognize here a really important book, both in general and specifically. Before talking about the specific contents at all, I would like to explain why this is in general so.

"The lectures that follow were delivered at the Lowell Institute in Boston in November and December, 1906, and in January, 1907, at Columbia University, in New York."-Preface, pg. 3.

Descartes has often been called the 'father of modern philosophy'. His attempts to find foundations for knowledge, and to reconcile the existence of the soul with the emerging science of his time, are among the most influential and widely studied in the history of philosophy. This is a classic and challenging introduction to Descartes by one of the most distinguished modern philosophers. Bernard Williams not only analyzes Descartes' project of founding knowledge on certainty, but uncovers the philosophical motives for his (...) search. With acute insight, he demonstrates how Descartes' _Meditations _are not merely a description but the very enactment of philosophical thought and discovery. Williams covers all of the key areas of Descartes' thought, including God, the will, the possibility of knowledge, and the mind and its place in nature. He also makes profound contributions to the theory of knowledge, metaphysics and philosophy generally. With a new foreword by John Cottingham. (shrink)

This book analyzes the support that should be given to minority views, reconsidering classic debates in Science and Technology Studies and examining numerous case studies.

One of the most influential men of his time, philosopher, psychologist, educator, and author William James (1842-1910) helped lead the transition from a predominantly European-centered nineteenth-century philosophy to a new "pragmatic" American philosophy. Helping to pave the way was his seminal book Pragmatism (1907), in which he included a chapter on "Truth," an essay which provoked severe criticism. In response, he wrote the present work, an attempt to bring together all he had ever written on the theory of knowledge, (...) including an article on the function of cognition, later polemic and expository contributions, and some replies to previous criticism. The result was a full and definitive expression of the pragmatist "epistemology" from James' point of view. In the book, he urges the reader to "turn away from abstractions, verbal solutions, fixed principles, and pretended absolutes and look for concreteness and facts, action and power," arguing that "the ultimate test for us of what a truth means is the conduct it dictates or inspires." For students, scholars--anyone interested in William James or the history of American philosophical thought--this book offers an in-depth exposition of the influential ideas of one of the greatest American thinkers. Unabridged republication of the edition originally published by Longmans, Green and Co., New York and London, 1909. (shrink)

Complexity, agency, and time -- The vicissitudes of experience -- Belief, spirituality, and time -- The human predicament -- Capital flows, sovereign decisions, and world resonance machines -- The theorist and the seer.

Noted psychologist and philosopher develops his own brand of pragmatism, based on theories of C. S. Peirce. Emphasis on "radical empiricism," versus the transcendental and rationalist tradition. One of the most important books in American philosophy. Note.

Two books bound together, from the religious period of one of the most renowned and representative thinkers. Written for laymen, thus easy to understand, it is penetrating and brilliant as well. Illuminations of age-old religious questions from a pragmatic perspective, written in a luminous style.

I argue that a common philosophical approach to the interpretation of physical theories—particularly quantum field theories—has led philosophers astray. It has driven many to declare the quantum field theories employed by practicing physicists, so-called ‘effective field theories’, to be unfit for philosophical interpretation. In particular, such theories have been deemed unable to support a realist interpretation. I argue that these claims are mistaken: attending to the manner in which these theories are employed in physical practice, I show that interpreting effective (...) field theories yields a robust foundation for a more refined approach to scientific realism in the context of quantum field theory. The paper concludes by briefly sketching some general morals for interpretive practice in the philosophy of physics. (shrink)