Die Dissoi Logoi - "Zweierlei Ansichten" - sind ein kurzer Traktat, der als Anhang zu den Schriften des kaiserzeitlichen Skeptikers Sextus Empiricus uberliefert wurde. Der von einem anonymen Autor wahrscheinlich an der Wende vom 5. zum 4. Jh. verfasste Text gibt einen einzigartigen Einblick in die Debatten und den Unterricht der Sophisten. ".

This volume brings historians of science and social historians together to consider the role of "little tools"--such as tables, reports, questionnaires, dossiers, index cards--in establishing academic and bureaucratic claims to authority and objectivity. From at least the eighteenth century onward, our science and society have been planned, surveyed, examined, and judged according to particular techniques of collecting and storing knowledge. Recently, the seemingly self-evident nature of these mundane epistemic and administrative tools, as well as the prose in which they are (...) cast, has demanded historical examination. The essays gathered here, arranged in chronological order by subject from the late seventeenth to the late twentieth century, involve close readings of primary texts and analyses of academic and bureaucratic practices as parts of material culture. The first few essays, on the early modern period, largely point to the existence of a "juridico-theological" framework for establishing authority. Later essays demonstrate the eclipse of the role of authority per se in the modern period and the emergence of the notion of "objectivity." Most of the essays here concern the German cultural space as among the best exemplars of the academic and bureaucratic practices described above. The introduction to the volume, however, is framed at a general level the closing essays also extend the analyses beyond Germany to broader considerations on authority and objectivity in historical practice. The volume will interest scholars of European history and German studies as well as historians of science. Peter Becker is Professor of Central European History, European University Institute. William Clark is Lecturer in History and Philosophy of Science, Cambridge University. (shrink)

Does the three‐dimensional (3D) conformation of interphase chromosomes merely reflect their function or does it actively contribute to gene regulation? The analysis of sex chromosomes that are subject to chromosome‐wide dosage compensation processes promises new insight into this question. Chromosome conformations are dynamic and largely determined by association of distant chromosomal loci in the nuclear space or by their anchoring to the nuclear envelope, effectively generating chromatin loops. The type and extent of such interactions depend on chromatin‐bound transcription regulators and (...) therefore reflects function. Dosage compensation adjusts the overall transcription activity of X chromosomes to assure balanced expression in the two sexes. Initial analyses of mammalian and Drosophila X chromosomes have led to the hypothesis that their conformations may not only reflect their functional state but may in turn contribute to the coordination of chromosome‐wide tuning of transcription. (shrink)

The naive misunderstanding among economists of the relationship between economics and philosophy is as profound as it is prevalent. To be sure, economists have concerned themselves with the philosophy of economics only so much as to familiarize themselves with methodology and its application to economic inquiry. Since economics is the oldest and perhaps the most “respectable” of the social sciences its scholars have developed a phobia for anything they might suspect to be even remotely unscientific. Consequently, they have erroneously narrowed (...) their understanding of the nature of economics. This narrowness prevails largely because most economists possess little or no training in general philosophy and especially in the philosophy of science. As a result of this apparent deficiency there exists in the minds of these economists confusion and inability to distinguish between teleology, axiology, and ethics as they do or do not apply to economics. (shrink)

The organization of eukaryotic genomes as chromatin provides the framework within which regulated transcription occurs in the nucleus. The association of DNA with chromatin proteins required to package the genome into the nucleus is, in general, inhibitory to transcription, and therefore provides opportunities for regulated transcriptional activation. Granting access to the cis‐acting elements in DNA, a prerequisite for any further action of the trans‐acting factors involved, requires the establishment of local heterogeneity of chromatin and, in some cases, extensive remodeling of (...) nucleosomal structures. Challenging problems relate to the establishment of this heterogeneity at the level of the single nucleosome and to the mechanisms that operate when nucleosomal arrays are reorganized. Recent developments indicate that chromatin reconstitution in cell‐free systems allows the biochemical analysis of the interplay between transcription factors and chromatin components that brings about regulated transcription. (shrink)

These specialised and annotated papers closely examine a number of Platonic texts including the Republic, Symposium and Gorgias. Extracts are in English translation.

This study examined whether worktime control buffered the impact of worktime demands on work-family interference (WFI), using data from 2,377 workers from various sectors of industry in The Netherlands. We distinguished among three types of worktime demands: time spent on work according to one's contract (contractual hours), the number of hours spent on overtime work (overtime hours), and the number of hours spent on commuting (commuting hours). Regarding worktime control, a distinction was made between having control over days off and (...) vacations (leave control) and having control over starting and finishing times (flextime). These three worktime demands were expected to have separate as well as joint effects on WFI, whereas worktime control should buffer these adverse effects of worktime demands on WFI. Stepwise regression analyses showed that working high numbers of contractual and overtime hours was indeed associated with high WFI. Further, worktime control indeed made a difference in terms of WFI: whereas leave control contributed directly to lower WFI, flextime buffered the adverse effects of long contractual workhours. Our results suggest that very long working days should be prevented, and that worktime control may be a powerful tool to help workers maintaining a good work-family balance. (shrink)

Local differences in chromatin organisation may profoundly affect the activity of eukaryotic genomes. Regulation at the level of DNA packaging requires the targeting of structural proteins and histone‐modifying enzymes to specific sites and their stable or dynamic interaction with the nucleosomal fiber. The “chromodomain”, a domain shared by many regulators of chromatin structure, has long been suspected to serve as a module mediating chromatin interactions in a variety of different protein contexts. However, recent functional analyses of a number of different (...) chromodomains revealed an unexpected diversity of interaction targets, including histones, DNA and even RNA. The chromodomains of today seem to have evolved from a common ancestral fold to fulfill various functions in different molecular contexts. Combining information gained from recent functional and structural studies of chromodomains with a bioinformatic classification of their structure could lead to the definition of sequence motifs with predictive quality for chromodomain function. BioEssays 26:133–140, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Often the target of uninformed or hostile criticism, the Enlightenment has been characterized as "shallow and pretentious intellectualism" and "unreasonable contempt for authority and tradition." In this provocative book--at once a scholarly study and a vigorous polemic--Peter Gay sets out to shatter old myths, to sort out illusion from reality, and to restore the men of the Enlightenment--Voltaire, Rousseau, Diderot--to the esteem they deserve.The nine related essays in The Party of Humanity fall into three divisions: three are on Voltaire, (...) presenting the great philosophe as a tough-minded, realistic man of letters who tried to reshape his world, rather than as a merely brittle and shallow wit. Then, three essays discuss the French Enlightenment as a whole and seek for the unity underlying the diversity of tempers and attitudes among its leaders. The last three, which include Mr. Gay's well-known critique of Carl Becker's The Heavenly City of the Eighteenth Century Philosophers, challenge some widely accepted views of the Enlightenment. The longest chapter here is a detailed examination of Rousseau and his reputation among his interpreters.What all nine essays have in common, apart from their portrayal of the philosophes as serious and engaged partisans of humanity, is that they are essays in the social history of ideas; they all treat ideas as inseparable from the specific social and cultural setting from which they emerge, and which they affect. (shrink)

Recent history makes clear that the quantum leaps being made in technology are the leading edge of a groundswell of paradigm shifts taking place in science, politics, economics, social institutions, and the expression of cultural values. Indeed it is the simultaneity and interdependence of these changes occurring in every dimension of human experience and endeavor that makes the present so historically distinctive. The essays gathered here give voice to perspectives on the always improvised relationship between technology and cultural values from (...) Africa, the Americas, Asia, Australia, Europe, and the Pacific. Contributors: Syed Muhammad Naquib Al-Attas, Roger T. Ames,Yoko Arisaka, Carl Becker, Francesca Bray, James Buchanan, Arindam Chakrabarti, Frank W. Derringh, Rolf Elberfeld, Charles Ess, Andrew Feenberg, Susantha Goonatilake, H. Jiuan Heng, Peter Hershock, Thomas P. Kasulis, George Khushf, David Farrell Krell, Joel J. Kupperman, William R. LaFleur, Lois Ann Lorentzen, David Loy, Joseph Margolis, Hans-Georg Möller, Robert Cummings Neville, Peimin Ni, Monica Atieno Opole, Kuruvilla Pandikattu SJ, Helen Petrovsky, Ramon Sentmartí, Kristin Shrader-Frechette, Vasanthi Srinivasan, Marietta Stepaniants, Vyacheslav S. Stiopin, Henk ten Have, Paul B.Thompson, Mary Tiles, David B.Wong. (shrink)

Quantum mechanics is humanity's finest scientific achievement. It explains why the sun shines and how your eyes can see. It's the theory behind the LEDs in your phone and the nuclear hearts of space probes. Every physicist agrees quantum physics is spectacularly successful. But ask them what quantum physics means, and the result will be a brawl. At stake is the nature of the Universe itself. What does it mean for something to be real? What is the role of consciousness (...) in the Universe? And do quantum rules apply to very small objects like electrons and protons, but not us? In What is Real?, Adam Becker brings to vivid life the brave researchers whose quest for the truth led them to challenge Bohr: David Bohm, who picked up Einstein's mantle and sought to make quantum mechanics deterministic, all while being hounded by the forces of McCarthyism; Hugh Everett, who argued that everything, big and small, must be governed by the same rules; and John Bell, who went to great lengths to eradicate the power of the god-like observer from the core of quantum physics. And they paid dearly, their reputations, careers, and sometimes lives ruined completely. But history has been kinder to them than their contemporaries were. As Becker shows, the brave intellectual giants have inspired a growing army of physicists and philosophers intent both on making a philosophically more satisfying theory of the universe and a more useful one as well. A gripping story of some of humanity's greatest ideas and the high cost with which many have pursued them, What is Real? is intellectual history at its passionate best. (shrink)

SummaryChallenging the common conception of Jean Bodin as an ‘anti-Aristotelian’ thinker, this article places Bodin's political thought in the context of oeconomics—the science, or art of the household—as it had developed in medieval and Renaissance commentaries on Aristotle's practical philosophy. The article argues that he thereby took part in a longstanding discussion in European political thought which saw the household as possessing a political dimension. Bodin's thought on the family is central to both his universal claims pertaining to his notion (...) of the political and his more particular interest in sovereignty and the origins of absolutism. The article explores Bodin's analysis of the household as the starting point of his inquiry into the nature of a commonwealth and the foundation of his conception of the state; it examines the relationship of la police and l'oeconomie in detail, and argues that the conjugal relationship is the determinant for Bodin's conception of absolute rule and of the origins of supreme power. (shrink)

Der Band untersucht rhetorische Strategien der emotionalen Kommunikation in Partnerwerbungsgesprächen. Ausgehend von der Annahme, dass eine bewusste Steuerung emotionaler Gesprächsprozesse durch einen strategischen Kommunikator die Erreichung des angestrebten Ziels wahrscheinlicher macht, geht er der Frage nach, welche Möglichkeiten sich in solchen Gesprächen bieten, mit Hilfe sprachlich-textlicher Mittel emotional zu überzeugen. Dabei konzentriert er sich - in Abgrenzung zu Studien emotionaler Körpersprache - ganz auf die verbale Seite der Kommunikation. Als Datenbasis dienen die Transkripte eines Korpus aus Face-to-Face-Gesprächen. Basierend auf einem (...) methodisch innovativen Ansatz zur Untersuchung des Verhältnisses von Sprache und Emotion, liefert der Band zahlreiche neue Erkenntnisse für die Rhetorik-, Emotions- und Gesprächsforschung. Dr. Lisa Becker promovierte im Fach Allgemeine Rhetorik an der Universität Tübingen. (shrink)

Das Buch bietet eine systematische Aufarbeitung der Forschung zum moralpsychologischen Ansatz von Lawrence Kohlberg und insbesondere seiner zahlreichen Kritiker.

As I write this, in November 1971, people are dying in East Bengal from lack of food, shelter, and medical caxc. The suffering and death that are occurring there now axe not inevitable, 1101; unavoidable in any fatalistic sense of the term. Constant poverty, a cyclone, and a civil war have turned at least nine million people into destitute refugees; nevertheless, it is not beyond Lhe capacity of the richer nations to give enough assistance to reduce any further suffering to (...) very small proportions. The decisions arid actions of human beings can prevent this kind of suffering. Unfortunately, human beings have not made the necessary decisions. At the individual level, people have, with very few exceptions, not responded to the situation in any signihczmt way. Generally speaking, people have not given large sums to relief funds; they have not written t0 their parliamentaxy representatives demanding increased government assistance; they have not demonstrated in the streets, held symbolic fasts, or done anything else directed toward providing thc refugees with the means to satisfy their essential needs. At thc government level, no govcrmmcnt has given the sort of massive aid that would enable the refugees to survive fm: more than a few days. Britain, for instance, has given rather more than most countries. It has, to date, given £14,750,000. For comparative purposes, B1~itain’s share of thc nonreccverabla development costs of the Anglo-French Concorde project is already in excess of £275,000,000, and on present estimates will reach £440,000,¤00. The implication is that the British government values a supersonic transport more than thirty times as.. (shrink)

The debate on empirical tests of social mechanisms suffers from a fragmented view on the relative benefit of the empirical method a researcher considers to be superior, compared to the flaws of all other methods. In this outlook. I argue that disciplinary barriers might be surmounted by a common methodological perspective on the analysis of social mechanisms. First, experimental, quantitative, qualitative, and simulation methods (agent-based modeling) are all required, but also capable to deal with the issue of causal identification, respectively. (...) Second, having established causal identification (among which I subsume strategies to deal with causal heterogeneity). each method disposes of genuine techniques to deal with the most crucial property of mechanism-based explanations: input-mechanism-output (IMO) relations. (shrink)

Kierkegaard understood his thinking as philosophy confronting its own end. In campaigning against the existential amnesia of the 19th century, he revived the intellectual figure of a kind of philosophizing with roots in both the Socratic method and the apophatic reflections of Meister Eckhart. The Young Hegelians philosophy of action thereby became action of the text. The aim: existentially to move the reader.".

This book describes how people can help animals in their community.