Research over the last decades has stimulated a paradigm shift in biology from assuming fixed and dichotomous male and female sexual strategies to an appreciation of significant variation in sex and sexual behaviour both within and between species. This has resulted in the development of a broader biological understanding of sexual strategies, sexuality and variation in sexual behaviour. However, current introductory biological textbooks have not yet incorporated these new research findings. Our analysis of the content of current biology texts suggests (...) that in undergraduate biology curricula variation in sexual behaviour, sexual strategies and sexuality barely feature, even though sex is discussed in a range of contexts. In this aspect, biological teaching is lagging behind current research. Here, we draw attention to new findings in the biology of sex, and suggest how these might be incorporated in undergraduate teaching to provide a more contemporary and inclusive education for biology students. (shrink)

_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

The linguistic expression of religious experience is problematic for both the experiencer and the philospher. For instance: is the religious experience nonverbal, i.e. does it utterly transcend all words, concepts, and thought? Or is it ineffable – not amenable to verbal expression? In either case, what can one make of all the talk and writings of those who do report religious experiences? The frequent references to ineffability, transcendence of thought and the like, lead one to wonder if the experiencers themselves (...) are not dis-satisfied with these expressions. If this is indeed the case, what is it about these expressions that produces this dissatisfaction? Are some expressions better suited to the experience than others? (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:53 HUME ON ARTIFICIAL LIVES with a Rejoinder to A.C. Maclntyre The variety of human cultures fascinated Enlightenment thinkers and evoked certain problems for philosophical discussion. Wide experience of other societies, as well as the study of history, disclosed moral systems interestingly different from modern European mores. Also a student of other cultures, historical and contemporary, David Hume is a moderate pluralist on the matter of alternative moral systems. (...) He acknowledges that there are systems of values other than that shared by his readers which qualify as moralities; but more interestingly, he also holds that there are some such systems which, despite the claims of their adherents, fail to qualify as moralities. Thus Hume opposes forms of relativism that allow any system which a community deems to be a moral code has to be acknowledged as constituting a genuine morality. In this paper I address the question of how Hume can discriminate among value systems and declare some to be moralities, some not. Given the design of his philosophical approach to morals, addressing this question is a matter of some importance for Hume, since he maintains that moral reflection takes its departure from everyday moral beliefs and sentiments. This being the case, we might expect that what should count as 'everyday moral beliefs and sentiments' would be whatsoever any individual or group puts forward as a morality, and that Hume's pluralism impedes him from raising a critical challenge to any system advanced, no matter how strange it might be. But Hume holds that certain systems advanced for the guidance of life which are sharply opposed to 54 everyday beliefs and sentiments do not constitute a morality, even if they number many as adherents. It is instructive to observe that A.C. Maclntyre believes that Hume's position is deeply flawed. He asserts that the treatment of rival tables of the virtues constitutes a most serious weakness in Hume's 2 theory of morals. Maclntyre contends that Hume's spurning of the monkish virtues, for instance, or his preference of Cicero's Offices over the Christian Whole Duty of Man, is devoid of theoretical justification and amounts to a matter of personal idiosyncrasy and eighteenth-century class elitism. Thus this seems a problem worthy of discussion. In what follows I shall: (a) lay out the problem of artificial lives as it arises in A Dialogue; (b) describe five points of differentiation between artificial lives and nonartificial lives; (c) review some less than fully satisfactory solutions to the problem; (d) introduce what I take to be the chief considerations supporting Hume's rejection of artificial lives; and finally (e) discuss whether Maclntyre 's objections to Hume's treatment of artificial lives are sustainable. 1. The Context of the Problem Hume deals with diversity of morals most expressly in A Dialogue, the short work appended to the second Enquiry. The essay records an exchange between one Palamedes, a lover of the novel and the striking, and his interlocutor, referred to merely as "I". Palamedes confounds the interlocutor by narrating a story about a distant people (the inhabitants of 'Fourli") whose mores include practices, apparently deemed moral by them, which sharply offend his, and presumably our, moral A sensibilities. Having elicited the interlocutor's 55 felt disapproval of those practices, Palamedes delights in revealing that the people of whom he has been speaking in cloaked terms are none other than the interlocutor's beloved Greeks of classical antiquity. Not satisfied with astonishing the interlocutor, he goes on to draw a strongly relativist conclusion about morals in general. The interlocutor confronts the choice of either abandoning his moral admiration of the civilization of the Greeks or of accepting some measure of the relativism in morals that Palamedes is advocating. The interlocutor does neither. He distinguishes between the principles of moral approbation or disapprobation and specific examples of approval or disapproval (E 333). He grants that there are examples of practices of which the ancients apparently approved and contrariwise we disapprove, but he denies that the existence of some such instances warrants the serious sort of relativism that Palamedes would foist on him. Obviously the number of such discrepancies cannot be overwhelming, otherwise the... (shrink)

Power consists in the capacity of A to command B, even against B's wishes, whether directly or indirectly. Questions to do with who possesses it and in what degree are obscured by inflationary shifts of definition (as where power encompasses action as such, or right action, or co?operation). These misjudged moves are generally marked by the assumption that democracy displaces power. But if democracy ultimately persists as a voting procedure, its object is to create power?holders. Democracy may endorse three electoral (...) principles: (a) majority rule, or (b) enhanced majority rule, or (c) unanimity. Its commonest electoral device is (a), but its strongest moral defence for (a) implicitly is (c), which legitimates forms of (d) veto and forms of minority rule. If (d) is fair, this need not follow from (a). Nor is (a) right in virtue of superior power. Democracy is commonly a combination of (a) plus (e) defence of individual and corporate rights. But this combination, while apt and convenient, is not incontestably coherent. Despite growing support for deliberation over election, if democracy must be impelled by (a), thus far does it sustain, not topple, power. If power persists more stably under democracies than elsewhere, sustained caution in regard to its supposed ?circularization? is fully warranted. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:53 HUME ON ARTIFICIAL LIVES with a Rejoinder to A.C. Maclntyre The variety of human cultures fascinated Enlightenment thinkers and evoked certain problems for philosophical discussion. Wide experience of other societies, as well as the study of history, disclosed moral systems interestingly different from modern European mores. Also a student of other cultures, historical and contemporary, David Hume is a moderate pluralist on the matter of alternative moral systems. (...) He acknowledges that there are systems of values other than that shared by his readers which qualify as moralities; but more interestingly, he also holds that there are some such systems which, despite the claims of their adherents, fail to qualify as moralities. Thus Hume opposes forms of relativism that allow any system which a community deems to be a moral code has to be acknowledged as constituting a genuine morality. In this paper I address the question of how Hume can discriminate among value systems and declare some to be moralities, some not. Given the design of his philosophical approach to morals, addressing this question is a matter of some importance for Hume, since he maintains that moral reflection takes its departure from everyday moral beliefs and sentiments. This being the case, we might expect that what should count as 'everyday moral beliefs and sentiments' would be whatsoever any individual or group puts forward as a morality, and that Hume's pluralism impedes him from raising a critical challenge to any system advanced, no matter how strange it might be. But Hume holds that certain systems advanced for the guidance of life which are sharply opposed to 54 everyday beliefs and sentiments do not constitute a morality, even if they number many as adherents. It is instructive to observe that A.C. Maclntyre believes that Hume's position is deeply flawed. He asserts that the treatment of rival tables of the virtues constitutes a most serious weakness in Hume's 2 theory of morals. Maclntyre contends that Hume's spurning of the monkish virtues, for instance, or his preference of Cicero's Offices over the Christian Whole Duty of Man, is devoid of theoretical justification and amounts to a matter of personal idiosyncrasy and eighteenth-century class elitism. Thus this seems a problem worthy of discussion. In what follows I shall: (a) lay out the problem of artificial lives as it arises in A Dialogue; (b) describe five points of differentiation between artificial lives and nonartificial lives; (c) review some less than fully satisfactory solutions to the problem; (d) introduce what I take to be the chief considerations supporting Hume's rejection of artificial lives; and finally (e) discuss whether Maclntyre 's objections to Hume's treatment of artificial lives are sustainable. 1. The Context of the Problem Hume deals with diversity of morals most expressly in A Dialogue, the short work appended to the second Enquiry. The essay records an exchange between one Palamedes, a lover of the novel and the striking, and his interlocutor, referred to merely as "I". Palamedes confounds the interlocutor by narrating a story about a distant people (the inhabitants of 'Fourli") whose mores include practices, apparently deemed moral by them, which sharply offend his, and presumably our, moral A sensibilities. Having elicited the interlocutor's 55 felt disapproval of those practices, Palamedes delights in revealing that the people of whom he has been speaking in cloaked terms are none other than the interlocutor's beloved Greeks of classical antiquity. Not satisfied with astonishing the interlocutor, he goes on to draw a strongly relativist conclusion about morals in general. The interlocutor confronts the choice of either abandoning his moral admiration of the civilization of the Greeks or of accepting some measure of the relativism in morals that Palamedes is advocating. The interlocutor does neither. He distinguishes between the principles of moral approbation or disapprobation and specific examples of approval or disapproval (E 333). He grants that there are examples of practices of which the ancients apparently approved and contrariwise we disapprove, but he denies that the existence of some such instances warrants the serious sort of relativism that Palamedes would foist on him. Obviously the number of such discrepancies cannot be overwhelming, otherwise the... (shrink)

The term intersectionality, which is generally attributed to Kimberlé Crenshaw, began as a metaphorical and conceptual tool used to highlight the inability of a single-axis framework to capture the lived experiences of black women. Whilst many disciplines have used the ‘tools’ of intersectionality before 1989, modern day usage of the term is usually associated with Crenshaw’s specific approach. The development of Crenshaw’s intersectionality, originated from the failure of both feminist and anti-racist discourse; to represent and capture the specificity of the (...) discrimination faced by black women. This failure resulted from an inability to identify the multiple grounds which constitute an... (shrink)