The highly structured mechanisms of cancers, their tendency to occur as a response to environmental stress, and the existence of oncogenes, suggest that neoplasticity may represent more than a biological disfunction. It is proposed that cancer exists as a phylogenetic mechanism serving to promote hyperevolution, albeit at the expense of the ontogeny, that is similar to a process recently discovered in bacterial mutations. Cell-surface-associated nucleic acid in tumorigenic cells and sperm cell vectorization of foreign DNA indicate the existence of essential (...) mechanisms necessary to the occurrence of cancer mediated hyperevolution. An analysis of the proposed mechanism indicates that for mutagenesis of chemical cytology, stress induced neoplasticity confers an evolutionary advantage of more than two orders of magnitude. (shrink)

At least three books struggle to emerge from this volume. One book, at the level of popular science, leads us through the development of physics, from Newton's laws to Bell's inequalities, in order to argue for the relevance of consciousness to the understanding of quantum theory. This is followed by a sketch of an interpretation of quantum mechanics. Interwoven with both is a memoir of Walker's teenage girlfriend, who died of Hodgkin's disease nearly fifty years ago. The theme which (...) holds the volume together is Walker's insistence on the importance of looking beyond materialism. (shrink)

ISBN-13: 978-0-226-11360-9 (cloth : alk. paper) ISBN-10: 0-226-11360-4 ... HM651.C64 2007 158.1—dc22 2007022671 The paper used in this publication meets the minimum requirements of the American National Standard for Information ...

The phrase ‘trading zone’ is often used to denote any kind of interdisciplinary partnership in which two or more perspectives are combined and a new, shared language develops. In this paper we distinguish between different types of trading zone by asking whether the collaboration is co-operative or coerced and whether the end-state is a heterogeneous or homogeneous culture. In so doing, we find that the voluntary development of a new language community—what we call an inter-language trading zone—represents only one of (...) four possible configurations. In developing this argument we show how different modes of collaboration result in different kinds of trading zone, how different kinds of trading zone may be ‘nested’ inside each other and discuss how a single collaboration might move between different kinds of trading zone over time. One implication of our analysis is that interactional expertise is a central component of at least one class of trading zone.Keywords: Trading zones; Interactional expertise; Interdisciplinarity; Creole. (shrink)

‘Interactional expertise’ is developed through linguistic interaction without full scale practical immersion in a culture. Interactional expertise is the medium of communication in peer review in science, in review committees, and in interdisciplinary projects. It is also the medium of specialist journalists and of interpretative methods in the social sciences. We describe imitation game experiments designed to make concrete the idea of interactional expertise. The experiments show that the linguistic performance of those well socialized in the language of a specialist (...) group is indistinguishable from those with full blown practical socialization but distinguishable from those who are not well socialized. The imitation game can also be used to indicate whether an individual can enter an esoteric domain and master the interactional expertise, a skill required by interpretative sociologists of science, anthropologists, ethnographers, and the like.Keywords: Expertise; Interactional expertise; Imitation game; Turing test; Colour blindness; Interpretative methods. (shrink)

In this four part exchange, Evan Selinger starts by stating that Collins’s empirical evidence in respect of linguistic socialization and its bearing on artificial intelligence and expertise is valuable; it advances philosophical and sociological understanding of the relationship between knowledge and language. Nevertheless, he argues that Collins mischaracterizes the data under review and thereby misrepresents how knowledge is acquired and understates the extent to which expert knowers are embodied. Selinger reconstructs the case for the importance of the body in (...) the initial acquisition of language and challenges Collins to show how a disembodied entity could become fluent in any language at all.Collins responds by accepting that his approach does not demonstrate quite as much about the irrelevance of the body as he thought it did but that even though he accepts all of Selinger’s claims, ‘the body’ as needed by the philosophical approach set out by Selinger is still a vestigial thing. Collins’s main point, however, is that the philosophical view of the body—the world is divided into embodied agents and unembodied entities—distracts attention from the more interesting empirically researchable question of how the ability to become socialized diminishes, if it does, as the body become more and more minimal. The right research question is not about whether a person can extrapolate from minimal sensory input but how much extrapolation is possible under different circumstances and how it is done.Dreyfus, having seen the whole of the exchange so far, agrees that both have a point but argues that Collins’s approach still misses the well established importance of bodily engagement for full understanding.Collins responds to this by trying to set out more clearly the position associated with the idea of interactional expertise.Keywords: Interactional expertise; Phenomenology; Turing test; Embodiment; Tacit knowledge; Socialization. (shrink)

In this four part exchange, Evan Selinger starts by stating that Collins’s empirical evidence in respect of linguistic socialization and its bearing on artificial intelligence and expertise is valuable; it advances philosophical and sociological understanding of the relationship between knowledge and language. Nevertheless, he argues that Collins mischaracterizes the data under review and thereby misrepresents how knowledge is acquired and understates the extent to which expert knowers are embodied. Selinger reconstructs the case for the importance of the body in (...) the initial acquisition of language and challenges Collins to show how a disembodied entity could become fluent in any language at all.Collins responds by accepting that his approach does not demonstrate quite as much about the irrelevance of the body as he thought it did but that even though he accepts all of Selinger’s claims, ‘the body’ as needed by the philosophical approach set out by Selinger is still a vestigial thing. Collins’s main point, however, is that the philosophical view of the body—the world is divided into embodied agents and unembodied entities—distracts attention from the more interesting empirically researchable question of how the ability to become socialized diminishes, if it does, as the body become more and more minimal. The right research question is not about whether a person can extrapolate from minimal sensory input but how much extrapolation is possible under different circumstances and how it is done.Dreyfus, having seen the whole of the exchange so far, agrees that both have a point but argues that Collins’s approach still misses the well established importance of bodily engagement for full understanding.Collins responds to this by trying to set out more clearly the position associated with the idea of interactional expertise.Keywords: Interactional expertise; Phenomenology; Turing test; Embodiment; Tacit knowledge; Socialization. (shrink)

Abstract: This essay critically examines whether there are ethical dimensions to the way that expertise, knowledge claims, and expressions of skepticism intersect on technical matters that influence public policy, especially during times of crisis. It compares two different perspectives on the matter: a philosophical outlook rooted in discourse and virtue ethics and a sociological outlook rooted in the so-called third-wave approach to science studies. The comparison occurs through metaphilosophical analysis and applied claims that clarify how the disciplinary orientations appear to (...) lead to different judgments about matters related to Robert Paarlberg's condemnation of activists who advise African politicians to ban genetically modified food. (shrink)

Against Mitchell et al.'s assertions, we argue that (1) the concordance between learning and awareness does not support any particular learning theory, (2) their propositional approach is at odds with examples of learned behaviours that contradict beliefs about causation, and (3) the relative virtues of the two approaches in terms of parsimony is more ambiguous than Mitchell et al. suggest.

“Hypernormal science” has minimal potential for contestation on matters of principle and practice so that information exchange can be unproblematic. Sciences comprise hypernormal domains and more contestable “normal” domains where knowledge diffusion, like acquiring linguistic fluency, depends on face-to-face interaction. Hypernormal domains belonging to molecular biology are contrasted with normal domains in gravitational wave detection physics. Sciences as a whole should not be confused with their typical domains. The analysis has immediate implications for proposed transitions out of the Covid-19 lockdown, (...) proposed solutions to the replication crisis, and, perhaps, our understanding of the early development of social studies of science. (shrink)

The risk of populism is ever-present in democratic societies. Here we argue that science provides one way in which this risk can be reduced. This is not because science provides a superior truth but because it (a) preserves and celebrates values that are essential for democracy and (b) contributes to the network of the checks and balances that constrain executive power. To make this argument, we draw on Wittgenstein’s idea of a form of life to characterize any social group as (...) being composed of two opposing elements: an organic aspect that defines what the group has in common and an enumerative aspect that describes the differing ways in which the organic core can be displayed. Whilst the organic faces of science and democracy are clearly different there are significant overlaps that include values such as disinterestedness, universalism and honesty. This overlap in values is the first way in which science can prevent populism: by providing moral leadership. The second, its role in a network of checks and balances, also depends on these values. Science does not contribute to the checks and balances because it provides epistemically superior knowledge; it contributes because it provides morally superior knowledge that, alongside institutions such a free press, independent judiciary and additional tiers of government, support the democratic ecosystem. Failures of democracy occur when this ecosystem is damaged – too much science leads to technocracy, but too little creates the conditions for populism. To prevent this, we argue that citizens must (re)learn the value of democratic values. These include endorsing an independent judiciary and other state institutions, even when these hinder policies of which they might approve and, of particular concern in this context, recognizing that independent experts, of which scientists are the exemplar, are part of this network of checks and balances. (shrink)

This paper examines potential ethical and legal issues arising during the research, develop- ment and clinical use of a proposed strategy in personalized medicine (PM): using human induced pluripotent stem cell (iPSC)-derived tissue cultures as predictive models of individ- ual patients to inform treatment decisions. We focus on epilepsy treatment as a likely early application of this strategy, for which early-stage stage research is underway. In relation to the research process, we examine issues associated with biological samples; data; health; vulnerable (...) populations; neural organoids; and what level of accuracy justifies using the iPSC-derived neural tissue system. In relation to clinical use, we examine potential uses in pre-natal screening, and effects on clinical decision-making. Although our focus is providing recommendations for researchers developing work in this area, we identify the novel issue of deciding on an acceptable accuracy level for the system. We also emphasize an issue thus far neglected in the ethics of PM: PM tends to represent treatment decisions as though they should be directed solely by biomedical information, but this in itself could be detri- mental to best personalizing treatment decisions in the clinic. (shrink)

A consistent finding reported in the literature is that epistemically suspect beliefs are less frequently endorsed by individuals with a greater tendency to think analytically. However, these results have been observed predominantly in Western participants. In the present work, we explore various individual differences known to predict epistemically suspect beliefs across both Western and Eastern cultures. Across four studies with Japanese and Western individuals, we find that the association between thinking style and beliefs varied as a function of culture. Specifically, (...) while Westerners who scored higher on measures of Type-2 analytic thinking tended to endorse epistemically suspect beliefs less, this association was not observed in Japanese samples, suggesting that the often-observed negative association between analytic thinking and epistemically suspect beliefs may be exclusive to Western individuals. Additionally, we demonstrate that a tendency to think holistically is positively associated with the endorsement of epistemically suspect beliefs within both samples. Overall, we discuss how various individual differences predict the endorsement of epistemically suspect beliefs across cultures. (shrink)

Harris presents neuroscience findings and reveals fantasy as the brain's default mode as it alters identity during unbearable trauma or loss. The book also presents case histories of cultural conflicts, and examines populist bias vs. elite global influence in a neuropsychoanalytic context.

Ted Shotter's founding of the London Medical Group 50 years ago in 1963 had several far reaching implications for medical ethics, as other papers in this issue indicate. Most significant for the joint authors of this short paper was his founding of the quarterly Journal of Medical Ethics in 1975, with Alastair Campbell as its first editor-in-chief. In 1980 Raanan Gillon began his 20-year editorship . Gillon was succeeded in 2001 by Julian Savulescu, followed by John Harris and Soren (...) Holm in 2004, with Julian Savulescu starting his second and current term in 2011. In 2000 an additional special edition of the JME, Medical Humanities , was published, under the founding joint editorship of Martyn Evans and David Greaves. In 2003 Jane Macnaughton succeeded David Greaves as joint editor. Deborah Kirklin, under whose auspices MH became an independent journal, took over in 2008, and she was succeeded in 2013 by Sue Eckstein. This short paper offers reminiscences and reflections from the two journals’ various editors.From the start the JME was committed to clearly expressed reasoned discussion of ethical issues arising from or related to medical practice and research. In particular, both Edward Shotter and Alastair Campbell, each a cleric , were at pains to make clear that the JME was not a religious journal and that it had no sort of partisan axe to grind.Campbell's appointment as founding editor was something of a surprise, as the original intention had been to appoint a medical doctor, who could be expected to know medical practice from the inside. However, in 1972 Campbell, a Joint Secretary of the Edinburgh Medical Group, had published Moral dilemmas in medicine. …. (shrink)

Toward a New Socialism offers a critical analysis of capitalism's failings and the imminent need for socialism as an alternative form of government. Dr. Richard Schmitt joins with Dr. Anatole Anton to compile a volume of essays exploring the benefits and consequences of a socialist system as an avenue of increased human solidarity and ethical principle.

This paper draws an earlier book (with Evans and Higgins) entitled _Bad Call: Technology’s Attack on Referees and Umpires and How to Fix It_ (hereafter _Bad Call_) and its various precursor papers. These show why it is that current match officiating aids are unable to provide the kind of accuracy that is often claimed for them and that sports aficianados have been led to expect from them. Accuracy is improving all the time but the notion of perfect accuracy is a (...) myth because, for example, lines drawn on sports fields and the edges of balls are not perfectly defined. The devices meant to report the exact position of a ball—for instance ‘in’ or ‘out’ at tennis—work with the mathematically perfect world of virtual reality, not the actuality of an imperfect physical world. Even if ball-trackers could overcome the sort of inaccuracies related to fast ball speeds and slow camera frame-rates the goal of complete accuracy will always be beyond reach. Here it is suggested that the purpose of technological aids to umpires and referees be looked at in a new way that takes the viewers into account. (shrink)

This paper is a critical examination of Harry Collins's investigation into a third form of knowledge, “interactional expertise.” We argue that although Collins makes a genuine contribution to the phenomenological literature on expertise, his account requires further critical evaluation and response due to pragmatic and ontological considerations. We contend that by refining (in some questionable ways) the category of interactional expertise so as to create epistemological equivalence between activists, sociologists, critics, journalists, and some science administrators, Collins potentially undermines the value (...) that a more rigorously construed concept of interactional expertise might have. We further show that Collins misunderstands the nature of embodiment in a way that is exacerbated by the sociological perspective that he adopts. (shrink)

Fringe science has been an important topic since the start of the revolution in the social studies of science that occurred in the early 1970s. The revolution was what Collins and Evans refer to as the "second wave of science studies," while this paper is best thought of as an exercise in "third wave science studies." The first wave was that period which reached its apogee in the aftermath of the Second World War when science was seen as unquestionably the (...) pre-eminent form of knowledge-making, and the role of philosophy and sociology was to understand how it was so and how societies could be arranged to nurture it best; the second wave was "social constructionism" which became folded into post-modernism in... (shrink)

Harry Collins interprets Hubert Dreyfus’s philosophy of embodiment as a criticism of all possible forms of artificial intelligence. I argue that this characterization is inaccurate and predicated upon a misunderstanding of the relevance of phenomenology for empirical scientific research.

This book is the result of an idea launched by the present editors of providing a gift to Dr. Runner in the form of a Festschrift written by former students. The response was overwhelming. Glenn Andreas, one of Dr. Runner's closest friends, and Paul Schrotenboer, secretary of the Reformed Ecumenical Synod, enthusiastically joined us, together with Bernard Zylstra of the Institute for Christian Studies and Harry Van Dyke of the Free University of Amsterdam, to form a committee for this purpose... (...) Upon the appearance of this publication the editors wish to express their sincere thanks to the members of the committee for the advice and encouragement they gave and for the work they have done. (shrink)

Reductionists about agency maintain that an agent’s causing something is reducible to states and events involving the agent causing something. Some worry that reductionism cannot accommodate robust forms of agency, such as self-determination. One reductionist answer to this worry, which I call ‘identification reductionism,’ contends that self-governing agents are identified with certain attitudes, and so these attitudes’ causing a decision count as the agent’s self-determining the decision. I argue that a prominent species of identification reductionism developed by Harry Frankfurt, Agnieszka (...) Jaworska, Jeffrey Seidman, and David Shoemaker—according to which an agent is identified with his (deepest) cares—is inadequate. (shrink)

Harry Stack Sullivan has been described as 'the most original figure in American psychiatry'. Challenging Freud's psychosexual theory, Sullivan founded the interpersonal theory of psychiatry, which emphasized the role of interpersonal relations, society and culture as the primary determinants of personality development and psychopathology. This concise and coherent account of Sullivan's work and life invites the modern audience to rediscover the provocative, groundbreaking ideas embodied in Sullivan's interpersonal theory and psychotherapy.

Whether or not there is a natural inclination to want freedom, and whether or not slaves (modern or ancient) are living in violation of such a natural inclination has been debated by scholars for centuries. David Walker’s APPEAL provides a starting point for an argument that settles the issue: given my interpretation of Walker’s naturalism and his approach to existential agency, slaves have a duty to insurrect even if there is no empirical evidence that a natural inclination exists. (...) And they have this duty even if they are likely to fail. Neither instrumentalist nor consequentialist reasoning provide a slave compelling reasons to rebel; all consequences of rebellion are almost certain to be deleterious and it is not unreasonable for persons to be subservient under conditions of slavery. I depict, and use Walker’s depiction of, slavery to defend his approach to naturalism and liberation; an approach arguably beneficial to how we should see contemporary slavery. (shrink)

From the late 1950s through the early 1970s, Harry F. Harlow's primate laboratory at the University of Wisconsin–Madison undertook a series of studies on infant rhesus macaque monkeys that gained the attention of both animal welfare advocates and the scientific community.1 Establishing one of the first primate research laboratories in 1932, Harlow began his career as a primate researcher by studying primate learning capabilities and shredding previous assumptions within psychology that primates were restricted to the conditioned learning of a rat. (...) As his need for subjects in particular age ranges and easily susceptible to study grew in the 1950s, he again broke research ground by establishing a captive breeding... (shrink)

alain locke's version of pragmatism, critical pragmatism, provides a way to see how a philosophy contributes resources for the abused, subjugated, and humiliated facing existential crisis and impossible odds of relief. That is, it provides reasoning methods, terms, words, depictions, explanations, queries, dispositions, spirit, and conceptual categories as resources. I will argue that a viable philosophy should provide resources and reasoning methods that make the management of abjection and existential crisis viable, given impossible odds of relief; it should be encoded (...) with, among other features, the sort of spirit needed to recite a Preface to a Twenty Volume Suicide Note,1 that is, a philosophic orientation... (shrink)