Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The paper focuses on processes of normalization through which dis/ability is simultaneously produced in specific collectives, networks, and socio-technological systems that enable the construction of such demarcations. Our point of departure is the cochlear implant, a neuroprosthetic device intended to replace and/or augment the function of the damaged inner ear. Unlike hearing aids, which amplify sounds, the CI does the work of damaged hair cells in the inner ear by providing sound signals to the brain. We examine the processes of (...) the CI’s genesis as well as its specific uses by and interrelations to the different and divergent actors that the CI assembles. We argue that the technological device and the implicated normalization process mobilize complex effects in varying socio-technical arrangements. The CI is conceived as a “boundary object” [89] or a “quasi-object” [49, 83], i.e., a metastabilized medium of translation that coordinates social, cultural, and technological action. Although intended to transform non-hearing or hard of hearing people into competent and “normal” hearing subjects, the CI system reproduces the asymmetrical structures of the disability discourse [14] through its function of “developing and maintaining coherence between intersecting social worlds” [89, 393]. Additionally, it initiates controversial discourses that have resulted in new forms of biosocial collectivities ranging from cochlear implantees with normal human hearing to human configurations who have passed through human enhancement. Our approach is thus situated at the intersection of disability and media studies and tackles the particular conditions technological media configurations impose upon the production of dis/ability. (shrink)

Against the backdrop of an aging world population increasingly affected by a diverse range of abilities and disabilities as well as the rise of ubiquitous computing and digital app cultures, this paper questions how mobile technologies mediate between heterogeneous environments and sensing beings. To approach the current technological manufacturing of the senses, two lines of thought are of importance: First, there is a need to critically reflect upon the concept of assistive technologies as artifacts providing tangible solutions for a specific (...) disability. Second, the conventional distinction between user and environment requires a differentiated consideration. This contribution will first review James Gibson’s concept of “affordances” and modify this approach by introducing theories and methods of Science and Technology Studies and Actor-Network Theory. Then, we present two case studies where we explore the relations between recent “assistive” app technologies and human sensory perception. As hearing and seeing are key in this regard, we concentrate on two specific media technologies: ReSound LINX2, a hearing aid which allows for direct connect with iPhone, iPad, or iPod Touch, and Camassia, an IOS app for sonic wayfinding for blind people. We emphasize the significance of dis-/abling practices for manufacturing novel forms of hearing and seeing and drawing on sources like promotional materials by manufacturers, ads, or user testimonials and reviews. Our analysis is interested in the reciprocal relationships between users and their socio-technical and media environments. By and large, this contribution will provide crucial insights into the contemporary entanglement of algorithm-driven technologies, daily practices, and sensing subjects: the production of techno-sensory arrangements. (shrink)

Scientific perspectivism, or perspectival realism, is a view according to which scientific knowledge is neither utterly objective nor independent of the world “as it is”, but always tied to some particular ways of conceptualization and interaction with Nature. In the present paper, I employ Robert Rosen’s concept of the modeling relation for arguing that there are two basic reasons why our knowledge of natural systems is perspectival in this sense. The first of these pertains to the dualism between a (...) system and its environment, which is necessarily imposed by a scientist focusing on the former. The second pertains to the complexity of complex systems; a complex system understood as a system in which different kinds of causal entailments intertwine together. As I discuss in the paper besides developing the argument, perspectivism thus understood ties together several issues ranging from organicism to emergentism and to processual philosophy, and from the ceteris paribus talk of biology to the measurement problem of quantum mechanics. I also discuss Rosen’s relational formalisms as a concrete example of how perspectival epistemology might directly suggest novel strategies and practices of doing theoretical science. (shrink)

In the debate about the moral status of human beings at the margins of life, arguments of species membership are often considered to be the least plausible ones. Against this backdrop, this article explores two possible ways to formulate feasible arguments of species membership. The first is an (in the broadest sense of the word) Aristotelian or neo‐Aristotelian argument; the second is an argument from the intrinsic logic of human rights, which Robert Spaemann refers toas a ‘transcendental‐pragmatic’ argument. On (...) these grounds, the article proposes a philosophical justification for an at least moderate speciesism. (shrink)

Whilst agreeing with Robert Pippin that Hegel undertakes his philosophical enterprise in light of Kant's insights into the failings of pre-critical metaphysics, this paper outlines the shortcomings of Pippin's Hegel interpretation by contrasting what I call 'apperceptive idealism' on the one hand with 'transcendental ontology' on the other. By privileging subject over substance, Pippin commits Hegel to an ontologically modest form of Kantianism that, in missing how reality as a whole is the main topic of Hegel’s philosophy, leaves no (...) room for a crucial Hegelian task, namely accounting for the presence of self-conscious thinking in nature. Appreciating the nature of Hegel's true ambitions whilst remaining aware of how his Logic maps a 'realm of shadows', opens up the possibility of understanding his philosophy as forging a middle path: Hegel is neither the subjective idealist of Pippin's interpretation nor the advocate of a revival of first-order metaphysical theorising depicted by so many of Pippin's critics. (shrink)

In this paper we show that Audi’s fallibilist foundationalism is beset by three unclarities. First, there is a conceptual unclarity in that Audi leaves open if and how to distinguish clearly between the concepts of fallibility and defeasibility. Second, there is a general unclarity: it is not always clear which fallibility/defeasibility-theses Audi accepts or denies. Finally, there is an unclarity of self-application because Audi does not specify his own claim that fallibilist foundationalism is an inductivist, and therefore itself fallible, thesis. (...) The critical part of our paper is supplemented by a constructive part, in which we present a space of possible distinctions between different fallibility and defeasibility theses. These distinctions can be used by Audi as a toolkit to improve the clarity of fallibilist foundationalism and thus provide means to strengthen his position. (shrink)

This collection of essays provides an exemplary overview of the diversity and relevance of current scholarship on German Idealism. The importance of German Idealism for contemporary philosophy has received growing attention and acknowledgment throughout competing fields of contemporary philosophy. Part of the growing interest rests on the claim that the works of Kant, Fichte, Schelling, Hegel remain of considerable interest for cultural studies, sociology, theology, aesthetics and other areas of interest. In the domain of philosophy, the renaissance of innovative readings (...) of German Idealism has taken scholarly debates beyond merely antiquarian perspectives. This renaissance has been a major factor of current efforts to bridge the gap between so-called “analytic” and so-called “continental” philosophy. The volume provides a selection of well-chosen examples of readings that contribute to systematic treatments of philosophical problems. It contains contributions by Markus Gabriel, Robert Pippin, Anders Moe Rasmussen, Sebastian Rödl. (shrink)

As Professor of Philosophy at the University of Sydney for over 20 years, György Márkus exerted a profound influence on a generation of philosophers and students from many disciplinary backgrounds. His legendary lecture courses, spanning the history of modern philosophy from the Enlightenment through to the late 20th century, were memorable for their breadth, erudition, and philosophical drama. Always modest despite his mastery of the tradition, Márkus’s approach to this history of philosophy never failed to emphasize its continuing role in (...) shaping our inherited understanding of philosophy as ‘its own time comprehended in thoughts’. This is especially true of his contribution to the philosophical discourse of modernity, which we could summarize as comprising an original philosophy of cultural modernity. In what follows, I briefly reconstruct Márkus’s account of the adventures of the concept of culture, focusing on his definitive essay ‘The Path of Culture: From the Refined to the High, From the Popular to Mass Culture’ but also referring to other relevant Márkus texts, offering some critical remarks on his account of culture and its relationship with modern aesthetics, both classical and contemporary. (shrink)

ABSTRACTMy paper aims to situate and contextualize György Márkus’s key writings on cultural modernity on the one hand in relation to their theoretical antecedents in Kant and Hegel’s conception of modern society as a society of culture and in Lukacs’s reception of Kant and Hegel in his early pre-Marxist works, and on the other hand in relation to an examination of the contemporary ramifications of certain tendencies in modern culture highlighted in Márkus’s writings. The paper is accordingly divided into two (...) parts. Part I sets out to reconstruct the presuppositions of Márkus’s theory of the high culture of classical modernity in order to bring out the descriptive strength and the analytic contribution of his approach in relation to the tradition of cultural critique in modernity, in particular in Western Marxism. Part II aims to show how Márkus’s theory of modern culture from the late eighteenth century to the end of World War II contains elements crucial to the theorization of contemporary culture, characterized by new forms of paradoxicality that go beyond his own model. (shrink)

This book argues that the Russian-British philosopher Isaiah Berlin should primarily be understood through British idealism. Though he adopted Kantian methodology and a view of people as purposive beings, he rejected the Idealists' monism and theories of positive liberty. Robert A. Kocis demonstrates how, like Michael Oakeshott and R. G. Collingwood, Berlin can be seen as a 'post-Idealist' thinker, invested in the implications of that rich tradition.

The eminent and award-winning historian Robert A. Gross presents his long-awaited, immersive journey through Concord in the age of Emerson and Thoreau.

This is the prologue to a collection of essays on eugenics and psychiatry.

Punishment misunderstood -- The ratchet effect in theory -- The mixed signs in suffering -- The legal punishers -- The legally punished -- The punitive impulse in American society -- The law against itself -- Coda : the psychology of punishment.

God deserves obedience simply because he’s God—or does he? Inspired by a passion for biblical as well as constitutional scholarship, in this bold exploration Yale Law Professor Robert A. Burt conceptualizes the political theory of the Hebrew and Christian Bibles. God’s authority as expressed in these accounts is not a given. It is no less inherently problematic and in need of justification than the legitimacy of secular government. In recounting the rich narratives of key biblical figures—from Adam and Eve (...) to Noah, Cain, Abraham, Moses, Job, and Jesus—In the Whirlwind paints a surprising picture of the ambivalent, mutually dependent relationship between God and his peoples. Taking the Hebrew and Christian Bibles as a unified whole, Burt traces God’s relationship with humanity as it evolves from complete harmony at the outset to continual struggle. In almost every case, God insists on unconditional obedience, while humanity withholds submission and holds God accountable for his promises. Contemporary political theory aims for perfect justice. The Bible, Burt shows, does not make this assumption. Justice in the biblical account is an imperfect process grounded in human—and divine—limitation. Burt suggests that we consider the lessons of this tension as we try to negotiate the power struggles within secular governments, and also the conflicts roiling our public and private lives. (shrink)

This chapter examines traditionalists’ arguments why Dungeons Dragons (DD) is good for us first, and then discusses the cases where it could be bad for us. The irony for Christian critics of DD, such as Schnoebelen, is that the philosophical and theological arguments of Christian traditionalists, such as Thomas Aquinas and J.R.R. Tolkien, provide some of the strongest arguments in favor of DD role‐playing. However, to be fair, these same arguments can be used to argue that a particular DD game, (...) under certain circumstances, can be bad. “Postmodernists” refers loosely to a group of philosophers and thinkers who question, if not outright reject, the core tenets of the traditionalists. If the traditionalists have the correct metaphysics about the real world, then it follows that DD is good, but that care must be taken to make sure the game does not become morally objectionable. (shrink)

Pharmacy Ethics: A Foundation for Professional Practice provides a model for examining and resolving ethical dilemmas, thereby helping student pharmacists understand the ethical decision-making process in professional practice.

Miscreants, in the form of deviants and dark personalities, impact organizations more than we realize. Most management instruction on ethics issues focuses on helping students to understand how to evaluate difficult situations, make ethical decisions, and engage in ethical actions. While this approach works well for the individual decision maker, it fails to help students learn how to anticipate and proactively prevent the unethical actions of others. Using ethical codes as a backdrop, “Thinking Like a Bad Guy” is a provocative (...) classroom activity to elicit critical and creative thinking among business students. The goal of this exercise is to facilitate student learning so they can anticipate the behaviors of bad actors and alter organizational processes and procedures to mitigate the ability of others to violate organizational ethical standards. (shrink)

This is a bilingual edition of the selected peer-reviewed papers that were submitted for the International Symposium on Jesuit Studies on the thought of the Jesuit Francisco Suárez (1548-1617). The symposium was co-organized in Seville in 2018 by the Departamento de Humanidades y Filosofía at Universidad Loyola Andalucía and the Institute for Advanced Jesuit Studies at Boston College. Suárez was a theologian, philosopher and jurist who had a significant cultural impact on the development of modernity. Commemorating the four-hundredth anniversary of (...) his death, the symposium studied the work of Suárez and other Jesuits of his time in the context of diverse traditions that came together in Europe between the late Middle Ages, the Renaissance, and early modernity. (shrink)

An anthology of the life and teachings of Tsongkhapa that includes transcendental aspects of sutra, tantra, insight meditation, mystic conversations, spiritual songs, and a new introduction by Robert Thurman.

Critically examines and revises many of Freud's seminal ideas about culture from the perspective of contemporary anthropology, psychoanalysis, evolutionary theory, and literature and the arts.

American Philosophy and Rudolf Steiner aspires to raise Steiners profile by digging into just one field of inquiry: philosophy. Before he became known to the world as a transmitter of clairvoyant wisdom, Steiner was an academic philosopher, editor of the scientific writings of Goethe and author of a foundational work in philosophy, The Philosophy of Freedom: The Basis for a Modern Worldview, published in 1894. That book expressed in philosophical terms many of the ideas that would later emerge as integral (...) to the spiritual science of Anthroposophy. (shrink)

It is widely recognized that Immanuel Kant was one of Karl Barth's most important intellectual influences, but how and to what extent this is the case remains an open question. In Presupposing God, Robert Hand demonstrates a deep consistency between Kant's and Barth's theological epistemologies, with this issue in mind. After arguing for a number of positive emphases in Kant's critical philosophy and religious epistemology in conversation with modern Kant scholarship, Presupposing God demonstrates how these emphases were obscured in (...) Kant's reception in the decades between Kant and Barth, and then explores the intellectual conditions under which Barth first encountered Kant. The argument proceeds to show how Barth wrestled with these varying interpretations and continued to utilize Kant with increased sophistication as his thought developed across the Romans commentaries, Anselm, and the Church Dogmatics. Presupposing God suggests that Kant can be an asset to theology, rather than the liability he is often taken to be, and that Barth is one of the better available examples of this in practice. (shrink)

This film is a 44-minute documentary film based around the stories of five eugenics survivor from the province of Alberta, Canada, made as part of the Living Archives on Eugenics in Western Canada project.

Matteo Ricci (1552-1610) was an Italian Jesuit and one of the first Christian missionaries to China in the modern era. He was a genuine polymath—a translator, cartographer, mathematician, astronomer, and musician. Above all, Ricci was a missionary for the gospel. As we briefly examine his 1603 seminal work, The True Meaning of the Lord of Heaven, our hope is that we, as evangelical educators, will perceive some of the deeper principles necessary for our own missionary work among unreached people.

Where does the mind begin and end? Most philosophers and cognitive scientists take the view that the mind is bounded by the skull or skin of the individual. Robert Wilson, in this provocative and challenging 2004 book, provides the foundations for the view that the mind extends beyond the boundary of the individual. The approach adopted offers a unique blend of traditional philosophical analysis, cognitive science, and the history of psychology and the human sciences. The companion volume, Genes and (...) the Agents of Life, explores the theme in the biological sciences. Written with verve and clarity, this ambitious book will appeal to a broad swathe of professionals and students in philosophy, psychology, cognitive science, and the history of the behavioural and human sciences. You can download the table of contents here. (shrink)

Stakeholder theory has become a central issue in the literature on business ethics / business and society. There are, however, a number of problems with stakeholder theory as currently understood. Among these are: 1) the lack of a coherent justificatory framework, 2) the problem of adjudicating between stakeholders, and 3) the problem of stakeholder identification. In this essay, I propose that a possible source of obligations to stakeholders is the principle of fairness (or fair play) as discussed in the political (...) philosophic literature of Rawls, Simmons, and Cullity among others. The principle of fairness states that, “Whenever persons or groups of persons voluntarily accept the benefits of a mutually beneficial scheme of co-operation requiring sacrifice or contribution on the parts of the participants and there exists the possibility of free-riding, there exist obligations of fairness on the part of these persons or groups to co-operate in proportion to the benefits accepted.” In this essay I discuss the gaps in the current stakeholder literature, elucidate and defend a principle of fairness that fills the gap, compare the fairness model to other similar models of business ethics, and draw some conclusions for the future of stakeholder theory. (shrink)

This is an introductory article on sociobiology, particularly its relationship to eugenics. Sociobiology developed in the 1960s as a field within evolutionary biology to explain human social traits and behaviours. Although sociobiology has few direct connections to eugenics, it shares eugenics’ optimistic enthusiasm for extending biological science into the human domain, often with reckless sensationalism. Sociobiology's critics have argued that sociobiology also propagates a kind of genetic determinism and represents the zealous misapplication of science beyond its proper reach that characterized (...) the eugenics movement. More recently, evolutionary psychology represents a sophistication of sociobiology that attends to the mind as the "missing link" between evolution and behaviour (Cosmides and Tooby 1992, Pinker 1997). (shrink)

1. The Situation in Cognition 2. Situated Cognition: A Potted Recent History 3. Extensions in Biology, Computation, and Cognition 4. Articulating the Idea of Cognitive Extension 5. Are Some Resources Intrinsically Non-Cognitive? 6. Is Cognition Extended or Only Embedded? 7. Letting Nature Take Its Course.

Written by the preeminent democratic theorist of our time, this book explains the nature, value, and mechanics of democracy. In a new introduction to this Veritas edition, Ian Shapiro considers how Dahl would respond to the ongoing challenges democracy faces in the modern world. “Within the liberal democratic camp there is considerable controversy about exactly how to define democracy. Probably the most influential voice among contemporary political scientists in this debate has been that of Robert Dahl.”—Marc Plattner, _New York (...) Times_ “An excellent introduction for novices, as well as a trusty handbook for experts and political science mavens.”—_Publishers Weekly_. (shrink)

Genes and the Agents of Life undertakes to rethink the place of the individual in the biological sciences, drawing parallels with the cognitive and social sciences. Genes, organisms, and species are all agents of life but how are each of these conceptualized within genetics, developmental biology, evolutionary biology, and systematics? The 2005 book includes highly accessible discussions of genetic encoding, species and natural kinds, and pluralism above the levels of selection, drawing on work from across the biological sciences. The book (...) is a companion to the author's Boundaries of the Mind (2004), also available from Cambridge, where the focus is the cognitive sciences. The book will appeal to a broad range of professionals and students in philosophy, biology, and the history of science. You can download the table of contents and the first chapter here. (shrink)