Philosophical discussions on causal inference in medicine are stuck in dyadic camps, each defending one kind of evidence or method rather than another as best support for causal hypotheses. Whereas Evidence Based Medicine advocates the use of Randomised Controlled Trials and systematic reviews of RCTs as gold standard, philosophers of science emphasise the importance of mechanisms and their distinctive informational contribution to causal inference and assessment. Some have suggested the adoption of a pluralistic approach to causal inference, and an inductive (...) rather than hypothetico-deductive inferential paradigm. However, these proposals deliver no clear guidelines about how such plurality of evidence sources should jointly justify hypotheses of causal associations. We here develop such guidelines by first giving a philosophical analysis of the underpinnings of Hill’s viewpoints on causality. We then put forward an evidence-amalgamation framework adopting a Bayesian net approach to model causal inference in pharmacology for the assessment of harms. Our framework accommodates a number of intuitions already expressed in the literature concerning the EBM vs. pluralist debate on causal inference, evidence hierarchies, causal holism, relevance, and reliability. (shrink)

This article sketches an idealized strategy for the identification of neural correlates of consciousness. The proposed strategy is based on a state space approach originating from the analysis of dynamical systems. The article then focuses on one constituent of consciousness, phenomenal awareness. Several rudimentary requirements for the identification of neural correlates of phenomenal awareness are suggested. These requirements are related to empirical data on selective attention, on completely intrinsic selection and on globally unconscious states. As an example, neuroscientific findings on (...) synchronized γ activity are categorized according to these requirements. (shrink)

This paper examines the issue of what the self is by reviewing neuropsychological research,which converges on the idea that the self may be more complex and differentiated than previous treatments of the topic have suggested. Although some aspects of self-knowledge such as episodic recollection may be compromised in individuals, other aspects—for instance, semantic trait summaries—appear largely intact. Taken together, these findings support the idea that the self is not a single, unified entity. Rather, it is a set of interrelated, functionally (...) independent systems. Implications for understanding the self in various areas of psychological research—e.g., neuroimaging, autism, amnesia, Alzheimer’s disease, and mirror self-recognition—are discussed in brief. (shrink)

According to the objective Bayesian approach to inductive logic, premisses inductively entail a conclusion just when every probability function with maximal entropy, from all those that satisfy the premisses, satisfies the conclusion. When premisses and conclusion are constraints on probabilities of sentences of a first-order predicate language, however, it is by no means obvious how to determine these maximal entropy functions. This paper makes progress on the problem in the following ways. Firstly, we introduce the concept of a limit in (...) entropy and show that, if the set of probability functions satisfying the premisses contains a limit in entropy, then this limit point is unique and is the maximal entropy probability function. Next, we turn to the special case in which the premisses are categorical sentences of the logical language. We show that if the uniform probability function gives the premisses positive probability, then the maximal entropy function can be found by simply conditionalising this uniform prior on the premisses. We generalise our results to demonstrate agreement between the maximal entropy approach and Jeffrey conditionalisation in the case in which there is a single premiss that specifies the probability of a sentence of the language. We show that, after learning such a premiss, certain inferences are preserved, namely inferences to inductive tautologies. Finally, we consider potential pathologies of the approach: we explore the extent to which the maximal entropy approach is invariant under permutations of the constants of the language, and we discuss some cases in which there is no maximal entropy probability function. (shrink)

The allegedly alternative theories of Phyletic Gradualism and Punctuated Equilibria are examined as regards the nature of their differences. The explanatory value of both models is determined by establishing their actual connection with reality. It is concluded that they are to be considered complementary rather than mutually exclusive at all levels of infraspecific, specific, and supraspecific evolution. So, in order to be described comprehensively, the pathways of evolution require at least two distinct models, each based on a discrete range of (...) real phenomena. [Phyletic Gradualism; Punctuated Equilibria; evolutionary theories; divergence models; additive speciation; microevolution; macroevolution; anagenesis.]. (shrink)

Narrative allegory is distinguished from mythology as reality from symbol; it is, in short, the proper intermedium between person and personification. Where it is too strongly individualized, it ceases to be allegory […]. In the community of scholars of intermedia research, the above quoted citation is commonly regarded as Coleridge’s coining of the term “intermedium” or “intermediality”. However, a short glance at the discursive strategy of his argument emphasizes that his notion of “intermedium” must be closely linked to the poetics (...) and aesthetics of 19th-century romanticism. For the romantic poet, the term of “intermedium” does not point to media relations or intermedia processes but to.. (shrink)

We study questionnaire responses to situations in which sacrificing one life may save many other lives. We demonstrate gender differences in moral judgments: males are more supportive of the sacrifice than females. We investigate a source of the endorsement of the sacrifice: antisocial preferences. First, we measure individual proneness to spiteful behavior, using an experimental game with monetary stakes. We demonstrate that spitefulness can be sizable—a fifth of our participants behave spitefully—but it is not associated with gender. Second, we find (...) that gender is consistently associated with responses even when we account for individual differences in the propensity to spitefulness. (shrink)

As digital media becomes more central to the lives of adolescents, it also becomes increasingly relevant for their sexual communication. Sexting as an important image-based digital medium provides opportunities for self-determined digital communication, but also carries specific risks for boundary violations. Accordingly, sexting is understood either as an everyday, or as risky and deviant behavior among adolescents. In the affectedness of boundary violations gender plays an important role. However, it is still unclear to what extent digital sexual communication restores stereotypical (...) gender roles and restrictive sexuality norms or, alternatively, enables new spaces of possibility. In this sense, current research points to a desideratum regarding adolescents’ orientations toward sexting as a practice between spaces of possibility and boundary violations. This paper discusses the possibilities, but also the risks, of intimate digital communication among adolescents. The main question is, how adolescents themselves perceive sexting practices and how they position themselves between both spaces for possibility and for the exchange of unwanted sexual content. For this purpose, orientations toward normalities and gender of students are reconstructed. To answer these questions, twelve single-sex, group discussions were carried out with students aged 16 and 17 at five different secondary schools in northern Germany. A total of 20 boys and 22 girls took part. The group discussions were structured by a narrative generating guideline. The analysis draws its methodology from the Documentary Method, regarding implicit and explicit forms of knowledge and discourse. It results in a typology of three types with different orientations. The study shows, that most of the students consider sexting to be a risky practice; only one type shows normality in the use of sexting. At the same time, some of the young people are interested in experimenting with image-based intimate digital communication. Further, gender differences in use and affectedness are also documented. In this way, orientations toward gender stereotypes “favor” both the attribution of responsibility to girls, and overlook the responsibility of students who perpetrated the boundary violation. The orientations of adolescents should be taken more into account in research as well as in educational programs for the prevention of sexual violence. (shrink)

Several authors have recently argued that the content of pains (and bodily sensations more generally) is imperative rather than descriptive. I show that such an account can help resolve competing intuitions about phantom limb pain. As imperatives, phantom pains are neither true nor false. However, phantom limb pains presuppose falsehoods, in the same way that any imperative which demands something impossible presupposes a falsehood. Phantom pains, like many chronic pains, are thus commands that cannot be satisfied. I conclude by showing (...) that some of the negative psychological consequences of chronic pain are a direct consequence of their imperative nature. (shrink)

The trials of life can wear us down. Unexpected events force us to face a new reality and unanswered prayers lead us to a growing frustration about why God doesn't intervene. We wonder if anything good can come out of this painful, dark, winter season. Grace Wabuke Klein knows that there is purpose in our darkest days and seasons of waiting. In Flourish, Grace meets the reader in their heartache, disappointment, and pain and gives encouragement and a fresh perspective (...) on the winter seasons we all go through, as well as practical steps to not just survive but to find purpose in the unknown and unexpected. Drawing insight from her own winter seasons, Grace reveals the divine purpose in each season of our lives. She explains how: -Fall is a time of release-a necessary season of letting go of offenses, unhealthy relationships, hurts, bad habits, toxic friendships, pride, unforgiveness and other heart issues before we can ever move on to the next season -Winter is a time of unexpected challenges and unknown futures-yet lessons learned in life's storms are deep and full of growth to shape us and makes us stronger. -Spring is a time of new things that require us to be open to new experiences, people, ideas, and perspective-stepping out into the unknown and uncomfortable. -Summer is a time when everything is flourishing-we clearly see how each season cultivated a deeper level of faith and spiritual muscles, developing our character and perseverance. Grace discovered there is value and unseen gifts in each season, but only in the hard seasons and storms of life are vital spiritual disciplines developed. Flourish connects with the reader in the tension and storms of life to bring a word of hope. (shrink)

The Ethical, Legal, and Social Implications (ELSI) program of the Human Genome Project stands as a model for how to organize bioethical inquiry for a rapidly changing field. Neuroscience has experienced significant growth in recent years and there is increasing interest in organizing critical reflection on this field, as evidenced by the creation of “neuroethics.” A nascent framework for reflection on the implications of neuroscience is emerging but significant work remains, given the pace and scope of neuroscientific developments. The adoption (...) of an ELSI program, modeled on that of the ELSI program of the Human Genome Project, promises a way for neuroscience to meet important organizational, educational, and policy objectives. Review of recent criticisms of the HGP ELSI program suggests that an ELSI program for neuroscience would face certain obstacles. Those interested in a neuroscience ELSI program will need to develop appropriate resources to overcome these obstacles. (shrink)

Discussions about brain data and privacy, particularly those advocating for human rights frameworks, at times, have embodied problematic undercurrents of, if not overt appeals to, neuro-exceptional...

Although the dream narrative, of (bio)logical necessity, originates with the dreamer, s/he typically does not know this. For the dreamer, the dream world is the real world. In this article I argue that this nightly misattribution is best explained in terms of the concept of mental ownership (e.g., Albahari, 2006; Klein, 2015a; Lane, 2012). Specifically, the exogenous nature of the dream narrative is the result of an individual assuming perspectival, but not personal, ownership of content s/he authored (i.e., “The (...) content in my head is not mine. Therefore it must be peripherally perceived”). Situating explanation within a theoretical space designed to address questions pertaining to the experienced origins of conscious content has a number of salutatory consequences. For example, it promotes predictive fecundity by bringing to light empirical generalizations whose presence otherwise might have gone unnoticed (e.g., the severely limited role of mental time travel within the dream narrative). -/- . (shrink)

Ist der menschliche Intellekt materiell? Oder können wir mit Verweis auf seine intentionalen Tätigkeiten wie allgemeine Erkenntnis oder Selbsterkenntnis zeigen, dass er immateriell ist? Besteht also ein Zusammenhang zwischen Intentionalität und Immaterialität? Mit Philosophie des Geistes im Spätmittelalter bietet Martin Klein eine umfassende Darstellung der Philosophie des Geistes von Johannes Buridan im Zusammenhang seiner Erkenntnistheorie, Metaphysik und Naturphilosophie. Vor dem Hintergrund neuester Editionen wird Buridan im Kontext der spätmittelalterlichen Debatte über die Natur des menschlichen Intellekts und seine kognitiven Vermögen (...) prätsentiert. In this volume, Martin Klein offers a comprehensive account of John Buridan's philosophy of mind in the context of the late medieval debate about the nature of the human intellect and how this influences its cognitive functioning. (shrink)

Cet ouvrage est l'hommage qu'une des deux filles de Jean Klein (1912-1998), Nita, comédienne et artiste, a décidé de rendre à son père, un des plus célèbres maîtres spirituels du XXe siècle, pour le centième anniversaire de sa naissance. Nita Klein a rassemblé ici de nombreux souvenirs de conversations avec Jean Klein, des inédits, des photographies autour de la question de l'art et de la spiritualité. Jean Klein a été philosophe et un maître spirituel remarquable auteur (...) d'une oeuvre essentielle qui a infuencé de nombreux enseignants contemporains comme Eric Baret, Jean-Bouchart D'Orval, Francis Lucille, Jean-Marc Mantel etc. Même si Jean Klein n'appartenait à aucune école, sa quête de la vérité a rencontré l'Advaïta Vedânta (Non-Dualité) dont il a dit lui-même que " ce n'est pas un système, une religion, une technique. Ce n'est même pas une philosophie, c'est simplement la vérité. " Mais Jean Klein était aussi violoniste (il pratiqua toute sa vie le violon) et s'intéressait à toutes les formes d'art : au théâtre, à la peinture (il était ami de Hans Hartung), à la danse (son autre fille, Malavika, est professeur de danse indienne). Il s'agit donc dans ce livre d'une rencontre entre l'intuition d'un artiste et la recherche indienne de la vérité, recherche plus orientée vers la perception globale de la Réalité que vers les certitudes offertes par le savoir. Nita Klein nous invite à découvrir comment la spiritualité authentique conduit à la création artistique ; comment, dans l'art du théâtre, l'interprétation d'un personnage, peut atteindre à la vérité, quand la personnalité du comédien consent à s'effacer. " En l'absence du "Moi", il y a seulement la vie. ", dit Jean Klein. Et pas seulement dans le théâtre, mais dans la peinture, le dessin, la danse. La Non-Dualité, avec Jean Klein, est une ouverture à la Beauté. (shrink)

Augmented Reality (AR) is commonly defined as a digital layer of information viewed on top of the physical world through a smartphone, tablet or eyewear. Increasingly, this understanding of AR is shifting to a dynamic framework of ‘smart things’, including wearable technology, sensors and artificial intelligence (AI), with the ability to intercede in key moments and to deliver contextual and meaningful experiences. The things that come into context are the logical next steps in an evolutionary development towards computers that are (...) better able to show empathy in relation to people: even more human-oriented, anticipative and ubiquitous. Thus, this outsourcing of meaning to empathic technologies points to one of the fundamental questions concerning the relation of human and technology – the nature of the trust that users place in technology. (shrink)

The Effect: An Introduction to Research Design and Causality is about research design, specifically concerning research that uses observational data to make a causal inference. It is separated into two halves, each with different approaches to that subject. The first half goes through the concepts of causality, with very little in the way of estimation. It introduces the concept of identification thoroughly and clearly and discusses it as a process of trying to isolate variation that has a causal interpretation. Subjects (...) include heavy emphasis on data-generating processes and causal diagrams. Concepts are demonstrated with a heavy emphasis on graphical intuition and the question of what we do to data. When we "add a control variable" what does that actually do? (shrink)

L'incommensurable fait apparaître qu'il est des fêlures irréductibles dans notre expérience révélant de l'infini du sein même de cette expérience: entre le plaisir et la jouissance ou bien le rapport social et l'intime. L'inouï dit, non pas l'extraordinaire ou l'insolite, mais ce qui peut être au contraire le plus commun de notre expérience--mais que nous n'entendons pas parce que nous ne savons pas déborder les cadres figés de cette expérience. La vraie vie fait signe vers ce que, tout en étant (...) en vie, nous risquons de n'être toujours que dans une apparence de vie, ou pseudo-vie, sans accéder à vraiment vivre. Trois concepts proposés par François Jullien pour ne pas laisser rabattre notre vie, mais la porter à son déploiement. Contre les facilités du prêche et du marché du Bonheur, il faut penser ces concepts comme outils pour 'changer la vie.'"--Page 4 of cover. (shrink)

Epistemic scoring rules are the en vogue tool for justifications of the probability norm and further norms of rational belief formation. They are different in kind and application from statistical scoring rules from which they arose. In the first part of the paper I argue that statistical scoring rules, properly understood, are in principle better suited to justify the probability norm than their epistemic brethren. Furthermore, I give a justification of the probability norm applying statistical scoring rules. In the second (...) part of the paper I give a variety of justifications of norms for rational belief formation employing statistical scoring rules. Furthermore, general properties of statistical scoring rules are investigated. Epistemic scoring rules feature as a useful technical tool for constructing statistical scoring rules. (shrink)

This book is the result of several decades of teaching experience in data structures and algorithms. It is self-contained but does assume some prior knowledge of data structures, and a grasp of basic programming and mathematics tools. Basic Concepts in Algorithms focuses on more advanced paradigms and methods combining basic programming constructs as building blocks and their usefulness in the derivation of algorithms. Its coverage includes the algorithms' design process and an analysis of their performance. It is primarily intended as (...) a textbook for the teaching of Algorithms for second-year undergraduate students in study fields related to computers and programming. Klein reproduces his oral teaching style in writing, with one topic leading to another, related one. Most of the classical and some more advanced subjects in the theory of algorithms are covered, though not in a comprehensive manner. The topics include Divide and Conquer, Dynamic Programming, Graph algorithms, probabilistic algorithms, data compression, numerical algorithms and intractability. Each chapter comes with its own set of exercises, and solutions to most of them are appended. (shrink)

L’heure qu’il est, le temps qu’il fait, l’espace du souvenir ou de la prévision : de quelque côté qu’on l’aborde, par le passé, le futur ou le présent, le temps s’échappe et nous fuit. Il est sans matière et pourtant nous habitons en lui, nous sommes emportés par lui, comme tout ce qui existe. Etienne Klein, à la fois physicien et philosophe, propose ici quelques pistes pour cerner la plus immédiate et la plus difficile de toutes les questions.

This paper presents the contributions of Alcindo Flores Cabral, professor of Chemistry at the Faculdade de Agronomia Eliseu Maciel, nowadays part of the Universidade Federal de Pelotas, to chemistry teaching. It is a contribution almost unknown to the Brazilian chemical community, although recognized as valuable by several renowned chemists abroad, like W. Hückel, G. Charlot, F. Strong, E. Fessenden and others. Cabral’s innovative helical representation is presented in connection not only with contemporary representations, but also an incursion is made into (...) the first helical systems proposed, those of Hinrichs and of Baumhauer. Some comments are made not only on Cabral’s Classificação Natural dos Elementos, published in 1946, but also about other texts he wrote for an efficient chemistry teaching. (shrink)

Este artigo apresenta a contribuição de Alcindo Flores Cabral (1907-1982) - professor de química da Faculdade de Agronomia Eliseu Maciel, hoje incorporada à Universidade Federal de Pelotas - ao ensino de química, uma contribuição quase desconhecida pela própria comunidade química brasileira, embora reconhecida como relevante por diversos químicos estrangeiros importantes, como W. Hückel, G. Charlot, F. Strong, E. Fessenden e outros. A inovadora representação helicoidal de Cabral é apresentada não só em conexão com representações contemporâneas, mas também inclui-se uma incursão (...) pelos primeiros sistemas helicoidais propostos, os de Hinrichs e de Baumhauer. Apresentam-se alguns comentários não somente sobre a Classificação natural dos elementos, publicada em 1946, mas também sobre outros textos escritos para tornar mais eficaz o ensino de química. (shrink)

O presente trabalho examina os aspectos históricos da extração do óleo de canela-sassafrás (Ocotea pretiosa Mez), rico em safrol, no Alto e Médio Vale do Itajaí, a partir de 1940, por iniciativa de Otto Grimm, no município de Rio do Sul. Apresenta-se o tema no contexto da memória química em Santa Catarina, e discutem-se os procedimentos utilizados, e principalmente os motivos que levaram tal indústria incipiente a não se converter em uma indústria de química fina. Para tanto, são apresentados alguns (...) dados pertinentes à química do safrol, indicando que tal indústria poderia ter evoluído, bem como os aspectos econômicos e sociais que, ao lado da proibição do corte da canela-sassafrás, levaram em 1990 à extinção definitiva dessa "química fina que poderia ter sido". (shrink)

Dos diferentes fatores associados a uma mudança de paradigma e, portanto, a uma revolução química, o menos discutido é o que envolve os assim chamados experimentos exemplares, mudanças radicais na metodologia de trabalho e nos procedimentos empíricos da química, mudanças e modificações estas que, no caso de uma ciência natural empírica, podem ter como consequência dados experimentais antes inacessíveis, levando, por fim, a uma nova abordagem de conceitos, hipóteses e teorias e desencadeando uma "revolução" química, um novo paradigma. Muito mais (...) do que uma revolução química, dever-se-ia optar por uma gradativa evolução química. Escolhemos três dessas situações como "exemplares": a modificação no procedimento empírico da química pneumática, com o uso da cuba pneumática contendo mercúrio; a introdução de novos métodos de extração de compostos orgânicos naturais, com a substituição do método pirogênico pelo de extração com solventes; um novo entendimento de "análise química", com a substituição da comparação de amostras tidas como autênticas pela decomposição do analito. (shrink)

The chemist Max von Pettenkofer studied with Justus von Liebig, and after leaving Giessen in 1844 did not immediately find an academic position. During the period 1844/1845 he wrote a cycle of 16 Chemical Sonnets, but published them only in 1886. The Sonnets have with few exceptions a historiographical character. We present a translation of the Sonette into Portuguese as well as commentaries about their content and their philosophical significance. We also comment rather briefly on Pettenkofer’s career as an empirical (...) chemist and later as a somewhat heterodox hygienist. (shrink)

In this essay, we aim to provide an overview of the periodic table’s origins and history, and of the elements which conspired to make it chemistry’s most recognisable icon. We pay attention to Mendeleev’s role in the development of a system for organising the elements and chemical knowledge while facilitating the teaching of chemistry. We look at how the reception of the table in different chemical communities was dependent on the local scientific, cultural and political context, but argue that its (...) eventual universal acceptance is due to its unique ability to accommodate possessed knowledge while enabling novel predictions. Furthermore, we argue that its capacity to unify apparently disconnected phenomena under a simple framework facilitates our understanding of periodicity, making the table an icon of aesthetic value, and an object of philosophical inquiry. Finally, we briefly explore the table’s iconicity throughout its representations in pop art and science fiction. (shrink)