Genome‐wide identification of transcription factor binding sites with the ChIP‐seq method is an extremely important scientific endeavor − one that should ideally be performed for every transcription factor in as many cell types as possible. A major hurdle on the way to this goal is the necessity for a specific, ChIP‐grade antibody for each transcription factor of interest, which is often not available. Here, we describe CETCh‐seq, a recently published method utilizing genome engineering with the CRISPR/Cas9 system to circumvent the (...) need for a specific antibody. Using the CETCh‐seq method, targeted genomic editing results in an epitope‐tagged transcription factor, which is recognized by a well‐characterized, standard antibody, efficacious for ChIP‐seq. We have used CETCh‐seq in human cancer cell lines as well as mouse embryonic stem cells. We find that roughly 60% of transcription factors tagged using CETCh‐seq produce a high quality ChIP‐seq map, a significant improvement over traditional antibody‐based methods. (shrink)

Gilles Deleuze's ideas are indispensable to understanding how truth and ethics no longer have theological reference points. Watkin's biblical critique enables us to culturally reengage with our Deleuze-influenced society.

What does 'autonomy' mean today? Is the Enlightenment understanding of autonomy still relevant for contemporary challenges? How have the limits and possibilities of autonomy been transformed by recent developments in artificial intelligence and big data, political pressures, intersecting oppressions and the climate emergency? The challenges to autonomy today reach across society with unprecedented complexity, and in this book leading scholars from philosophy, economics, linguistics, literature and politics examine the role of autonomy in key areas of contemporary life, forcefully defending a (...) range of different views about the nature and extent of resistance to autonomy today. These essays are essential reading for anyone who wants to understand the predicament and prospects of one of modernity's foundational concepts and one of our most widely cherished values. (shrink)

Difficult Atheism shows how contemporary French philosophy is rethinking the legacy of the death of God in ways that take the debate beyond the narrow confines of atheism into the much broader domain of post-theological thinking. Christopher Watkin argues that Alain Badiou, Jean-Luc Nancy and Quentin Meillassoux each elaborate a distinctive approach to the post-theological, but that each approach still struggles to do justice to the death of God.

Michel Serres is a major twentieth-century thinker who has made decisive contributions to major debates across disciplines ranging from the history of science to literary studies and philosophy. This is the first monograph to offer a comprehensive assessment of Serres’ thought from his early work on Leibniz to his final publications in 2019. The first three chapters carefully explore Serres’ ‘global intuition’, how he understands and engages with the world, and his characteristic ‘figures of thought’, the repeated intellectual moves that (...) characterize his unique approach. Chapters Four to Six explore in detail Serres’ revolutionary contributions to three key areas: language, objects, and ecology. (shrink)

Contemporary French philosophy is laying fresh claim to the human. Through a series of independent, simultaneous initiatives, arising in the writing of diverse current French thinkers, the figured of the human is being transformed and reworked. -/- Christopher Watkin draws out both the promises and perils inherent in these attempts to rethink humanity’s relation to ‘nature’ and ‘culture’, to the objects that surround us, to the possibility of social and political change, to ecology and even to our own (...) brains. This comparative assessment makes visible for the first time one of the most important trends in French thought today. (shrink)

"Phenomenology or Deconstruction? challenges traditional understandings of the relationship between phenomenology and deconstruction through new readings of the work of Maurice Merleau-Ponty, Paul Ricoeur and Jean-Luc Nancy. A constant dialogue with Jacques Derrida's engagement with phenomenological themes provides the impetus to establishing a new understanding of 'being' and 'presence' that exposes significant blindspots inherent in traditional readings of both phenomenology and deconstruction." "This new reading of being and presence fundamentally re-draws our understanding of the relation of deconstruction and phenomenology, and (...) provides the first sustained discussion of the possibilities and problems for any future 'deconstructive phenomenology.'" --Book Jacket. (shrink)

Hugely influential, Michel Foucault's work has not only impacted a diverse range of disciplines—from history and sociology to fine arts, feminism, and gay and lesbian studies—but has also profoundly shaped Western culture at a street level. -/- Yet until now there has been no overarching systematic approach to his work from a Reformed perspective—let alone one that is as fair and accessible as Watkin's. After walking us through key elements of Foucault's thought, Watkin both critiques and answers Foucault (...) through the Bible's teaching on history, power, and identity. His insights are necessary reading for anyone who wants to engage thoughtfully with the ideas of our culture. (shrink)

Under the influence of Emmanuel Levinas and Jacques Derrida, the theme of absolute alterity still dominates the thinking of the ethical in Continental philosophy. This article examines an alternative ethical démarche, Jean-Luc Nancy's ‘singular plurality’, which refuses to start with the opposition of same and other, arguing instead for a primacy of relation, the ‘in-common’ and the ‘with’. The article first distinguishes Nancy's ‘singular plural’ from other recent attempts to disengage ethical thinking from the Levinasian framework, before showing how Nancy (...) proceeds otherwise than in terms of sameness and alterity while still maintaining an ethical impetus. Foregrounding what is politically and philosophically at stake in the difference between Nancy and the Levinasian/Derridean model, the article concludes by considering how Nancy can be defended against critics who mistakenly argue that he discounts alterity. (shrink)

From the background noise, nothing follows. Or sometimes. But that’s another story. From the five volumes of his Hermès series and through to The Natural Contract in 1990, Michel Serres has rooted the origins of human language firmly in the rhythms and calls of the natural world.1 To date, the Anglophone reception of this complex and varied oeuvre has been slender to the point of emaciation, but one area where he has received some small fraction of the attention he deserves (...) is in his elaboration of a theory of semiotic meaning in dialogue with information theory and fluid dynamics.2 Since 2001, however, Serres has been expanding his account of biosemiotics3 with four key texts (2001, 2005.. (shrink)

Michel Serres's relation to ecocriticism is complex. On the one hand, he is a pioneer in the area, anticipating the current fashion for ecological thought by over a decade. On the other hand, 'ecology' and 'eco-criticism' are singularly infelicitous terms to describe Serres's thinking if they are taken to indicate that attention should be paid to particular 'environmental' concerns. For Serres, such local, circumscribed ideas as 'ecology' or 'eco-philosophy' are one of the causes of our ecological crisis, and no progress (...) can be made while such narrow concerns govern our thinking. This chapter intervenes in the ongoing discussion about the relation of Serres to ecology by drawing on some of Serres's more recent texts on pollution and dwelling, and this fresh material leads us to modulate existing treatments of Serres and ecology. I insist on the inextricability of two senses of ecology in Serres's approach: a broader meaning that refers to the interconnectedness and inextricability of all entities (natural and cultural, material and ideal), and a narrower sense that evokes classically 'environmental' concerns. Serres's recent work leads us to challenge some of the vectors and assumptions of the debate by radicalising the continuity between 'natural' and 'cultural' phenomena, questioning some of the commonplaces that structure almost all ecological thinking, and arguing that the entire paradigm of ecology as 'conservation' and 'protection' is bankrupt and self-undermining. After outlining the shape of Serres's 'general ecology' and its opposition to ecology as conservation, this chapter asks what sorts of practices and values a Serresian general ecology can engender when it considers birdsong, advertising, industrial pollution and money to be manifestations of the same drive for appropriation through pollution. A response is given in terms of three key Serresian motifs: the world as fetish, parasitic symbiosis, and global cosmocracy. (shrink)

We trace the genealogy and tensions of postmodern atheism through a series of encounters: Heidegger's reading of Nietzsche's “God is dead,” Foucault's critique of Sartre's humanism, Jean‐Luc Nancy's rejection of Alain Badiou's atheism, and the questions Derrida raises about Nancy's own position. We argue that there are plural postmodern atheisms, each of which defends its own claim to be following through on the consequences of the death of God more radically than the alternatives.

On 2 June I woke to the news that Michel Serres, philosopher, mountaineer, broadcaster, grandfather, historian of science, lover of rugby, mathematician, and inimitable writer, had passed away at the age of 88. This sad news came at a moment when I found myself deeply immersed in Serres’ writing, putting the finishing touches to a monograph on his work. In the days that followed his death I found myself reflecting at length on the fascination that Serres’ thought has held for (...) me since my first, felicitous encounter, and why it is needed today more than ever. I had never written a full-length academic monograph on a single thinker before I decided to embark on Michel Serres: Figures of Thought. I may never do so again. So what led me to spend four years of my life up to my neck in the writing of a thinker who had never featured in a course I have taken, whose books had never been recommended to me, and whom I never met? This article is my attempt to answer those questions, and to reflect upon his singularity and importance as a thinker. (shrink)

Much French philosophy of the late twentieth and early twenty-first centuries has been marked by the positive valorization of alterity, an ethical position that has recently received a vigorous assault from Alain Badiou’s privilege of sameness. This article argues that Badiou shares a great deal in common with the philosophies of alterity from which he seeks to distance himself, and that Michel Serres’s little-known account of alterity offers a much more radical alternative to the ethics of difference. Drawing on both (...) translated and as yet untranslated works, I argue that the Serresian ontology of inclination, along with his conceptual personae of the hermaphrodite and the parasite, informs ethical and political positions that offer a distinctive ethics and politics that present fresh insights about the relation between the singular and the universal, the contingency of market exchange, and the nature of violence. (shrink)

It is possible to study the idea of the “death of the author” as a quaint museum piece of faded 1960s structuralist memorabilia, as an idea that characterized an era that, whatever it once was, is certainly not our own. Such a presentation is the fare in countless graduate literature courses and a sin to which some, if not many, of us would plead guilty. However, the idea of the death or disappearance of the author has, since the two inaugural (...) essays that launched its theoretical voyage,1 generated a steady stream of assessments and reassessments up to the present day.2One relatively recent five-page intervention by Jacques Rancière3 introduces but leaves undeveloped a number of reflections that, when taken.. (shrink)

One of the most important thinkers of our time, Jacques Derrida continues to have a profound influence on postmodern thought and society. Christopher Watkin explains Derrida's complex philosophy with clarity and precision, showing not only what Derrida says about metaphysics, ethics, politics, and theology but also what assumptions and commitments underlie his positions. He then brings Derrida into conversation with Reformed theology through the lens of John 1:118, examining both similarities and differences between Derrida and the Bible. Learn (...) why Derrida says what he says and how Christians can receive and respond to his writing in a balanced, biblical way that is truly beneficial to cultural engagement. (shrink)

Reading Genesis 1 and 2, we are tempted to see only problems to solve. Yet these two chapters burst with glorious truths about God, our world, and ourselves. In fact, their foundational doctrines are among the richest sources of insight as we pursue robust, sensitive, and constructive engagement with others about contemporary culture and ideas. -/- With deftness and clarity, Christopher Watkin reclaims the Trinity and creation from their cultural despisers and shows how they speak into, question, and (...) reorient some of today's most important debates. (shrink)

Recent work on Alain Badiou and Jacques Rancière has rightly identified equality both as a central theme in their own thinking and as the key notion in contemporary radical political thought more broadly, but a focus on the differences between their respective accounts of equality has failed to clarify a major problem that they share. The problem is that human equality is said to rest on a particular human capacity, leaving Badiou's axiomatic equality and Rancière's assumed equality vulnerable to the (...) charge of having a blind spot for some of society's most vulnerable. This article introduces an alternative understanding of equality drawn from the thought of Jean-Luc Nancy, an equality that does not rely on a human capacity to guarantee or verify it but rests on Nancy's notion of sense. The article explores the advantages of Nancy's account of equality in relation to sense over and against an alternative reading that focuses on Nancy's evocation of the suffering human body, before addressing, in conclusion, the problems with which Nancy's idea of equality will have to grapple, and why, despite these problems, it is still preferable to the Badiouian and Rancièrian approaches. (shrink)

Both Nancy and Badiou probe the contemporary power of the political, seeking to refashion communism as, respectively, an ontology that issues an imperative, and an as yet unrealized hypothesis to be seized in the present. In both accounts of politics, the limit of the human and the animal plays a crucial yet hidden role. Badiou's articulation of the ‘human animal’ and the ‘immortal’ poses troubling problems for the relation between the limits of the human and the limits of the political. (...) In contrast, in the second volume of his Deconstruction of Christianity, Nancy reworks his notion of the human animal as a ‘being of sense’ in a way that poses awkward questions for his ontology of those who have nothing in common. For both Nancy and Badiou—but in opposite ways—the question of the limits and scope of the political is inextricably intertwined with the nature of the human/animal distinction. (shrink)

This chapter wagers that dance holds a singular, irreducible place in Nancy's work, that it cannot be reduced to thought about dance, and that it provides a way to understanding Nancy's approach to visual culture in general, to equality, and to the circulation of sense in terms of what he calls singular plural being. The chapter takes its starting point from Nancy's discussions of dance in the as yet untranslated Allitérations, a series of email exchanges from 2003 and 2004 followed (...) by transcriptions of face-to-face exchanges between Nancy and choreographer Mathilde Monnier loosely addressing the question of the relation between philosophy and dance, and a conversation between Nancy, Monnier and film-maker Claire Denis. In the first half of the book Nancy raises two questions, each presenting a pair of seemingly irreconcilable demands: 1. How can we understand dance as something open to everyone while retaining the privilege of professional expertise? 2. How can we understand dance in a way that maintains its uniqueness, not reducing it to an example of thought or a vehicle for thought, and yet still allowing for a relation between dance and thought? Both questions invite us to think the privilege of dance together with its openness; its singularity together with its plurality. As Nancy and Monnier grapple with these seemingly contradictory demands in Allitérations, their conversation opens up onto a fresh way to think political equality, and a different way to understand – or ‘catch’, a much more suitable term that I shall introduce later in this chapter – the sense of the world. It is by taking a detour via ‘The Image: Mimesis and Methexis’ that we can also see how Nancy's approach to dance can open to a new way of engaging with visual culture in general. -/- The point in this chapter is not simply to use dance as an example or illustration that helps us better to understand Nancy's approach to visual culture or the Nancean singular plural or his notion of ‘sense’, for in considering dance in terms of art, singular plurality and sense, we shall also be drawn to reassess sense, art and the singular plural in terms of dance. (shrink)

From Plato to Postmodernism presents the cultural history of the West in one concise volume. Nearly four thousand years of Western history are woven together into an unfolding story in which we see how movements and individuals contributed to the philosophy, literature and art that have shaped today's world. The story begins with the West's Greco-Roman and Judeo-Christian origins, moving through the Middle Ages, Renaissance, Enlightenment and Romanticism to twenty-first century postmodernity. The author covers key figures such as Moses, Michelangelo, (...) Mozart and Marx, setting them in context and highlighting their main contributions. Illustrations and a comprehensive glossary help explain important terms such as ‘gothic', ‘baroque', ‘stream of consciousness' and ‘the death of God', and clarify movements such as Neoplatonism, Renaissance humanism and existentialism. -/- For students, this book bridges the gap between what is taught in schools and the cultural knowledge required at university, providing an indispensible grounding in the story of Western culture. For all readers, it offers an invitation to take an enjoyable tour through the fascinating history of Western thought, literature and art. (shrink)

The growing field of neuro-philosophy throws up important issues for our society about how we understand the persistence of personal identity over time: if my brain is damaged or otherwise altered, do I become a different person? This chapter explores some of the work of the French neuro-philosopher Catherine Malabou as she asks, and tries to answer, this fundamental question about who we think we are, giving a non-reductive materialist account of self-identity. I argue that Malabou has implicit within her (...) writing the seeds of a more adequate account which would not understand identity and personhood to be immanent to the material brain but would embrace a broader notion of identity distributed across relationships, institutions, and shared common narratives. (shrink)

Sign language interpreting is a cognitively challenging task performed mostly by second language learners. SLI students must first gain language fluency in a new visuospatial modality and then move between spoken and signed modalities as they interpret. As a result, many students plateau before reaching working fluency, and SLI training program drop-out rates are high. However, we know little about the requisite skills to become a successful interpreter: the few existing studies investigating SLI aptitude in terms of linguistic and cognitive (...) skills lack baseline measures. Here we report a 3-year exploratory longitudinal skills assessments study with British Sign Language -English SLI students at two universities. Our aims were two-fold: first, to better understand the prerequisite skills that lead to successful SLI outcomes; second, to better understand how signing and interpreting skills impact other aspects of cognition. A battery of tasks was completed at four time points to assess skills, including but not limited to: multimodal and unimodal working memory, 2-dimensional and 3-dimensional mental rotation, and English comprehension. Dependent measures were BSL and SLI course grades, BSL reproduction tests, and consecutive SLI tasks. Results reveal that initial BSL proficiency and 2D-MR were associated with selection for the degree program, while visuospatial working memory was linked to continuing with the program. 3D-MR improved throughout the degree, alongside some limited gains in auditory, visuospatial, and multimodal working memory tasks. Visuospatial working memory and MR were the skills closest associated with BSL and SLI outcomes, particularly those tasks involving sign language production, thus, highlighting the importance of cognition related to the visuospatial modality. These preliminary data will inform SLI training programs, from applicant selection to curriculum design. (shrink)

A reflection on "sense" in the thought of Jean-Luc Nancy.

Nancy has been criticised for rejecting the politics of emancipation that characterises the thought of some of his more militant contemporaries. To be sure, he does distance himself from the rhetoric of emancipation. He considers that the grand modern emancipation narrative of the Enlightenment, and of the revolutions of the late eighteenth century, expired with the end of the Cold War, and that the ideal of emancipation carried by this narrative is dangerous insofar as it imposes “ultimate sense” on history (...) and assumes an “essence of humanity” that is to be liberated. It would be a mistake, however, to assume that Nancy’s rejection of the modern, linear account of emancipatory politics is a refusal of emancipation per se. Indeed, his reason for rejecting modernity’s simple narrative of emancipatory progress is that this framing of history is by a long chalk not emancipatory enough, and that it has far too much in common with the identitarian politics against which it seeks to set itself. So it should come as no surprise that Nancy uses emancipatory language in his very rejection of the politics of emancipation, arguing for example that we need “emancipation from a certain thinking of emancipation.” This article makes the case for Nancy as a rich and radical thinker of emancipation whose thought, far from being apolitical when it comes to liberation, offers us a broad, robust and practical account of the emancipatory. This case is made by weaving together two important strands of Nancy’s thought. First, his deconstruction of Christianity is examined in the light of the claim that Christianity is “in itself and by itself in a state of surpassing” and that Christianity’s self-surpassing is “perhaps its deepest tradition.” This leads, secondly, to a consideration of Nancy’s frequent meditations on Pascal’s statement that “man infinitely exceeds/surpasses man.” When they are taken together, what emerges from these two strands of Nancy’s thought is a pattern of emancipation that goes beyond simple historical ruptures to operate across multiple temporalities at once, each populated by plural vectors of continuity and change. Nancy seeks emancipation from a double slavery: the slavery of absolutising a continuity with the past, and that born of the ideological fantasy of a simple rupture with the past. Instead, he offers us an account of emancipation that is capable of navigating a subtler course through multiple dynamics of continuity and change. The article concludes by briefly examining Nancy’s use of the term ressourcement to characterise this radical account of emancipation, evoking the importance of the gesture described by this term for the biblical prophets, for the magisterial reformers and for Vatican II. Far from being weak in its emancipatory potential, Nancy’s thought takes the modern emancipatory imperative and returns it to us with greater depth, breadth and potency. (shrink)

Paul Ricoeur repeatedly maintained that his philosophical reflection was autonomous from theological influence. Those who seek to contest this view have hitherto sought to deny the autonomy of philosophy from theology, but this article makes a more radical argument: not that philosophy is not autonomous, but that autonomy is not philosophical. According to Ricoeur’s own understanding of the structure of philosophical systems, the very notion of autonomy to which philosophy makes claim can only be thought as a theological notion. The (...) argument has two parts. First, philosophy is theological in its own structure, and secondly, the relation between philosophy and theology can only be thought theologically. (shrink)

Paul Ricoeur repeatedly maintained that his philosophical reflection was autonomous from theological influence. Those who seek to contest this view have hitherto sought to deny the autonomy of philosophy from theology, but this article makes a more radical argument: not that philosophy is not autonomous, but that autonomy is not philosophical. According to Ricoeur’s own understanding of the structure of philosophical systems, the very notion of autonomy to which philosophy makes claim can only be thought as a theological notion. The (...) argument has two parts. First, philosophy is theological in its own structure, and secondly, the relation between philosophy and theology can only be thought theologically. (shrink)

An interview exploring the complexity of contemporary French philosophical atheism, in the light of Difficult Atheism: Post-Theological Thinking in Badiou, Nancy and Meillassoux (Edinburgh UP, 2011).

This book contains important technical innovations, including comparative measures for the testable content, depth, and unity of scientific theories. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich (...) scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

Arguments from perceptual variation challenge the view that colors are objective properties of objects, properties that objects have independent of how they are perceived. This paper attempts, first, to diagnose one central reason why arguments from perceptual variation seem especially challenging for objectivists about color. Second, we offer a response to this challenge, claiming that once we focus on determinate colors rather than the determinables they determine, a response to arguments from perceptual variation becomes apparent. Third, our nominal opponents are (...) relationalist (like Cohen in The red and the real: an essay on color ontology, Oxford University Press, Oxford, 2009) and we will argue that the main argument for rejecting objectivism commits the relationalist to a position that is more radical than the one he would wish to endorse. Fourth, we suggest that insight into which properties could be relational may be found by looking to our best scientific theories. (shrink)

Business success depends on the ability to build trust. Trusted brands succeed and sustain. Trusted leaders inspire followers, grow companies, revenues, and futures. But sadly, deceit has infected business and become widespread. Far too many leaders now use their own 'alternative facts', to mislead and mis-inform their customers, colleagues, and communities. The skilfulness and ease with which some leaders now lie has become a Lie-Ability. And when customers stop trusting the products, services, or the stories a leader tells, then the (...) business suffers. If business leaders don't lead a truth renaissance, we are all lost. People no longer trust politicians or the media. And many of the institutions and professions we used to turn to have also lost trust. The only people that can really save us now are business leaders. We need to become truth advocates and activists. We must re-establish a new norm where we tell the truth to ourselves, to our employees, to our shareholders, to our customers and to society at large. This book explores the 7 Deadly Lies that business tells itself, the 7 Dark Arts of Deception that are still used with monotonous regularity to manipulate the narrative. We offer C-suite leaders and senior managers a clear path out of deceit. We offer a solution to the Lie-Ability of some leaders by developing a deeper understanding of truth, how to reclaim it and how to build back trust. (shrink)