Entry into mitosis is driven by the activity of kinases, which phosphorylate over 7000 proteins on multiple sites. For cells to exit mitosis and segregate their genome correctly, these phosphorylations must be removed in a specific temporal order. This raises a critical and important question: how are specific phosphorylation sites on an individual protein removed? Traditionally, the temporal order of dephosphorylation was attributed to decreasing kinase activity. However, recent evidence in human cells has identified unique patterns of dephosphorylation during mammalian (...) mitotic exit that cannot be fully explained by the loss of kinase activity. This suggests that specificity is determined in part by phosphatases. In this review, we explore how the physicochemical properties of an individual phosphosite and its surrounding amino acids can affect interactions with a phosphatase. These positive and negative interactions in turn help determine the specific pattern of dephosphorylation required for correct mitotic exit. (shrink)

Hemispatial neglect in imagery implies a spatially organised representation. Reaction times in memory for arrays of locations from shifted viewpoints indicate processes analogous to actual bodily movement through space. Behavioral data indicate a privileged role for this process in memory. A proposed spatial mechanism makes contact with direct recordings of the representations of location and orientation in the mammalian brain.

Conceptual engineering and conceptual ethics are branches of philosophy concerned with questions about how to assess and ameliorate our representational devices (such as concepts and words). It's a part of philosophy concerned with questions about which concepts we should use (and why), how concepts can be improved, when concepts should be abandoned, and how proposals for amelioration can be implemented. Central parts of the history of philosophy have engaged with these issues, but the focus of this volume is on applications (...) to work in contemporary philosophy of language and mind, epistemology, gender and race theory, ethics, philosophy of science, and philosophical logic. This is the first volume devoted entirely to conceptual engineering and conceptual ethics. The volume explores the possibilities, benefits, problems, and applications of conceptual engineering and conceptual ethics. It consists of twenty chapters written by leading philosophers. (shrink)

Which concepts should we use to think and talk about the world and to do all of the other things that mental and linguistic representation facilitates? This is the guiding question of the field that we call ‘conceptual ethics’. Conceptual ethics is not often discussed as its own systematic branch of normative theory. A case can nevertheless be made that the field is already quite active, with contributions coming in from areas as diverse as fundamental metaphysics and social/political philosophy. In (...) this pair of papers, we try to unify the field, reflecting on its basic nature, structure, and methodology. (shrink)

This paper elaborates and defends an expressivist account of the claims of mind-independence embedded in ordinary moral thought. In response to objections from Zangwill and Jenkins it is argued that the expressivist 'internal reading' of such claims is compatible with their conceptual status and that the only 'external reading' available doesn't commit expressivisists to any sort of subjectivism. In the process a 'commitment-theoretic' account of the semantics of conditionals and negations is defended.

Saul Kripke has been a major influence on analytic philosophy and allied fields for a half-century and more. His early masterpiece, Naming and Necessity, reversed the pattern of two centuries of philosophizing about the necessary and the contingent. Although much of his work remains unpublished, several major essays have now appeared in print, most recently in his long-awaited collection Philosophical Troubles. In this book Kripke’s long-time colleague, the logician and philosopher John P. Burgess, offers a thorough and self-contained guide (...) to all of Kripke’s published books and his most important philosophical papers, old and new. It also provides an authoritative but non-technical account of Kripke’s influential contributions to the study of modal logic and logical paradoxes. Although Kripke has been anything but a system-builder, Burgess expertly uncovers the connections between different parts of his oeuvre. Kripke is shown grappling, often in opposition to existing traditions, with mysteries surrounding the nature of necessity, rule-following, and the conscious mind, as well as with intricate and intriguing puzzles about identity, belief and self-reference. Clearly contextualizing the full range of Kripke’s work, Burgess outlines, summarizes and surveys the issues raised by each of the philosopher’s major publications. Kripke will be essential reading for anyone interested in the work of one of analytic philosophy’s greatest living thinkers. (shrink)

Which concepts should we use to think and talk about the world, and to do all of the other things that mental and linguistic representation facilitates? This is the guiding question of the field that we call ‘conceptual ethics’. Conceptual ethics is not often discussed as its own systematic branch of normative theory. A case can nevertheless be made that the field is already quite active, with contributions coming in from areas as diverse as fundamental metaphysics and social/political philosophy. In (...) this pair of papers, we try to unify the field, reflecting on its basic nature, structure, and methodology. (shrink)

Some people argue that the distribution of medical resources should be sensitive to agents’ responsibility for their ill-health. In contrast, others point to the social determinants of health to argue that the collective agents that control the conditions in which agents act should bear responsibility. To a large degree, this is a debate in which those who hold individuals responsible currently have the upper hand: warranted appeals to individual responsibility effectively block allocation of any significant degree of responsibility to collective (...) agents. We suggest that a different understanding of individual responsibility might lead to a fairer allocation of blame. Scaffolded agency is individual agency exercised in a context in which opportunities and affordances are structured by others. Appeals to scaffolded agency at once recognize the role of the individual and of the collective agents who have put the scaffolds in place. (shrink)

Botswana’s history is one of an unwavering exercise of self-determination and quest for self-rule. Post-independence, self-government prioritized an overarching philosophy of Kagisano or social harmony within which the aims of education were framed, in conjunction with a political commitment to Botho through democracy. For economic and social reasons the current educational policy of Botswana is based on outcomes based education (OBE), with its metrics of quantifiable outcomes. The article argues that Olúfemi Táíwò’s analysis of decolonization provides a philosophical lens through (...) which to interpret Botswana’s current educational pathway within the prevailing decolonization discourse. OBE clearly exhibits features of neo-colonialism, as it pertains to the national value principles. We draw on Ndlovu-Gatsheni decolonial epistemic perspective to frame the discussion that were possible to integrate OBE with Botswana’s ethnically inclusive, community-based view of democracy and associated virtues, this would be a worthwhile goal for education and could lead to a particular form of indigenised democracy. Substantive distinctions among the concepts of decolonization, neo-colonialism, and decoloniality, underwrite this thesis. We see the project of envisaging a future of education in Botswana as having to do with disentangling colonialist-imperialist cultural reproduction from indigenous aspirations. (shrink)

I defend hedonism about moral value by first presenting an argument for moral skepticism, and then showing that phenomenal introspection gives us a unique way to defeat the skeptical argument and establish pleasure's goodness.

McKenna’s critique (rather than criticisms) of idealized approaches to epistemology is an important contribution to the literature. In this brief discussion, I set out his main concerns about more idealized approaches, within and beyond social epistemology, before turning to some issues I think he neglects. I suggest that it’s important to pay attention to the prestige hierarchy in philosophy, and to how that hierarchy can serve ideological purposes. The greater prestige of more abstract approaches plays a role in determining what (...) issues and what voices we attend to. (shrink)

An account of how a rational agent should revise beliefs in the light of new evidence.

This book highlights the philosophical and creative basis of knowledge co-production by all citizens regardless of socio-economic background in contrast with neoliberal ideology. Exploring beginning, transitional and theorised practices, the book is a memoir of the author's extensive personal and educational experience. Each topic is discussed in relation to a number of pragmatist themes that run throughout to illustrate how the process of dialectical emergence underpins and substantiates meaningful human living. Building on the work of American Pragmatism, this is a (...) systematic and detailed reintroduction of pragmatism to educators worldwide for progressive educational change. (shrink)

Introduction -- Cultural theories of people -- Identities in standard English -- Language and social institutions -- The cultural self -- The self's identities -- Theories of identities and selves -- Theories of norms and institutions -- Social reality and human subjectivity.

This Handbook provides an interdisciplinary discussion on the role and complexity of ethics in education. Its central aim is to democratise scholarship by highlighting diverse voices, ideas, and places. It is organised into three sections, each examining ethics from a different perspective: ethics and education historically; ethics within institutional practice, and emerging ethical frameworks in education. Important questions are raised and discussed, such as the role of past ethical traditions in contemporary education, how educators should confront ethical dilemma, how schools (...) should be organised to serve all children, and how pluralism, democracy, and technology impact ethics in education. It offers new insights and opportunities for renewal in the complex and often contentious task of ethics and education. (shrink)

Causal theories of action, perception and knowledge are each beset by problems of so-called ‘deviant’ causal chains. For each such theory, counterexamples are formed using odd or co-incidental causal chains to establish that the theory is committed to unpalatable claims about some intentional action, about a case of veridical perception or about the acquisition of genuine knowledge. In this paper I will argue that three well-known examples of a deviant causal chain have something in common: they each violate Yablos proportionality (...) constraint on causation. I will argue that this constraint provides the key to saving causal theories from deviant chains. (shrink)

Thomas Kelly, “Quine and Epistemology”: For Quine, as for many canonical philosophers since Descartes, epistemology stands at the very center of philosophy. In this chapter, I discuss some central themes in Quine's epistemology. I attempt to provide some historical context for Quine's views, in order to make clear why they were seen as such radical challenges to then prevailing orthodoxies within analytic philosophy. I also highlight aspects of his views that I take to be particularly relevant to contemporary epistemology.

Time passes; sometimes swiftly, sometimes interminably, but always it passes. We see the world change as events emerge from the shroud of the future, clandestinely slinking into the past almost immediately as though they are reluctant to meet our gaze: children are born, old friends and relatives die, governments once full of youthful enthusiasm wane. If the Earth were sentient, it might feel itself being torn apart as tectonic plates diverge, and chuckle as it outlived species upon species of transient (...) parasites. How could anyone possibly deny that time passes? (shrink)

How may we characterize the intrinsic structure of physical quantities such as mass, length, or electric charge? This article shows that group-theoretic methods—specifically, the notion of a free and transitive group action—provide an elegant way of characterizing the structure of scalar quantities, and uses this to give an intrinsic treatment of vector quantities. It also gives a general account of how different scalar or vector quantities may be algebraically combined with one another. Finally, it uses this apparatus to give a (...) simple intrinsic treatment of Newtonian gravitation. (shrink)

We explain and explore class-theoretic potentialism—the view that one can always individuate more classes over a set-theoretic universe. We examine some motivations for class-theoretic potentialism, before proving some results concerning the relevant potentialist systems (in particular exhibiting failures of the $\mathsf {.2}$ and $\mathsf {.3}$ axioms). We then discuss the significance of these results for the different kinds of class-theoretic potentialists.

For more than 60 years, Chomsky has been an intellectual Colossus bestriding the worlds of language, philosophy, and the cognitive sciences, and focusing attention on the whole field and emphasizing the crucial importance of domains overlooked by the mainstream. One such area is the study of first‐language acquisition. This chapter considers “atypical acquisition” to cover two conceptually related situations. First, it covers a variety of cases where there is an obvious “poverty of the stimulus” in that children either receive or (...) perceive no linguistic input at the essential early stages referred to as critical periods. Second, it covers where there is rather the opposite situation. The chapter presents atypicality in language acquisition that stems from the learner's atypical neurological profile rather than environmental or input properties. It focuses on Developmental Language Disorder, Autism Spectrum Disorder, and the case of the polyglot‐savant Christopher to exemplify atypical acquisition. (shrink)

This book was written with my University of Mississippi "Philosophy of Religion" students in mind. Many of them have no prior experience with philosophy. That is why Chapter One begins with a crash course in philosophy, with an emphasis on the basic concepts in logic, metaphysics, and epistemology. While not all students may need to cover that material, quite a few will. And for the rest, a refresher never hurts. I am sure this applies to many "Philosophy of Religion" courses (...) taught elsewhere. With that in mind, instructors are advised to begin with Chapter One. The subsequent chapters have been arranged in sequence, with each chapter building on the prior ones. However, the chapters are not that tightly bound, so instructors could cover the chapters out of sequence without much disruption. Key terms are underlined. Sometimes the key terms also occur with an associated hyperlink. Other terms have a hyperlink without a corresponding key term. In the print the hyperlink is included as a footnote, in the ebooks the term is hyperlinked [Production - check the ebooks will have hyperlinbks - amend wording here if not]. In general, the hyperlinks follow a pattern. First, key terms are often linked to entries in online academic encyclopedias - either The Stanford Encyclopedia of Philosophy, The Internet Encyclopedia of Philosophy, or The Encyclopedia Britannica. [Students are recommended also to consult The Encyclopedia of Philosophy (1967), edited by Paul Edwards; it is still an excellent resource and has entries corresponding to many key terms. Almost every university library has a copy.] Second, named individuals are sometimes linked to an encyclopedia entry. In both sorts of cases, the URL is provided in an endnote at the end of each chapter. No other description of the contents of the web page will be given. In most other cases, a short description of the contents of the web page is provided in the endnote. Each chapter includes an annotated bibliography for more advanced material. Helpful material is also available on the website for this book. This material includes a glossary, a sample syllabus (with recommended readings), study questions, and a test bank, among other features. (shrink)

Informally rigorous mathematical reasoning is relevant. So too should be the premises to the conclusions of formal proofs that regiment it. The rule Ex Falso Quodlibet induces spectacular irrelevance. We therefore drop it. The resulting systems of Core Logic C and Classical Core Logic C+ can formalize all the informally rigorous reasoning in constructive and classical mathematics respectively. We effect a revised match-up between deducibility in Classical Core Logic and a new notion of relevant logical consequence. It matches better the (...) deducibility relation of Classical Core Logic than does the Tarskian notion of consequence. It is implosive, not explosive. (shrink)