CHAPTER ONE Augustine the Philosopher There are, according to Augustine in the early work entitled soliloquia, two principal (indeed, strictly speaking, ...

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

In his great poemThe Wreck of the DeutschlandGerard Manley Hopkins evokes the conversions of Paul and Augustine as two contrasting examples of the way in which God may intervene in human affairs:With an anvil-dingAnd with fire in him forge thy willOr rather, rather then, stealing as SpringThrough him, melt him but master him still:Whether at once, as once at a crash Paul,Or as Austin, a lingering-out sweet skill….