Research in the field of planarian regeneration on the one hand, and a general survey of embryology on the other, throw doubt upon the reality of supra-cellular controls, which are still at the basis of all modern concepts of morphogenesis. The necessity of referring to such controls, which have never been convincingly demonstrated, is probably due to the fact that two aspects of cell behaviour have been underestimated: 1) the capacity of cells to change their individualities for a time independently (...) of other cells; 2) the social behaviour of cells, which is the consequence of the reciprocal exchange of information. Pattern formation and pattern remodeling in normal development results from readjustments of cell populations to local or global changes. The common responses of cell populations to disturbances are enhanced mitotic activity, cessation of specific syntheses and cell migration. In the young embryo these may promptly restore the unity of the injured primordium, leading to so-called restitution; this is based on a normal sequence of further readjustments in the primordium. In older organisms the same responses give rise to cell interactions which may be the starting point for further sequential readjustments — in some instances these are comparable to those that originally organized the primordium in question during development. The desirability of giving up the notion of morphogenetic field is discussed. (shrink)

The control of pattern formation and the significance of gradients is reconsidered on the basis of the concept of cell sociology (which takes into account continuous exchange of information between cells and the possibility of autonomous progression in differentiation). Not all traits of a pattern are imposed by a single prepattern, which would be an organized molecular framework or a gradient. Patterns are unfolded in steps; these are readjustments of a cell population to intrinsic and extrinsic changes in cell activities. (...) Prepatterns are the various components of the programme of every readjustment and are established by information of various origins, which can be dissociated experimentally: determination (elementary social prepattern), pre-existing organization (antecedent pp.), surrounding cell populations (environmental pp.), position among other tissues (positional pp.) and the organization of inducers (imprinting pp.). Every transitory pattern formed during a readjustment serves as antecedent pp. during the next readjustment. Covert graded patterns result from various aspects of the social behaviour of cells (growth, aggregation, induction, cell renewal) and may serve as antecedent or imprinting prepatterns. They appear as water marks in the final patterns, or generate overt graded patterns. They also manifest themselves in temporal patterns, particularly in gradients of relative growth. (shrink)

The principles of automation (automatism and programming) in the unfolding of spatio-temporal patterns during animal development are deduced from experimental data reconsidered from the point of view of cell sociology. The developmental programme in the egg is not part of the genetic information but a part of the cytoplasmic information. Throughout development cells store extra-cellular information released by their neighbours in the form of cytoplasmic information. Successive determinations cannot be considered as successive reprogrammings of cells: each one consists of a (...) selection of one specific programme from the total information previously stored. This programme specifies cell interactions in the determined population as a whole; it is very imprecise and is progressively completed during the course of further differentiation by information released by neighbouring cell populations. Complicated patterns may emerge from only two homogeneous populations involved in distinct differentiation pathways and confronting each other. Consequently the egg developmental programme provides gene effectors and specific physico-chemical conditions necessary for the starting of at least two distinct differentation pathways. Experimental data suggest that there are two components in this programme. One is a molecular machinery which starts at fertilization in the whole cytoplasm. It yields two programmes of differentiation, typically first an endodermal and then an ectodermal one. The other component of the egg developmental programme, which does not require specific information, allows the interception of the first (endodermal) programme. The application of informatics to developmental automatism is discussed in the latter part of the paper. (shrink)

This article is concerned with the problem of the relation between the genetic information contained in the DNA and the emergence of visible structure in multicellular animals. The answer is sought in a reappraisal of the data of experimental embryology, considering molecular, cellular and organismal aspects. The presence of specific molecules only confers a tissue identity on the cells when their concentration exceeds the threshold of differentiation. When this condition is not fulfilled the activity of the genes that code for (...) the specific molecules in question only confers on them a histogenetic potency, i.e. the capacity to form the corresponding tissue in further development (or to transdifferentiate to that tissue). The progressive restriction of histogenetic potencies during development reflects the irreversible repression of more and more genes. The establishment of a given tissue identity under the influence of an inducing tissue (or a morphogenetic hormone) is only possible when the cells have acquired the competence to respond. Tissue differentiation proceeds progressively during development thanks to the cytoplasmic memory that cells retain collectively (or sometimes individually) of the items of information successively registered by their ancestors cells. The increasing complexity of visible structure emerging during development results only from the progression of tissue differentiation. This involves continual exchange of information among the cells and leads to (1) cell displacements and rearrangements, particularly during organogenesis and (2) extreme diversification of cell individualities within tissues, particularly during postembryonic growth. A mutation (just as a teratogenic factor) evokes an anomaly that is localized in both space and time because it alters a certain aspect of cell behaviour (particularly cell surface adhesiveness or mitotic activity) at the time when this is involved in the establishment of a particular structural trait. Neither the organization of the adult nor the modalities of development are encoded in the DNA. The automatic concatenation of cell interactions in the embryo and the structural amplification it entails is conditioned by the specific biochemical composition of the cytoplasm of the egg and by the heterogeneous distribution of its inclusions. (shrink)

Embryonic and adult field do not exhibit the same properties because they are formed by cell populations whose activities cannot be compared in all respects. Dominant cells are not distributed in the same manner; the same mechanisms are not involved for remodelling of the field, especially after an amputation.In adult organisms, cell equilibrium is disturbed a first time by elimination of differentiated tissues which provokes dedifferentiation and proliferation, and a second time by healing, which restores cell equilibrium of a distal (...) end. Undifferentiated cells begin to differentiate immediately after their production and they reform the missing levels, following a sequence either basipetal or basifugal according to the place of their production . The differentiating regenerate temporarily exhibits embryonic field properties in various experimental conditions which suppress the dominance of the stump or supplies additional undifferentiated material. (shrink)

The principles of automation in animal development, as previously inferred from the concept of Cell Sociology do not fit in well with the current concept of sequential gene derepression. A more adequate explanation for those principles has been found in the literature dealing with the biochemical aspects of differentiation. Since oocytes and embryonic cells contain a greater variety of mRNAs than differentiated cells, as well as many tissue-specific (luxury) substances, it is concluded that the diversification of tissues consists of a (...) progressive selection of specific metabolic strategies, mediated by cell-to-cell contacts, from a broad range of pre-existing strategies. For each tissue, prior to its final determination, one luxury metabolic strategy is progressively intensified and becomes dominant. The others are either suppressed or maintained as latent metabolic strategies. The latter may on occasion become dominant again (transdifferentiation). These phenomena require a theory which considers gene regulation as the activation of otherwise repressed genes by specific activator RNAs. The high (apparently maximal) transcriptional activity on the lampbrush chromosomes may represent the synthesis of all the kinds of activator RNAs which are required for the reactivation of the genes during early development. A general conception is propounded of the automatism and programming of animal development, as inferred from the confrontation of these ideas with the concept of Cell Sociology. (shrink)

Routine management of geriatric problems often raises ethical problems, particularly regarding autonomy of the old person. The carers or children may be unaware of the sensitivity of role reversal in dealing with the financial affairs; the need for a residential carer may compromise the old person’s privacy. Attending a day centre confers much benefit, but one must understand the old person’s resistance to change in the proposal of a new daily regimen. Similarly his or her autonomy must be the priority (...) in planning for admittance to an old age home, and not the assumption that the family knows best. A common dilemma is the assessment of an old person’s competency in decision making, either about management of his affairs, or regarding consent to treatment, or participation in research. Because cognitive capacity is not always identical with competency, meaningful tools have recently been developed in which the emphasis is on the specific situation to be investigated. (shrink)

La première lettre de Paul aux Corinthiens (11/2-16) est le premier écrit issu des religions monothéistes à avoir lié le voile des femmes à leur relation à Dieu. Ce passage, comparé à d'autres textes de Paul et aux coutumes païennes de son temps, permet de distinguer deux courants : la tradition théologique de Paul et les coutumes du monde. Le voile des femmes étant le signe visible de leur subordination, Paul n'a pas réussi àconcilier sa tradition théologique d'égalité fondamentale entre (...) les baptisés avec la coutume du voile. (shrink)

_Murdered Father, Dead Father: Revisiting the Oedipus Complex_ examines the progressive construction of the notion of paternal function and its central relevance in psychoanalysis. The distinction between the _murdered father _and the _dead father_ is seen as providing a paradigm for the understanding of different types of psychopathologies, as well as works of literature, anthropology and historical events. New concepts are introduced, such as "_a father is being beaten_", and a distinction between the _descriptive après coup_ and the _dynamic après (...) coup_ that provides a model for a psychoanalytic understanding of temporality. The book includes a reflection on how the concepts of the _death instinct_ and the _negative_, in their connection with that which is at the limits of representability, are an aid to an understanding of Auschwitz, a moment of rupture in European culture that the author characterizes as " the murder of the dead father". Perelberg’s book is an important clinical and intellectual marker, and will be required reading for psychoanalysts, psychotherapists, anthropologists, and historians, as well as students in all these disciplines. (shrink)

Although there is a vast literature on aggression, comparatively little has been written on the issue of violence and even fewer clinical discussions have been published on the violent patient. This pioneering book presents a collection of case studies on the intensive psychoanalytic treatment of patients who have committed serious acts of violence against themselves or others. Each detailed clinical account demonstrates the effectiveness of the psychoanalytic treatment and furthers our understanding of the nature of violence. _The Psychoanalytic Understanding of (...) Violence and Suicide _also contains a comprehensive review of the existing literature on aggression and violence from America, England and France, presenting major themes contained in this literature which will be of interest to all those working with violent and suicidal patients. (shrink)

_Time, Space, and Phantasy_ examines the connections between time, space, phantasy and sexuality in clinical practice. It explores the subtleties of the encounter between patient and analyst, addressing how aspects of the patient’s unconscious past are actualised in the present, producing new meanings that can be re-translated to the past. Perelberg’s analysis of Freud’s Multi-dimensional model of temporality suggests that he always viewed the constitution of the individual as non-linear. In Freud’s formulations, the individual is decentred and ruled by different (...) temporalities, most of which escape their consciousness. Perelberg identifies the similarities between this and Einstein’s theory of relativity which states that rather than being absolute, time depends on the relative position and speed of the observing individual suggesting that rather than being a reality, time is an abstraction, connecting objects and events. Throughout this text, Perelberg draws together connections between time, mental space, and phantasy showing how time is constantly reshaped in the light of new events and experiences. This book will be of interest to psychoanalysts, psychotherapists, psychologists, and social workers. (shrink)

Gene editing tools are ‘revolutionizing’ microbiological research. Much of the public debate focuses on the possibility of human germ line applications. The use of genome editing to alter non-human animals, however, will have more immediate impacts on our daily lives. Genome edited animals are used for basic biological and biomedical research and could soon play a role in the livestock industry and ecosystem management. Genome editing thus provides an occasion to rethink societal narratives about the relationships between humans and other (...) animals. Even though the technique can be easily incorporated as an example into a conventional storyline about the development of the modern life sciences as striving for control over nature, it can also help to highlight the anthropocentric biases expressed in these narratives and demonstrate the continuities between humans and other animals. (shrink)

Data is essential to governing those emerging matters of concern that confront the agrifood every day. But data is no neutral intermediary. It disrupts, exposes, and creates new social, economic, political, and environmental possibilities, whilst simultaneously hiding, excluding, and foreclosing others. Scholars have become attuned to both the constitutive role of data in creating everyday worlds, and the need to develop critical accounts of the materialities, spatialities and multiplicities of data relationships. Whereas this emerging work develops insight to the capacity (...) for data topologies to reterritorialise the spatial performances of everyday life, it has largely reduced the associated temporal dimensions to matters of fact. The effect of these performances has been to naturalize the temporal quality of speed and elide the multiple temporalities required to enact contemporary data worlds. Applying the lenses of infrastructuring, performativity and ferality, this paper explores temporality and data in the everyday worlds produced through the New Zealand kiwifruit industry’s focus on dry matter. The paper argues that temporalities are deeply embedded in the kiwifruit industry’s data relations. We show that while temporal data relations are critical to the industry, we also highlight ways in which those relations introduce new, potentially destabilizing performances into kiwifruit relations. (shrink)

Respecting and encouraging autonomy in the elderly is basic to the practice of geriatrics. In this paper, we examine the practice of cardiopulmonary resuscitation (CPR) and "artificial" feeding in a geriatric unit in a general hospital subscribing to jewish orthodox religious principles, in which the sanctity of life is a fundamental ethical guideline. The literature on the administration of food and water in terminal stages of illness, including dementia, still shows division of opinion on the morality of withdrawing nutrition. We (...) uphold the principle that as long as feeding by naso-gastric (N-G) or percutaneous endoscopic gastrostomy (PEG) does not constitute undue danger or arouse serious opposition it should be given, without causing suffering to the patient. This is part of basic care, and the doctor has no mandate to withdraw this. The question of CPR still shows much discrepancy regarding elderly patients' wishes, and doctors' opinions about its worthwhileness, although up to 10 percent survive. Our geriatric patients rarely discuss the subject, but it is openly ventilated with families who ask about it, who are then involved in the decision-making, and the decision about CPR or "do-not-resuscitate" (DNR) is based on clinical and prognostic considerations. (shrink)

L’article interroge l’identité en situation, c’est-à-dire la manière de faire face aux moments historiques en cours en Afrique. La situation précoloniale des sociétés africaines, la colonisation responsable de la crise identitaire des États africains, les Indépendances, la phase post-coloniale qui est celle de l’État moderne, donnent à comprendre qu’il existe maintes approches de l’identité en fonction des réalités socio-historiques de l’Afrique. Citons la négritude comme expression de l’identité nègre, le panafricanisme comme fédération des États africains, l’africanologie comme une didactique de (...) l’Afrique, enfin la promotion de valeurs éthiques transversales. (shrink)

This article questions how contemplative contemporary cinema “sexualize” the landscapes. Through the filmography of four directors, Abbas Kiarostami, Apichatpong Weerasethakul, Lars von Trier and B...

Modularity has become a central and remarkably useful concept in evolutionary developmental biology, offering an explanation of how independent, interacting units make possible developmental events and evolutionary changes. These modules exist at several different levels of organization, from genes to signal transduction pathways to cell populations. Cell populations, which are multicellular modules, provide an opportunity both to clarify our notion of modularity and to reexamine such central concepts as cell-to-cell communication. Rosine Chandebois’s work on “cell sociology” is reframed (...) in the language of modularity in order to show how groups of cells maintain their collective identity during development and how signaling information from the group’s environment is received by the constituent cells. In a “test case” for our account of multicellular modules, we consider the vertebrate neural crest, a migratory cell population made up of several subpopulations. The neural crest proves yet again to be a complex case, showing the importance of taking into account both developmental and evolutionary transformations of multicellular modules. (shrink)

Discover how the automatic choices you make in life-- without even noticing-- can sabotage you. Fogel and Rosin show you how to learn to interrupt your self-defeating behavior and make better choices.

Ce livre clôt une vie de travail au point de rencontre de la philosophie et des sciences. C'est tout notre vieux monde qui est ainsi ausculté, du cosmos à la cellule vivante, du hériodonte à l'homme, avec Kant, Merleau-Ponty ou d'Espagnat, Hawking, Berthoz, Damasio ou Chandebois, mais surtout avec Bergson. Ce dernier est quelque peu occulté aujourd'hui. Cet ouvrage le réhabilite, sans toutefois méconnaître les progrès accomplis depuis Bergson par les neurosciences et la neurophysiologie.

Volume Four, as indicated by the anthology's subtitle, is in honor of Simone de Beauvoir (1908-1986) and Martin Heidegger (1889-1976). The chapters do not necessarily mention Simone de Beauvoir or Martin Heidegger. The 16 chapters (by professional philosophers and other professional scholars) are directed to issues related to death, life extension, and anti-death. Most of the 400-plus pages consist of scholarship unique to this volume. Includes index. -/- -/- The titles of the 16 chapters are as follows: -/- -/- 1. (...) Mechanism, Galileo’s Animale And Heidegger’s Gestell: Reflections On The Lifelessness Of Modern Science by GiorgioBaruchello -/- -/- 2. Simone De Beauvoir by Debra Bergoffen -/- 3. Existentialism by Steven Crowell -/- -/- 4. Time Wounds All Heels by William Grey -/- -/- 5. The Ethical Importance Of Death by Jenann Ismael -/- 6. The Poetics Of Death: Intimations And Illusions by Lawrence Kimmel -/- -/- 7. Death And Aesthetics by Keith Lehrer -/- -/- 8. Ageing And Existentialism: Simone De Beauvoir And The Limits Of Freedom by Shannon M. Mussett -/- -/- 9. Life Extension And Meaning by Carol O’Brien -/- -/- 10. Consciousness As Computation: A Defense Of Strong AI Based On Quantum-State Functionalism by R. Michael Perry -/- -/- 11. Reality Shifts: On The Death And Dying Of Dr. Timothy Leary by Carol Sue Rosin -/- -/- 12. Extraterrestrial Liberty And The Great Transmutation by Charles Tandy -/- -/- 13. A Time Travel Schema And Eight Types Of Time Travel by Charles Tandy -/- -/- 14. Boredom, Experimental Ethics, And Superlongevity by Mark Walker -/- -/- 15. Exopolitics: The Death Of Death by Alfred Lambremont Webre -/- -/- 16. Embryo Cloning: Current State Of The Medical Art And Its Far-Reaching Consequences For Multiple Applications by Panayiotis M.Zavos. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Feminist Studies 45, no. 1. © 2019 by Feminist Studies, Inc. 67 Leila J. Rupp Queer Dilemmas of Desire The dilemmas of desire confronting young women in contemporary US society are all too familiar. In the face of the persistent double standard that separates sluts from good girls, young women mobilize a variety of strategies: they lack desire, deny desire, restrain desire, police desire, and sometimes embrace desire. They (...) confront expectations to be sexy but not too sexual even as they insist on the right to be just as sexually active as men. Even in the hookup scene on college campuses, potentially liberating in its facilitation of noncommittal sexual encounters, young women worry about hooking up too much. It is a familiar story, but one that most often leaves behind young women with queer desires. Where they do appear, there are hints that they are not as likely to suppress their desires as straight women, no doubt because it is hard to ignore one’s desires when they fly in the face of heteronormative expectations. But it is also hard to come to grips with queer desires, and that is why the dilemmas I explore here are different. Unlike young straight women working to control their desires, the queer students whose stories I tell report awareness and acceptance of their attractions, sometimes from a very young age. Yet they encounter other kinds of dilemmas, especially uncertainty about the boundary between erotic love and intense friendship, a dilemma harking back to an earlier world of romantic friendship. And in the end, despite a contemporary social context in which nonnormative sexualities are more visible than ever before, 68 Leila J. Rupp experiencing queer desires continues to elicit confusion. Much has changed, but much has not. We know a great deal about straight dilemmas of desire. On the one hand, the double standard that separates sluts from good girls has persisted, despite the loosening of restrictions we associate with the sexual revolution of the long 1960s. In the face of slut shaming, young women continue to mobilize a variety of strategies, which Deborah Tolman has documented so eloquently in Dilemmas of Desire. Young women of color face additional obstacles to enjoying their desire, as the Latina girls we encounter in Lorena Garcia’s Respect Yourself, Protect Yourself make clear through their policing of their own and other girls’ sexuality in the face of racist stereotypes of unrestrained sexuality and teenage motherhood.1 On the other hand, a whole raft of commentators depict young women increasingly insisting on the right to be just as sexual as men. From Ariel Levy’s Female Chauvinist Pigs to Peggy Orenstein’s Girls and Sex to Nancy Jo Sales’ American Girls, critics lament young women embracing sex as a form of empowerment.2 The tension arising from the contradictory responses of young women to the demands placed on their sexuality is nowhere clearer than in the ongoing debate about the impact of hookup culture on women. Is hooking up good for women because it allows them to be sexual while pursuing their studies and career goals unencumbered by intimate relationships, as Hannah Rosin has suggested? Or is it, as Kathleen Bogle first argued in Hooking Up, exploitative in fashioning sexual encounters around men’s preference for sex without commitment? Or is it somewhere in between, with some 1. See Leora Tanenbaum, Slut! Growing up Female with a Bad Reputation (New York: HarperCollins, 2000); Emily White, Fast Girls: Teenage Tribes and the Myth of the Slut (New York: Berkeley Books, 2002); Sarah A. Miller, “’How You Bully a Girl:’ Sexual Drama and the Negotiation of Gendered Sexuality in High School,” Gender & Society 30, no. 5 (2016): 721–44; Deborah L. Tolman, Dilemmas of Desire: Teenage Girls Talk about Sexuality (Cambridge, MA: Harvard University Press, 2002); and Lorena Garcia, Respect Yourself, Protect Yourself: Latina Girls and Sexual Identity (New York: New York University Press, 2012). 2. Ariel Levy, Female Chauvinist Pigs: Women and the Rise of Raunch Culture (New York: Free Press, 2005). See also Peggy Orenstein, Girls and Sex: Navigating the Complicated New Landscape (New York: HarperCollins, 2016); Nancy Jo Sales, American Girls: Social Media and the Secret Lives of... (shrink)