We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Philosophy is an exciting and accessible subject, and this engaging text acquaints students with the core problems of philosophy and the many ways in which they are and have been answered. Introducing Philosophy: A Text with Integrated Readings, Eighth Edition, insists both that philosophy is very much alive today and that it is deeply rooted in the past. Accordingly, it combines substantial original sources from significant works in the history of philosophy and current philosophy with detailed commentary and explanation that (...) help to clarify the readings. The selections range from the oldest known fragments to cutting-edge essays in feminism, multiculturalism, and cognitive science. At the end of each chapter is a summary, a list of review questions, a glossary, and a bibliography with suggestions for further reading. Important philosophical terms are carefully introduced in the text and also summarized at the end of each chapter, and brief biographies of the philosophers are provided at the end of the book. New to the Eighth Edition: Addressing the needs of a new generation of students, Robert C. Solomon has included for the first time more than 300 study and review questions. Appearing throughout the text and at the end of each chapter, these questions require immediate feedback from students. They encourage students to articulate the central ideas of what they have just read, instead of just "passing through" on the way to the next reading . New selections expand and update the chapters on religion, knowledge, mind and body, freedom, ethics, justice, and beauty. The selections include work by Charles Hartshorne, Cory Juhl, Friedrich Nietzsche, Jean-Paul Sartre, Sextus Empiricus, Edmund L. Gettier, David Braddon-Mitchell and Frank Jackson, Colin McGinn, Daniel Dennett, Harry Frankfurt, Gilbert Harman, Emma Goldman, and Arthur C. Danto. A companion website at www.oup.com/us/solomon8e features 300 study and review questions (100 multiple-choice, 100 true-or-false, and 100 fill-in-the-blank), discussion questions, chapter overviews and summaries, topical links, suggestions for further reading, and PowerPoint lecture aids. (shrink)

What methodology should philosophers follow? Should they rely on methods that can be conducted from the armchair? Or should they leave the armchair and turn to the methods of the natural sciences, such as experiments in the laboratory? Or is this opposition itself a false one? Arguments about philosophical methodology are raging in the wake of a number of often conflicting currents, such as the growth of experimental philosophy, the resurgence of interest in metaphysical questions, and the use of formal (...) methods. This outstanding collection of specially-commissioned chapters by leading international philosophers discusses these questions and many more. It provides a comprehensive survey of philosophical methodology in the most important philosophical subjects: metaphysics, epistemology, philosophy of language, philosophy of mind, phenomenology, philosophy of science, ethics, and aesthetics. A key feature of the collection is that philosophers discuss and evaluate contrasting approaches in each subject, offering a superb overview of the variety of methodological approaches - both naturalistic and non-naturalistic - in each of these areas. They examine important topics at the heart of methodological argument, including the role of intuitions and conceptual analysis, thought experiments, introspection, and the place that results from the natural sciences should have in philosophical theorizing. The collection begins with a fascinating exchange about philosophical naturalism between Timothy Williamson and Alexander Rosenberg, and also includes contributions from the following philosophers: Lynne Rudder Baker, Matt Bedke, Greg Currie, Michael Devitt, Matthew C. Haug, Jenann Ismael, Hilary Kornblith, Neil Levy, E.J. Lowe, Kirk Ludwig, Marie McGinn, David Papineau, Matthew Ratcliffe, Georges Rey, Jeffrey W. Roland, Barry C. Smith, Amie L. Thomasson, Valerie Tiberius, Jessica Wilson, and David W. Smith. (shrink)

In other words, it's a perfect season for naysayers, and philosophers have risen to the occasion. The most radical is Colin McGinn, former Wilde Reader of Mental Philosophy at Oxford, who has recently taken a position at Rutgers University in New Jersey. The Problem of Consciousness is a collection of eight essays, two of which have not previously been published. McGinn's central thesis is that the problem of consciousness is systematically insoluble by us (Martians or demigods might have better luck). (...) Our brains just weren't meant to get a grip on this tough problem, but--there, there, it's all right--we mustn't draw the conclusion from the fact that we can't understand it, that the mind is intrinsically mysterious. After all, whoever promised that we should be able to understand all possible good science? (shrink)

This is a review of The Character of Mind by Colin McGinn.

In Wittgenstein on Meaning, Colin McGinn argues that the skeptical argument that Kripke distills from Wittgenstein's rule-following considerations generates at most what might be called meaning skepticism (the non-factuality view of meaning), and not concept skepticism (the non-factuality view of concepts). If correct, this would mean the skeptical reasoning is far less significant than Kripke thinks. Others have seemed to agree with McGinn. I argue that McGinn is wrong here--that, in fact, Kripke's skeptical reasoning has a straightforward extension to concepts. (...) Whether the reasoning succeeds, however, is another matter, which I do not address here. (shrink)

Colin McGinn urged that while a brain state P explains consciousness, a conception P is cognitively inaccessible to us. This paper argues that McGinn's argument for his form of materialism is committed to P being epiphenomenal or causally inert relative to such things as the movements of our bodies. As a result, McGinn's materialism creates a duality in the brain and thereby faces the same problem of epiphenomenalism which plagues the Cartesian dualist.

Can we succeed in giving consciousness a naturalistic explanation, that is, an explanation in “broadly physical terms”? This is the “problem of consciousness” which, along with other aspects of the mind-body problem, is explored by McGinn in a collection of eight independently written but related, sometimes overlapping papers, all but two previously published. The papers span a decade and divergent approaches. The resulting juxtaposition of two contrasting “resolutions” of the problem by the same author invites their comparison.

I discuss McGinn's distinction between strong and weak externalism.

Exactly what is McGinn saying when he claims that we cannot solve the mind-body problem? Just what is cognitively closed to us? The text suggests at least four possibilities. I work through each them in some detail, and I come to two principal conclusions. First, by McGinn's own understanding of the mind-body problem, he needs to show that we are cognitively closed to how brains generate consciousness, but he argues for something else, that we are cognitively closed to the brain (...) property in virtue of which the brain is the basis of consciousness. Second, it turns out that McGinn is not entitled to any of the four closure possibilities. (shrink)

In this paper, I discuss Colin McGinn’s claim that the mind is not miraculous but merely mysterious, and that this mystery is due to the limits of our cognitive faculties. To adequately present the flow and unity of McGinn’s overall argument, I offer an extended and uninterrupted précis of his case, followed by a critique. I will argue that McGinn’s argument is unsuccessful if it is intended to persuade non-naturalists, but nevertheless may be a plausible position for a naturalist, qua (...) naturalist, to take on the mind. (shrink)

This paper examines two objections by Colin McGinn to panexperientialist metaphysics as a solution to the mind-body problem. It begins by briefly stating how the `ontological problem' of the mind-body relationship is central to the philosophy of mind, summarizes the difficulties with dualism and materialism, and outlines the main tenets of panexperientialism. Panexperientialists, such as David Ray Griffin, claim that theirs is one approach to solving the mind-body problem which does not get stuck in accounting for interaction nor in the (...) difficulties with emergentism and epiphenomenalism . McGinn attacks panexperientialism on two fronts: the Whiteheadian distinction between `consciousness' and `experience' and the notion of consciousness emerging from `non-conscious experience'; and the implicit `absurdities' inherent in the notion of experience and self-agency in the fundamental particles of physics. Griffin's defence fails to satisfactorily address challenge ; though a model is presented by the author which may offer panexperientialism a way out. McGinn's challenge is an attempted reductio which Griffin rejects: that panexperientialism contradicts the evidence of modern quantum- relativistic physics. The author's analysis of the opposing positions shows that both philosophers are arguing from incompatible `geometries of discourse' and radically inconsistent metaphysical assumptions. The paper concludes that a resolution of both the mind-body problem in general, and of the McGinn-Griffin dispute in particular, needs to involve an epistemological shift to include extra-rational ways of knowing. (shrink)

An exploration of the ethics of practical engineering through analyses of eighteen case studies. The Ethical Engineer explores ethical issues that arise in engineering practice, from technology transfer to privacy protection to whistle-blowing. Presenting key ethics concepts and real-life examples of engineering work, Robert McGinn illuminates the ethical dimension of engineering practice and helps students and professionals determine engineers' context-specific ethical responsibilities. McGinn highlights the "ethics gap" in contemporary engineering-- the disconnect between the meager exposure to ethical issues in engineering (...) education and the ethical challenges frequently faced by engineers. He elaborates four "fundamental ethical responsibilities of engineers" (FEREs) and uses them to shed light on the ethical dimensions of diverse case studies, including ones from emerging engineering fields. After examining the extent to which the actions of engineers in the cases align with the FEREs, McGinn recapitulates key ideas used in analyzing the cases and spells out the main lessons they suggest. He identifies technical, social, and personal factors that induce or press engineers to engage in misconduct and discusses organizational, legal, and individual resources available to those interested in ethically responsible engineering practice. (shrink)

Analyses of the concept of prestige are as divergent as they are rare. In the realm of politics, uncertainty and confusion about the nature of prestige manifest themselves in the concoction and circulation of invalid arguments: arguments whose prima facie plausibility rests upon a lack of perspicuous thought about prestige. “The meaning of ‘prestige’ is in fact not unrelated to that lack of clear political thinking which is the menace of our times.” Sir Harold Nicolson's remark, made some three decades (...) ago, applies with at least equal force in our own day. (shrink)

ABSTRACT Theories of the influence of technology on modern Western society have failed to take into account the important role played by a widespread pattern of sociotechnical practice. The pattern in question involves the interplay of technology, rights, and numbers. This paper argues that in the context of an ever more potent technological arsenal and an ever increasing number of individuals who have access to its elements and believe themselves entitled to use them in maximalist ways, adherence to the traditional (...) notion of individual human rights is anachronistic and increasingly problematic for the quality of life in contemporary society. To combat this situation, I criticise the idea of human rights as timelessly valid and offer a contextualised account of these constructs, one able to take on board the implications of their maximalist exercise in a populous technological society. I conclude by illustrating the struggles being waged over the adaptation of human rights to techno‐demographic reality in two areas of contemporary Western society: urban planning and medicine. (shrink)

“Probably Peirce’s best-known works are the first two articles in a series of six that originally were collectively entitled Illustrations of the Logic of Science and published in Popular Science Monthly from November 1877 through August 1878. The first is entitled ‘The Fixation of Belief’ and the second is entitled ‘How to Make Our Ideas Clear.’ In the first of these papers Peirce defended, in a manner consistent with not accepting naive realism, the superiority of the scientific method over other (...) methods of overcoming doubt and ‘fixing belief.’” — Robert Burch, “Charles Sanders Peirce,” entry in the Stanford Encyclopedia of Philosophy (2021 revision) -/- “Pragmatist epistemologies often explore how we can carry out inquiries in a self-controlled and fruitful way. (Where much analytic epistemology centres around the concept of knowledge, considered as an idealised end-point of human thought, pragmatist epistemology centres around the concept of inquiry, considered as the process of knowledge-seeking and how we can improve it.) So pragmatists often provide rich accounts of the capacities or virtues that we must possess in order to inquire well, and the rules or guiding principles that we should adopt. A canonical account is Peirce’s classic early paper ‘The Fixation of Belief‘. Here Peirce states that inquiry is a struggle to replace doubt with “settled belief“, and that the only method of inquiry that can make sense of the fact that at least some of us are disturbed by inconsistent beliefs, and will subsequently reflect upon which methods of fixing belief are correct is the Method of Science, which draws on the Pragmatic Maxim described above. This contrasts with three other methods of fixing belief: i) refusing to consider evidence contrary to one’s favored beliefs (the Method of Tenacity), ii) accepting an institution’s dictates (the Method of Authority), iii) developing the most rationally coherent or elegant-seeming belief-set (the A Priori Method).“ — Catherine Legg, “Pragmatism,” entry in the Stanford Encyclopedia of Philosophy (2021 revision). (shrink)

The task of giving some sort of interpretation of Wittgenstein's Remarks on Colour is an extraordinarily difficult one. The book is exceptionally fragmentary. Many of the remarks seem to raise questions that are then left completely unanswered, or to invite us to imagine various circumstances that are then left without any further comment. Although nearly all the remarks are related in one way or another to the problem of colour, the range of topics that Wittgenstein touches on is extremely wide, (...) and covers areas that are not normally mentioned in contemporary philosophical discussions of colour. For example, apart from the familiar ‘Why can't there be a transparent white?’ and ‘Why can't there be a reddish-green?’, he asks ‘Can a transparent piece of glass have the same colour as an opaque piece of paper?’, ‘Is white always the lightest colour?’, ‘Do I see blond hair in the black and white photograph of a blond youth?’, ‘Does it make sense to point to a colour in the iris of a Rembrandt eye and ask for the walls of my room to be painted the same colour?’, ‘Do the colour-blind have the same concept of colour-blindness as the normally sighted?’, ‘Can normal vision be described?’, and so on. (shrink)

According to most accounts of trust, you can only trust other people (or groups of people). To trust is to think that another has goodwill, or something to that effect. I sketch a different form of trust: the unquestioning attitude. What it is to trust, in this sense, is to settle one’s mind about something, to stop questioning it. To trust is to rely on a resource while suspending deliberation over its reliability. Trust lowers the barrier of monitoring, challenging, checking, (...) and questioning. Trust sets up open pipelines between yourself and parts of the external world. Trust permits external resources to have a similar relationship to one as one’s internal cognitive faculties. This creates efficiency, but at the price of exquisite vulnerability. We must trust in this way because we are cognitively limited beings in a cognitively overwhelming world. Crucially, we can hold the unquestioning attitude towards objects and technologies. When I trust my climbing rope, I stop worrying about its reliability. When I trust my online calendaring system, I simply go to the events indicated, without question. But, one might worry, how could one ever hold such a normatively loaded attitude as trust towards mere objects? How could it ever make sense to feel betrayed by an object? Trust is our engine for expanding and outsourcing our agency — for binding external processes into our practical selves. Thus, we can be betrayed by our smartphones in the same way that we can be betrayed by our memory. When we trust, we try to make something a part of our agency, and we are betrayed when our part lets us down. To unquestioningly trust something is to let it in—to attempt to bring it inside one’s practical functioning. This suggests a new form of gullibility: agential gullibility, which occurs when agents too hastily and carelessly integrate external resources into their own agency. (shrink)

Frege takes the view that “like ethics, logic can also be called a normative science.” The parallel that he detects depends upon his commitment to the idea of objective constraints on thought and action, against which particular acts or particular pieces of reasoning can be judged. The point of the comparison is to get us to see that logic is not an empirical science, concerned with laws of thought in a psychological sense; rather, the laws of logic are ‘prescriptions for (...) making judgement’. Hookway also detects a parallel, but it prompts him to move in the opposite direction: the point of the parallel is to bring us to appreciate the role of human emotional responses in our ordinary cognitive assessments of the truth of propositions, the soundness of inferences, the relevance of doubts, the appropriateness of questions, and so on. He argues that appreciation of this point enables us to solve some central epistemological problems, in particular, the problem of epistemological scepticism. I argue that Hookway shows, at best, that without our emotional convictions, our ordinary practices could not get off the ground, but that this, on its own, does not amount to a satisfying reply to the sceptic. (shrink)

Value capture occurs when an agent’s values are rich and subtle; they enter a social environment that presents simplified — typically quantified — versions of those values; and those simplified articulations come to dominate their practical reasoning. Examples include becoming motivated by FitBit’s step counts, Twitter Likes and Re-tweets, citation rates, ranked lists of best schools, and Grade Point Averages. We are vulnerable to value capture because of the competitive advantage that such crisp and clear expressions of value have in (...) our private reasoning and our public justification. There is, however, a price. In value capture, we take a central component of our autonomy — our ongoing deliberation over the exact articulation of our values — and we outsource it. And the metrics to which we outsource usually engineered for the interests of some external force, like a large-scale institution’s interest in cross-contextual comprehensibility and quick aggregability. That outsourcing cuts off one of the key benefits to personal deliberation. In value capture, we no longer adjust our values and their articulations in light of own rich experience of the world. Our values should often be carefully tailored to our particular selves or our small-scale communities, but in value capture, we buy our values off the rack. In some cases – like decreasing CO2 emissions – the costs of non-tailored values are outweighed by the benefit of precise collective coordination. In other cases, like in our aesthetic lives, they are not. This suggests that we should want different values suited to different scales. We should want value federalism. Some values are perhaps best pursued at the largest-scale level, others at smaller scales. The problem occurs when we exhibit an excess preference for the largest-scale values – when we consistently let the universal metrics swamp our quieter interests. (shrink)

Since the middle of the 20th century Ludwig Wittgenstein has been an exceptionally influential and controversial figure wherever philosophy is studied. This is the most comprehensive volume ever published on Wittgenstein: thirty-five leading scholars explore the whole range of his thought, offering critical engagement and original interpretation.

We define two notions for intuitionistic predicate logic: that of a submodel of a Kripke model, and that of a universal sentence. We then prove a corresponding preservation theorem. If a Kripke model is viewed as a functor from a small category to the category of all classical models with morphisms between them, then we define a submodel of a Kripke model to be a restriction of the original Kripke model to a subcategory of its domain, where every node in (...) the subcategory is mapped to a classical submodel of the corresponding classical model in the range of the original Kripke model. We call a sentence universal if it is built inductively from atoms using ∧, ∨, ∀, and →, with the restriction that antecedents of → must be atomic. We prove that an intuitionistic theory is axiomatized by universal sentences if and only if it is preserved under Kripke submodels. We also prove the following analogue of a classical model-consistency theorem: The universal fragment of a theory Γ is contained in the universal fragment of a theory Δ if and only if every rooted Kripke model of Δ is strongly equivalent to a submodel of a rooted Kripke model of Γ. Our notions of Kripke submodel and universal sentence are natural in the sense that in the presence of the rule of excluded middle, they collapse to the classical notions of submodel and universal sentence. (shrink)

Recent conversation has blurred two very different social epistemic phenomena: echo chambers and epistemic bubbles. Members of epistemic bubbles merely lack exposure to relevant information and arguments. Members of echo chambers, on the other hand, have been brought to systematically distrust all outside sources. In epistemic bubbles, other voices are not heard; in echo chambers, other voices are actively undermined. It is crucial to keep these phenomena distinct. First, echo chambers can explain the post-truth phenomena in a way that epistemic (...) bubbles cannot. Second, each type of structure requires a distinct intervention. Mere exposure to evidence can shatter an epistemic bubble, but may actually reinforce an echo chamber. Finally, echo chambers are much harder to escape. Once in their grip, an agent may act with epistemic virtue, but social context will pervert those actions. Escape from an echo chamber may require a radical rebooting of one's belief system. (shrink)