The ethical principle of ‘respect for persons’ in clinical research has traditionally focused on protecting individuals’ autonomy rights, but respect for participants also includes broader, although less well understood, ethical obligations to regard individuals’ rights, needs, interests and feelings. However, there is little empirical evidence about how to effectively convey respect to potential and current participants. To fill this gap, we conducted exploratory, qualitative interviews with participants in a clinical genomics implementation study. We interviewed 40 participants in English or Spanish (...) about their experiences with respect in the study and perceptions of how researchers in a hypothetical observational study could convey respect or a lack thereof. Most interviewees were female, identified as Hispanic/Latino or non-Hispanic white, reported annual household income under US$60 000 and did not have a Bachelor’s degree ; 30% had limited health literacy. We identified four key domains for demonstrating respect: personal study team interactions, with an emphasis on empathy, appreciation and non-judgment; study communication processes, including following up and sharing results with participants; inclusion, particularly ensuring materials are understandable and procedures are accessible; and consent and authorisation, including providing a neutral informed consent and keeping promises regarding privacy protections. While the experience of respect is inherently subjective, these findings highlight four key domains that may meaningfully demonstrate respect to potential and current research participants. Further empirical and normative work is needed to substantiate these domains and evaluate how best to incorporate them into the practice of research. (shrink)

Traditional accounts of the emergence of professional biology have privileged not only metropolis over province, but research over teaching and laboratory over museum. This paper seeks to supplement earlier studies of the ‘transformation of biology’ in the late nineteenth century by exploring in detail the developments within three biology departments in Northern English civic colleges. By outlining changes in the teaching practices, research topics and the accommodation of the departments, the authors demonstrate both locally contingent factors in their development and (...) continuities with existing traditions in natural history. The appointment of Arthur Milnes Marshall in preference to Louis Miall to the new zoology chair in Manchester in 1879 casts light on contemporary views of the laboratory and museum as ‘equal though different’. The transformation in biology, in Northern England at least, was shaped more by such local institutional changes than by a phoenix-like rise of the laboratory from the ashes of the museum—more by the rhetorical construction of a professional academic community than any dramatic shift in sites. In this period the biology laboratory supplemented, rather than eclipsed, the museum, and the dichotomy between the ‘naturalist’ and the ‘experimentalist’ was far from clear-cut. (shrink)

Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

As improvements in neuroscience have enabled a better understanding of disorders of consciousness as well as methods to treat them, a hurdle that has become all too prevalent is the denial of coverage for treatment and rehabilitation services. In 2011, a settlement emerged from a Vermont District Court case, Jimmo v. Sebelius, which was brought to stop the use of an “improvement standard” that required tangible progress over an identifiable period of time for Medicare coverage of services. While the use (...) of this standard can have deleterious effects on those with many chronic conditions, it is especially burdensome for those in the minimally conscious state, where improvements are unpredictable and often not manifested through repeatable overt behaviors. Though the focus of this paper is on the challenges of brain injury and the minimally conscious state, which an estimated 100,000 to 200,000 individuals suffer from in the United States, the post-Jimmo arguments presented can and should have a broad impact as envisioned by the plaintiffs who brought the case on behalf of multiple advocacy groups representing patients with a range of chronic care conditions. (shrink)

Marketers must first perceive ethics and social responsibility to be important before their behaviors are likely to become more ethical and reflect greater social responsibility. However, little research has been conducted concerning marketers' perceptions regarding the importance of ethics and social responsibility as components of business decisions. The purpose of this study is to develop a reliable and valid scale for measuring marketers' perceptions regarding the importance of ethics and social responsibility. The authors develop an instrument for the measurement of (...) the perceived role of ethics and social responsibility (PRESOR). Evidence that the scale is valid is presented through the assessment of scale reliability, as well as content and predictive validity. Finally, future research needs and the value of this construct to marketing are discussed. (shrink)

Identifying the determinants of reproductive success in small-scale societies is critical for understanding how natural selection has shaped human evolution and behavior. The available evidence suggests that status-accruing behaviors such as hunting and prosociality are pathways to reproductive success, but social egalitarianism may diminish this pathway. Here we introduce a mixed longitudinal/cross-sectional dataset based on 45 years of research with the Batek, a population of egalitarian rain forest hunter-gatherers in Peninsular Malaysia, and use it to test the effects of four (...) predictors of lifetime reproductive success: foraging return rate, sharing proclivity, cooperative foraging tendency, and kin presence. We found that none of these factors can explain variation in lifetime reproduction among males or females. We suggest that social egalitarianism, combined with strikingly low infant and juvenile mortality rates, can mediate the pathway between foraging, status-accruing behavior, and reproductive success. Our approach advocates for greater theoretical and empirical attention to quantitative social network measures, female foraging, and fitness outcomes. (shrink)

Watershed planning has typically been approached as a technical problem in which water quality and quantity as influenced by the hydrology, topography, soil composition, and land use of a watershed are the significant variables. However, it is the human uses of land and water as resources that stimulate governments to seek planning. For the past decade or more, many efforts have been made to create democratic planning processes, which, it is hoped, will be viewed as legitimate by those the plans (...) regulate. This article uses a case study of the Cache River watershed in southernmost Illinois to analyze the complicated historical and political economic context of a specific watershed planning process that occurred from 1993 through 1995. This article assesses the claims made about the democratic, grass-roots, deliberative nature of the planning process and casts doubt on the legitimacy of its outcomes. It also proposes an alternative form of governance that would be both democratic and capable of generating outcomes viewed as legitimate by most affected parties. (shrink)

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

As understanding of the human microbiome improves, novel therapeutic targets to improve human health with microbial therapeutics will continue to expand. We outline key considerations of balancing risks and benefits, optimising access, returning key results to research participants, and potential conflicts of interest.

Das Bueh ist das erste Mal in der Sammlung "Schriften zur wissenschaftlichen W eltauffassung", herausgegeben von M. Schlick und Ph. Frank, B. 11, 1937, erschienen. Da nach clem Tod von Schlick und der Cbersiedlung von Frank an die Harvard Universitat die Sammlung nieht mehr fortgese§t wird, erscheint es nun in seiner Neuausgabe selbstandig. Das Werk ist eigentlich ziemlich unbekannt ge­ blieben und nicht zur Wirkung gekommen, weil bereits im naehsten J ahr nach seinem Erscheinen infolge der Bese§ung Osterreichs durch die (...) Nationalsozialisten der Verkauf der "Schriften" mit dem der iibrigen "unerwiinschten" Werke eingestellt worden ist. Dnd 1945 ist bei der Eroberung Wiens der gesamte Bestand an Exemplaren des Werkes mit dell anderen Biichern des Springer-Verlages verbrannt. Die Neu­ auflage, die dadureh notwendig geworden ist, konnte ieh nach einem J ahrzehnt nieht unverandert lassen. Ieh muBte nieht bloB die neue Literatur hinzunehmen, sondern ieh habe das Buch zum groBen Teil neu gefaBt und aueh inhalt­ lich ergauzt. 1m ersten Teil sind die Absehnitte iiber das System der Werte neu hinzugekommen; der zweite Teil iiber das Werturteil ist zum groBten Teil neu geschrieben worden und aueh hier ist ein neuer Abschnitt iiber die hypo­ thetische Begriindung iiberindividueller Wertungen hinzuge­ fiigt worden. Ich habe midi bemiiht, auf diesem schwierigen und noch wenig in wissenschaftlicher Weise untersuchten Gebiet durch logische Analyse und durch empirische Fest­ stellungen KIarheit zu gewinnen, nnd ieh habe gesncht zu zeigen, daB man, wenn man auch noch so entschieden IV Vorwort. (shrink)

Der Band dokumentiert Beiträge zum 18. Symposium des Mediävistenverbandes, das im Frühjahr 2019 in Tübingen stattgefunden hat. Das Thema greift aktuelle Debatten über Autorschaft, Urheberrecht, Originalität und Plagiat auf, die anzeigen, dass diese Konzepte neuerdings in Bewegung geraten sind. Die Beiträge des Bandes fragen aus unterschiedlichen Fachperspektiven, ob und inwiefern die Verfahren des Umgangs mit Autorschaft zwischen Mittelalter und Moderne am Ende stärker vergleichbar sind als gemeinhin angenommen. So werden die aus der Moderne gebildeten Kategorien von Kreativität hinterfragt und unterlaufen. (...) Zugleich zeigt sich, dass eben diejenigen Kreativitätsprozesse der Moderne, die den hohen normativen Ansprüchen einer Geniekultur nicht entsprechen, nicht einfach Defizienzerscheinungen sind, sondern Variationen vielfach geübter Techniken, zu deren Verständnis die mittelalterliche Produktivität dient. Schaffen und Nachahmen sind nicht in einen "künstlerischen" Bereich der Kultur sektorierbar, sondern sie erweisen sich als Grundstruktur menschlichen Handelns auch im wissenschaftlichen, ethischen oder religiösen Feld. So liegt mit diesem Band ein starkes Plädoyer für die Anerkennung der kreativen Kraft der Nachahmung vor. (shrink)

Warum verlief die Evolution bis zum Menschen und ist nicht auf einer früheren Stufe stehen geblie­ben? Verdanken wir unser Dasein einer über Millionen von Jahren abgelaufenen Kette von Zufällen? Kann man das Leben aus toter Materie erklären? Und was ist Leben überhaupt? Die Antworten, die die Naturwissenschaft auf diese grundlegenden Fragen gibt, können ein tieferes Nachdenken nicht befriedigen. In diesem Buch wird gezeigt, dass in der naturalistischen und darwi­nistischen Erklärung des Lebens und seiner Evolution ein entscheidender Faktor übersehen wird, nämlich (...) der erkennende Mensch. Die Fragen nach dem Lebendigen und nach Richtung und Sinn der Evolution können beantwortet werden, wenn das erkennende Bewusstsein nicht als Zuschauer, sondern als integraler Bestandteil der Wirklich­keit mitberücksichtigt wird. In der Selbstanschauung des Erkennens können die Kräfte und Gesetze organischer Entwicklung beobachtet und erforscht werden. Es zeigt sich, dass die Evolution kein zufälliges Geschehen war, sondern der organische Gesamtprozess der Menschwerdung. (shrink)

This examination considers the influence of the seventeenth century Cambridge Platonist Cudworth upon the thought of the late eighteenth century German thinker Herder. It focuses upon Herder's use of Cudworth's philosophy to create a revised version of Spinoza's metaphysics. Both Cudworth and Herder were concerned with the problem of determinism. Cudworth outlined a number of difficulties relating to this problem in the thought of Spinoza and proposed amendments, particularly the introduction of the middle principle of plastik, which would mediate between (...) the Ideas of transcendent reason and mechanical materialism. We find these amendments to Spinoza's philosophy also employed in Herder's contribution to the Pantheism Controversy, in which he too offers a revised Spinozism and introduces his own middle principle of Kraft. This demonstrates an important but under-explored English contribution to a key development in German intellectual history. The Pantheism Controversy was an epoch-making event, helping to bring an end to the German Enlightenment and to inaugurate the Romantic movement. Herder's version of Spinoza's thought revived the philosopher's fortunes, and Herder's notion of Kraft became central to Romantic aesthetics. Finally, Herder's use of Cudworth demonstrates the important but overlooked source of Platonic realism in German Romantic thought. (shrink)

This examination considers the influence of the seventeenth century Cambridge Platonist Cudworth upon the thought of the late eighteenth century German thinker Herder. It focuses upon Herder's use of Cudworth's philosophy to create a revised version of Spinoza's metaphysics. Both Cudworth and Herder were concerned with the problem of determinism. Cudworth outlined a number of difficulties relating to this problem in the thought of Spinoza and proposed amendments, particularly the introduction of the middle principle of plastik, which would mediate between (...) the Ideas of transcendent reason and mechanical materialism. We find these amendments to Spinoza's philosophy also employed in Herder's contribution to the Pantheism Controversy, in which he too offers a revised Spinozism and introduces his own middle principle of Kraft. This demonstrates an important but under-explored English contribution to a key development in German intellectual history. The Pantheism Controversy was an epoch-making event, helping to bring an end to the German Enlightenment and to inaugurate the Romantic movement. Herder's version of Spinoza's thought revived the philosopher's fortunes, and Herder's notion of Kraft became central to Romantic aesthetics. Finally, Herder's use of Cudworth demonstrates the important but overlooked source of Platonic realism in German Romantic thought. (shrink)

Hans-Jørgen Schanz (1948-2022) har i mere end 50 år været en af de mest tænksomme og væsentlige danske intellektuelle, og han var samtidig som professor den bærende og ikke mindst samlende kraft på Idéhistorie ved Aarhus Universitet. Forskningsmæssigt spændte han meget vidt over områder som metafysik, modernitet, politisk filosofi, kunstfilosofi, religionsfilosofi og teologi. Han har begået omkring 40 bøger og et utal af artikler, og han havde en uforlignelig beundringsværdig evne til at tænke selv og insisterede gennem hele sit (...) årelange virke på, at tænkningen skulle være båret af ånd. Han var derudover en meget skattet foredragsholder på højskoler, sognegårde, Folkeuni-versitetet, teologiske konventer og efter- og videreuddannelsesregi. (shrink)

Publisher's description: Warum können Normen und Gesetze zu bestimmten Handlungen verpflichten? Was genau ist eine rechtliche oder moralische Verpflichtung, wie wirkt sie und wie entsteht sie? Und wer darf und kann überhaupt wirksam verpflichten? Antwortversuche auf derlei Fragen führen zu den Grundlagen und Voraussetzungen von Rechtstheorie und Moralphilosophie. Gelingt es, solche Grundlagen auf die Natur des Menschen und damit auf die Möglichkeiten und Bedingungen seines Erkennens, Wollens und Handelns zurückzuführen, so kann eine Letztbegründung von Recht und Moral versucht werden. In (...) der Folge liesse sich eine Konzeption des natürlichen Rechts herleiten, die ihrerseits die Grundlage für das heute vorherrschende positivistische Rechtsverständnis bilden würde. Francisco Suárez S. J. (1548-1617) unternimmt einen solchen Versuch in seinen verschiedenen Schriften zur Rechtphilosophie und Moraltheologie und leistet damit nicht nur einen historisch relevanten Beitrag zur Naturrechtstradition der Frühen Neuzeit, sondern ebenso zu systematischen Problemstellungen der heutigen philosophischen Debatte, beginnend bei der Fundierung von Moralität im individuellen Gewissen bis hin zu Wesen und Ausgestaltung des Völkerrechts. Stefan Schweighöfer zeigt die Verbindungslinien zwischen den verschiedenen Werken von Francisco Suárez und rekonstruiert so philosophische Positionen, die man gewöhnlich erst in der Tradition Kants verortet. Dabei werden insbesondere auch die Schriften berücksichtigt, die bisher in keiner modernen Sprache zugänglich sind. (shrink)

This chapter focuses on one of the common fallacies in Western philosophy called “stolen concept”. The fallacy of the stolen concept is most closely associated with the works of novelist Ayn Rand and those who find her philosophy persuasive. The defining characteristic of the fallacy is “the act of using a concept while ignoring, contradicting or denying the validity of the concepts on which it logically and genetically depends”. To the extent that one could be said to use a fallacy (...) intentionally, it is more likely to occur when there is a failed attempt to point to a contradiction. The easiest way to avoid stealing concepts is to ensure that contradictions are instituted at the same conceptual level or utilizing a lower‐order concept to contradict a higher‐order one. When higher‐order concepts are used to refute the truth of a lower‐order concept, we have the fallacy. (shrink)

In “A Case Study in Unethical Transgressive Bioethics” Laurence McCullough and colleagues (2010) call for signers to disavow the Letter of Concern (LoC) regarding Maria New's ongoing work with and...

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)