Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

Power has been studied in various guises in both the social cognition and the reasoning literatures. In this paper, three experiments are reported in which this factor was investigated in the domain of deontic thinking. Power of source of deontic statements was varied within several scenarios, and participants judged the degree to which they thought an injunction would be carried out. In the first experiment, permission statements were used, and it was found that, as predicted, power was positively related to (...) degree of endorsement of deontic conclusions across scenarios. In the second experiment, these findings were generalised across three further deontic domains (threat, warning, and promise) and two different syntactic forms (conjunctive and disjunctive). In the third experiment, the hypothesis that power effects were mediated by subjective judgements of conditional probability was investigated and confirmed. It is argued that these results favour theories that give a general role to probabilistic factors, rather than those based on domain-specific schemas. (shrink)

Logic today is a ramified discipline existing on many levels. It is actively pursued by philosophers, mathemeticians, and computer specialists. The reason is that it is widely employed to solve a number of problems both in the theory of knowledge and in mathematics and computer science. But the broad spectrum of application of contemporary logic does not change the fact that its basic content has the nature of philosophical methodology. In contemporary logic it is the forms of thought and the (...) methods of scientific cognition, the modes of organization of scientific knowledge, and the procedures for the introduction of various concepts, abstractions, and idealizations that are studied. This places logic in intimate contact with epistemology and methodology. The distinctiveness of the approach taken by formal logic to this particular subject consists simply of its studying all these procedures pertaining to concrete cognition through the use of special formal languages, of algebraic, topological, and other exact techniques. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

Co-authored letter to the APA to take a lead role in the recognition of teaching in the classroom, based on the participation in an interdisciplinary Conference on the Role of Advocacy in the Classroom back in 1995. At the time of this writing, the late Myles Brand was the President of Indiana University and a member of the IU Department of Philosophy.

The objectives of this study were to develop a high-density chromosome bin map of homoeologous group 7 in hexaploid wheat, to identify gene distribution in these chromosomes, and to perform comparative studies of wheat with rice and barley. We mapped 2148 loci from 919 EST clones onto group 7 chromosomes of wheat. In the majority of cases the numbers of loci were significantly lower in the centromeric regions and tended to increase in the distal regions. The level of duplicated loci (...) in this group was 24% with most of these loci being localized toward the distal regions. One hundred nineteen EST probes that hybridized to three fragments and mapped to the three group 7 chromosomes were designated landmark probes and were used to construct a consensus homoeologous group 7 map. An additional 49 probes that mapped to 7AS, 7DS, and the ancestral translocated segment involving 7BS also were designated landmarks. Landmark probe orders and comparative maps of wheat, rice, and barley were produced on the basis of corresponding rice BAC/PAC and genetic markers that mapped on chromosomes 6 and 8 of rice. Identification of landmark ESTs and development of consensus maps may provide a framework of conserved coding regions predating the evolution of wheat genomes. (shrink)

High-spin states in the odd-odd N = Z nucleus Co-54 have been investigated by the fusion-evaporation reaction Si-28(S-32,1 alpha 1p1n)Co-54. Gamma-ray information gathered with the Ge detector array Gammasphere was correlated with evaporated particles detected in the charged particle detector system Microball and a 1 pi neutron detector array. A significantly extended excitation scheme of Co-54 is presented, which includes a candidate for the isospin T = 1, 6(+) state of the 1f(7/2)(-2) multiplet. The results are compared to large-scale shell-model (...) calculations in the fp shell. Effective interactions with and without isospin-breaking terms have been used to probe isospin symmetry and isospin mixing. A quest for deformed high-spin rotational cascades proved negative. This feature is discussed by means of cranking calculations. (shrink)

This is a collection of lectures and papers, written during the past ten years. They are all concerned with the logical properties of the Absolute and to this extent are a denial of the author's 1948 argument designed to disprove the existence of an Absolute Being. The first three lectures on Absolute-theory are a systematic account of the notion of a unique, necessary Existent and the repercussions such a notion has upon other philosophical problems such as space and time, substance (...) and causality, life and mind, value and evil, etc., and finally, the relation of logical necessity between this notion and a rational eschatology. The twelve remaining lectures cumulatively demonstrate the path toward a revisionary metaphysics which is logically founded upon Absolute-theory. Each is a complete essay in itself and the titles are largely descriptive of the contents. "The Teaching of Meaning" is an interchange between the author and other contemporary philosophers interested in the subject. "Some Reflections on Necessary Existence" concerns the propriety of affirming a categorically necessary existent and searches for a feasible ontological argument in the realm of value. "Freedom and Value" explores the relation between the two, while "Metaphysics and Affinity" explores the relation between thought and being, between the realities of our environment and our metaphysical approaches to them. "Hegel's Use of Teleology" is a thoroughgoing study of teleology in the works of Hegel. A description of our fragmentational approach to reality is contained in "The Diremptive Tendencies of Western Philosophy." The "Logic of Mysticism" is a refutation of Stace's account and a sketch of mysticism as a logical matter, i.e., as a frame of mind connected with some sort of absolute. "Essential Probabilities" is an attempt to formulate and connect the eidetic method in philosophy with modalities, especially probability, considering its role in an a priori framework. "The Logic of Ultimates" sets out the important theorems in an absolutist logic, refutes common candidates for absolute status, and finally proposes some sort of 'infinite' teleology as a viable form of absolutism. "The Systematic Unity of Value" is an analysis of the ways and means of asserting common values and of relating them to their logical keystone found in Absolute-theory. "Intentional Inexistence" establishes intentionality as categorical and defines its working mode which culminates in a picture of 'unitive logic'. The final paper, "Toward a Neo-Neo-Platonism," is the delineation of what a metaphysic ought to envisage through a unifying, living logic which embodies the absolute. All in all, this is a refreshing, meaty reconsideration of some very out-of-vogue topics.--G. M. K. (shrink)

Epsilon terms indexed by contexts were used by K. von Heusinger to represent definite and indefinite noun phrases as well as some other constructs of natural language. We provide a language and a complete first order system allowing to formalize basic aspects of this representation. The main axiom says that for any finite collection S 1,…,S k of distinct definable sets and elements a 1,…,a k of these sets there exists a choice function assigning a i to S i for (...) all i≤k. We prove soundness and completeness theorems for this system S ε i fin. (shrink)

An implicit association test (IAT) measures differential association of 2 target concepts with an attribute. The 2 concepts appear in a 2-choice task (e.g., flower vs. insect names), and the attribute in a 2nd task (e.g., pleasant vs. unpleasant words for an evaluation attribute). When instructions oblige highly associated categories (e.g., flower + pleasant) to share a response key, performance is faster than when less associated categories (e.g., insect + pleasant) share a key. This performance difference implicitly measures differential association (...) of the 2 concepts with the attribute. In 3 experiments, the IAT was sensitive to (a) near-universal evaluative differences (e.g., flower vs. insect), (b) expected individual differences in evaluative associations (Japanese + pleasant vs. Korean + pleasant for Japanese vs. Korean subjects), and (c) consciously disavowed evaluative differences (Black + pleasant vs. White + pleasant for self-described unprejudiced White subjects). (PsycINFO Database Record (c) 2016 APA, all rights reserved). (shrink)

PURPOSE:To report the localization of a gene causing drusen and macular degeneration in a previously undescribed North American family. METHODS:Genetic mapping studies were performed using linkage analysis in a single family with drusen and atrophic macular degeneration. RESULTS:The clinical manifestations in this family ranged from fine macular drusen in asymptomatic middle-aged individuals to atrophic macular lesions in two children and two elderly patients. We mapped the gene to chromosome 6q14 between markers D6S2258 and D6S1644. CONCLUSIONS:In a family with autosomal dominant (...) drusen and atrophic macular degeneration, the gene maps to a 3.2-cM region on chromosome 6q14. This locus appears to be distinct from, but adjacent to, the loci for cone-rod dystrophy 7 (CORD7) and North Carolina macular dystrophy (MCDR1). Future identification of the gene responsible for the disease in this family will provide a better understanding of macular degeneration. (shrink)