Different families of transport proteins catalyze transmembrane solute translocation, employing different mechanisms and energy sources. Several of these functionally dissimilar proteins nevertheless exhibit similar strutural units, consisting of six tightly packed α‐helices which may comprise all or part of a transmembrane channel. It is now recognized that some of these families arose independently of each other by convergence, while others arose from common precursors by divergence. The former families apparently arose at different times in evolutionary history, in different groups of (...) organisms, employing different routes. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Integrating personality, behavioral, and cognitive theories of change, the author examines the operations, measurement, and evolution of behavioral and ethical standards that distinguish capitalism from other ideologies.

Whether on personal health, politics, or climate change, we are constantly bombarded with more numerous 'breaking news' articles than we have time for. In such an environment, how can we tell which to read, or which is even true. Science of the Earth, Climate and Energy helps readers understand major issues that affect us individually and the world as a whole. In language that a non-scientist can follow easily, the book first explains the general principles of science, its nature and (...) how it works, with a certain degree of emphasis on the meaning of the words "uncertainty" and "fact, before it goes into the related topics of the earth, its climate and energy sources at a level that does not require a background in science. Finally, the book addresses what individuals and societies can do to mitigate problems associated with both climate change and limited resources. (shrink)

There is not, of course, a one-to-one relation between policy conclusions and the conclusions of positive economics; if there were, there would be no ...

Starting from the earlier notions of stationary action principles, these tutorial notes shows how Schwinger's Quantum Action Principle descended from Dirac's formulation, which independently led Feynman to his path-integral formulation of quantum mechanics. Part I brings out in more detail the connection between the two formulations, and applications are discussed. Then, the Keldysh-Schwinger time-cycle method of extracting matrix elements is described. Part II will discuss the variational formulation of quantum electrodynamics and the development of source theory.

This study assessed the extent to which college students, tomorrow's executives, agreed with various commonly heard assertions regarding the tactics of those climbing the corporate career ladder. The study used essentially the same data collection instrument as that used in a recent study of business executives. The results indicate a highly significant relationship of the opinions to church affiliation, citizenship, and race of the subjects. Moderate levels of significant opinion differences related to the subjects' school, age, social class, and gender. (...) The subjects' opinions were not significantly related to their academic department, gradepoint average, or work experience. (shrink)

This study assessed the extent to which college students, tomorrow's executives, agreed with various commonly heard assertions regarding the tactics of those climbing the corporate career ladder. The study used essentially the same data collection instrument as that used in a recent study of business executives. The results indicate a highly significant relationship of the opinions to church affiliation, citizenship, and race of the subjects. Moderate levels of significant opinion differences related to the subjects' school, age, social class, and gender. (...) The subjects' opinions were not significantly related to their academic department, gradepoint average, or work experience. (shrink)

What is the exact nature of the consumption function? Can this term be defined so that it will be consistent with empirical evidence and a valid instrument in the hands of future economic researchers and policy makers? In this volume a distinguished American economist presents a new theory of the consumption function, tests it against extensive statistical J material and suggests some of its significant implications.Central to the new theory is its sharp distinction between two concepts of income, measured income, (...) or that which is recorded for a particular period, and permanent income, a longer-period concept in terms of which consumers decide how much to spend and how much to save. Milton Friedman suggests that the total amount spent on consumption is on the average the same fraction of permanent income, regardless of the size of permanent income. The magnitude of the fraction depends on variables such as interest rate, degree of uncertainty relating to occupation, ratio of wealth to income, family size, and so on.The hypothesis is shown to be consistent with budget studies and time series data, and some of its far-reaching implications are explored in the final chapter. (shrink)

Servant leadership has been theorized as a model where the moral virtue of humility co-exists with action-driven behavior. This article provides an empirical study that tests how these two apparently paradoxical aspects of servant leadership interact in generating follower engagement, while considering the hierarchical power of the leader as a contingency variable. Through a three-way moderation model, a study was conducted based on a sample of 232 people working in a diverse range of companies. The first finding is that humble (...) leaders showed the highest impact on follower engagement regardless of their hierarchical position. Less humble leaders in lower hierarchical positions seem to be able to compensate for that through a strong action-oriented leadership style. Most notably for leaders in high hierarchical positions, the moral virtue of humility seems to strengthen the impact of their action-oriented leadership the most. These findings provide empirical support and a better understanding of the interplay between the moral virtue of humility and the action-oriented behaviors of servant leadership. (shrink)

El presente trabajo estudia la concepción erótica de la subjetividad en la Fenomenología del espíritu de Hegel. Las tesis que intentamos mostrar son dos. La primera es que la concepción erótica de la subjetividad tiene un sentido muy restringido: es la referencia negativa y puramente inmediata a la cosa viva, la aniquilación del objeto natural que no alcanza la completa negación del ser-otro porque la dimensión erótica de la subjetividad requiere e implica la autonomía del objeto en cuestión. La segunda (...) tesis es que, en cuanto posicionamiento práctico y negativo de la autoconciencia respecto de su objeto, la concepción erótica de la subjetividad no se limita al Capítulo IV, aunque es en este último, y específicamente en su parte introductoria, donde se establecen los caracteres propios de dicha concepción. (shrink)

The aim of this paper is twofold. Firstly, to systematize Butler’s reading of the introductory part and section A of chapter IV of the Phenomenology of Spirit through the joint approach of Subjects of Desire, The Psychic Life of Power and You Be My Body for Me. Secondly, to take a critical position regarding the Butlerian hermeneutics. The existing research lacks a critical approach. We seek to problematize her reading so as to be able to contribute critically to the corpus (...) of complementary bibliography on this issue. (shrink)

El presente trabajo aborda de manera exploratoria la recepción argentina de la Phänomenologie des Geistes de 1807 en los años 60. Nuestro propósito consiste en examinar las obras más destacadas, delimitar los lineamientos interpretativos, las problemáticas de interés más acuciantes, los interlocutores principales y las obras disponibles. En primer lugar, presentamos el tema y señalamos los antecedentes más relevantes. En segundo lugar, nos detenemos en la década de 1960. Sostenemos que los intereses fundamentales de esta etapa se dividen en cuatro (...) temáticas: i. la dialéctica de las figuras de la conciencia, ii. los escritos juveniles de Hegel y su relación con la Phä., iii. las interpretaciones francesas y iv. la relación entre Hegel y Marx. Examinamos las obras más significativas de este periodo a la luz de esta estructuración temática. Finalmente, en tercer lugar, realizamos algunas consideraciones conclusivas que nos permiten dar con una caracterización general de la cuestión desarrollada. (shrink)

The backlash against the Olympic Games reflects the failure of the major global institutions in dealing with the social and ethical consequences of globalisation in areas such as the environment, poverty, terrorism and natural disasters. Disillusionment with the Olympic Games mirrors the disenchantment with the perceived values of globalisation, including winning at any price, commercial exploitation by MNCs, intense national rivalry, cronyism, cheating and corruption and the competitive advantage of advanced nations. How could the Olympic Movement reverse this perception? The (...) most important change would be in the area of leadership. Revitalising the Olympic spirit will require a revolution at the IOC. Character, credibility and communication will be the critical success factors. Before appointing the next President of the IOC, there is an exciting opportunity to reconceptualise the Games as a platform for building a framework of global values to counter-balance the naked economic priorities currently dictating the pattern of globalisation. In reinventing the Olympic Games, it is important to recognise that the modern Games are based upon an anachronism. The idea that amateur sport is both the key to individual moral development and world harmony is largely an invention of the British aristocracy, whereas the original Greek Games not only celebrated the classical ideal of `a sound mind in a sound body', but also involved professional athletes and commercial activity. In making the Olympic Charter relevant to the 21st century, and in making the Olympics more than just a speculator sporting event, there is a strong case for the Games to include a wider spectrum of activities, including arts programs and policy forums, which address the well-being of all humanity in a competitive global economy. (shrink)

Entrevista com o geógrafo brasileiro Milton Santos, onde ele faz uma profunda reflexão sobre o Brasil e o mundo atual, abordando criticamente temas como a globalização, a ideologização da vida social, a geografia como disciplina crítica e o papel do intelectual nos dias atuais.