The history of the Euclidean Steiner tree problem, which is the problem of constructing a shortest possible network interconnecting a set of given points in the Euclidean plane, goes back to Gergonne in the early nineteenth century. We present a detailed account of the mathematical contributions of some of the earliest papers on the Euclidean Steiner tree problem. Furthermore, we link these initial contributions with results from the recent literature on the problem.

Oppression and the Human Condition is both a valuable teaching tool and an insightful addition to scholarship on the philosophy of Jean-Paul Sartre. Students and teachers will find it an excellent and accessible introduction to Sartre's existentialism, ideal for courses in existentialist and 20th century philosophy. Equally, Sartre scholars will find that the book, especially the sections on oppression and "bad faith," gives them much to think about. Author Thomas Martin applies Sartre's philosophy to contemporary issues and concerns, (...) and draws on two case studies to make his point. The cases examine modern-day oppressors--in one case an anti-semite, in the other a sexist who objectifies women--in the context of Sartre's "bad faith." The case studies also reinforce Martin's argument that Sartre's early philosophy, especially his concept of "bad faith," provides a framework for discussions of oppressions such as racism and sexism. (shrink)

Martin argues that literary studies remain mired in the anomalies of a linguistic methodology derived from early 20th-century language philosophy, a view challenged not only by theoretical physics, but also by compelling advances in philosophic semantics.

The paper is an attempt to set the social and historical background against which the Royal Institution was founded, and to trace the events in its very early history. The founder of the Institution was Benjamin Thompson, Count Rumford, that soldier of fortune who took service with the Elector Palatine of Bavaria, and it was in the course of his duties in Munich that his interest in the practical problems of philanthropy was aroused.In London, in the concluding years of the (...) eighteenth century, he was drawn into the group of philanthropists and reformers among whom William Wilberforce was the leading figure, and Sir Thomas Bernard, Treasurer of the Foundling Hospital, one of the most active members. The focus of their activities was the Society for Bettering the Condition and Increasing the Comforts of the Poor, and to this Society Rumford submitted his proposals for a new scientific institution in London, designed to improve the lot of the poor and the working classes by the application of science to useful purposes.It was decided to make an appeal for funds, Rumford's proposals were circulated, and the Count succeeded in interesting the President of the Royal Society, Sir Joseph Banks, who took the Chair at the early meetings and allowed them to be held at his house, 32 Soho Square. At a meeting held there on 7 March 1799, the new institution was formed by resolution of the subscribers of 50 guineas each, who became the first Proprietors of the Royal Institution of Great Britain, as it was afterwards named in its Royal Charter. (shrink)

The paper covers a period of little more than two years in the early history of the Royal Institution, but it is the period in which the house in Albemarle Street was purchased and Count Rumford devoted all his energies to establishing in it the Institution he had conceived. The house was enlarged and adapted to its new purpose; at first a temporary and later the well-known lecture theatre were built. The first Resident Professor and lecturer in the new theatre (...) was Thomas Garnett, whose brief and unhappy connection with the Royal Institution is recorded. (shrink)

Calling post-modernism merely "the last tortured gasps of the old paradigm, not the birth-cries of the new," Martin (affiliations, academic or otherwise, not noted) seeks to move along to a "post-Western" perspective on history. He writes from a Green viewpoint (anarchist, feminist, and ecological), giving much credit to American anarchist Murray Bookchin, who he calls the last great Western philosopher. Double-spaced. Annotation copyrighted by Book News Inc., Portland, OR.

One professor of literature renounces his fight to discriminate wrong from right readings. He succumbs to pressures from theorists and practitioners in the profession at large and enters a world of unimagined intellectual freedom. After all, to suggest that some readings might be wrong is not only to engage in intellectual discrimination, but to enter into complicity with a number of imperious gestures that carry dire political consequences. Coming to terms with his newfound freedom to embrace all interpretations of texts (...) as equally valid, he outlines for those who follow thirteen rules that guide hermeneutical practice in our postmodern age. (shrink)

Greening the Past argues that 'western civilization' is rapidly approaching a crisis unique in world history, and that a new world-view now emerging is best encapsulated by a Green, anarchist-ecological analysis. The approach outlined in this book embraces general systems theory and recent discoveries in physics as well as key philosophical issues such as the nature of time, objectivity and causality, and an eco-psychological view of human nature. It includes new interpretations of the place of myth and language in historical (...) writing and urges a re-evaluation of the dialectical method. (shrink)

Multigene delivery and expression systems are emerging as key technologies for many applications in contemporary biology. We have developed new methods for multigene delivery and expression in eukaryotic hosts for a variety of applications, including production of protein complexes for structural biology and drug development, provision of multicomponent protein biologics, and cell‐based assays. We implemented tandem recombineering to facilitate rapid generation of multicomponent gene expression constructs for efficient transformation of mammalian cells, resulting in homogenous cell populations. Analysis of multiple parameters (...) in living cells may require co‐expression of fluorescently tagged sensors simultaneously in a single cell, at defined and ideally controlled ratios. Our method enables such applications by overcoming currently limiting challenges.Here, we review recent multigene delivery and expression strategies and their exploitation in mammalian cells. We discuss applications in drug discovery assays, interaction studies, and biologics production, which may benefit in the future from our novel approach. (shrink)

While artists often present their works as communicating to and through them, this idea has rarely been taken seriously, nor empirically studied from a communicational perspective. Building upon the pragmatist tradition, we show how this particular form of communication takes place. Using Peirce’s concept of abduction, we argue that a creative process essentially happens when a resonance between two materials leads to the unification of these materials into a new whole. Drawing upon a case study, we show how we can (...) retrace such resonances by paying close attention to the interactions between participants collectively involved in a creative project. This paper makes an important contribution to communication studies by revealing the communicational mechanism of our creative impulsions. It also opens new avenues for the study of artistic endeavors as well as other creative activities such as science, politics, or design. (shrink)

Controversy and activism have long been linked to the subject of primate research. Even in the midst of raging ethical debates surrounding fertility treatments, genetically modified foods and stem-cell research, there has been no reduction in the campaigns of activists worldwide. Plying their trade of intimidation aimed at ending biomedical experimentation in all animals, they have succeeded in creating an environment where research institutions, often painted as guilty until proven innocent, have avoided addressing the issue for fear of becoming targets. (...) One area of intense debate is the use of primates in stroke research. Despite the fact that stroke kills more people each year than AIDS and malaria, and less than 5% of patients are candidates for current therapies, there is significant opposition to primate stroke research. A balanced examination of the ethics of primate stroke research is thus of broad interest to all areas of biomedical research. (shrink)

This book applies Augustine's thought to current questions of teaching and learning. The essays are written in an accessible style and is not intended just for experts on Augustine or church history.

The application of machine learning and artificial intelligence in healthcare domains has received much attention in recent years, yet significant questions remain about how these new tools integrate into frontline user workflow, and how their design will impact implementation. Lack of acceptance among clinicians is a major barrier to the translation of healthcare innovations into clinical practice. In this systematic review, we examine when and how clinicians are consulted about their needs and desires for clinical AI tools. Forty-five articles met (...) criteria for inclusion, of which 24 were considered design studies. The design studies used a variety of methods to solicit and gather user feedback, with interviews, surveys, and user evaluations. Our findings show that tool designers consult clinicians at various but inconsistent points during the design process, and most typically at later stages in the design cycle. We also observed a smaller amount of studies adopting a human-centered approach and where clinician input was solicited throughout the design process. A third of all studies reported on clinician trust in clinical AI algorithms and tools. The surveyed articles did not universally report validation against the “gold standard” of clinical expertise or provide detailed descriptions of the algorithms or computational methods used in their work. To realize the full potential of AI tools within healthcare settings, our review suggests there are opportunities to more thoroughly integrate frontline users’ needs and feedback in the design process. (shrink)

The study of anarchism as a philosophical, political, and social movement has burgeoned both in the academy and in the global activist community in recent years. Taking advantage of this boom in anarchist scholarship, Nathan J. Jun and Shane Wahl have compiled twenty-six cutting-edge essays on this timely topic in New Perspectives on Anarchism.

Controversy and activism have long been linked to the subject of primate research. Even in the midst of raging ethical debates surrounding fertility treatments, genetically modified foods and stem-cell research, there has been no reduction in the campaigns of activists worldwide. Plying their trade of intimidation aimed at ending biomedical experimentation in all animals, they have succeeded in creating an environment where research institutions, often painted as guilty until proven innocent, have avoided addressing the issue for fear of becoming targets. (...) One area of intense debate is the use of primates in stroke research. Despite the fact that stroke kills more people each year than AIDS and malaria, and less than 5% of patients are candidates for current therapies, there is significant opposition to primate stroke research. A balanced examination of the ethics of primate stroke research is thus of broad interest to all areas of biomedical research. (shrink)