This volume brings together a number of original articles by leading Leibniz scholars to address the meaning and significance of Leibniz’s notions of compossibility and possible worlds. In order to avoid the conclusion that everything that exists is necessary, or that all possibles are actual, as Spinoza held, Leibniz argued that not all possible substances are compossible, that is, capable of coexisting. In Leibniz’s view, the compossibility relation divides all possible substances into disjoint sets, each of which constitutes a possible (...) world, or a way that God might have created things. For Leibniz, then, it is the compossibility relation that individuates possible worlds; and possible worlds form the objects of God’s choice, from among which he chooses the best for creation. Thus the notions of compossibility and possible worlds are of major significance for Leibniz’s metaphysics, his theodicy, and, ultimately, for his ethics. Given the fact, however, that none of the approaches to understanding Leibniz’s notions of compossibility and possible words suggested to date have gained universal acceptance, the goal of this book is to gather a body of new papers that explore ways of either refining previous interpretations in light of the objections that have been raised against them, or ways of framing new interpretations that will contribute to a fresh understanding of these key notions in Leibniz’s thought. (shrink)

"The documents gathered in this volume cut a winding path through the tumultuous final thirty-three months of Leibniz's life, from March 1714 to his death on 14 November 1716. The disputes with Newton and his followers over the discovery of the calculus and, later, over the issues in natural philosophy and theology that came to dominate Leibniz's correspondence with Samuel Clarke certainly loom large in the story of these years. But as the title of this volume is intended to convey, (...) the letters exchanged between Leibniz and Caroline of Brandenburg-Ansbach, Electoral Princess of Braunschweig-Luneburg and later Princess of Wales, also figure prominently in their telling, and I have included their complete extant correspondence from 1714 to 1716. These letters are of particular interest inasmuch as they provide valuable insights into how and why Leibniz's correspondence with Clarke arose, and why it developed as it did, with Caroline in the role of influential go-between; whence the title, The Leibniz-Caroline-Clarke Correspondence. But there is more; for these letters provide a window into the evolving personal relationship between Leibniz and Caroline. Much of the early correspondence between Leibniz and Caroline after her arrival in England is filled with thoughtful and engaging exchanges about philosophy, literature, and politics, about people Caroline was meeting in England, about those known by Leibniz far and wide, about the new royal family in England, headed by George I (Georg Ludwig of Braunschweig-Luneburg), as well as gossip about affairs of state in both England and Europe at large. Beyond the interest they hold for Leibniz scholars in particular, many of these exchanges should also be of interest to historians of early 18th-century England and Europe, and especially to those interested in the period immediately preceding and following the Hanoverian succession to the throne of England. But even quite early on in their correspondence Leibniz seemed to sense a threat to his relationship with Caroline, and a worrisome paranoia began to creep into some of his letters to her, letters in which he expressed concerns about her continuing allegiance to him now that she had been installed in England amongst his rivals. As the correspondence progressed, Leibniz's paranoia only deepened; but it was nevertheless prophetic of a tragic truth to come. For the letters exchanged between Leibniz and Caroline document the rather sad story of the slow but steady erosion of Caroline's loyalty to Leibniz after she departed Hanover on 12 October 1714 and landed in England at Margate in Kent on 22 October as the new Princess of Wales and future Queen of England. In 1727 the Scottish poet James Thomson penned A Poem Sacred to the Memory of Sir Isaac Newton, calling him "our philosophic sun," and it was by force of the political and cultural mass of this sun that Caroline was eventually, and inexorably, drawn into its orbit, and away from Leibniz". (shrink)

The U.S. and Canadian health care systems are more similar than is commonly believed. This article debunks some of the powerful myths about these health care systems and opens up the discussion for greater policy learning from both sides of the border. Cross-border comparisons can yield a number of lessons from common policy challenges such as cost control, physician organization and payment, and the organization of health coverage and services for Native Americans and Indigenous Canadians.

In 1676 Leibniz reluctantly left Paris, headed for Hanover, to take up the position of counselor and librarian to Johann Friedrich, duke of Brunswick—Lüneburg—Calenberg. He was to remain in the employ of a succession of dukes and electors of Hanover—the last being Georg Ludwig, who became George I of England in 1714—until his death in November 1716. During this time he also became a familiar at the court in Berlin of the elector of Brandenburg (later King of Prussia) and at (...) the imperial court in Vienna. This paper traces the important relationships that developed between Leibniz and a number of the ladies of these courts. (shrink)

End-of-life decision making is fraught with ethical challenges. Withholding or withdrawing life support therapy is widely considered ethical in patients with high treatment burden, poor premorbid status, or significant projected disability even when such treatment is not “futile.” Whether such withdrawal of therapy in the aftermath of attempted suicide is ethical is not well established in the literature. We provide a clinical vignette and propose criteria under which such withdrawal would be ethical. We suggest that it is appropriate to withdraw (...) life support, regardless of the cause of the critical illness or disability, when the following criteria are met: Surrogates request withdrawal of care and the adequacy of surrogates is confirmed, an external reasonability standard is met, passage of time, perhaps 72 hours, to allow certainty regarding the patient's wishes, and psychiatric morbidity should be considered as grounds for withdrawal only in truly treatment-refractory cases. Fundamentally, we believe the question to ask is, “If this were not an attempted suicide, would a request to withdraw care be reasonable?” We believe that under these circumstances, such withdrawal of life support, even in an individual who has attempted suicide, does not constitute physician assistance with suicide and is distinct from physician aid-in-dying in several important respects. (shrink)

End-of-life decision making is fraught with ethical challenges. Withholding or withdrawing life support therapy is widely considered ethical in patients with high treatment burden, poor premorbid status, or significant projected disability even when such treatment is not ?futile.? Whether such withdrawal of therapy in the aftermath of attempted suicide is ethical is not well established in the literature. We provide a clinical vignette and propose criteria under which such withdrawal would be ethical. We suggest that it is appropriate to withdraw (...) life support, regardless of the cause of the critical illness or disability, when the following criteria are met: (1) Surrogates request withdrawal of care and the adequacy of surrogates is confirmed, (2) an external reasonability standard is met, (3) passage of time, perhaps 72 hours, to allow certainty regarding the patient's wishes, and (4) psychiatric morbidity should be considered as grounds for withdrawal only in truly treatment-refractory cases. Fundamentally, we believe the question to ask is, ?If this were not an attempted suicide, would a request to withdraw care be reasonable?? We believe that under these circumstances, such withdrawal of life support, even in an individual who has attempted suicide, does not constitute physician assistance with suicide and is distinct from physician aid-in-dying in several important respects. (shrink)

While he was in the employ of the Elector of Mainz, between 1668 and 1671, Leibniz produced a series of important studies in natural law. One of these, dated between 1670 and 1671, is especially noteworthy since it contains Leibniz's earliest sustained attempt to develop an account of justice. Central to this account is the notion of what Leibniz would later come to call `disinterested love', a notion that remained essentially unchanged in Leibniz's work from this period to the end (...) of his life. Through his notion of disinterested love, Leibniz sought to resolve the supposed conflict between self- and other-regarding motives. For a variety of reasons, many commentators have failed to understand the basis of Leibniz's proposed resolution. My purpose in the present paper is to clarify the terms in which Leibniz effected this resolution, as well as to point out important developments in his later thought concerning the relation between pleasure, good, and happiness. (shrink)

One argument that Leibniz employed to rule out the possibility of a world soul appears to turn on the assumption that the very notion of an infinite number or of an infinite whole is inconsistent. This argument was considered in a series of three papers published in The Leibniz Review: in the first, by Laurence Carlin, the argument was delineated and analyzed; in the second, by myself, the argument was criticized and rejected; in the third, by Richard Arthur, an attempt (...) was made to defend Leibniz’s argument against my criticisms. In the present paper, I take up the matter again in an attempt to clarify the issues involved and to defend my original criticisms of the argument against the objections raised by Arthur. (shrink)

One argument that Leibniz employed to rule out the possibility of a world soul appears to turn on the assumption that the very notion of an infinite number or of an infinite whole is inconsistent. This argument was considered in a series of three papers published in The Leibniz Review: in the first, by Laurence Carlin, the argument was delineated and analyzed; in the second, by myself, the argument was criticized and rejected; in the third, by Richard Arthur, an attempt (...) was made to defend Leibniz’s argument against my criticisms. In the present paper, I take up the matter again in an attempt to clarify the issues involved and to defend my original criticisms of the argument against the objections raised by Arthur. (shrink)

This paper is the first phase of a longitudinal study of the class of 2014 on the effectiveness of ethics education at a business university. This phase of the project establishes the baseline attributes of incoming college freshmen with a pretest of the students’ ethical proclivity as measured by Defining Issues Test (DIT-2) scores. The relationship between the students’ ethical reasoning and their behavior in experimental stock trading sessions is then examined. In the trading simulations, randomly selected students were provided (...) with the option of receiving privileged insider information about the final payoff of several stocks. The students could either accept or reject such information, with acceptance considered illegal insider trading. The results of the pretest indicate that moral reasoning as measured by the DIT-2 is related to insider trading behavior, with students with higher DIT-2 scores being less likely to accept insider information. The paper also presents demographic differences across DIT-2 scores and trading behavior as a foundation for the longitudinal examination of changes in students’ moral cognition characteristics and behavior during their undergraduate career. (shrink)

In this book Gregory Browne rejects the views of David Hume and the Logical Positivists, and argues that there are necessary factual truths, which include a wide range of truths from many fields of knowledge. Browne argues for the necessity of Newton's Laws and truths about natural kinds, and for the factuality of definitional truths and truths of logic and mathematics. Browne synthesizes the work of Kripke, Putnam, Quine and others, but goes beyond the usual discussions of the meanings (...) and definitions of terms to discuss the references of various kinds of terms, and specifically to develop a theory of kinds, distinguishing 'Deep Kinds' and 'Shallow Kinds' . His theory of Deep Kinds does not accept all of the assumptions commonly associated wtih a theory of natural kinds. (shrink)

My aim in this paper is to elucidate Leibniz’s account of moral normativity and the relation between motivation and obligation. I argue against the recent interpretation of Christopher Johns, according to which Leibniz’s moral theory is actually a deontological theory, having more in common with Kantian moral theory than with any form of consequentialism. I argue that for Leibniz reason is not itself the source of practical normativity and real obligation; the source of that is rather the agent’s desire for (...) his own happiness or perfection. For Leibniz, reason in its practical role functions instrumentally: the desire for one’s own happiness is the source of practical normativity, and reason functions only to transfer that normativity from the end that it does not determine to the means to those ends that it does determine. (shrink)

End-of-life decision making is fraught with ethical challenges. Withholding or withdrawing life support therapy is widely considered ethical in patients with high treatment burden, poor premorbid status, or significant projected disability even when such treatment is not “futile.” Whether such withdrawal of therapy in the aftermath of attempted suicide is ethical is not well established in the literature. We provide a clinical vignette and propose criteria under which such withdrawal would be ethical. We suggest that it is appropriate to withdraw (...) life support, regardless of the cause of the critical illness or disability, when the following criteria are met: Surrogates request withdrawal of care and the adequacy of surrogates is confirmed, an external reasonability standard is met, passage of time, perhaps 72 hours, to allow certainty regarding the patient's wishes, and psychiatric morbidity should be considered as grounds for withdrawal only in truly treatment-refractory cases. Fundamentally, we believe the question to ask is, “If this were not an attempted suicide, would a request to withdraw care be reasonable?” We believe that under these circumstances, such withdrawal of life support, even in an individual who has attempted suicide, does not constitute physician assistance with suicide and is distinct from physician aid-in-dying in several important respects. (shrink)

In the first section of this paper I discuss what Leibniz meant by a miracle and why Leibniz’s definition of the best of all possible worlds implies that it is a world in which miracles are minimized. In the second part of the paper I argue that human happiness within the best of all possible worlds also requires, on Leibniz’s principles, that miracles must there be minimized. In the third section of the paper I consider what, if any, miracles actually (...) remain possible for Leibniz within the best of all possible worlds. In the final section I discuss one important kind of event upon which Leibniz vacillated whether it required miraculous intervention -- namely, the elevation of the sensitive soul to rationality -- and some speculation about the cause of this vacillation in Leibniz is offered. (shrink)

White matter tracts are known to be susceptible to injury following concussion. The objective of this study was to determine whether contact play in sport could alter white matter metabolite levels in female varsity athletes independent of changes induced by long-term exercise. Metabolite levels were measured by single voxel proton magnetic resonance spectroscopy in the prefrontal white matter at the beginning and end of season in contact and non-contact varsity athletes. Sedentary women were scanned once, at a time equivalent to (...) the Off-Season time point. Metabolite levels in non-contact athletes did not change over a season of play, or differ from age matched sedentary women except that non-contact athletes had a slightly lower myo-inositol level. The contact athletes had lower levels of myo-inositol and glutamate, and higher levels of glutamine compared to both sedentary women and non-contact athletes. Lower levels of myo-inositol in non-contact athletes compared to sedentary women indicates long-term exercise may alter glial cell profiles in these athletes. The metabolite differences observed between contact and non-contact athletes suggest that non-contact athletes should not be used as controls in studies of concussion in high-impact sports because repetitive impacts from physical contact can alter white matter metabolite level profiles. It is imperative to use athletes engaged in the same contact sport as controls to ensure a matched metabolite profile at baseline. (shrink)

In this paper I wish to examine the nature and role of "the phenomena of God" in Leinbiz's mature thought. In the first part of the paper, I discuss the nature of the universal harmony and argue that they are the perceptiual states of finite substances and the relations among them that constitute God's phenomena. In the second part of the paper, I attempt to specify the theoretical role that God's phenomena play in Leibniz's phenomenalism. This leads finally to a (...) discussion of Leibniz's teleological reasoning in the investigation of nature and of how that justification undercuts the argument for God's existence from the pre-established harmony. (shrink)

I undertake to examine how Descartes understood the relationship between physics and mathematics. My thesis is that what distinguishes the objects of mathematics from those of physics on Descartes's view is that the former are considered in abstraction from a material substratum while the latter are considered as involving a material substratum. Since it has often been maintained that Descartes identified matter with extension, and hence rejected the notion of a material substratum, I attempt in the first part of my (...) paper to establish the textual basis for ascribing a substratum view to Descartes. In the second part of the paper, I present the case for my thesis concerning Descartes's account of the difference between the objects of mathematics and those of physics. (shrink)

These essays apply influential, pathbreaking psychological studies about women's lives to literature. In their analyses of fictional portraits, contributors both challenge and confirm psychological theories about female identity, about 'connection/separation' as developmental catalysts, and about the impact of gender on 'voice,' moral decision-making, and epistemology in relation to classical and contemporary literary texts, written by both women and men.

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

This is a superbly crafted and exhaustively researched account of the development of Leibniz’s thought, his ambitious plans and undertakings, his myriad intellectual engagements, and his ceaseless comings and goings across Europe. It captures, accurately and in great detail, the remarkably expansive mind of a singularly creative thinker. It is an extraordinary achievement, for the task of writing an intellectual biography of Leibniz is huge. To read even a portion of what he wrote and read, in the languages in which (...) he wrote and read it, to come to grips with the nuances of religion, politics, and intellectual practice that define his world, and to identify the hundreds of individuals, illustrious and forgotten, with whom he interacted would challenge even the most skilled and dedicated scholar. There is no doubt that Antognazza has met this challenge with a biography that surpasses any available account of Leibniz’s life.The book is divided into three parts. A brief introduction surveys past attempts at capturing the breadth of Leibniz’s thought and articulates “four basic, underlying theses” that unify the chapters to follow. They are: first, that Leibniz’s life and work need to be assessed as a whole as opposed to focusing narrowly on his contributions to one or another field; second, that Leibniz’s life and thought are integrated to a remarkable degree and that it is a mistake to. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Remembering Grayson Douglas Browning (1929–2023)Gregory Pappas, David Hildebrand, and William T. MyersBrowning, Grayson Douglas was born on March 7, 1929, in Seminole, Oklahoma.He received his PhD from the University Texas, Austin, 1958, where he returned later in 1972 to become its Philosophy Department chairman for four years.He was president of the Southwestern Philosophical Association in 1977, of the Florida Philosophical Association in 1967, and of the Southern Society (...) for Philosophy and Psychology in 1972.He was not only a member of the Society for Advancement of America Philosophy; he encouraged all of his students to attend and become members of this society. Among these former students are Bill Myers, David Hildebrand, and Gregory Pappas.He thought that this was one of the best societies, not only because of its pluralism and scholarship, but because it was a community. He was right!He was the author of several books of philosophy, including Act and Agent and Ontology and the Practical Arena, and he co-edited Philosophers of Process (with William T. Myers). He also has published poetry in Voices, A Journal of Poetry and the Beloit Poetry Journal.In the last years of his life, Doug Browning was a retired Professor of Philosophy, living outside Georgetown, Texas, where he labored at length over poems and novels, staying up throughout the night reading, writing, listening to jazz, and smoking cigars, and enjoying life in his countryside hacienda with his beautiful wife, Becky. During that time, he managed to write and publish sixteen books of fiction. [End Page 106]For us (his former students), one of the most important philosophical contributions of Doug Browning was his insistence that if there is a key lesson from American Philosophy, it is the importance of lived experience ("La Vida") as the "starting point" of philosophical investigation.As he wrote in one of his last published essays:[T]he point is that, wherever one thinks we should start, we can't start with the world. We can't start with the world and we can't test our theories by testing them against the world. Whatever we take to indicate or to provide evidence of a "real" world apart from experience must be found, can only be found, in experience. It must be found in the glass of Barrilito, the aroma of a good cigar, conversation among friends, hotel hallways, cats, thunderstorms, oak trees, and all of the brazen and all of the unpretentious things that we encounter and live among in our day-to-day lives.1Gregory PappasTexas A&M UniversityDavid HildebrandUniversity of Colorado DenverWilliam T. MyersBirmingham-Southern Collegenote1. Douglas Browning, "Dewey and Ortega on the Starting Point," Pragmatism in the Americas, edited by Gregory Fernando Pappas (Fordham UP, 2011), p. 155.Copyright © 2024 The Board of Trustees of the University of Illinois... (shrink)

Report submitted by Gregory B. Sadler, Pilot Project Coordinator to Sonya Brown, WAC Activity Director, Fayetteville State University, June 28 2011. -/- A Pilot program focused on improving student performance in carrying out Close Readings in humanities-based discipline courses was developed and implemented under the auspices of Writing Across the Curriculum and Title III at Fayetteville State University in Winter and Spring 2011. Five faculty were involved in the Pilot, myself as the coordinator, and four other faculty from (...) four different disciplines as participants. -/- The central idea behind the Pilot was that by focusing on the lower-order skills which are scaffolded as components into the higher-order activity of Close Reading of texts, and redesigning courses to emphasize development of these lower-order skills, student performances in Close Readings would also be improved. This did turn out to be the case. Most of the supporting data is qualitative rather than quantitative. -/- It is recommended that similar activities be continued, but that participating faculty be required to provide much more prescriptively structured and detailed assessment data and information about their course design. (shrink)