A unifying theory of general anesthetic-induced unconsciousness must explain the common mechanism through which various anesthetic agents produce unconsciousness. Functional-brain-imaging data obtained from 11 volunteers during general anesthesia showed specific suppression of regional thalamic and midbrain reticular formation activity across two different commonly used volatile agents. These findings are discussed in relation to findings from sleep neurophysiology and the implications of this work for consciousness research. It is hypothesized that the essential common neurophysiologic mechanism underlying anesthetic-induced unconsciousness is, as with (...) sleep-induced unconsciousness, a hyperpolarization block of thalamocortical neurons. A model of anesthetic-induced unconsciousness is introduced to explain how the plethora of effects anesthetics have on cellular functioning ultimately all converge on a single neuroanatomic/neurophysiologic system, thus providing for a unitary physiologic theory of narcosis related to consciousness. (shrink)

From Bohm-Bawerk on, political economists have seemingly blown great holes in Marxism, disproving its key concepts and falsifying Marx's predictions. In this book, Geoffrey Pilling maintains that even the most devastating of such factual analyses are fruitless because they misconstrue the nature of Marx's critique. In Pilling's presentation, Marx's critique of political economy is not "economic" but philosophic. In criticizing political economy, Marx transcends it and in so doing is essentially immune from any analysis which turns on "facts." According to (...) Pilling, "Marx's work cannot be reduced to a series of results, to be tested against the 'facts' of capitalist development". Pilling, following the lead of Lenin, seeks to overturn the "shallow empiricism" which has led to the degeneration of Marxism. It is Pilling's aim to recover the "philosophical method" of Capital, i.e., to re-work Capital in the light of Hegel's Logic, to rehabilitate dialectic over empiricism. Pilling begins by showing how "... Marx's critique of political economy [is] of a philosophic nature, rather than one concerned with the details of economic theory alone". Marx, as we know, rejects the individualism of political economy which derives from Locke. He condemns the uncritical and "ahistorical" character of political economy, i.e., the tendency to treat the categories of economics as natural. According to Pilling's. (shrink)