Obwohl Claude Lefort auaerhalb Frankreichs nur Eingeweihten bekannt sein durfte, war er einer der einflussreichsten politischen Theoretiker fur den franzosischen Diskurs seit dem Zweiten Weltkrieg. Nach dem Krieg hatte er in diversen Projekten an der Etablierung einer franzosischen kritischen Linken pragend mitgewirkt, die sich gegen die partei- und Sowjetunionstreue Linie Sartres durchzusetzen hatte. So entwickelte er ein Verstandnis des kommunistischen Totalitarismus, das dann gleichsam eine Kontrastfolie fur seine Demokratie- und Menschenrechtstheorie abgeben konnte. In allen diesen Aspekten lassen sich wesentliche Entwicklungen (...) auch der internationalen politiktheoretischen Debatten auf seine Diskussionsbeitrage zuruckfuhren. Am bekanntesten ist sicherlich seine These von der Verortung des Kerns der Demokratie in einer streitbaren Zivilgesellschaft, welche sich der staatlichen Kontrolle ebenso entzieht, wie sie die Besetzung des "leeren Ortes der Macht" durch die politischen Akteure verhindert. Der Band rekonstruiert die Demokratie- und Politiktheorie Leforts und bettet jene bekannte These in vielfaltige und sehr viel weiter reichende theoretische Kontexte ein. In der Arbeit mit den Ideen Leforts konnen die Beitrager daruber hinaus zeigen, dass Leforts Theorie auch fur aktuelle Phanomene und Debatten (wie z.B. die Occupy!-Bewegung, die Debatte um den Populismus und diejenige um die Konstitutionalisierung des Volkerrechts) nach wie vor von groaer Originalitat und ungeminderter Bedeutung ist. (shrink)

Taking his critique of totalitarianizing conceptions of community as a starting point, this text examines Jean-Luc Nancy's work of an ‘ontology of plural singular being’ for its political implications. It argues that while at first this ontology seems to advocate a negative or an anti-politics only, it can also be read as a ‘theory of communicative praxis’ that suggests a certain ethos – in the form of a certain use of symbols (which is expressed only inaptly by the word ‘style’) (...) that would render the ontological plurality of singulars perceptible and practically effective. Finally, some recent texts by Nancy even sidestep the ontology of being-with and face the question of what politics, faced with demands of justice, could be and what a democratic politics could provide. Both of these aspects in Nancy's work, however, still remain to be spelled out more politically. (shrink)

Postural reflexes are essential for locomotion and postural stability, and may play an important role in the etiology of chronic back pain. It has recently been theoretically predicted, and with the help of unilateral perturbations of the trunk experimentally confirmed that the sensorimotor control must lower the reflex amplitude for increasing reflex delays to maintain spinal stability. The underlying neuromuscular mechanism for the compensation of postural perturbations, however, is not yet fully understood. In this study, we applied unilateral and bilateral (...) sudden external perturbations to the trunk of healthy subjects and measured the muscular activity and the movement onset of the trunk. We found that the onset of the trunk muscle activity is prior to, or coincident with, the onset of the trunk movement. Additionally, the results of our experiments imply that the muscular response mechanism integrates distant sensory information from both sides of the body. These findings rule out a simple monosynaptic stretch reflex in favor of a more complex polysynaptic postural reflex mechanism to compensate postural perturbations. Moreover, the previously predicted negative correlation between reflex delay and reflex gain was also confirmed for bilateral perturbations. (shrink)

O positivismo jurídico é predominantemente ensinado e aplicado há décadas por profissionais da área jurídica brasileira, geralmente com referência à construção teórica de Hans Kelsen (1881-1973), deixando à margem muitos outros estudos que oferecem importantes formulações e conceitos para a compreensão do Direito contemporâneo. Este artigo se junta a algumas poucas pesquisas sobre outros referenciais teóricos acerca do positivismo jurídico, analisando a regra de reconhecimento no pensamento teórico de Herbert Hart (1907-1992), apresentando-a como incremento e superação da teoria imperativista de (...) John Austin (1790-1859). A partir de pesquisa bibliográfica, mostramos que, em Hart, a regra de reconhecimento (modalidade de regra secundária) apresenta-se indispensável para a certeza necessária ao Direito, bem como para aferir a validade do sistema jurídico. (shrink)

Historically, one of the most controversial aspects of Darwinian evolution has been the prominent role that randomness and random change play in it. Most biologists agree that mutations in DNA have random effects on fitness. However, fitness is a highly simplified scalar representation of an enormously complex phenotype. Challenges to Darwinian thinking have focused on such complex phenotypes. Whether mutations affect such complex phenotypes randomly is ill understood. Here I discuss three very different classes of well-studied molecular phenotypes in which (...) mutations cause nonrandom changes, based on our current knowledge. What is more, this nonrandomness facilitates evolutionary adaptation. Thus, living beings may translate DNA change into nonrandom phenotypic change that facilitates Darwinian evolution. (shrink)

Systems involving many interacting variables are at the heart of the natural and social sciences. Causal language is pervasive in the analysis of such systems, especially when insight into their behavior is translated into policy decisions. This is exemplified by economics, but to an increasing extent also by biology, due to the advent of sophisticated tools to identify the genetic basis of many diseases. It is argued here that a regularity notion of causality can only be meaningfully defined for systems (...) with linear interactions among their variables. For the vastly more important class of nonlinear systems, no such notion is likely to exist. This thesis is developed with examples of dynamical systems taken mostly from mathematical biology. It is discussed with particular reference to the problem of causal inference in complex genetic systems, systems for which often only statistical characterizations exist. (shrink)

Mutational robustness facilitates evolutionary innovations. Gene duplications are unique kinds of mutations, in that they generally increase such robustness. The frequent association of gene duplications in regulatory networks with evolutionary innovation is thus a special case of a general mechanism linking innovation to robustness. The potential power of this mechanism to promote evolutionary innovations on large time scales is illustrated here with several examples. These include the role of gene duplications in the vertebrate radiation, flowering plant evolution and heart development, (...) which encompass some of the most striking innovations in the evolution of life. BioEssays 30:367–373, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

BackgroundFreezing of gait is a disabling burden for Parkinson’s disease patients with poor response to conventional therapies. Combined deep brain stimulation of the subthalamic nucleus and substantia nigra moved into focus as a potential therapeutic option to treat the parkinsonian gait disorder and refractory FoG. The mechanisms of action of DBS within the cortical-subcortical-basal ganglia network on gait, particularly at the cortical level, remain unclear.MethodsTwelve patients with idiopathic PD and chronically-implanted DBS electrodes were assessed on their regular dopaminergic medication in (...) a standardized stepping in place paradigm. Patients executed the task with DBS switched off, conventional STN DBS and combined STN+SN DBS and were compared to healthy matched controls. Simultaneous high-density EEG and kinematic measurements were recorded during resting-state, effective stepping, and freezing episodes.ResultsClinically, STN+SN DBS was superior to conventional STN DBS in improving temporal stepping variability of the more affected leg. During resting-state and effective stepping, the cortical activity of PD patients in STIM OFF was characterized by excessive over-synchronization in the theta, alpha, and high-beta band compared to healthy controls. Both active DBS settings similarly decreased resting-state alpha power and reduced pathologically enhanced high-beta activity during resting-state and effective stepping compared to STIM OFF. Freezing episodes during STN DBS and STN+SN DBS showed spectrally and spatially distinct cortical activity patterns when compared to effective stepping. During STN DBS, FoG was associated with an increase in cortical alpha and low-beta activity over central cortical areas, while with STN+SN DBS, an increase in high-beta was prominent over more frontal areas.ConclusionsSTN+SN DBS improved temporal aspects of parkinsonian gait impairment compared to conventional STN DBS and differentially affected cortical oscillatory patterns during regular locomotion and freezing suggesting a potential modulatory effect on dysfunctional cortical-subcortical communication in PD. (shrink)

Es scheint mir fruchtbar, bestimmte theologisch-anthropologische Grundkonzeption des Alten Testaments im Rahmen des Imperfektibilitäts-Diskurses zu beschreiben. Ausgangspunkt für die besonders an Gen 6,5 (im Kontext von Gen 6-8) anknüpfende Position der „Unfähigkeit des Menschen zur Vervollkommnung“: Alle Reflexionen geschehen in Gen 6,5ff. nur von Gott her und auf das Verhältnis Mensch-Gott hin; es gibt keine individuell/kollektive Unterscheidung bei dieser Problematik, sowohl der einzelne Mensch wie auch die Menschheit sind imperfektibel. Das Konzept ist offen für einen Inklusionsansatz, der vom Differenzprinzip her (...) denkt, verfolgt selbst aber eine andere, theologische, Zielrichtung und führt den Lesenden die Angewiesenheit des Menschen auf Gottes Gnade sowie ihre Zusage vor Augen. (shrink)

In discussing the works of 16th-century theorists Francisco de Vitoria and Alberico Gentili, this article examines how two different conceptions of a global legal community affect the legal character of the international order and the obligatory force of international law. For Vitoria the legal bindingness of ius gentium necessarily presupposes an integrated character of the global commonwealth that leads him to as it were ascribe legal personality to the global community as a whole. But then its legal status and its (...) consequences have to be clarified. For Gentili on the other hand, sovereign states in their plurality are the pinnacle of the legal order(s). His model of a globally valid ius gentium then oscillates between being analogous to private law, depending on individual acceptance by states and being natural law, appearing in a certain sense as a form rather of morality than of law. (shrink)

Recombination is often considered a disruptive force for well‐adapted phenotypes, but recent evidence suggests that this cost of recombination can be small. A key benefit of recombination is that it can help create proteins and regulatory circuits with novel and useful phenotypes more efficiently than point mutation. Its effectiveness stems from the large‐scale reorganization of genotypes that it causes, which can help explore far‐flung regions in genotype space. Recent work on complex phenotypes in model gene regulatory circuits and proteins shows (...) that the disruptive effects of recombination can be very mild compared to the effects of mutation. Recombination thus can have great benefits at a modest cost, but we do not understand the reasons well. A better understanding might shed light on the evolution of recombination and help improve evolutionary strategies in biochemical engineering. (shrink)

This article examines a series of Schelling-like models of residential segregation, in which agents prefer to be in the minority. We demonstrate that as long as agents care about the characteristics of their wider community, they tend to end up in a segregated state. We then investigate the process that causes this and conclude that the result hinges on the similarity of informational states among agents of the same type. This is quite different from Schelling-like behavior and suggests that segregation (...) is an instance of macrobehavior that can arise from a wide variety of micromotives. (shrink)

Biologists frequently draw on ideas and terminology from engineering. Evolutionary systems biology—with its circuits, switches, and signal processing—is no exception. In parallel with the frequent links drawn between biology and engineering, there is ongoing criticism against this cross-fertilization, using the argument that over-simplistic metaphors from engineering are likely to mislead us as engineering is fundamentally different from biology. In this article, we clarify and reconfigure the link between biology and engineering, presenting it in a more favorable light. We do so (...) by, first, arguing that critics operate with a narrow and incorrect notion of how engineering actually works, and of what the reliance on ideas from engineering entails. Second, we diagnose and diffuse one significant source of concern about appeals to engineering, namely that they are inherently and problematically metaphorical. We suggest that there is plenty of fertile ground left for a continued, healthy relationship between engineering and biology. (shrink)

This introduction to the Common Knowledge symposium titled “Comparative Relativism” outlines a variety of intellectual contexts where placing the unlikely companion terms comparison and relativism in conjunction offers analytical purchase. If comparison, in the most general sense, involves the investigation of discrete contexts in order to elucidate their similarities and differences, then relativism, as a tendency, stance, or working method, usually involves the assumption that contexts exhibit, or may exhibit, radically different, incomparable, or incommensurable traits. Comparative studies are required to (...) treat their objects as alike, at least in some crucial respects; relativism indicates the limits of this practice. Jensen argues that this seeming paradox is productive, as he moves across contexts, from Lévi-Strauss's analysis of comparison as an anthropological method to Peter Galison's history of physics, and on to the anthropological, philosophical, and historical examples offered in symposium contributions by Barbara Herrnstein Smith, Eduardo Viveiros de Castro, Marilyn Strathern, and Isabelle Stengers. Comparative relativism is understood by some to imply that relativism comes in various kinds and that these have multiple uses, functions, and effects, varying widely in different personal, historical, and institutional contexts that can be compared and contrasted. Comparative relativism is taken by others to encourage a “comparison of comparisons,” in order to relativize what different peoples—say, Western academics and Amerindian shamans—compare things “for.” Jensen concludes that what is compared and relativized in this symposium are the methods of comparison and relativization themselves. He ventures that the contributors all hope that treating these terms in juxtaposition may allow for new configurations of inquiry. (shrink)

This English translation of Friedrich Nietzsche in seinen Werken offers a rare, intimate view of the philosopher by Lou Salomé, a free-thinking, Russian-born intellectual to whom Nietzsche proposed marriage at only their second meeting. Published in 1894 as its subject languished in madness, Salomé's book rode the crest of a surge of interest in Nietzsche's iconoclastic philosophy. She discusses his writings and such biographical events as his break with Wagner, attempting to ferret out the man in the midst of (...) his works. Salomé's provocative conclusion -- that Nietzsche's madness was the inevitable result of his philosophical views -- generated considerable controversy. Nietzsche's sister, Elisabeth Förster-Nietzsche, dismissed the book as a work of fantasy. Yet the philosopher's longtime acquaintance Erwin Rohde wrote, "Nothing better or more deeply experienced or perceived has ever been written about Nietzsche." Siegfried Mandel's extensive introduction examines the circumstances that brought Lou Salomé and Nietzsche together and the ideological conflicts that drove them apart. (shrink)

When Nietzsche published his pamphlet The Case of Wagner in 1888 he succeeded in catching the attention of the reading public after many years of neglect. His radical critique of Wagner is viewed as influential in reception history. The Twilight of the Idols captures the essence of Nietzsche's late philosophy. The work shows Nietzsche at the high point of his creative powers and provides a vivid example of experimental philosophy in practice.

The last posthumous manuscripts from 1888 bear witness to an enormous stylistic and intellectual radicalization. The Antichrist purports to be a total "reevaluation of all values." In Ecce homo, Nietzsche explores the genealogy of his own thinking, opening up new dimensions of self-reflection. Nietzsche contra Wagner sums up the many years of Nietzsche's continuing critique of Wagner, while the Dionysian Dithyrambs seek to breathe new life into lyric poetry.

In his writings, Richard Wagner imagines art as something natural. This paradox was only befitting for Wagner’s contradictory historical stance: that of an eminently modern artist loathing the modern world. For him, nature served as a yardstick apt to find the modern world deficient on all counts. But how can something ahistorical, nature, be used to judge a historical phenomenon, modernity? To arrive at the verdict Wagner was keen on, he had to fill his concept of nature (...) with historical content attributed to myth. (shrink)

“How does music stand to image and concept?” (KSA 1, 104) This query in the aesthetics of media is central to Nietzsche’s Birth of Tragedy and related early texts; it shapes both their form and content. Nietzsche searches for a mode of non-conceptual philosophizing; he wishes to organize thought as a sequence of suggestive images – thoughts, that is, about that very relationship. Nietzsche’s success or failure in that endeavour becomes clearer against the foil of the 1795 controversy between Friedrich (...) Schiller and Johann Gottlieb Fichte. These disputants rigidly opposed concept and image; they identified a potential for mediation, at best, in the aftermath. Yet Nietzsche realizes that concepts are images whose character as such fell into oblivion. He undermines the established opposition, too, by introducing sound as a third medium. In spite of these insights, both Schiller and Fichte get clearer about possible coalescences of media than Nietzsche who, at the end of The Birth of Tragedy, forces their harmony by opting for Wagner’s ‘total work of art’. (shrink)

In a recent communication an uncountably categorical group has been constructed that has a non-locally-modular geometry and does not allow the interpretation of a field. We consider a system Δ of elementary axioms fulfilled by some special subgroups of the above group. We show that Δ is complete and stable, but not superstable. It is not even a R-group in the sense discussed by Wagner.

Nietzsches Wagner-Kritik äußert sich unter anderem darin, die Oper 'Carmen' als Gegenmodell zum überhitzen "Sirocco" des 'Tristan' übershwänglich zu loben. Die Miszelle schlägt vor, Nietzsches Begeisterung darauf zurückzuführen, dass er in der Personenkonstellation der 'Carmen' ein Metapher für seine eigene Beziehung zu Wagner und - vor allem - zu Wagners Werk erkennt. Indem die Person Carmen in diesm Bild die Rolle von so etwas wie Nietzsches 'Wagnerisimus' übernimmts, spiegelt sie dessen Ausgeliefertsein an die Verfügungsgewalt des Künstlers über sein (...) Werk wider.Nietzsche's critique of Wagner is especially apparent through his effusive praise of Carmen as the antithesis of the overheated "Scirocco" of Tristan. The author suggests that Nietzsche's excitement is rooted in his seeing the characters' relationships as a metaphor for his relationship to Wagner and Wagner's work. With the character of Carmen overtaking the role of Nietzche's "Wagnerianism," the opera plot mirrors Nietzsche's feeling of being at the mercy of the artist's control over his work. (shrink)

Friedrich Nietzsche, den Gottfried Benn als das "grosste Ausstrahlungsphanomen der Geistesgeschichte" bezeichnete, steht im Zentrum dieses Buches. Es enthalt die Vortrage der Ringvorlesung, welche die Freiburger Forschungsstelle "Nietzsche-Kommentar" zum 100. Geburtstag der Heidelberger Akademie der Wissenschaften organisierte. - In der konstruktiven Auseinandersetzung mit Nietzsche beleuchten die Aufsatze Nietzsches Bedeutung als Leitfigur moderner Lebensphilosophie, Kulturdiagnose und Anthropologie. Nietzsches Kritik an der philosophischen Tradition, sein Konzept der Umwertung, seine Psychologie, sein Geschichtsdenken, seine Beziehung zu Darwin, Schopenhauer, Wagner und Heidegger, seine Lyrik (...) sowie die Charakteristika seines Stils gehoren zum breitgefacherten Themenspektrum.Der Band enthalt Beitrage von Dieter Borchmeyer, Gunter Figal, Hans-Martin Gauger, Volker Gerhardt, Katharina Gratz, Lore Huhn, Helmuth Kiesel, Ludger Lutkehaus, Klaus Monig, Barbara Neymeyr, Annemarie Pieper, Jochen Schmidt und Andreas Urs Sommer. (shrink)