Given immunity’s general role in the organism’s economy—both in terms of its internal environment as well as mediating its external relations—immune theory has expanded its traditional formulation of preserving individual autonomy to one that includes accounting for nutritional processes and symbiotic relationships that require immune tolerance. When such a full ecological alignment is adopted, the immune system becomes the mediator of both defensive and assimilative environmental intercourse, where a balance of immune rejection and tolerance governs the complex interactions of the (...) organism’s ecological relationships. Accordingly, immunology, which historically had affiliated with the biology of individuals, now becomes a science concerned with the biology of communities. With this translocation, the ontological basis of the organism is undergoing a profound change. Indeed, the recent recognition of the ubiquity of symbiosis has challenged the traditional notions of biological individuality and requires a shift in the metaphysics undergirding biology, in which a philosophy of the organism must be characterized by ecological dialectics “all-the-way-down.”. (shrink)

Developmental biology is a theory of interpretation. Developmental signals are interpreted differently depending on the previous history of the responding cell. Thus, there is a context for the reception of a signal. While this conclusion is obvious during metamorphosis, when a single hormone instructs some cells to proliferate, some cells to differentiate, and other cells to die, it is commonplace during normal development. Paracrine factors such as BMP4 can induce apoptosis, proliferation, or differentiation depending upon the history of the responding (...) cells. In addition, organisms have evolved to alter their development in response to differences in temperature, diet, the presence of predators, or the presence of competitors. This allows them to develop the phenotype, within the limits imposed by the genotype, best suited for the immediate habitat of the organism. Most developing organisms have also evolved to expect developmental signals from symbionts, and these organisms develop abnormally if the symbiont signals are not present. Thus Hoffmeyer’s “vertical semiotic system” of genetic communication and “horizontal semiotic system” of ecological communication are integrated during development. (shrink)

Developmental biology is expanding into several new areas. One new area of study concerns the production of adult-onset phenotypes by exposure of the fetus or neonate to environmental agents. These agents include maternal nutrients, developmental modulators (endocrine disruptors), and maternal care. In all three cases, a major mechanism for the generation of the altered phenotype is chromatin modification. Nutrient conditions, developmental modulators, and even maternal care appear to alter DNA methylation and other associated changes in chromatin that regulate gene expression. (...) This brings a new, under-appreciated, dimension of gene regulation into developmental biology, and it also demonstrates the poverty of the nature versus nurture framework for discussing phenotype production. Moreover, while such epigenetic mechanisms undermine genetic determinism, they add a layer of probabilistic biological causality for the maintenance of social inequalities. (shrink)

Holobionts are multicellular eukaryotes with multiple species of persistent symbionts. They are not individuals in the genetic sense— composed of and regulated by the same genome—but they are anatomical, physiological, developmental, immunological, and evolutionary units, evolved from a shared relationship between different species. We argue that many of the interactions between human and microbiota symbionts and the reproductive process of a new holobiont are best understood as instances of reciprocal scaffolding of developmental processes and mutual construction of developmental, ecological, and (...) evolutionary niches. Our examples show that mother, fetus, and different symbiotic microbial communities induce or constitute conditions for the development and reproduction of one another. These include the direct induction of maternal or fetus physiological changes, the restructuring of ecological relations between communities, and evolutionary selection against undesirable competitors. The mutual scaffolding and niche constructing processes start early—prior to amniotic rupture. We are evolutionarily, physiologically, and developmentally integrated holobiont systems, strung together through mutual reliance and mutual construction. Bringing the processes of niche construction and developmental scaffolding together to interpret holobiont birth conceptually scaffolds two new directions for research: in niche construction, identifying the evolutionary implications of organisms actively constructing multiple overlapping niches and scaffolds, and in Evolutionary Developmental Biology, characterizing evolutionary and ecological processes as developmental causes. (shrink)

Although Caenorhabditis elegans was chosen and modified to be an organism that would facilitate a reductionist program for neurogenetics, recent research has provided evidence for properties that are emergent from the neurons. While neurogenetic advances have been made using C. elegans which may be useful in explaining human neurobiology, there are severe limitations on C. elegans to explain any significant human behavior.

Holobionts, consisting of a host and diverse microbial symbionts, function as distinct biological entities anatomically, metabolically, immunologically, and developmentally. Symbionts can be transmitted from parent to offspring by a variety of vertical and horizontal methods. Holobionts can be considered levels of selection in evolution because they are well-defined interactors, replicators/reproducers, and manifestors of adaptation. An initial mathematical model is presented to help understand how holobionts evolve. The model offered combines the processes of horizontal symbiont transfer, within-host symbiont proliferation, vertical symbiont (...) transmission, and holobiont selection. The model offers equations for the population dynamics and evolution of holobionts whose hologenomes differ in gene copy number, not in allelic or loci identity. The model may readily be extended to include variation among holobionts in the gene identities of both symbionts and host. (shrink)

Embryology is an intensely visual field, and it has provided the public with images of human embryos and fetuses. The responses to these images can be extremely powerful and personal, and the images (as well as our reactions to them) are conditioned by social and political agendas. The image of the 'autonomous fetus' abstracts the fetus from the mother, the womb, and from all social contexts, thereby emphasizing 'individuality'. The image of 'sacred DNA' emphasizes DNA as the unmoved mover, the (...) eidos, the soul of the human being. Since fertilization involves the forming of a new constellation of DNA in the zygote, the act of fertilization is being perceived as the secular and technical equivalent of ensoulment. This privileges fertilization above the other possible scientifically valued times when 'human life' begins. (shrink)

The ArgumentWhile postmodernism has had very little influence in biology, it can provide a framework for discussing the context in which biology is done. Here, four biological views of the body/self are contrasted: the neural, immunological, genetic, and Phenotypic bodies. Each physical view of the body extrapolates into a different model of the body politic, and each posits a different relationship between bodies of knowledge. The neural view of the body models a body politic wherein society is defined by its (...) culture and laws. The genetic view privileges views of polities based on ethnicity and race. The immune body extrapolates into polities that can defend themselves against other such polities. The phenotypic view of the body politic stands in opposition to these three major perspectives and integrates them without given any predominance. The view of science as a “neural” body of knowledge contends that science is aperspectival and objective. The perspective of the “immune” body is that science exists to defend the interests of its creators. The genetic view of science is that science is the basis of all culture. The extrapolation of the phenotypic body to science insists upon the utilitarian rationale for scientific enterprises. In all instances, the genetic view of the body/body politic/body of science is presently in ascendance. (shrink)

From the 1930s through the 1970s, C. H. Waddington attempted to reunite genetics, embryology, and evolution. One of the means to effect this synthesis was his model of the epigenetic landscape. This image originally recast genetic data in terms of embryological diagrams and was used to show the identity of genes and inducers and to suggest the similarities between embryological and genetic approaches to development. Later, the image became more complex and integrated gene activity and mutations. These revised epigenetic landscapes (...) presented an image of how mutations could alter developmental pathways to yield larger phenotypic changes. These diagrams became less important as the operon became used to model differential gene regulation. (shrink)

Introduction: working together on individuality / Lynn K. Nyhart and Scott Lidgard -- The work of biological individuality: concepts and contexts / Scott Lidgard and Lynn K. Nyhart -- Cells, colonies, and clones: individuality in the volvocine algae / Matthew D. Herron -- Individuality and the control of life cycles / Beckett Sterner -- Discovering the ties that bind: cell-cell communication and the development of cell sociology / Andrew S. Reynolds -- Alternation of generations and individuality, 1851 / (...) Lynn K. Nyhart and Scott Lidgard -- Spencer's evolutionary entanglement: from liminal individuals to implicit collectivities / Snait Gissis -- Biological individuality and enkapsis: from Martin Heidenhain's synthesiology to the völkisch national community / Olivier Rieppel -- Parasitology, zoology, and society in France, ca. 1880-1920 / Michael A. Osborne -- Metabolism, autonomy, and individuality / Hannah Landecker -- Bodily parts in the structure-function dialectic / Ingo Brigandt -- Commentaries: historical, biological, and philosophical perspectives -- Distrust that particular intuition: resilient essentialisms and empirical challenges in the history of biological individuality / James Elwick -- Biological individuality: a relational reading / Scott F. Gilbert -- Philosophical dimensions of individuality / Alan C. Love and Ingo Brigandt. (shrink)

An examination of the history and arguments behind W.K. Clifford and William James's landmark essays and subsequent impact on the importance of knowledge-based evidence.

This chapter contains sections titled: Socrates Café Café Philosophique Philosophy for Everyone Sophistry The Examined Life Oblivion Conclusion (Who is Ben's Mom?).

In the last decade, the familiar problem of the regress of reasons has returned to prominent consideration in epistemology. And with the return of the problem, evaluation of the options available for its solution is begun anew. Reason’s regress problem, roughly put, is that if one has good reasons to believe something, one must have good reason to hold those reasons are good. And for those reasons, one must have further reasons to hold they are good, and so a regress (...) of reasons looms. In this new study, Aikin presents a full case for infinitism as a response to the problem of the regress of reasons. Infinitism is the view that one must have a non-terminating chain of reasons in order to be justified. The most defensible form of infinitism, he argues, is that of a mixed theory – that is, epistemic infinitism must be consistent with and integrate other solutions to the regress problem. (shrink)

Deep disagreements are disagreements wherein the dialectical conditions for fruitful argumentative exchange do not obtain. One view from within these disagreements is that the other side has been duped or is so deeply ignorant of and complacent with some illusion, there is no hope for exchange. The Dark Enlightenment's critique of liberal democracy and progressive politics (which gave rise to the alt‐right movement) proceeds on this premise, calling their critical philosophy ‘the red pill’ and terming the opposition's program ‘the Cathedral’. (...) Despite the depth of their disagreement with progressives, there is evidence for an optimistic program of critical dialogue in this instance of deep disagreement. (shrink)

In this paper, the authors argue for two main claims: first, that the epistemic results of group deliberation can be superior to those of individual inquiry; and, second, that successful deliberative groups depend on individuals exhibiting deliberative virtues. The development of these group-deliberative virtues, the authors argue, is important not only for epistemic purposes but political purposes, as democracies require the virtuous deliberation of their citizens. Deliberative virtues contribute to the deliberative synergy of the group, not only in terms of (...) improving the quality of the group's present decisions, but also improving the background conditions for continued group deliberation. The authors sketch a preliminary schedule of these group-deliberative virtues modelled on Aristotle's conception of virtue as the mean between two extreme vices. The virtues discussed in this article include deliberative wit, friendliness, empathy, charity, temperance, courage, sincerity, and humility. (shrink)

My objective in this paper is to compare two philosophical problems, the problem of the criterion and the problem of deep disagreement, and note a core similarity which explains why many proposed solutions to these problems seem to fail along similar lines. From this observation, I propose a kind of skeptical solution to the problem of deep disagreement, and this skeptical program has consequences for the problem as it manifests in political epistemology and metaphilosophy.

This paper offers an account of a fallacy we will call bothsiderism, which is to mistake disagreement on an issue for evidence that either a compromise on, suspension of judgment regarding, or continued discussion of the issue is in order. Our view is that this is a fallacy of a unique and heretofore untheorized type, a fallacy of meta-argumentation. The paper develops as follows. After a brief introduction, we examine a recent bothsiderist case in American politics. We use this as (...) a pivot point to survey the theoretical literature on the fallacy. The most prominent theory is that bothsiderism is a case of dialogue-shifting. This view fails, we maintain, to explain how bothsiderism might be persuasive. We argue, rather, bothsiderism is a kind of meta-argumentative fallacy. (shrink)

What follows is a taxonomy of arguments that regresses of inferential justification are vicious. They fall out into four general classes: conceptual arguments from incompleteness, conceptual arguments from arbitrariness, ought-implies-can arguments from human quantitative incapacities, and ought-implies can arguments from human qualitative incapacities. They fail with a developed theory of "infinitism" consistent with valuational pluralism and modest epistemic foundationalism.

Three forms of the straw man fallacy are posed: the straw, weak, and hollow man. Additionally, there can be non-fallacious cases of any of these species of straw man arguments.

Why We Argue : A Guide to Political Disagreement in an Age of Unreason presents an accessible and engaging introduction to the theory of argument, with special emphasis on the way argument works in public political debate. The authors develop a view according to which proper argument is necessary for one's individual cognitive health; this insight is then expanded to the collective health of one's society. Proper argumentation, then, is seen to play a central role in a well-functioning democracy. Written (...) in a lively style and filled with examples drawn from the real world of contemporary politics, and questions following each chapter to encourage discussion, Why We Argue reads like a guide for the participation in, and maintenance of, modern democracy. An excellent student resource for courses in critical thinking, political philosophy, and related fields, Why We Argue is an important contribution to reasoned debate. What's New in the Second Edition: Updated examples throughout the book, including examples from the 2016 U.S. election and first years of the Trump presidency; Expanded coverage of dialectical fallacies, including coverage of new types of fallacies and of sites where such fallacies thrive ; Revised For Further Thought questions and definitions of Key Terms, included at the end of each chapter; The addition of five new chapters: Deep Disagreement Argument by Analogy Argument between the Ads The Owl of Minerva Argumentative Responsibility and Repair. (shrink)

Why We Argue : A Guide to Political Disagreement presents an accessible and engaging introduction to the theory of argument, with special emphasis on the way argument works in public political debate. The authors develop a view according to which proper argument is necessary for one’s individual cognitive health; this insight is then expanded to the collective health of one’s society. Proper argumentation, then, is seen to play a central role in a well-functioning democracy. Written in a lively style and (...) filled with examples drawn from the real world of contemporary politics, and questions following each chapter to encourage discussion, Why We Argue : A Guide to Political Disagreement reads like a guide for the participation in, and maintenance of, modern democracy. An excellent student resource for courses in critical thinking, political philosophy, and related fields, Why We Argue : A Guide to Political Disagreement is an important contribution to reasoned debate. (shrink)

Free speech fallacies are errors of meta-argument. One commits a free speech fallacy when one argues that since there are apparent restrictions on one’s rights of free expression, procedural rules of critical exchange have been broken, and consequently, one’s preferred view is dialectically better off than it may otherwise seem. Free speech fallacies are meta-argumentative, since they occur at the level of assessing the dialectical situation in terms of norms of argument and in terms of meta-evidential principles of interpreting how (...) and why people follow (or fail to follow) argumentative rules. Our plan here is to begin with a brief explanation of meta-argument and meta-argumentative fallacy. We will then turn to the variety of forms of the free speech fallacy, which we will explain as meta-argumentatively erroneous. (shrink)

I will assume here the defenses of epistemic infinitism are adequate and inquire as to the variety standpoints within the view. I will argue that infinitism has three varieties depending on the strength of demandingness of the infinitist requirement and the purity of its conception of epistemic justification, each of which I will term strong pure, strong impure, and weak impure infinitisms. Further, I will argue that impure infinitisms have the dialectical advantage.

The straw man fallacy consists in inappropriately constructing or selecting weak versions of the opposition’s arguments. We will survey the three forms of straw men recognized in the literature, the straw, weak, and hollow man. We will then make the case that there are examples of inappropriately reconstructing stronger versions of the opposition’s arguments. Such cases we will call iron man fallacies. The difference between appropriate and inappropriate iron manning clarifies the limits of the virtue of open-mindedness.

In this paper, I will argue for a complex of three theses. First, that the problem of deep disagreement is an instance of the regress problem of justification. Second, that the problem of deep disagreement, as a regress problem, depends on a dialecticality requirement for arguments. Third, that the dialecticality requirement is plausible and defensible.

Though textbook tu quoque arguments are fallacies of relevance, many versions of arguments from hypocrisy are indirectly relevant to the issue. Some arguments from hypocrisy are challenges to the authority of a speaker on the basis of either her sincerity or competency regarding the issue. Other arguments from hypocrisy purport to be evidence of the impracticability of the opponent’s proposals. Further, some versions of hypocrisy charges from impracticability are open to a counter that I will term tu quoque judo.

Epistemic infinitism is the view that infinite series of inferential relations are productive of epistemic justification. Peirce is explicitly infinitist in his early work, namely his 1868 series of articles. Further, Peirce's semiotic categories of firsts, seconds, and thirds favors a mixed theory of justification. The conclusion is that Peirce was an infinitist, and particularly, what I will term an impure infinitist. However, the prospects for Peirce's infinitism depend entirely on the prospects for Peirce's early semantics, which are not good. (...) Peirce himself revised the semantic theory later, and in so doing, it seems also his epistemic infinitism. (shrink)

Pragmatism’s naturalism is inconsistent with the phenomenological tradition’s anti-naturalism. This poses a problem for the methodological consistency of phenomenological work in the pragmatist tradition. Solutions such as phenomenologizing naturalism or naturalizing phenomenology have been proposed, but they fail. As a consequence, pragmatists and other naturalists must answer the phenomenological tradition’s criticisms of naturalism.

In this paper, I argue for three theses. First, that the problem of Deep Disagreement is usefully understood as an instance of the skeptical Problem of the Criterion. Second, there are structural similarities between proposed optimistic answers to deep disagreement and the problem of the criterion. Third, in light of these similarities, there are both good and bad consequences for proposed solutions to the problem of deep disagreement.