Examines the cultural implications of society's declining appreciation and recognition of common sense while exploring the process by which the concept is learned.

In Socrates among Strangers, Joseph P. Lawrence reclaims the enigmatic sage from those who have seen him either as a prophet of science, seeking the security of knowledge, or as a wily actor who shed light on the dangerous world of politics while maintaining a prudent distance from it. The Socrates Lawrence seeks is the imprudent one, the man who knew how to die. The institutionalization of philosophy in the modern world has come at the cost of (...) its most vital concern: the achievement of life wisdom. Those who have ceased to grow (those who think they know) close their ears to the wisdom of strangers—and Socrates, who stood face to face with death, is the archetypal stranger. His avowal of ignorance, Lawrence suggests, is more needed than ever in an age defined by technical mastery and expert knowledge. (shrink)

In dynamic epistemic logic and other fields, it is natural to consider relativization as an operator taking sentences to sentences. When using the ideas and methods of dynamic logic, one would like to iterate operators. This leads to iterated relativization. We are also concerned with the transitive closure operation, due to its connection to common knowledge. We show that for three fragments of the logic of iterated relativization and transitive closure, the satisfiability problems are fi1 11–complete. Two of these fragments (...) do not include transitive closure. We also show that the question of whether a sentence in these fragments has a finite (tree) model is fi0 01–complete. These results go via reduction to problems concerning domino systems. (shrink)

Introduction.--Aristotle.--The seventeenth century.--The eighteenth century.--Biology.--Nature.--Evolution.--The problem.--The three elements.--The teleological order.--Appendix: Clerk Maxwell on determinism and free will. Fechner on the tendency to stability.

Pediatric psychopharmacology is a relatively new science. Although the use of psychotropic medications in children has risen in the past decade, there are few standard treatments for serious psychiatric or developmental disorders of childhood. The relative absence of standard treatments is further complicated by the fact that many of the agents used in pediatric psychopharmacology have been adapted from other fields. Therefore, investigators have a responsibility to make incremental progress from concept through pilot studies and large-scale, multisite efficacy and safety (...) trials. Thus, although there is a pressing need to conduct medication trials that can guide clinical practice, there are scientific and ethical considerations to bear in mind when designing clinical trials in pediatric psychopharmacology. This article reviews essential ethical and scientific issues that are relevant to designing clinical trials in children with psychiatric and developmental disorders. Using examples from recently published literature, the article describes the challenges and pitfalls of various clinical trial study designs. The application of sound ethical and scientific principles is necessary to ensure that clinical trials are properly conducted and to guard against ambiguous results that can not guide practice. (shrink)

The philosophy of Schelling has for too long been lost in the shadows of Fichte and Hegel. While one might dispute Martin Heidegger’s judgment that Schelling was actually the most creative and far-reaching thinker of German Idealism, it betrays both ignorance and intellectual indolence to simply deny his importance. Schelling was not only a significant co-author of “Hegelian” idealism, he was also its first and perhaps most penetrating critic. He outlived Hegel by over 20 years and, as Manfred Frank demonstrates (...) in one of the following essays, developed the arguments against Hegel that were subsequently taken up by Feuerbach, Marx, and Kierkegaard. (shrink)

The philosophy of Schelling has for too long been lost in the shadows of Fichte and Hegel. While one might dispute Martin Heidegger’s judgment that Schelling was actually the most creative and far-reaching thinker of German Idealism, it betrays both ignorance and intellectual indolence to simply deny his importance. Schelling was not only a significant co-author of “Hegelian” idealism, he was also its first and perhaps most penetrating critic. He outlived Hegel by over 20 years and, as Manfred Frank demonstrates (...) in one of the following essays, developed the arguments against Hegel that were subsequently taken up by Feuerbach, Marx, and Kierkegaard. (shrink)

The problem of the relationship between art and philosophy is deeply rooted in the philosophical tradition. When Plato excluded artists from the philosophers’ mythical republic, he seemed to be assuming a strict opposition between art and philosophy. Artists do not know what they are saying. Because their creation is grounded in the madness of inspiration, they would be unable to give accounts for their doctrines even if doctrines could be gleaned from their works. Philosophers, on the other hand, must be (...) able to provide such accounts. They commit themselves to providing reasons for their conclusions. (shrink)

Environmental philosophers tend to be particularly wary of the language of “transcendence.” From Heidegger to contemporary feminism, we find the idea that the failure to respect nature is grounded in Platonism and Abrahamic religion. The denial of earth began, we are told, with the separation of the intelligible form from the actual thing, or, even worse, of the creator from the created. From this point of view what we need is a restored pantheistic sense, a new and revitalized paganism. I (...) counter this assertion by a reading of Plato’s Phaedrus that shows that respect itself is grounded in the recognition of transcendence. With the Bookof Job, I maintain that the voice of the transcendent God is what enables Job not only to see past his sufferings but for the first time to encounter the beauty of nature. Overcoming anthropocentrism requires a relationship to transcendence as such. (shrink)

If Lewis prefers the political Plato to the apolitical Socrates, I take my stand with Socrates. I also regard Plato as having been more profoundly invested in establishing a philosophical religion than in establishing a philosophical politics. Cultivating trust in the Good is ultimately of more importance than arming a state against potential enemies. Courage is a virtue greater than prudence. Plato’s Laws, on my reading, is less concerned with maintaining the order of the state than with civilizing its inhabitants. (...) In light of this contention, I understand Plato as being more Socratic—more open to question and thus more flexible—than Lewis’s reading seems to allow. This is why I think Plato provides more attention to his extended preambles to the laws than to the laws themselves. As seriously as Plato took the quest for true law, he realized that any positive code of law has to be subject to constant revision. (shrink)

This paper seeks to disclose the underlying tension in Kant’s Critique of Judgment. It is the tension between Logos and Eros which is apparent in much of Western philosophy but surfaces perhaps most dramatically in Kant’s third Critique. Despite its manifest commitment to rationality, significant philosophical expression is unthinkable without inspiration. As Plato put it, philosophy is a “divine madness,” a madness which cannot comprehend its own origin, and yet has as its goal the establishment of a rational Logos as (...) the ground of both thinking and action. Kant’s Critique of Judgment is in part a reflection upon the “Dionysian” not only in art, but in thinking as well. (shrink)

This paper seeks to disclose the underlying tension in Kant’s Critique of Judgment. It is the tension between Logos and Eros which is apparent in much of Western philosophy but surfaces perhaps most dramatically in Kant’s third Critique. Despite its manifest commitment to rationality, significant philosophical expression is unthinkable without inspiration. As Plato put it, philosophy is a “divine madness,” a madness which cannot comprehend its own origin, and yet has as its goal the establishment of a rational Logos as (...) the ground of both thinking and action. Kant’s Critique of Judgment is in part a reflection upon the “Dionysian” not only in art, but in thinking as well. (shrink)

This paper seeks to disclose the underlying tension in Kant’s Critique of Judgment. It is the tension between Logos and Eros which is apparent in much of Western philosophy but surfaces perhaps most dramatically in Kant’s third Critique. Despite its manifest commitment to rationality, significant philosophical expression is unthinkable without inspiration. As Plato put it, philosophy is a “divine madness,” a madness which cannot comprehend its own origin, and yet has as its goal the establishment of a rational Logos as (...) the ground of both thinking and action. Kant’s Critique of Judgment is in part a reflection upon the “Dionysian” not only in art, but in thinking as well. (shrink)

Toshihiko Izutzu’s Ishiki to Honshitsu, recently translated into German under the title of Bewusstsein und Wesen, represents a Zen-inspired clarification of a deep underlying tension that characterizes the figure of Socrates: on the one hand a commitment to a fully public form of discourse and on the other hand a recognition of the elusively private dimension of language . Izutzu lets his philosophical encounter between East and West find its focal point in that tradition of Persian Sufism which culminates in (...) the thought of Mulla Sadra. It is here that Wesen takes on flesh. Remarkably enough, Plato too had his Persian encounter, as can be inferred from the “Myth of the True Earth” that comes at the end of the Phaedo and represents the last recorded words of Socrates. The ancient Persian legend of Hūrqalyā, the Celestial Earth of emerald cities that Henri Corbin recounted a generation ago, is almost certainly Plato’s source. The resurrection world it depicts is a world of Wesen that can be cognitively appropriated only through the kind of direct intuition that is the goal of Zen meditation. (shrink)

When Emmanuel Levinas writes (in the preface of Totality and Infinity) that Franz Rosenzweig’s Stern der Erlösung is “a work too often present in this book to be cited,” he effectively names his debt to F. W. J. Schelling as well, for Rosenzweig’s work was a sustained attempt to carry to completion Schelling’s great philosophical fragment, the Weltalter. Scholars of Levinas have explored Levinas’s relationship to Schelling, but I confess that, as a Schelling scholar, I knew nothing of this connection (...) until rather recently. I credit above all the energetic work of Jason Wirth for helping me see its importance — and more generally the importance of reading Schelling in the context of recent work in continental philosophy. None of this has been easy. The very thing that Schelling and Levinas have in common, their resistance to the implicit solipsism of overcoming mystery with clarity, make them poor candidates for quick appropriation and comparison. Indeed, Schelling anticipated Nietzsche by openly mocking the scholars who make it their business to “appropriate and compare.” Mockery and ridicule is, ofcourse, not Levinas’s way of going about things. Even so, he too is so relentless in his polemic against the totalizing desire to know that he forces his reader to pause and question just what a proper scholarly response to his work might be. As such, the very first result of taking up the question of Schelling and Levinas might be that we are forced to set aside the scholarly mask, testimony of one’s acquiescence to the order of the same, in order to step forth as the human beings that we are. Whether this is an act of humility or of arrogance is not at all clear. Dispensing with the pretense of knowledge takes a kind of boldness on our part — for what but knowledge might give us a claim to the attention of others? (shrink)

This paper explores Schelling's life-long fascination with Spinoza. Through moments of ambivalence and enthusiasm, one aspect of the latter's thought remains central for Schelling: the intellectual intuition of God/Nature. While he consistently emphasizes the non-objectifiable nature of the intuition (as constituting the ground of freedom), the influence of Spinoza is still apparent in what Schelling calls the Ullvordellklichkeit des Seills. Freedom is a response to an ungroundable necessity that consciousness lives out of, but behind which it can never penetrate. This (...) insight provokes a reading of Spinoza that departs from the conventional rationalist interpretation and gestures to an a-theological, yet mystical, understanding, which awakens a feeling not only for the sublime in nature, but for the sublime that lies at "the heart of what is." In the ensuing silence of the self, substance reveals itself as living spirit. Through this interpretation, the Neoplatonic truth of Spinoza becomes visible. (shrink)

This paper explores Schelling's life-long fascination with Spinoza. Through moments of ambivalence and enthusiasm, one aspect of the latter's thought remains central for Schelling: the intellectual intuition of God/Nature. While he consistently emphasizes the non-objectifiable nature of the intuition (as constituting the ground of freedom), the influence of Spinoza is still apparent in what Schelling calls the Ullvordellklichkeit des Seills. Freedom is a response to an ungroundable necessity that consciousness lives out of, but behind which it can never penetrate. This (...) insight provokes a reading of Spinoza that departs from the conventional rationalist interpretation and gestures to an a-theological, yet mystical, understanding, which awakens a feeling not only for the sublime in nature, but for the sublime that lies at "the heart of what is." In the ensuing silence of the self, substance reveals itself as living spirit. Through this interpretation, the Neoplatonic truth of Spinoza becomes visible. (shrink)

The metaphysics of presence has led not only to the closure of rationalized systems that define modernity, but also to what can appear as its opposite, the freely flowing movement of information (and of capital) characteristic of the post-modern “de-centered” world. Ideas, after all, require a depth dimension that ultimately proves irreconcilable with the one-dimensionality of the purely present. It is for this reason that the rejection of metaphysics (which is only the final consequence of the metaphysics of presence) fails (...) to solve our dilemma. An alternative strategy is to attempt the recovery of the living heart of metaphysics, its open and ecstatic gaze, rather than its final consequence, the constrictive will to closure, determination, and power. This is the genuinely Socratic possibility, a metaphysics not of presence but of radical transcendence. To clarify that possibility, it is necessary to show how Socrates himself was characterized less by practical and political concerns than by a metaphysical vision directed not to presence but to the unknowable region that opens with death. Socrates’ irony and courage have the same source, what I call a metaphysics of “silence.”. (shrink)

The basic principles of scientific research from the great French physiologist whose contributions in the 19th century included the discovery of vasomotor nerves; nature of curare and other poisons in human body; more.

These two volumes represent a preliminary publication of texts that will ultimately find their place in the slowly emerging historical-critical edition of Schelling that is being published by the Bavarian Academy of Sciences and Humanities. Given the significance of the Weltalter-project as Schelling’s projected main work, the publication is clearly an important one. It supplements the three separate versions of the first book of the Weltalter, which have long been available. While these older versions will remain definitive, they do not (...) adequately reflect the sheer dimensions of what is probably the most dramatic shipwrecked project in the history of philosophy: Schelling’s intended systematic response to Hegel’s contemporaneous system of the whole. The materials gathered in these two new volumes approach the 400-plus pages previously available. Even this still pales in comparison to the 1000 or so pages that still remain in the Berlin Nachlass and the roughly 2000 pages that were destroyed during the World War II bombing of the University of Munich library. Eight thick volumes of dense philosophical prose, written and abandoned by a figure heralded by Martin Heidegger as the true genius of German philosophy, is indeed a shipwreck worth understanding more closely. These new materials will help make that possible. (shrink)

Recent empirical work has offered strong support for ‘biased pluralism’ and ‘economic elite’ accounts of political power in the United States, according a central role to ‘business interest groups’ as a mechanism through which corporate influence is exerted. Here, we propose an additional channel of influence for corporate interests: the ‘policy-planning network,’ consisting of corporate-dominated foundations, think tanks, and elite policy-discussion groups. To evaluate this assertion, we consider one key policy-discussion group, the Council on Foreign Relations. We first briefly review (...) the origins of this organization and then review earlier findings on its influence. We then code CFR policy preferences on 295 foreign policy issues during the 1981–2002 period. In logistic regression analyses, we find that the preferences of more affluent citizens and the CFR were positive, statistically significant predictors of foreign policy outcomes while business interest group preferences were not. These findings are discussed with a consideration of the patterns of CFR ‘successes’ and ‘failures’ for the issues in our dataset. Although a full demonstration of a causal connection between corporate interests, the policy-planning network and policy outcomes requires further research, we conclude that this has been shown to be a plausible mechanism through which corporate interests are represented and that ‘biased pluralism’ researchers should include it in their future investigations. (shrink)

In our article, we share the lessons we have learned after creating and running a successful legal laboratory over the past seven years at Yale Law School. Our legal laboratory, which focuses on the intersection of law and severe brain injury, represents a unique pedagogical model for legal academia, and is closely influenced by the biomedical laboratory.

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)