We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

These notes discuss formalizing contexts as first class objects. The basic relationships are: ist(c,p) meaning that the proposition p is true in the context c, and value(c,p) designating the value of the term e in the context c Besides these, there are lifting formulas that relate the propositions and terms in subcontexts to possibly more general propositions and terms in the outer context. Subcontextx are often specialised with regard to time, place and terminology. Introducing contexts as formal objects will permit (...) axiomatizations in limited contexts to be expanded to transcend the original limitations. This seems necessary to provide AI programs using logic with certain capabilities that human fact representation and human reasoning possess. Fully implementing transcendence seems to require further extensions to mathematical logic, ie. beyond the nonmonotonic inference methods first invented in AI and now studied as a new domain of logic. (shrink)

This book provides practical and research-based chapters that offer greater clarity about the particular kinds of teacher reflection that matter and avoids talking about teacher reflection generically, which implies that all kinds of reflection are of equal value.

Logical AI develops computer programs that represent what they know about the world primarily by logical formulas and decide what to do primarily by logical reasoning--including nonmonotonic logical reasoning. It is convenient to use logical sentences and terms whose meaning depends on context. The reasons for this are similar to what causes human language to use context dependent meanings. This note gives elements of some of the formalisms to which we have been led. Fuller treatments are in [McC93], [Guh91] and (...) [MB94] and the references cited in the Web page [Buv95]. The first main idea is to make contexts first class objects in the logic and use the formula ist(c,p) to assert that the proposition p is true in the context c. A second idea is to formalize how propositions true in one context transform when they are moved to different but related contexts. An ability to transcend the outermost context is needed to give computer programs the ability to reason about the totality of all they have thought about so far [McC96]. (shrink)

“...it seems that hardly anybody proposes to use different variables for propositions and for truth-values, or different variables for individuals and individual concepts.” (Carnap 1956, p. 113).

Used as the basis of the program at the Equinox Holistic Alternative School in Toronto, The Holistic Curriculum advocates for an integrative approach to teaching and learning with a focus on developing a deep connection between mind and body.

A Companion to Medieval Christian Humanismexplores Christian humanism in the writings of key medieval thinkers. It explores questions pertaining to human dignity, the human person's place in the cosmos, and the educational ideals involved in shaping the human person.

How induction was understood took a substantial turn during the Renaissance. At the beginning, induction was understood as it had been throughout the medieval period, as a kind of propositional inference that is stronger the more it approximates deduction. During the Renaissance, an older understanding, one prevalent in antiquity, was rediscovered and adopted. By this understanding, induction identifies defining characteristics using a process of comparing and contrasting. Important participants in the change were Jean Buridan, humanists such as Lorenzo Valla and (...) Rudolph Agricola, Paduan Aristotelians such as Agostino Nifo, Jacopo Zabarella, and members of the medical faculty, writers on philosophy of mind such as the Englishman John Case, writers of reasoning handbooks, and Francis Bacon. (shrink)

This volume offers an English translation of John of St. Thomas's Cursus theologicus I, question I, disputation 2. In this particular text, the Dominican master raises questions concerning the scientific status and nature of theology. At issue, here, are a number of factors: namely, Christianity's continual coming to terms with the "Third Entry" of Aristotelian thought into Western Christian intellectual culture - specifically the Aristotelian notion of 'science' and sacra doctrina's satisfaction of those requirements - the Thomistic-commentary tradition, and (...) the larger backdrop of the Iberian Peninsula's flourishing "Second Scholasticism." In this latter context, John of St. Thomas applies the theological principles of Thomas Aquinas to the Scholastic disputes preoccupying Thomist, Franciscan, and Jesuit theologians, such as Cajetan, Bañez, Luis de Molina, Vazquez, Suárez - to name only a few - in a tour de force of theological thinking throughout the entire period of Scholasticism. In the process - and not insignificantly - the status quaestionis of theology's scientific character is clearly framed and answered according to John's satisfaction. Key to John of St. Thomas's resolution of the question is his understanding of the continuity of the power of human reason with the super-intelligibility of divine revelation spelled out in terms of what he calls "virtual revelation." This text presented in this volume is a quintessential example of the deep and abiding harmony that flourished between faith and reason as well as grace and nature within the golden era of Baroque Scholasticism. (shrink)

This wide-ranging, multidisciplinary collection of newly commissioned articles brings together distinguished voices in the field of Africana philosophy and African-American social and political thought. Provides a comprehensive critical survey of African-American philosophical thought. Collects wide-ranging, multidisciplinary, newly commissioned articles in one authoritative volume. Serves as a benchmark work of reference for courses in philosophy, social and political thought, cultural studies, and African-American studies.

Roboethics is the recent offshoot of computer ethics that pays special attention to the alterations that need to be made to computer ethics when we give the computer mobility and a means to interact directly in the human environment. The closely related field of machine morality explores how ethical systems and behaviors may be programmed into social robotics applications. As robots move from the factory floor into our homes and work lives, they stand to change key aspects of the way (...) our lives are lived. In order to be successful, these machines must be programmed with the ability to navigate the human life world without committing ethical faux pas or moral outrage. Thus, the roboethicist is tasked not only with critiquing the attempts of robots engineers to achieve the integration of these machines into our life world, but also, and more importantly, with suggesting means of achieving better results than what is presently on offer. (shrink)

This chapter explores the notion of popular participation advocated by philosopher-statesmen of the past such as Marcus Tullius Cicero, Leonardo Bruni and Francesco Guicciardini, and its political outcomes in relation to the common good. It highlights the significant similarities between traditional republicanism and the ideas of Philip Pettit. Drawing on the writings of Niccolò Machiavelli, it argues that the people are much more likely than the few to make decisions that promote the common good within republics. It also suggests that (...) political democracy, owing to normative and empirical grounds, is more desirable than philosophical republicanism that empowers neutral or ‘depoliticised’ experts and representatives to act on behalf of the people. The chapter explains how popular marginalisation and elite empowerment resulted in the collapse of the regimes served by republican philosopher-statesmen. (shrink)

"The Treatise on the Origin of Humanity (Yuanren lun) by the Huayan patriarch Zongmi classifies various teachings of Buddhism on a scale of relative profundity, and specifically critiques the weaknesses of the teachings of Confucianism and Daoism, which he regards as inferior to Buddhism. This work formed the basis for some of the arguments in later East Asian history on the relationship of the three teachings." --.

A review with commentary on Mark A. Bedau and Emily C. Parke (eds): The Ethics of Protocells: Moral and Social Implications of Creating Life in the Laboratory (Basic Bioethics series) MIT Press, Cambridge,MA, 2009, 365 pp, ISBN 978-0-262-01262-1, ISBN 978-0-262-51269-5.

A review with commentary on the book, Understanding Beliefs, Nils J. Nilsson, MIT Press, 2014.