The concept of minimal risk has been used to regulate and limit participation by adolescents in clinical trials. It can be understood as setting an absolute standard of what risks are considered minimal or it can be interpreted as relative to the actual risks faced by members of the host community for the trial. While commentators have almost universally opposed a relative interpretation of the environmental risks faced by potential adolescent trial participants, we argue that the ethical concerns against the (...) relative standard may not be as convincing as these commentators believe. Our aim is to present the case for a relative standard of environmental risk in order to open a debate on this subject. We conclude by discussing how a relative standard of environmental risk could be defended in the specific case of an HIV vaccine trial among adolescents in South Africa. (shrink)

ABSTRACT For some years now, the history of modern mathematics and the history of modern science have developed independently. A step toward a reunification that would benefit both disciplines could come about through a revived appreciation of mathematical practice. Detailed studies of what mathematicians actually do, whether local or broadly based, have often led in recent work to examinations of the social, cultural, and national contexts, and more can be done. Another recent approach toward a historical understanding of the abstractness (...) of modern mathematics has been to see it as a species of modernism, and this thesis will be tested by the raft of works on the history of modern applied mathematics currently under way. (shrink)

The prime number theorem, established by Hadamard and de la Vallée Poussin independently in 1896, asserts that the density of primes in the positive integers is asymptotic to 1/ln x. Whereas their proofs made serious use of the methods of complex analysis, elementary proofs were provided by Selberg and Erdos in 1948. We describe a formally verified version of Selberg's proof, obtained using the Isabelle proof assistant.

1.1 Some examples of rule induction on permutations . . . . . . . 6 1.2 Ways of making new permutations . . . . . . . . . . . . . . . 7 1.3 Further results . . . . . . . . . . . . . . . . . . . . . . . . . . 8 1.4 Removing elements . . . . . . . . . . (...) . . . . . . . . . . . . . . 8.. (shrink)

Henri Poincaré was not just one of the most inventive, versatile, and productive mathematicians of all time--he was also a leading physicist who almost won a Nobel Prize for physics and a prominent philosopher of science whose fresh and surprising essays are still in print a century later. The first in-depth and comprehensive look at his many accomplishments, Henri Poincaré explores all the fields that Poincaré touched, the debates sparked by his original investigations, and how his discoveries still contribute to (...) society today. Math historian Jeremy Gray shows that Poincaré's influence was wide-ranging and permanent. His novel interpretation of non-Euclidean geometry challenged contemporary ideas about space, stirred heated discussion, and led to flourishing research. His work in topology began the modern study of the subject, recently highlighted by the successful resolution of the famous Poincaré conjecture. And Poincaré's reformulation of celestial mechanics and discovery of chaotic motion started the modern theory of dynamical systems. In physics, his insights on the Lorentz group preceded Einstein's, and he was the first to indicate that space and time might be fundamentally atomic. Poincaré the public intellectual did not shy away from scientific controversy, and he defended mathematics against the attacks of logicians such as Bertrand Russell, opposed the views of Catholic apologists, and served as an expert witness in probability for the notorious Dreyfus case that polarized France. Richly informed by letters and documents, Henri Poincaré demonstrates how one man's work revolutionized math, science, and the greater world. (shrink)

Some maladaptive thought processes are characterized by reflexive and habitual patterns of cognitive and emotional reactivity. We review theoretical and empirical work suggesting that mindfulness—a state of nonjudgmental awareness of the present moment—can facilitate the discontinuation of such automatic mental operations. We propose a framework that suggests a series of more specific mechanisms supporting the de-automatizing function of mindfulness. Four related but distinct elements of mindfulness (awareness, attention, focus on the present, and acceptance) can each contribute to de-automatization through subsequent (...) processes, including discontinuing automatic inference, enhancing cognitive control capacity, facilitating metacognitive insight, and preventing suppression or thought distortion. De-automatizing can, in turn, allow enhancement of adaptive self-control ability and increased well-being. (shrink)

Mathematicians use the word ‘deep’ to convey a high appreciation of a concept, theorem, or proof. This paper investigates the extent to which the term can be said to have an objective character by examining its first use in mathematics. It was a consequence of Gauss's work on number theory and the agreement among his successors that specific parts of Gauss's work were deep, on grounds that indicate that depth was a structural feature of mathematics for them. In contrast, French (...) mathematicians had a less structural, more problem-oriented approach to mathematics and did not speak of depth so readily. (shrink)

The first part of this paper surveys the current literature in the history of nineteenth-century mathematics in order to show that the question “Did the increasing abstraction of mathematics lead to a sense of anxiety?” is a new and valid question. I argue that the mathematics of the nineteenth century is marked by a growing appreciation of error leading to a note of anxiety, hesitant at first but persistent by 1900. This mounting disquiet about so many aspects of mathematics after (...) 1850 is seldom discussed. The second part explores the issue of anxiety in mathematical life through an interesting account of an address made by a mathematician in 1911, Oscar Perron. The third and final part ventures some conclusions about the value of anxiety as a question for historians of mathematics to pursue. (shrink)

This edited volume, aimed at both students and researchers in philosophy, mathematics and history of science, highlights leading developments in the overlapping areas of philosophy and the history of modern mathematics. It is a coherent, wide ranging account of how a number of topics in the philosophy of mathematics must be reconsidered in the light of the latest historical research and how a number of historical accounts can be deepened by embracing philosophical questions.

The American Journal of Bioethics, Volume 11, Issue 6, Page W1-W3, June 2011.

The lives of few mathematicians offer the drama that is presented by the life of L. E. J. Brouwer, correctly identified on the cover of this book as a topologist, intuitionist, and philosopher, and before we go any further, it will be worth indicating why.It is not just that Brouwer would rank high among mathematicians for his work in topology alone: he set standards for rigour and created a theory of dimension for topological spaces, and his fixed-point theorem is of (...) great importance. Nor is it just that his philosophy of intuitionism created a new and vibrant branch of logic, that is, arguably, the only viable alternative to naïve, classical logic outside the enclave of professional logicians. Rather, it is that there is a tension, popularly taken to amount to a contradiction, in the fundamental ideas behind his topology and his intuitionism. Added to that, he took a highly principled stand on mathematical issues that led him into confrontations with major figures and a certain degre .. (shrink)

The primrose path and prisoner's dilemma paradigms may require cognitive (executive) control: The active maintenance of context representations in lateral prefrontal cortex to provide top-down support for specific behaviors in the face of short delays or stronger response tendencies. This perspective suggests further tests of whether altruism is a type of self-control, including brain imaging, induced affect, and dual-task studies.

No mathematician did more to change mathematics in the second half of the twentieth century than Alexandre Grothendieck. This would have been true even if he had been a quiet figure with a liking for playing the piano and walking in the hills but, as this book makes very clear, he was far from that, and his character and his way of working enhanced his impact. Above all, there was his abrupt departure from the world of mathematics in 1970 and (...) his occasional interventions in it since.This review was submitted a few days before Grothendieck's death in November 2014—Editor.As a teenager, Grothendieck had lived with his mother protected from the Nazis by courageous Huguenots in the village of Le Chambon-sur-Lignon. Immediately after the war, he went to the University of Montpellier where he studied mathematics and soon made his way to Nancy and was introduced to Dieudonné and Schwartz, who were members of Bourbaki. His first original work was in the theory of Banach spaces where, in the wo .. (shrink)

This Editorial reports an exchange in form of a comment and reply on the article “History and Nature of the Jeffreys–Lindley Paradox” (Arch Hist Exact Sci 77:25, 2023) by Eric-Jan Wagenmakers and Alexander Ly.