A new system of algebraic logic is described. it is closely related to cylindric and polyadic algebras, and is axiomatized by a small number of very simple equations.

This chapter opens with a discussion on Kevin Smith, Star Wars and terrorism. Terrorism means something only within a specific way of thinking about right and wrong, or, more generally, an ethical theory or framework. One very popular and powerful ethical framework is utilitarianism, which views the moral life as about producing the greatest good for the greatest number, maximizing pleasure over pain or happiness over unhappiness. The chapter describes many terrorist attacks and highlights that workers building Death Star II (...) are different from the innocents of Gaza, Hiroshima, Alderaan, and Madrid in that these workers were actively contributing to the evil intention and military goals of the enemy. The chapter further points out that the ability to challenge the dominant cultural lens through which most of us look at the world and ask critical questions of our own “side” is as rare today as it is important. (shrink)

There is perhaps no more important value than fundamental human equality. And yet, despite large percentages of people affirming the value, the resources available to explain and defend the basis for such equality are few and far between. In his newest book, Charles Camosy provides a thoughtful defense of human dignity. Telling personal stories like those of Jahi McMath, Terri Schiavo, and Alfie Evans, Camosy, a noted bioethicist and theologian, uses an engaging style to show how the influence of (...) secularized medicine is undermining fundamental human equality in the broader culture. And in a disturbing final chapter, Camosy sounds the alarm about the next population to fall if we stay on our current trajectory: dozens of millions of human beings with dementia. Heeding this alarm, Camosy argues, means doing two things. First, making urgent and genuine attempts to dialogue with a secularized culture which cannot see how it is undermining one of its most foundational values. Second, religious communities which hold the Imago Dei sacred must mobilize their existing institutions (and create new ones) to care for a new set of human beings our throwaway culture may deem nonpersons. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

Philosophy confronts two existential crises: the threats to its existence from scientists like Stephen Hawking who claim that philosophy is dead; and the threat to life itself from catastrophic climate change. The essay’s first theoretical part critiques Nietzsche’s claim that philosophy’s primary function is to guarantee the future of life. The essay’s second practical part claims that philosophy must meet the challenge of life’s extinction through a revised model for ethics in education. Taking its start from recent conceptualizations of philosophy (...) as a ‘field discipline,’ this part considers African American models for delivering ethics in education to under-resourced communities. The third part shows how these theoretical models may be actualized in the practice of an African field philosopher. (shrink)

In the twenty-first century, Stephen Hawking proclaimed the death of philosophy. Only science can address philosophy’s perennial questions about human values. The essay first examines Nietzsche’s nineteenth century view to the contrary that philosophy alone can create values. A critique of Nietzsche’s contention that philosophy rather than science is competent to judge values follows. The essay then analyzes Edward O. Wilson’s claim that his scientific research provides empirically-based answers to philosophy’s questions about human values. Wilson’s bold new hypothesis about the (...) ‘social conquest of the earth’ challenges Nietzsche’s vision of philosophy’s mission. Confronting both Nietzsche and Wilson, the essay then considers three theoretical proposals for a consilience of philosophy, science, engineering and technology. The conclusion presents a working African model of consilience that addresses the existential problem of poverty in the Global South. (shrink)

This is a philosophical study by a group of scholars from Malawi on issues related to ethics. The author deals such issues as corruption/anti-corruption; political leadership and ethical transformation; economic ethics and free market; law and ethics; African traditional ethics--ubuntu; African work ethics, education and ethics; popular music and ethics; journalism ethics; technology and ethical implication; etc.

The paper examines the loss of African identity within the modern/ contemporary era. African identity has been a recurrent theme in all domains of African studies, serving as a major intellectual concern of many African scholars. Debates on the reality of African Philosophy are anchored on the questions surrounding African identity giving rise to thoughts and contents of that philosophy. Despite the volumes already generated on the theme, the controversial circumstances that engendered the subject of African identity makes its intellectual (...) concern sustainable and almost inexhaustible. The question of African identity is basically an ontological question of the reality of Africa cum the being of an African. The series of infiltration and appraisals of Africa by foreign elements tend to plunge the continent into crises of identity. In addition to the various approaches to the subject, the nature-culture perspective presents the argument that if culture is ideally the product of a people’s nature, African culture represents the objective manifestation of the Africanity of the continent and its organic/holistic content. Such frame of thought embellished with philosophic tools provides further locus for a more feasible and stable definition of African identity as the holistic nature and character of being African. (shrink)

Previous studies have found Forsyth’s Ethical Position Questionnaire (EPQ) to vary between countries, but none has made a systematic evaluation of its psychometric properties across consumers from many countries. Using confirmatory factor analysis and multi-group LISREL analysis, this paper explores the factor structure of the EPQ and the measurement equivalence in five societies: Austria, Britain, Brunei, Hong Kong and USA. The results suggest that the modified scale, measuring idealism and relativism, was applicable in all five societies. Equivalence was found across (...) Britain, Brunei and USA, but the original scale cannot be used validly. (shrink)

Interaction between Peter Singer and Christian ethics, to the extent that it has happened at all, has been unproductive and often antagonistic. Singer sees himself as leading a 'Copernican Revolution' against a sanctity of life ethic, while many Christians associate his work with a 'culture of death'. Charles Camosy shows that this polarized understanding of the two positions is a mistake. While their conclusions about abortion and euthanasia may differ, there is surprising overlap in Christian and Singerite arguments, and (...) disagreements are interesting and fruitful. Furthermore, it turns out that Christians and Singerites can even make common cause, for instance in matters such as global poverty and the dignity of non-human animals. Peter Singer and Christian ethics are far closer than almost anyone has imagined, and this book is valuable to those who are interested in fresh thinking about the relationship between religious and secular ethics. (shrink)

This essay contrasts Nietzsche’s remarks on elite education with W.E.B. Du Bois’ demand for democratized education. The essay takes their remarks as springboards for a twenty-first century philosophy of education rather than an historical account of their philosophies. Both thinkers cultivated Kant and Hegel’s dream that the spirit of freedom guided by reason would unite all the world’s peoples. Both held that education was key to realizing the dream. Their judgments about qualifying for education separated them. Nietzsche insisted that only (...) the elite should receive the fullest measure of education. Du Bois believed that in the future virtually every human being would receive a university-level education. The essay’s principal point is to show how contemporary technology can make Du Bois’ dream a reality. An African philosopher’s working model demonstrates a path to universal university education. (shrink)

Timothy Murphy has done those of us in the field of bioethics a great service by being forthright about how irreligious centers of power work against theology and theologians. This has opened the door to direct and honest conversation about some facts that were previously known but rarely discussed publicly. Now, eight years after Murphy’s important article appeared in the American Journal of Bioethics, there is room to engage the facts and arguments surrounding the role for theology in the field. (...) It is important, first of all, to agree that if theology is to be excluded while other normative traditions included this must be defended on the basis of a coherent set of defensible claims, not merely raw assertions and power plays. Once the field comes to terms with the fact that no coherent set of defensible claims exist which can justify excluding theology from the field, this will create the conditions for the possibility of the kind of intellectual solidarity which can transform bioethics into a field that is at once much more diverse and inclusive while also of its very nature interested in robust debate which includes references first principles and metaphysical foundations. (shrink)

Healthcare ethics committees (HEC) have emerged as institutional forums for addressing bioethical dilemmas. Psychiatrists have important roles to play on these committees. Their skills in group process assessment, mental status examination, and character assessment have diverse applications. Psychiatrists can facilitate communication within the committee and as HEC-based clinical ethics consultants. HECs must be concerned with how they arrive at ethical decisions, guarding against political influence or individual monopolization. Psychiatrists can assist these efforts as organizational consultants to HECs. The perception of (...) psychiatrists as reflective, tolerant of ambiguity, humanizing, and approachable about ethical aspects of health care suggests they would make excellent committee leaders. Psychiatrists also have important committee roles to play as ethics educators and policy makers. More demographic data is needed to investigate psychiatrist participation on HECs. Studies of how they are perceived by their ethics committee colleagues may reveal new roles and potential pitfalls for HEC psychiatrists. (shrink)

The environmental elbow room model of free will posits the unshared proportion of environmental variance in twins is a measure of the degree to which free will may be exercised with respect to one’s life outcomes for a trait. This model attempts to unify the behavioral genetic study of socially important psychological characteristics such as intelligence and academic achievement with Dennett’s broadly compatibilist elbow room notion of free will. We demonstrate that the philosophy and genetics underlying the environmental elbow room (...) model are both fundamentally flawed. Philosophically the degree to which an outcome might be predicted in a given situation does not give any sense of whether the course of action to achieve an outcome was free or unfree. With respect to genetics, quantities such as heritability and its environmental complement, even when they do reflect the actions of independently identifiable causes are not indicative of the chain of decisions one would have to evaluate to judge if an action was freely chosen. We show the contemporary human behavioral genetics focus on heritability is wholly misplaced for purposes of making decisions about policy and free will alike. Variance components sample a single instance of the distribution of variation arising from different sources and do not constrain outcomes in other contexts. The claim that the high heritability of a trait, life outcomes included, makes us less free to change it is similar in key ways to Jensenism’s contention that high heritability makes social change impossible. (shrink)

In 1972, R.C. Lewontin concluded that it follows from the fact that the large majority of human genetic variation (≈ 85%) is among individuals within local populations that racial taxonomy is unjustified. Three decades later, Edwards demonstrated that while the accuracy with which individuals may be assigned to groups is poor for a single locus, consideration of multi‐locus data allows for highly accurate assignments. Edwards concluded that Lewontin's dismissal of racial taxonomy was unwarranted. Edwards misidentified the aim of Lewontin's critique, (...) which was directed at the utility of racial classification and not at assigning individuals to groups using genetic data. Moreover, Edwards conflated distinct kinds of correlation when sketching out his argument. If we follow Edwards’ argument to its natural terminus, it becomes clear that it is consideration of all of the correlation structure among local groups in human genetic data that renders racial taxonomy scientifically useless. Lewontin considers the correlation structure relevant to his analysis of racial taxonomy and does not make his eponymous misstep. Rather, critics of Lewontin who use racial taxonomies in their work are the primary offenders when it comes to committing Lewontin's fallacy. (shrink)

Evolutionary investigations of human crania typically take a limited view of cranial diversity as they discount the possibility that human cranial variation could simply be due to the effects of random genetic drift, gene flow and mutation in favor of natural selection and developmental changes. Natural selection alone cannot explain similarities between patterns of cranial and molecular diversity observed in humans. It appears that the amount of phenotypic variance in the human cranium decreases at the population level as a function (...) of distance from Sub‐Saharan Africa much in the same way as observed for human molecular data.1 BioEssays 29:1185–1188, 2007. © 2007 Wiley Periodicals, Inc. (shrink)