How does microbiota research impact our understanding of biological individuality? We summarize the interdisciplinary summer school on "Microbiota, Symbiosis and Individuality: Conceptual and Philosophical Issues" (July 2019), which was supported by a European Research Council starting grant project "Immunity, DEvelopment, and the Microbiota" (IDEM). The summer school centered around interdisciplinary group work on four facets of microbiota research: holobionts, individuality, causation, and human health. The conceptual discussion of cutting-edge empirical research provided new insights into microbiota and highlights the value of (...) incorporating into meetings experts from other disciplines, such as philosophy and history of science. (shrink)

In this paper we address the issue of how to think about immunity. Many immunological writings suggest a straightforward option: the view that the immune system is primarily a system of defense, which naturally invites the talk of strong immunity and strong immune response. Despite their undisputable positive role in immunology, such metaphors can also pose a risk of establishing a narrow perspective, omitting from consideration phenomena that do not neatly fit those powerful metaphors. Building on this analysis, we argue (...) two things. First, we argue that the immune system is involved not only in defense. Second, by disentangling various possible meanings of ‘strength’ and ‘weakness’ in immunology, we also argue that such a construal of immunity generally contributes to the distortion of the overall picture of what the immune system is, what it does, and why it sometimes fails. Instead, we propose to understand the nature of the immune system in terms of contextuality, regulation, and trade-offs. We suggest that our approach provides lessons for a general understanding of the organizing principles of the immune system in health and disease. For all this to work, we discuss a wide range of immunological phenomena. (shrink)

A distinction between different notions of “structure” and “function” is suggested for interpreting the overwhelming amount of data on microbiome structure and function. Sequence data, biochemical agents, interaction networks, taxonomic communities, and their dynamics can be linked to potential or actual biochemical activities, causal roles, and selected effects, respectively. This conceptual clarification has important methodological consequences for how to interpret existing data and approach open questions in contemporary microbiome research practice. In particular, the field will have to start thinking about (...) notions of function more directly. Also see the video abstract here https://youtu.be/j5pq5uGld1k. (shrink)

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

In our commentary on Lynch et al.’s target paper, we focus on decomposition as a research strategy. We argue that not only the presumptive microbial causes but also their supposed phenotypic effects need to be decomposed relative to each other. Such a dual decomposition strategy ought to improve the way in which causal claims in microbiome research can be made and understood.

I will offer a conceptual analysis of different notions of structure and function of viral immunogens and of different structure-function relationships. My focus will then be on the mechanisms by which the desired immune response is induced and why strategies based on three-dimensional molecular antigen structures and their rational design are limited in their ability to induce the desired immunogenicity. I will look at the mechanisms of action of adjuvants (thus the wordplay with Janeway's "immunologist's dirty little secret"). Strategies involving (...) adjuvants and other (more successful) vaccination strategies rely on taking into account activities and functions ("what is going on"), and not just the structures involved ("who is there"), in binding in a "lock and key" fashion. Functional patterns as well as other organizational and temporal patterns, I will argue, are crucial for inducing the desired immune response and immunogenicity. The 3D structural approach by itself has its benefitsand its limits, which I want to highlight by this philosophical analysis, pointing out the importance of structure-function relationships. Different functional aspects such as antigenicity, immunogenicity, and immunity need to be kept separate and cannot be reduced to three-dimensional structures of vaccines. Taking into account different notions of structure and function and their relationships might thus advance our understanding of the immune system and rational HIV vaccine design, to which end philosophy can provide useful tools. (shrink)

'Structure' and 'function' are both ambiguous terms. Discriminating different meanings of these terms sheds light on research and explanatory practice in molecular biology, as well as clarifying central theoretical concepts in the life sciences like the sequence-structure-function relationship and its corresponding scientific "dogmas". The overall project is to answer three questions, primarily with respect to proteins: What is structure? What is function? What is the relation between structure and function? The results of addressing these questions lead to an answer to (...) the title question, what the statement 'structure determines function' means. (shrink)

The increased incidence of morbidity and mortality due to Clostridium difficile infection, had led to the emergence of fecal microbial transplantation (FMT) as a highly successful treatment. From this, a 32 strain stool substitute has been derived, and successfully tested in a pilot human study. These approaches could revolutionize not only medical care of infectious diseases, but potentially many other conditions linked to the human microbiome. But a second revolution may be needed in order for regulatory agencies, society and medical (...) practitioners to accept and utilize these interventions, monitor their long term effects, have a degree of control over their use, or at a minimum provide guidelines for donors and recipients. (shrink)

The paper deals with the question of the structure of knowledge and the precise relationship between propositional "knowledge that" and dispositional "knowledge how." In the first part of my essay, I provide an analysis of the term 'knowing how' and argue that the usual alternatives in the recent epistemological debate – knowing how is either a form of propositional or dispositional knowledge – are misleading. In fact it depends on the semantic and pragmatic context of the usage of this term (...) whether 'knowing how' refers to a type of dispositional knowledge, to propositional knowledge, or to a hybrid form of both. Only in the first case, can one say that dispositional know how cannot be reduced to any form of propositional knowledge. Yet, this case is the most interesting one to consider in the investigation of the nature of knowledge, if one assumes that knowing that p presupposes "having found out that p." Having found something out, however, presupposes certain acts of epistemic inquiry and corresponding epistemic abilities. Examined more carefully, it is shown that the dispositional knowledge-how is a necessary condition for propositional knowledge-that, hence propositional knowledge-that is a species of the dispositional knowledge-how. Accordingly, dispositional knowledge has to be understood as being at the very core of our notion of knowledge, including propositional knowledge. (shrink)

When in doubt, for the embryo. New arguments on the moral status of human embryos. - In the first part of our essay we distinguish the philosophical from the legal and political level of the embryo debate and describe our indirect justification strategy. It consists in renouncing a determination of the dignity-giving φ-properties and instead starting from premises that are undoubted by all discussion partners. In the second part we reconstruct and criticize the species, continuum, identity and potentiality arguments. The (...) species argument only has a certain plausibility, if at all, as a critical argument. From the continuum argument and identity argument we take over the idea of numerical identity (NI) and link it with the core idea of the potentiality argument (P). So we come to the NIP argument: -/- (NIP) -/- (1) Every living human body that is the bearer of (or has) potential φ-properties has dignity. (2) Every viable human embryo is a living human body that is the bearer of (or has) potential φ properties. Therefore, (3) Every viable human embryo has dignity. -/- Reversibly comatose people and newborns are protected because they have the potential to have actual personal characteristics in the future; our thesis is that embryos that are capable of development also have the same potential in moral terms. The basic idea of numerical identity, with which we support the second premise, is that every human being, from embryonic existence to adulthood, forms a physical unity. In a detailed part, we deal with the crown princess, gametes, parthenogenesis, somatic cell, pronuclear stage, biological heteronome early embryo, multiple, fusion, Siamese twin, hydatidiform mole and finally trophoblast problems. In a third part, the indirect argument is supplemented by a metatheoretical cautionary argument. It states that in situations where there is doubt as to whether a being falls within the scope of a moral norm, but there are sufficiently strong reasons for this subsumption, it must be assumed that this is the case if the contrary assumption and the positive effects it may have are in no acceptable proportion to the moral harm that would result if that subsumption were not made. The main result of our considerations is therefore: When in doubt, for the embryo. (shrink)

In his "Ontological proof", Kurt Gödel introduces the notion of a second-order value property, the positive property P. The second axiom of the proof states that for any property φ: If φ is positive, its negation is not positive, and vice versa. I put forward that this concept of positiveness leads into a paradox when we apply it to the following self-reflexive sentences: (A) The truth value of A is not positive; (B) The truth value of B is positive. Given (...) axiom 2, sentences A and B paradoxically cannot be both true or both false, and it is also impossible that one of the sentences is true whereas the other is false. (shrink)

ObjectiveTo determine to what extent physical fitness indicators and/or moderate to vigorous physical activity may account for final mathematics academic performance awarded at the end of primary school.MethodsSchool-aged youth were sampled in a repeated-measures, longitudinal design in Grade 6, and again in Grade 9. The youth completed a fitness test battery consisting of: flamingo balance test, standing long jump, backward obstacle course, plate tapping, sit ups, sit and reach, handgrip, and 20-m shuttle run. APmath scores were obtained for all children (...) at the end of Grade 5, end of Grade 8, and end of Grade 9. In a sub-sample of Grade 6 youth, MVPA was measured objectively via SenseWear Pro Armbands for seven consecutive days, with measurements repeated in Grade 9.ResultsMath scores decreased from Grade 6 to 9 for both boys and girls. MVPAOB was reduced by ∼45.7 min from Grade 6 to 9. Significant main and interaction effects are noted for each fitness indicator. A backward stepwise multiple regression analysis determined significant shared variance in final APmath grade to the change scores from Grade 6 to Grade 9 in: ΔAPmath, Δbackward obstacle course, Δsit and reach, and Δsit-ups [R2 = 0.494, F = 43.67, p < 0.0001]. A second regression was performed only for the youth who completed MVPAOB measurements. In this sub-sample, MVPAOB did not significantly contribute to the model.ConclusionLongitudinal changes in youth fitness and their delta change in APmath score accounted for 49.4% of the variance in the final math grade awarded at the end of Grade 9. Aerobic power, upper body strength, and muscular endurance share more common variance to final math grade in boys, whereas whole-body coordination was the more relevant index in girls; this finding suggests that future research exploring the relationship of AP and PF should not be limited to cardiorespiratory fitness, instead encompassing muscular and neuro-muscular components of PF. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:82 HISTORY OF PHILOSOPHY phy) than the aspects considered in the earlier chapters. The attempts of these men to formulate theories of the cosmos and of natural phenomena, to take the place of Aristotle's natural philosophy, are described as honest and original speculative endeavors, with a few features which can be construed as anticipations of seventeenth-century scientific philosophy, but basically lacking the soundness of method and evidence that could (...) make them adequate substitutes for the Aristotelian system. "The Aristotelian tradition of natural philosophy," as Kristeller states, "was not overthrown by the outside attacks of the humanists or Platonists, nor by the suggestive theories of the natural philosophers. It yielded only in and after the seven~ teenth century, when the new science of Galileo and his successors was able to deal with its subject matter on the basis of a firmly established and superior method" (p. 96). All of the essays in this book are distinguished by their concern for historical truth and objectivity, by their attempt to present the thought of the eight authors in the context of the times and in terms of the interests and purposes of the writers themselves, and by the rich and enlightened perspectives of historical understanding brought to bear on the subjects discussed. But what is most attractive, and indeed striking, in this work of Kristeller, as in the other books and essays he has written on Renaissance thought, is his own conviction that the cultural and philosophical ideals which characterized the Italian Renaissance are of intrinsic and enduring value in their own right.Unlike many other expositers and partisans of Renaissance thought, who extol it because it anticipated modem science, or because it was secularist,or anti-scholastic, or "this-worldly"rather than "other-worldly", Kristeller admires it for just what it was. And to those who define philosophy as logical analysis, or as existentialism,or as pragmatism or neo=seholasticism, and on that basis claim that the Italian Renaissance made no contribution to philosophy, Kristeliermakes no apologies. There is no necessary repugnance between scholarship and philosophy, or between original thought and an understanding and appreciation of the classics,nor is cultural barbarism a necessary prerequisite of the pursuit of truth. The values which Kristellerdefends in our time are very much those which Erasmus defended in the sixteenth century. "There is such a thing as the autonomy of culture," Kristeller remarks (p. 94), "and it has always been the task and duty of scholars to defend this territory against the deeper inroads of religious and politicalinfluences." The inroads in our time have been made by differentfanaticisms than those of the sixteenth century, but the defense of the integrity of scholarship and of liberal culture has been a task and duty to which Paul Kristeller has been faithful throughout his long and fruitfulcareer. ER~S~ A. MooDY University of California, Los Angeles Ren$ Descartes: Regulae ad direct~onem ingenii. Texte critique ~tabli par Giovanni Crapulli, avec la version hollandaise du XVH ~m~ si~ele. (La Haye: Martinus Nijhoff, 1966. -" Archives Intemationales d'histeire des iddes, t. 12. Pp. xxxiii + 80 + 80* + 40. Guilders 38.75.) This edition of the Regulae is important because for the first time since the great AdamTannery edition of 1896--1913 a major work of Descartes has been independently re-edited from the sources according to the most advanced editorial principles. The historian of philosophy -the user--will ask four questions: (1) Why a new edition? (2) What does it offer? (3) How does it affect the AT text? (4) What edition should be used and cited? Here briefly, are the answers as one user sees them. 1. The Regulae were posthumously published in 1701. Besides this edito princeps (A) there exists the so-called Hanover manuscript (H) with emendations by Leibniz (L). These were kdam's sources. But the Regulae became known first through the Dutch translation of Glazemaker, published in 1684 (N) which Adam knew but did not use. This led Dr. Crapulli to a review of the whole editorial problem. He concluded that A, H and N were prepared from BOOK REVIEWS 83 three different manuscripts, none of them Descartes's original (which is lost... (shrink)

Infinite time register machines (ITRMs) are register machines which act on natural numbers and which are allowed to run for arbitrarily many ordinal steps. Successor steps are determined by standard register machine commands. At limit times register contents are defined by appropriate limit operations. In this paper, we examine the ITRMs introduced by the third and fourth author (Koepke and Miller in Logic and Theory of Algorithms LNCS, pp. 306–315, 2008), where a register content at a limit time is set (...) to the lim inf of previous register contents if that limit is finite; otherwise the register is reset to 0. The theory of these machines has several similarities to the infinite time Turing machines (ITTMs) of Hamkins and Lewis. The machines can decide all ${\Pi^1_1}$ sets, yet are strictly weaker than ITTMs. As in the ITTM situation, we introduce a notion of ITRM-clockable ordinals corresponding to the running times of computations. These form a transitive initial segment of the ordinals. Furthermore we prove a Lost Melody theorem: there is a real r such that there is a program P that halts on the empty input for all oracle contents and outputs 1 iff the oracle number is r, but no program can decide for every natural number n whether or not ${n \in r}$ with the empty oracle. In an earlier paper, the third author considered another type of machines where registers were not reset at infinite lim inf’s and he called them infinite time register machines. Because the resetting machines correspond much better to ITTMs we hold that in future the resetting register machines should be called ITRMs. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:260 HISTORY OF PHILOSOPHY Christian business" is not knowledge but experience. He founds religious certainty on individual inspiration and emphasizes charity against external written law. A man inspired by God becomes autonomous and acquires a mind of his own--independent of external authorities. This valuable study (pp. 5-109) is followed by an extensive bibliography (pp. 113--209) in which it could be added that Vald~s' Al[abeto Cristiano was reprinted in 1948 (...) by the Editorial "La Aurora" of Buenos Aires. In 1946 this publisher considered (in the Preface to his reprint of Vald~s' Dicilogo de Doctrina Cristiana, p. 12) republishing also Vald6s' Ciento y diez consideraciones divinas. PAUL T. FUrIRMAN~ Columbia Theological Seminary Descartes. Oeuvres philosophiques. Tome I (1618-1637.) Textes 6tablis, pr6sent6s et annot6s par Ferdinand Alqui6. l~dition illustr6e. (Paris: Garnier Fr6res, 1965. [Glassiques Garnier.] Pp. 829 + 12 plates.) The publication of this massive paperbound volume is an event in Descartes studies. It is the first in a three-volume edition of Descartes' complete philosophical works in French, an edition which is original in its plan, up-to-date in scholarship, worked from the sources, and superbly annotated, the only truly new edition since Charles Adam completed the great AT in 1913. Professor Alqui6 defines the word "philosophical" almost as broadly as Descartes did. To the specifically philosophical texts he adds generous portions of the non-mathematical scientific works. All Latin texts are given in French translation (the Meditations are to appear bilingually.) The spelling is modern. The AT pagination appears in the margin, but the volume number should be given there too. Scholars working with AT and AM (Adam-Milhaud's Correspondance de D.) should take note of the textual corrections and emendations in this Edition dlquid. In the battle of Descartes interpretation Professor Alqui6 takes the chronological stand. Where Martial Gueroult sees a marvellously wrought monolithic system, there Alqui6 sees development and growth: to understand Descartes one must follow his "itin6raire philosophique" step by step. In his new role as editor he practices what he preached. This is the first edition to take us in unbroken, rigorously chronological sequence from the first extant writing through the year of the Discours de la mdthode. Even the correspondence is broken up and inserted between the writings in its chronological place. (Just about half of Descartes' letters of this period--none written to him--are given:.58 as against 27 in the Pl6i'ade edition.) The volume opens with a few (too few) paragraphs from the Compendium Musicae of 1618 and sections from the Cogitationes privatae, including the complete text of Baillet's account of the Dream of Descartes. The Regulae appear in a new, annotated translation by Jacques Brunschvicg. Le Monde et le Traitd de l'Homme, treated as one manuscript, is here, all but complete. After the Discours de la mdthode we get the first six chapters of the Dioptrique and four of the ten chapters of Mdtdores. All omitted chapters are summarized. The little Traitd de la m~canique brings up the rear. The missing Gdom(trie is to appear in a companion volume of collected mathematical writings, promised for some later date. The reader who never read all of Descartes' writings between 1618 and 1637 in fl~eir chronological order will find a new vista opening up. This is particularly true of the sixty-odd pages of earliest writings. But here the editor's principle of excluding "mathematical " texts works against his clear intention of keeping interpretation out: "Une ~dition BOOK REVIEWS 261 de Descartes," he writes, "n'est pas une th~se sur la philosophie de Descartes." Alqui6 here (and only here) excludes not only all purely mathematical texts but also those on mechanics, optics, acoustics, hydraulics, automata, etc., and even epistemologically significant items like "hi omni questione debet dari aliquod medium," "Si funis," and the full text of the ars memoriae passage. The only exception is Descartes' answer to Beeckman's problem regarding free fall, truncated at the point where Descartes with the characteristic dlan of these years continues: "Ut autem hujus scientiae fundamenta jaciam...". AlquiCs general justification for the exclusion of "mathematics" rests upon the evidence that Descartes himself... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:82 HISTORY OF PHILOSOPHY phy) than the aspects considered in the earlier chapters. The attempts of these men to formulate theories of the cosmos and of natural phenomena, to take the place of Aristotle's natural philosophy, are described as honest and original speculative endeavors, with a few features which can be construed as anticipations of seventeenth-century scientific philosophy, but basically lacking the soundness of method and evidence that could (...) make them adequate substitutes for the Aristotelian system. "The Aristotelian tradition of natural philosophy," as Kristeller states, "was not overthrown by the outside attacks of the humanists or Platonists, nor by the suggestive theories of the natural philosophers. It yielded only in and after the seven~ teenth century, when the new science of Galileo and his successors was able to deal with its subject matter on the basis of a firmly established and superior method" (p. 96). All of the essays in this book are distinguished by their concern for historical truth and objectivity, by their attempt to present the thought of the eight authors in the context of the times and in terms of the interests and purposes of the writers themselves, and by the rich and enlightened perspectives of historical understanding brought to bear on the subjects discussed. But what is most attractive, and indeed striking, in this work of Kristeller, as in the other books and essays he has written on Renaissance thought, is his own conviction that the cultural and philosophical ideals which characterized the Italian Renaissance are of intrinsic and enduring value in their own right.Unlike many other expositers and partisans of Renaissance thought, who extol it because it anticipated modem science, or because it was secularist,or anti-scholastic, or "this-worldly"rather than "other-worldly", Kristeller admires it for just what it was. And to those who define philosophy as logical analysis, or as existentialism,or as pragmatism or neo=seholasticism, and on that basis claim that the Italian Renaissance made no contribution to philosophy, Kristeliermakes no apologies. There is no necessary repugnance between scholarship and philosophy, or between original thought and an understanding and appreciation of the classics,nor is cultural barbarism a necessary prerequisite of the pursuit of truth. The values which Kristellerdefends in our time are very much those which Erasmus defended in the sixteenth century. "There is such a thing as the autonomy of culture," Kristeller remarks (p. 94), "and it has always been the task and duty of scholars to defend this territory against the deeper inroads of religious and politicalinfluences." The inroads in our time have been made by differentfanaticisms than those of the sixteenth century, but the defense of the integrity of scholarship and of liberal culture has been a task and duty to which Paul Kristeller has been faithful throughout his long and fruitfulcareer. ER~S~ A. MooDY University of California, Los Angeles Ren$ Descartes: Regulae ad direct~onem ingenii. Texte critique ~tabli par Giovanni Crapulli, avec la version hollandaise du XVH ~m~ si~ele. (La Haye: Martinus Nijhoff, 1966. -" Archives Intemationales d'histeire des iddes, t. 12. Pp. xxxiii + 80 + 80* + 40. Guilders 38.75.) This edition of the Regulae is important because for the first time since the great AdamTannery edition of 1896--1913 a major work of Descartes has been independently re-edited from the sources according to the most advanced editorial principles. The historian of philosophy -the user--will ask four questions: (1) Why a new edition? (2) What does it offer? (3) How does it affect the AT text? (4) What edition should be used and cited? Here briefly, are the answers as one user sees them. 1. The Regulae were posthumously published in 1701. Besides this edito princeps (A) there exists the so-called Hanover manuscript (H) with emendations by Leibniz (L). These were kdam's sources. But the Regulae became known first through the Dutch translation of Glazemaker, published in 1684 (N) which Adam knew but did not use. This led Dr. Crapulli to a review of the whole editorial problem. He concluded that A, H and N were prepared from BOOK REVIEWS 83 three different manuscripts, none of them Descartes's original (which is lost... (shrink)

Book review on Pavel Gregorić – George Karamanolis (vyd.) Pseudo-Aristotle: De Mundo (On The Cosmos). A Commentary. Cambridge (Cambridge University Press) 2021, 245 str.

Este libro, resultado de un esfuerzo compartido por diversas instituciones, investigadores y editores, encabezados por el Grupo de Investigación E Pluribus Unum? Ethnic Identities in Transnational Integration Processes in the Americas de la Universidad de Bielefeld, trata un tema central para el futuro de nuestras mestizas sociedades latinoamericanas: la necesaria construcción -en el presente que vivimos- de la interculturalidad en nuestra América Latina. Esto en el nuevo contexto donde los ..

Frank Knight (1921) famously distinguished the epistemic modes of certainty, risk, and uncertainty in order to characterize situations where deterministic, probabilistic or possibilistic foreknowledge is available. Because our probabilistic knowledge is limited, i.e. because many systems, e.g. the global climate, cannot be described and predicted probabilistically in a reliable way, Knight's third category, possibilistic foreknowledge, is not simply swept by the probabilistic mode. This raises the question how to justify possibilistic predictionsincluding the identication of the worst case. The development of (...) such a modal methodology is particularly vital with respect to predictions of climate change. I show that a methodological dilemma emerges when possibilistic predictions are framed in traditional terms and argue that a more nuanced conceptual framework, distinguishing dierent types of possibility, should be used in order to convey our uncertain knowledge about the future. The new conceptual scheme, however, questions the applicability of standard rules of rational decision-making, thus generating new challenges. (shrink)

Gregor Moder’s Hegel and Spinoza: Substance and Negativity is a lively entry into current debates concerning Hegel, Spinoza, and their relation. Hegel and Spinoza are two of the most influential philosophers of the modern era, and the traditions of thought they inaugurated have been in continuous dialogue and conflict ever since Hegel first criticized Spinoza. Notably, eighteenth- and nineteenth-century German Idealists aimed to overcome the determinism of Spinoza’s system by securing a place for the freedom of the subject within it, (...) and twentieth-century French materialists such as Althusser and Deleuze rallied behind Spinoza as the ultimate champion of anti-Hegelian materialism. This conflict, or mutual rejection, lives on today in recent discussions about materialism. Contemporary thinkers either make a Hegelian case for the productiveness of concepts of the negative, nothingness, and death, or in a way that is inspired by Spinoza they abolish the concepts of the subject and negation and argue for pure affirmation and the vitalistic production of differences. Hegel and Spinoza traces the historical roots of these alternatives and shows how contemporary discussions between Heideggerians and Althusserians, Lacanians and Deleuzians are a variation of the disagreement between Hegel and Spinoza. Throughout, Moder persuasively demonstrates that the best way to read Hegel and Spinoza is not in opposition or contrast but together: as Hegel and Spinoza. (shrink)

The cosmological relevance of emptiness—that is, space without bodies—is not yet sufficiently appreciated in natural philosophy. This paper addresses two aspects of cosmic emptiness from the perspective of natural philosophy: the distances to the stars in the closer cosmic environment and the expansion of space as a result of the accelerated expansion of the universe. Both aspects will be discussed from both a historical and a systematic perspective. Emptiness can be interpreted as “coming” in a two-fold sense: whereas in the (...) past, knowledge of emptiness, as it were, came to human beings, in the future, it is coming, insofar as its relevance in the cosmos will increase. The longer and more closely emptiness was studied since the beginning of modernity, the larger became the spaces over which it was found to extend. From a systematic perspective, I will show with regard to the closer cosmic environment that the Earth may be separated from the perhaps habitable planets of other stars by an emptiness that is inimical to life and cannot be traversed by humans. This assumption is a result of the discussion of the constraints and possibilities of interstellar space travel as defined by the known natural laws and technical means. With the accelerated expansion of the universe, the distances to other galaxies (outside of the so-called Local Group) are increasing. According to the current standard model of cosmology and assuming that the acceleration will remain constant, in the distant future, this expansion will lead first to a substantial change in the epistemic conditions of cosmological knowledge and finally to the completion of the cosmic emptiness and of its relevance, respectively. Imagining the postulated completely empty last state leads human thought to the very limits of what is conceivable. (shrink)

In 1936 R.A.Fisher asked the pointed question, "Has Mendel's Work Been Rediscovered?" The query was intended to open for discussion whether someone altered the data in Gregor Mendel's classic 1866 research report on the garden pea, "Experiments in Plant-Hybridization." Fisher concluded, reluctantly, that the statistical counts in Mendel's paper were doctored in order to create a better intuitive fit between Mendelian expected values and observed frequencies. That verdict remains the received view among statisticians, so I believe. Fisher's analysis is a (...) tour de force of so-called "Goodness of Fit" statistical tests using c2 to calculate significance levels, i.e., P-values. In this presentation I attempt a defense of Mendel's report, based on several themes. (1) Mendel's experiments include some important sequential design features that Fisher ignores. (2) Fisher uses particular statistical techniques of Meta-analysis for pooling outcomes from different experiments. These methods are subject to critical debate. and (3) I speculate on a small modification to Mendelian theory that offers some relief from Fisher's harsh conclusion that Mendel's data are too good to be true. (shrink)

De mundo is a protreptic to philosophy in the form of a letter to Alexander the Great and is traditionally ascribed to Aristotle. It offers a unique view of the cosmos, God and their relationship, which was inspired by Aristotle but written by a later author. The author provides an outline of cosmology, geography and meteorology, only to argue that a full understanding of the cosmos cannot be achieved without a proper grasp of God as its ultimate cause. To ensure (...) such a grasp, the author provides a series of twelve carefully chosen interlocking analogies, building a complex picture in the reader's mind. The work develops a distinctly Aristotelian picture of God and the cosmos while paying tribute to pre-Aristotelian philosophers and avoiding open criticism of rival schools of philosophy. De mundo exercised considerable influence in late antiquity and then in the Renaissance and Early Modern times. (shrink)

De mundo is a protreptic to philosophy in the form of a letter to Alexander the Great and is traditionally ascribed to Aristotle. It offers a unique view of the cosmos, God and their relationship, which was inspired by Aristotle but written by a later author. The author provides an outline of cosmology, geography and meteorology, only to argue that a full understanding of the cosmos cannot be achieved without a proper grasp of God as its ultimate cause. To ensure (...) such a grasp, the author provides a series of twelve carefully chosen interlocking analogies, building a complex picture in the reader's mind. The work develops a distinctly Aristotelian picture of God and the cosmos while paying tribute to pre-Aristotelian philosophers and avoiding open criticism of rival schools of philosophy. De mundo exercised considerable influence in late antiquity and then in the Renaissance and Early Modern times. (shrink)

Geist hat keine Konjunktur in den Kulturwissenschaften. Die poststrukturalen Theorieformationen der letzten Jahrzehnte distanzierten sich von Geist und Geisteswissenschaft, welche prominent und methodologisch mit dem Namen Wilhelm Dilthey verknüpft wird. Dilthey ist der Knotenpunkt eines Netzwerkes, das Philosophie, Literatur, Pädagogik, Religion und (Kultur-)Geschichte als Umgebung von Personen tradiert. Diese Syntheseleistung funktioniert nicht primär hermeneutisch, sondern als genealogischer Überlieferungsverkehr. (Auto-) Biografische Techniken und Verkehrsformen zeigen und erzeugen eine "Ökonomie geistigen Lebens", die das Leben mit der Wissenschaft "befreunden" muss. Die Logistik szenischer (...) Begegnung changiert zwischen Dokument und Monument. In dieser Konkretion werden Haut, Hand und Kopf eines theoretischen Lebens zu Oberflächen, in denen sich Kulturgeschichten, Wissenspoetologien und Ideengeschichten einrichten können. (shrink)