A frequent objection to the fine-tuning argument has been that although certain necessary conditions for life were admittedly exceedingly improbable, still, the many possible alternative sets of conditions were all equally improbable, so that no special significance is to be attached to the realization of the conditions of life. Some authors, however, have rejected this objection as fallacious. The object of this paper is to state the objection to the fine-tuning argument in a more telling form than has been done (...) hitherto, and to meet the charge of fallacy. (shrink)

In the Dialogues Hume attaches great importance to an objection to the design argument which states, negatively, that from phenomena which embody evil as well as good there can be no analogical inference to the morally perfect deity of traditional theism and, positively, that the proper conclusion as regards moral character is an indifferent designer. The first section of this paper sets out Hume's points, and the next three offer an updating of Hume's objection which will apply to Swinburne's Bayesian (...) form of the design argument. The final section concludes that Hume's objection, suitably developed, holds against most of the main theistic arguments, even in their Bayesian form. (shrink)

This paper re-examines an argument of kirk's aimed at refuting quine's inference from the underdetermination of physical theory to the indeterminacy of translation. it is claimed that kirk's argument is unsuccessful; unsuccessful, at any rate, if we make what has seemed until recently the only possible assumption about quine's criterion for individuating theories. but in recent publications quine has proposed a rather different criterion, and in the light of this, it is conceded, kirk's argument may well take effect. it is (...) then argued that quine's new criterion has disastrous effects; it not merely opens a way for kirk's criticism of one of the props of the indeterminacy thesis, but puts that thesis itself at risk. (shrink)

R kirk ("analysis", volume 33, 1973, pages 195-201) proposes an argument against quine's deduction of indeterminacy of translation from underdetermination of physical theory. the present paper is a reply to kirk, aimed primarily at showing that his argument is "ignoratio elenchi".

Everybody negotiates. But not everybody negotiates ethically. One driver of unethical negotiation behavior is power. Yet, we still haven’t discovered the principalmoderating and mediating influences between power and ethical negotiation behavior. In this pair of experimental studies we’re interested in finding out how resilience and moral identity affect an individual’s ethical behavior in both simple and complex negotiations when primed for power.

An incomplete science begets imperfect models. Nevertheless, the target article advocates for jettisoning deep-learning models with some competency in object recognition for toy models evaluated against a checklist of laboratory findings; an approach which evokes Alan Newell's 20 questions critique. We believe their approach risks incoherency and neglects the most basic test; can the model perform its intended task.

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

© 2015 Elsevier Inc.Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within an intracellular parasitophorous vacuole that is selectively permeable to small molecules through unidentified mechanisms. We have identified GRA17 as a Toxoplasma-secreted protein that localizes to the parasitophorous vacuole membrane and mediates passive transport of small molecules across the PVM. GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing Apicomplexa. The PVs of GRA17-deficient parasites have aberrant morphology, reduced permeability to (...) small molecules, and structural instability. GRA17-deficient parasites proliferate slowly and are avirulent in mice. These GRA17-deficient phenotypes are rescued by complementation with Plasmodium EXP2. GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a molecular basis for PVM permeability and nutrient access. (shrink)

Purports to be a "critical survey of the fundamental problems of logic and epistemology and their metaphysical implications," but is mainly an exposition. It is difficult to discover a unifying thesis explaining why the author chose to compare precisely these two philosophers.--C. M.

This paper examines the developments in the aftermath of Caesar’s assassination on the Ides of March 44 bce in the context of developments concerning the allocation of the consular provinciae of that year. It argues that the consuls, M. Antonius and P. Cornelius Dolabella, initially sought compromise with the conspirators, and the passage of the lex de permutatione provinciarum on the Kalends of June represents a genuine turning point. The historical implications of its provisions led to increasing hostility, and ultimately (...) the Mutinian War. Last, but not least, this paper seeks to demonstrate the integral role of C. Octavius in prompting this consequential change in attitude. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Facial emotion recognition (FER) deficits interfere with interpretation of social situations and selection of appropriate responses. Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms are independently associated with social difficulties and might exacerbate the influence of deficient FER, because children with ADHD symptoms have fewer compensatory resources in social situations when they misinterpret emotions. Very few studies have tested this hypothesis in a community context, where child ADHD symptoms vary on a continuum. The current study extended this work by utilising a community sample (N (...) = 87) of boys and girls in middle childhood (M = 7.83 years) and testing for moderation of FER effects separately by ADHD symptom type (ADHD-I = inattentive, H = hyperactive/impulsive, C = combined) using linear regression. While lower FER was associated with more social problems, this relationship was qualified by the presence of ADHD symptoms. Specifically, only children with relatively high ADHD symptoms in our community sample showed this inverse relationship, which was clearest among children with elevated ADHD-C or ADHD-I symptoms. No gender differences were observed. These results support our primary hypothesis, extend prior findings to boys and girls in the community, and have implications for understanding how ADHD symptoms and FER influence youth social deficits. (shrink)