A photoaffinity analog of cGMP has been used to biochemically identify a new ligand-binding subunit of the retinal rod cGMP-activated ion channel, as well as amino acids in contact with cGMP in the original subunit. Covalent tethering of this probe to channels in excised menbrane patches has revealed a functional heteogeneity in the ligand-binding sites that may arise from the two biochemically identified subunits.

The powerful combination of genetic, developmental and molecular approaches possible with the fruit fly, Drosophila melanogaster, has led to a profound understanding of the genetic control of early developmental events. However, Drosophila is a highly specialized long germ insect, and the mechanisms controlling its early development may not be typical of insects or Arthropods in general. The beetle, Tribolium castaneum, offers a similar opportunity to integrate high resolution genetic analysis with the developmental/molecular approaches currently used in other organisms. Early results (...) document significant differences between insect orders in the functions of genes responsible for establishing developmental commitments. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

Philosophy &Public Affairs, Volume 47, Issue 2, Page 208-254, Spring 2019.

Alexis de Tocqueville once wrote that "the people reign over the American political world like God over the universe," unwittingly casting democracy as the political instantiation of the death of God. According to Jeffrey W. Robbins, Tocqueville's assessment remains an apt observation of modern democratic power, which does not rest with a sovereign authority but operates as a diffuse social force. By linking radical democratic theory to a contemporary fascination with political theology, Robbins envisions the modern experience of democracy (...) as a social, cultural, and political force transforming the nature of sovereign power and political authority. Robbins joins his work with Michael Hardt and Antonio Negri's radical conception of "network power," as well as Sheldon Wolin's notion of "fugitive democracy," to fashion a political theology that captures modern democracy's social and cultural torment. This approach has profound implications not only for the nature of contemporary religious belief and practice but also for the reconceptualization of the proper relationship between religion and politics. Challenging the modern, liberal, and secular assumption of a neutral public space, Robbins conceives of a postsecular politics for contemporary society that inextricably links religion to the political. While effectively recasting the tradition of radical theology as a political theology, this book also develops a comprehensive critique of the political theology bequeathed by Carl Schmitt. It marks an original and visionary achievement by the scholar the _Journal of the American Academy of Religion_ hailed "one of the best commentators on religion and postmodernism.". (shrink)

The case (Dawson et al. 2024) describes an Institutional Review Board (IRB) chair who seeks consultation about waiving the requirement that investigators obtain prospective, informed consent for co...

In this article, we describe four theoretical and methodological problems that have impeded implicit attitude research and the popular understanding of its findings. The problems all revolve around assumptions made about the relationships among measures, constructs, cognitive processes, and features of processing. These assumptions have confused our understandings of exactly what we are measuring, the processes that produce implicit evaluations, the meaning of differences in implicit evaluations across people and contexts, the meaning of changes in implicit evaluations in response to (...) intervention, and how implicit evaluations predict behavior. We describe formal modeling as one means to address these problems, and provide illustrative examples. Clarifying these issues has important implications for our understanding of who has particular implicit evaluations and why, when those evaluations are likely to be particularly problematic, how we might best try to change them, and what interventions are best suited to minimize the effects of implicit evaluations on behavior. (shrink)

According to an influential contextualist solution to skepticism advanced by Keith DeRose, denials of skeptical hypotheses are, in most contexts, strong yet insensitive. The strength of such denials allows for knowledge of them, thus undermining skepticism, while the insensitivity of such denials explains our intuition that we do not know them. In this paper we argue that, under some well-motivated conditions, a negated skeptical hypothesis is strong only if it is sensitive. We also consider how a natural response on behalf (...) of DeRose appears to be equally available to his primary rival (viz., the sensitivity theorist). (shrink)

While effectively recasting the tradition of radical theology as a political theology, this book also develops a comprehensive critique of the political theology bequeathed by Carl Schmitt.

The proposal that the criminal justice system should focus on rehabilitation – rather than retribution, deterrence, or expressive denunciation – is among the least popular ideas in legal philosophy. Foremost among rehabilitation’s alleged weaknesses is that it views criminals as blameless patients to be treated, rather than culpable moral agents to be held accountable. This article offers a new interpretation of the rehabilitative approach that is immune to this objection and that furnishes the moral foundation that this approach has lacked. (...) The view rests on the principle that moral agents owe it to one another to maintain the dependability of their moral capacities. Agents who culpably commit criminal wrongs, however, betray an unacceptable degree of moral unreliability. Punishment, on this theory, consists in the enforcement of the duties that offenders have to reduce their own likelihood of recidivism. (shrink)

Scientists’ identities and social locations influence their work, but the content of scientific work can also influence scientists. Theory from feminist science studies, autoethnographic accounts, interviews, and experiments indicate that the substance of scientific research can have profound effects on how scientists are treated by colleagues and their sense of belonging in science. I bring together these disparate literatures under the framework of professional cultures. Drawing on the Survey of Earned Doctorates and the Web of Science, I use computational social (...) science tools to argue that the way scientists write about sex in their research influences the future gender ratio of PhDs awarded across 53 subfields of the life sciences over a span of 47 years. Specifically, I show that a critical paradigm of “feminist biology” that seeks to de-essentialize sex and gender corresponds to increases in women’s graduation rates, whereas “sex difference” research—sometimes called “neurosexism” because of its emphasis on essential, categorical differences—corresponds to decreases in women’s graduation rates in most fields. (shrink)

Journal of Political Philosophy, EarlyView.

Penelope Maddy advances a purportedly naturalistic account of mathematical methodology which might be taken to answer the question 'What justifies axioms of set theory?' I argue that her account fails both to adequately answer this question and to be naturalistic. Further, the way in which it fails to answer the question deprives it of an analog to one of the chief attractions of naturalism. Naturalism is attractive to naturalists and nonnaturalists alike because it explains the reliability of scientific practice. Maddy's (...) account, on the other hand, appears to be unable to similarly explain the reliability of mathematical practice without violating one of its central tenets. (shrink)

Journal of Political Philosophy, EarlyView.

Journal of Political Philosophy, EarlyView.

Journal of Political Philosophy, EarlyView.

It has long been assumed that the more modern we become, the less religious we will be. Yet a recent resurrection in faith has challenged the certainty of this belief. In these original essays and interviews, leading hermeneutical philosophers and postmodern theorists John D. Caputo and Gianni Vattimo engage with each other's past and present work on the subject and reflect on our transition from secularism to postsecularism. As two of the figures who have contributed the most to the theoretical (...) reflections on the contemporary philosophical turn to religion, Caputo and Vattimo explore the changes, distortions, and reforms that are a part of our postmodern faith and the forces shaping the religious imagination today. Incisively and imaginatively connecting their argument to issues ranging from terrorism to fanaticism and from politics to media and culture, these thinkers continue to reinvent the field of hermeneutic philosophy with wit, grace, and passion. (shrink)

In this paper, I consider an argument for the claim that any satisfactory epistemology of mathematics will violate core tenets of naturalism, i.e. that mathematics cannot be naturalized. I find little reason for optimism that the argument can be effectively answered.

C. S. Jenkins has recently proposed an account of arithmetical knowledge designed to be realist, empiricist, and apriorist: realist in that what’s the case in arithmetic doesn’t rely on us being any particular way; empiricist in that arithmetic knowledge crucially depends on the senses; and apriorist in that it accommodates the time-honored judgment that there is something special about arithmetical knowledge, something we have historically labeled with ‘a priori’. I’m here concerned with the prospects for extending Jenkins’s account beyond arithmetic—in (...) particular, to set theory. After setting out the central elements of Jenkins’s account and entertaining challenges to extending it to set theory, I conclude that a satisfactory such extension is unlikely. (shrink)

Philip Kitcher's account of scientific progress incorporates a conception of explanatory unification that invites the so-called 'obsessive unifier' worry, to wit, that in our drive to unify the phenomena we might impose artificial structure on the world and consequently produce an incorrect view of how things, in fact, are. I argue that Kitcher's attempt to address this worry is unsatisfactory because it relies on an ability to choose between rival patterns of explanation which itself rests on the relevant choice having (...) already been made. I also suggest a way of answering the worry that Kitcher is not likely to endorse. (shrink)

It has long been assumed that the more modern we become, the less religious we will be. Yet a recent resurrection in faith has challenged the certainty of this belief. In these original essays and interviews, leading hermeneutical philosophers and postmodern theorists John D. Caputo and Gianni Vattimo engage with each other's past and present work on the subject and reflect on our transition from secularism to postsecularism. As two of the figures who have contributed the most to the theoretical (...) reflections on the contemporary philosophical turn to religion, Caputo and Vattimo explore the changes, distortions, and reforms that are a part of our postmodern faith and the forces shaping the religious imagination today. Incisively and imaginatively connecting their argument to issues ranging from terrorism to fanaticism and from politics to media and culture, these thinkers continue to reinvent the field of hermeneutic philosophy with wit, grace, and passion. (shrink)

This paper argues that Philip Kitcher's epistemology of mathematics, codified in his Naturalistic Constructivism, is not naturalistic on Kitcher's own conception of naturalism. Kitcher's conception of naturalism is committed to (i) explaining the correctness of belief-regulating norms and (ii) a realist notion of truth. Naturalistic Constructivism is unable to simultaneously meet both of these commitments.

Why do some physicians continue to treat patients who are clearly dying or persistently unconscious, while others consider medical intervention to be futile past a certain point? No doubt, medical decisions vary in part because clinical information is often ambiguous in individual cases and because it may support more than one reasonable interpretation of a patient's chances for survival or improvement if a particular treatment is administered. Also, cases vary considerably to the extent that a patient's or a family member's (...) preferences for treatment are communicated, understood, and implemented. But, beyond these contingencies, patients at the end of life may receive more, less, or different treatment because physicians themselves are social actors, individuals who bring to bear on their clinical decisions a variety of personal attitudes, values, concerns, and interests. Legal defensiveness, religious vitalism, authoritarianism, intolerance of ambiguity, and other traits may influence physicians’ behavior, but each may be concealed under the rubric of what is “medically indicated” or “medically appropriate.”. (shrink)

Why do some physicians continue to treat patients who are clearly dying or persistently unconscious, while others consider medical intervention to be futile past a certain point? No doubt, medical decisions vary in part because clinical information is often ambiguous in individual cases and because it may support more than one reasonable interpretation of a patient's chances for survival or improvement if a particular treatment is administered. Also, cases vary considerably to the extent that a patient's or a family member's (...) preferences for treatment are communicated, understood, and implemented. But, beyond these contingencies, patients at the end of life may receive more, less, or different treatment because physicians themselves are social actors, individuals who bring to bear on their clinical decisions a variety of personal attitudes, values, concerns, and interests. Legal defensiveness, religious vitalism, authoritarianism, intolerance of ambiguity, and other traits may influence physicians’ behavior, but each may be concealed under the rubric of what is “medically indicated” or “medically appropriate.”. (shrink)

This paper examines the problem of ontotheology as it was defined by Martin Heidegger, and how it has subsequently been approached by those philosophers and theologians who have followed in his wake. It argues that Heidegger’s initial analysis of the onto‐theological condition was mistaken by its presumption of a radical divide between philosophy and theology. Furthermore, many of the key thinkers who have followed after Heidegger have merely reinscribed this supposed divide between thought and faith, rather than genuinely questioning the (...) terms Heidegger thought self‐evident. The result, even among some of the most radical and influential contemporary thinkers such as Emmanuel Levinas, John Caputo, and Jean‐Luc Marion, has been a contemporary philosophy deprived of questions of faith and a theology unaccountable to its place in the world. In response to this shortcoming of contemporary philosophical and theological thought, Jacques Derrida has approached the problem of ontotheology from the dual perspective of both thought and faith, and thereby, has provided a new path of thought beyond the problem of ontotheology and towards a renewed appreciation for the possibilities for a genuine philosophical theology. (shrink)

Introduction: The ontological condition -- The problem of philosophical theology -- Interlude 1, on political boundaries and profit: The path of theology : a study of Dietrich Bonhoeffer -- The path of phenomenology : a study of Edmund Husserl -- Interlude 2, on translations: Phenomenology turned theology -- Interlude 3, on bibliolatry: Otherwise than overcoming -- Postlude: on the feminine and ontotheology.

We argue that the dual-system approach and, particularly, the default-interventionist framework favored by De Neys unnecessarily constrains process models, limiting their range of application. In turn, the accommodations De Neys makes for these constraints raise questions of parsimony and falsifiability. We conclude that the extent to which processes possess features of system 1 versus system 2 must be tested empirically.

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 35.1 (2002) 22-49 [Access article in PDF] Kenneth Burke: A Dialogue of Motives Jeffrey W. Murray [Figures] Introduction In "Four Master Tropes," Appendix D of A Grammar of Motives (1969a), Kenneth Burke investigates the tropes of metaphor, metonymy, synecdoche, and irony. His "primary concern with them... [is] not with their purely figurative usage, but with their role in the discovery and description of 'the truth'" (...) (1969a, 503). Burke's placement of "the truth" in quotation marks reflects his rejection of any simplistically objectivist notion of truth. He is not interested in how these rhetorical figures ornament truth, as if truth existed prior to the entrance of rhetoric. Rather, the relationship between these four master tropes and truth is more complicated. Truth is, for Burke, a rhetorical product as much as a rhetorical precursor. Hence, the tropes function not only epistemologically in the discovery of truth, but also ontologically in the very constitution of truth. 1 Burke's subsequent discussion of metaphor, metonymy, synecdoche, and irony illustrates how each trope functions dramatistically to make, and to make known, the world.When Burke discusses the trope of irony, the relationship between rhetoric and truth is further complicated. Irony is dialogical. 2 Whereas metaphor, metonymy, and synecdoche offer particular perspectives for viewing and knowing the world, irony offers a "perspective of perspectives" (1969a, 512). Ultimately, irony depends upon the perspectives of Others—of other symbol users—and is thus an explicitly dialogical rather than rhetorical trope. Moreover, this inclusion of the voices of Others in the construction of "truth" distinguishes irony as ethical. Irony may, in fact, offer the clearest view of Burke's own incipient theory of ethics. Over against his few explicit discussions of ethics, which reflect either an Aristotelian or Kantian approach to ethics, 3 Burke's development of the master trope of irony as a dialogical vehicle for the construction of intersubjective [End Page 22] truth reveals his maturing approach to ethics and a tacit synthesis of his dramatistic accounts of epistemology, ontology, and ethics.Yet another concept is even more foundational for Burke's incipient theory of ethics within a dramatistic framework. Recalcitrance precedes irony as an account of the presencing of otherness in and through language. Prior to the experience of irony as a clash of perspectives, recalcitrance is the very crashing in of the second perspective. It is the resistance that is met by any particular symbolic framing of the world. Together, recalcitrance and irony form the core of Burke's (underdeveloped) dramatistic theory of ethics and constitute the groundwork for his proposed final installment of his trilogy, which might instead be appropriately "A Dialogue of Motives."Using Emmanuel Levinas's phenomenology of the Other and reconception of ethics as the call to responsibility, 4 this article will demonstrate that Burke's notions of recalcitrance and irony are the groundwork for a full dramatistic description of the phenomenological encounter with the Other and of the nature of the ethical encounter. Moreover, this discussion of recalcitrance and irony will be placed in the context of Burke's two major works, A Grammar of Motives (1969a) and A Rhetoric of Motives (1969b), in an attempt to indicate the implicit trajectory of these works toward the third volume of the trilogy, referred to here as "A Dialogue of Motives." 5 The addition of "A Dialogue of Motives" will rectify Burke's lack of emphasis on ethics and upon the Other, and together, Burke's A Grammar of Motives, A Rhetoric of Motives, and "A Dialogue of Motives"will recast traditional philosophy's main branches of ontology, epistemology, and ethics into dramatistic—i.e., grammatical, rhetorical, and dialogical—terms.In addition, this proposed completion of Burke's trilogy provides a unique conception of dialogue that promises to expand and enrich existing conceptions of dialogue within the field of communication studies. Specifically, a dramatistic notion of dialogue bifurcates traditional notions of two-way, dialogical communication into a "rhetoric" of motives that seeks identification and a "dialogue" of motives that maintains difference. To that end, Burke's notion of dialectic will be discussed in order to... (shrink)

Duncan Pritchard has argued that his basis-relative anti-luck construal of a safety condition on knowing avoids the problem with necessary truths that safety conditions are often thought to have, viz., that beliefs the contents of which are necessarily true are trivially safe. He has further argued that adding an ability condition to truth, belief, and his anti-luck safety conditions yields an adequate account of knowledge. In this paper, we argue that not only does Pritchard’s anti-luck safety condition have a problem (...) with necessary truths, adding an ability condition is of no help. Indeed, the same sort of case that precipitates Pritchard’s introduction of an ability condition shows the inadequacy of his completed anti-luck account of knowledge. Moreover, reconstruing safety as an anti-risk condition as Pritchard has recently done does not fix the problem we’ve identified. We conclude by entertaining a radical suggestion to the effect that the failures of safety-based accounts of modal knowledge are due to failures of doxastic success rather than failures to satisfy an anti-luck (or anti-risk) condition. Accepting this radical suggestion makes available the view that there is, after all, no special problem between safety and necessary truths. (shrink)

Kenneth Burke: A Dialogue of Motives employs the philosophy of ethics of Emmanuel Levinas to develop a uniquely dramatistic philosophy of ethics. Jeffrey Murray analyzes Kenneth Burke's A Grammar of Motives and A Rhetoric of Motives and offers the notion of "a dialogue of motives" as a completion of Burke's proposed trilogy and as a supplement to Burke's own tools for rhetorical criticism.