We contend that diagrams are tools not only for communication but also for supporting the reasoning of biologists. In the mechanistic research that is characteristic of biology, diagrams delineate the phenomenon to be explained, display explanatory relations, and show the organized parts and operations of the mechanism proposed as responsible for the phenomenon. Both phenomenon diagrams and explanatory relations diagrams, employing graphs or other formats, facilitate applying visual processing to the detection of relevant patterns. Mechanism diagrams guide reasoning about how (...) the parts and operations work together to produce the phenomenon and what experiments need to be done to improve on the existing account. We examine how these functions are served by diagrams in circadian rhythm research. (shrink)

Cognitive science is, more than anything else, a pursuit of cognitive mechanisms. To make headway towards a mechanistic account of any particular cognitive phenomenon, a researcher must choose among the many architectures available to guide and constrain the account. It is thus fitting that this volume on contemporary debates in cognitive science includes two issues of architecture, each articulated in the 1980s but still unresolved: " • Just how modular is the mind? – a debate initially pitting encapsulated mechanisms against (...) highly interactive ones. • Does the mind process language-like representations according to formal rules? – a debate initially pitting symbolic architectures against less language-like architectures. " Our project here is to consider the second issue within the broader context of where cognitive science has been and where it is headed. The notion that cognition in general—not just language processing—involves rules operating on language-like representations actually predates cognitive science. In traditional philosophy of mind, mental life is construed as involving propositional attitudes—that is, such attitudes towards propositions as believing, fearing, and desiring that they be true—and logical inferences from them. On this view, if a person desires that a proposition be true and believes that if she performs a certain action it will become true, she will make the inference and perform the action. (shrink)

We contrast reactive and endogenously active perspectives on brain activity. Both have been pursued continuously in neurophysiology laboratories since the early 20thcentury, but the endogenous perspective has received relatively little attention until recently. One of the many successes of the reactive perspective was the identification, in the second half of the 20th century, of the distinctive contributions of different brain regions involved in visual processing. The recent prominence of the endogenous perspective is due to new findings of ongoing oscillatory activity (...) in the brain at a wide range of time scales, exploiting such techniques as single-cell recording, EEG, and fMRI. We recount some of the evidence pointing to ways in which this endogenous activity is relevant to cognition and behavior. Our major objective is to consider certain implications of the contrast between the reactive and endogenous perspectives. In particular, we relate these perspectives to two different characterizations of explanation in the new mechanistic philosophy of science. In a basic mechanistic explanation, the operations of a mechanism are characterized qualitatively and as functioning sequentially until a terminating condition is realized. In contrast, a dynamic mechanistic explanation allows for non-sequential organization and emphasizes quantitative modeling of the mechanisms's behavior. For example, with appropriate parameter values a set of differential equations can be used to demonstrate ongoing oscillations in a system organized with feedback loops. We conclude that the basic conception of mechanistic explanation is adequate for reactive accounts of brain activity, but dynamical accounts are required to explain sustained, endogenous activity. (shrink)

Diagrams have distinctive characteristics that make them an effective medium for communicating research findings, but they are even more impressive as tools for scientific reasoning. Focusing on circadian rhythm research in biology to explore these roles, we examine diagrammatic formats that have been devised to identify and illuminate circadian phenomena and to develop and modify mechanistic explanations of these phenomena.

Explanations in the life sciences frequently involve presenting a model of the mechanism taken to be responsible for a given phenomenon. Such explanations depart in numerous ways from nomological explanations commonly presented in philosophy of science. This paper focuses on three sorts of differences. First, scientists who develop mechanistic explanations are not limited to linguistic representations and logical inference; they frequently employ diagrams to characterize mechanisms and simulations to reason about them. Thus, the epistemic resources for presenting mechanistic explanations are (...) considerably richer than those suggested by a nomological framework. Second, the fact that mechanisms involve organized systems of component parts and operations provides direction to both the discovery and testing of mechanistic explanations. Finally, models of mechanisms are developed for specific exemplars and are not represented in terms of universally quantified statements. Generalization involves investigating both the similarity of new exemplars to those already studied and the variations between them. (shrink)

Aisha, age 24 months, sees her older sister trip over a toy and squeals “Kiki fell!” At 30 months her doll falls behind the couch, and she asks “Where dolly falled?” At 48 months her computer mouse falls behind a stack of computer manuals under the desk, and she asks “Where did that silly mouse fall?” Both her world and her sentences are getting more complex as she gets older, but there is one oddity: the past‐tense verb fell shows a (...) U‐shaped developmental pattern. Aisha gets it right at 24 months, wrong at 30 months, and right again at 48 months. Why? (shrink)

Something remarkable is happening in the cognitive sciences. After a quarter of a century of cognitive models that were inspired by the metaphor of the digital computer, the newest cognitive models are inspired by the properties of the brain itself. Variously referred to as connectionist, parallel distributed processing, or neutral network models, they explore the idea that complex intellectual operations can be carried out by large networks of simple, neuron-like units. The units themselves are identical, very low-level and 'stupid'. Intelligent (...) performance is derived from the pattern of connection strengths between units, and the fundamental cognitive activity is pattern recognition and completion. Connectionism and the Mind provides an introduction to this newly emerging approach to understanding the mind. The first few chapters focus on network architecture, offering accessible treatment of the equations that describe learning and the propagation of activation. Furthermore, the reader is walked step-by-step through the activities of networks engaged in pattern recognition, learning, and cognitive tasks such as memory retrieval and prototype formation. The remainder of the book addresses the implications of connectionism for theories of the mind, both philosophical and psychological. Foe example: What Role is played by pattern recognition and completion as basic as cognitive functions? Connectionist models have particular strength in learning and pattern recognition; should they be limited to those functions, or can they provide an overall account of cognitive functioning? In particular, can connectionist models provide an adequate account of the ability to employ linguistic and other symbol systems, or must an adequate system incorporate symbol processing as a basic cognitive capacity? Finally, Connectionism and the Mind examines the relation of connectionist models to philosophical accounts of propositional attitudes, and to a variety of other inquiries in cognitive psychology, linguistics, developmental psychology, artificial intelligence and neuroscience. (shrink)

Two widely accepted assumptions within cognitive science are that (1) the goal is to understand the mechanisms responsible for cognitive performances and (2) computational modeling is a major tool for understanding these mechanisms. The particular approaches to computational modeling adopted in cognitive science, moreover, have significantly affected the way in which cognitive mechanisms are understood. Unable to employ some of the more common methods for conducting research on mechanisms, cognitive scientists’ guiding ideas about mechanism have developed in conjunction with their (...) styles of modeling. In particular, mental operations often are conceptualized as comparable to the processes employed in classical symbolic AI or neural network models. These models, in turn, have been interpreted by some as themselves intelligent systems since they employ the same type of operations as does the mind. For this paper, what is significant about these approaches to modeling is that they are constructed specifically to account for behavior and are evaluated by how well they do so—not by independent evidence that they describe actual operations in mental mechanisms. (shrink)

Connectionism and the Mind provides a clear and balanced introduction to connectionist networks and explores theoretical and philosophical implications. Much of this discussion from the first edition has been updated, and three new chapters have been added on the relation of connectionism to recent work on dynamical systems theory, artificial life, and cognitive neuroscience. Read two of the sample chapters on line: Connectionism and the Dynamical Approach to Cognition: http://www.blackwellpublishing.com/pdf/bechtel.pdf Networks, Robots, and Artificial Life: http://www.blackwellpublishing.com/pdf/bechtel2.pdf.

The mechanistic perspective has dominated biological disciplines such as biochemistry, physiology, cell and molecular biology, and neuroscience, especially during the 20th century. The primary strategy is reductionist: organisms are to be decomposed into component parts and operations at multiple levels. Researchers adopting this perspective have generated an enormous body of information about the mechanisms of life at scales ranging from the whole organism down to genetic and other molecular operations.

Developing models of biological mechanisms, such as those involved in respiration in cells, often requires collaborative effort drawing upon techniques developed and information generated in different disciplines. Biochemists in the early decades of the 20th century uncovered all but the most elusive chemical operations involved in cellular respiration, but were unable to align the reaction pathways with particular structures in the cell. During the period 1940-1965 cell biology was emerging as a new discipline and made distinctive contributions to understanding the (...) role of the mitochondrion and its component parts in cellular respiration. In particular, by developing techniques for localizing enzymes or enzyme systems in specific cellular components, cell biologists provided crucial information about the organized structures in which the biochemical reactions occurred. Although the idea that biochemical operations are intimately related to and depend on cell structures was at odds with the then-dominant emphasis on systems of soluble enzymes in biochemistry, a reconceptualization of energetic processes in the 1960s and 1970s made it clear why cell structure was critical to the biochemical account. This paper examines how numerous excursions between biochemistry and cell biology contributed a new understanding of the mechanism of cellular respiration. (shrink)

Both in biology and psychology there has been a tendency on the part of many investigators to focus solely on the mature organism and ignore development. There are many reasons for this, but an important one is that the explanatory framework often invoked in the life sciences for understanding a given phenomenon, according to which explanation consists in identifying the mechanism that produces that phenomenon, both makes it possible to side-step the development issue and to provide inadequate resources for actually (...) explaining development. When biologists and psychologists do take up the question of development, they find themselves confronted with two polarizing positions of nativism and empiricism. However, the mechanistic framework, insofar as it emphasizes organization and recognizes the potential for self-organization, does in fact provide the resources for an account of development which avoids the nativism-empiricism dichotomy. (shrink)

Cognitive science is the multidisciplinary scientific study of cognition and its role in intelligent agency. It examines what cognition is, what it does, and how it works.

Explaining the complex dynamics exhibited in many biological mechanisms requires extending the recent philosophical treatment of mechanisms that emphasizes sequences of operations. To understand how nonsequentially organized mechanisms will behave, scientists often advance what we call dynamic mechanistic explanations. These begin with a decomposition of the mechanism into component parts and operations, using a variety of laboratory-based strategies. Crucially, the mechanism is then recomposed by means of computational models in which variables or terms in differential equations correspond to properties of (...) its parts and operations. We provide two illustrations drawn from research on circadian rhythms. Once biologists identified some of the components of the molecular mechanism thought to be responsible for circadian rhythms, computational models were used to determine whether the proposed mechanisms could generate sustained oscillations. Modeling has become even more important as researchers have recognized that the oscillations generated in individual neurons are synchronized within networks; we describe models being employed to assess how different possible network architectures could produce the observed synchronized activity. (shrink)

Although a reactive framework has long been dominant in cognitive science and neuroscience, an alternative framework emphasizing dynamics and endogenous activity has recently gained prominence. We review some of the evidence for endogenous activity and consider the implications not only for understanding cognition but also for accounts of explanation offered by philosophers of science. Our recent characterization of dynamic mechanistic explanation emphasizes the coordination of accounts of mechanisms that identify parts and operations with computational models of their activity. These can, (...) and should, be extended to incorporate attention to mechanisms that are not only active, but endogenously active. (shrink)

We argue that diagrams are not just a communicative tool but play important roles in the reasoning of biologists: in characterizing the phenomenon to be explained, identifying explanatory relations, and developing an account of the responsible mechanism. In the first two tasks diagrams facilitate applying visual processing to the detection of patterns that constitute phenomena or explanatory relations. Diagrams of a mechanism serve to guide reasoning about what parts and operations are needed and how potential parts of the mechanism are (...) related to each other. Further they guide the development of computational models used to determine how the mechanism will behave. We illustrate each of these uses of diagrams with examples from research on circadian rhythms. (shrink)

Mechanistic explanation is the dominant approach to explanation in the life sciences, but it has been challenged as incompatible with a conception of humans as agents whose capacity for self-direction endows them with freedom and dignity. We argue that the mechanical philosophy, properly construed, has sufficient resources to explain how such characteristics can arise in a material world. Biological mechanisms must be regarded as active, not only reactive, and as organized so as to maintain themselves far from thermodynamic equilibrium. Notions (...) from systems biology make key contributions, particularly Gánti’s chemoton, Ruiz-Mirazo and Moreno’s basic autonomy, and Barandiaran and Moreno’s adaptive autonomous agents. The reconstrual is then extended to mental life by conceiving of cognitive mechanisms as control components in inherently active systems, as illustrated in models offered by Randall Beer and Cees van Leeuwen. (shrink)

Mechanistic explanation is the dominant approach to explanation in the life sciences, but it has been challenged as incompatible with a conception of humans as agents whose capacity for self-direction endows them with freedom and dignity. We argue that the mechanical philosophy, properly construed, has sufficient resources to explain how such characteristics can arise in a material world. Biological mechanisms must be regarded as active, not only reactive, and as organized so as to maintain themselves far from thermodynamic equilibrium. Notions (...) from systems biology make key contributions, particularly Gánti’s chemoton, Ruiz-Mirazo and Moreno’s basic autonomy, and Barandiaran and Moreno’s adaptive autonomous agents. The reconstrual is then extended to mental life by conceiving of cognitive mechanisms as control components in inherently active systems, as illustrated in models offered by Randall Beer and Cees van Leeuwen. (shrink)

We explore the crucial role of diagrams in scientific reasoning, especially reasoning directed at developing mechanistic explanations of biological phenomena. We offer a case study focusing on one research project that resulted in a published paper advancing a new understanding of the mechanism by which the central circadian oscillator in Synechococcus elongatus controls gene expression. By examining how the diagrams prepared for the paper developed over the course of multiple drafts, we show how the process of generating a new explanation (...) vitally involved the development and integration of multiple versions of different types of diagrams, and how reasoning about the mechanism proceeded in tandem with the development of the diagrams used to represent it. (shrink)

This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

Sguardo d'insieme -- Armonia delle sfere celesti : Hildegard von Bingen, symphonia -- Il tempo di Dio : Johann Sebastian Bach, Cantata Gottes Zeit -- Trasmutazioni : Wolfgang Amadeus Mozart, Die Zauberflöte -- "Questo bacio vada al mondo intero" : Ludwig van Beethoven, An die Freude -- Viaggio d'inverno : Franz Schubert, Winterreise -- Inni all notte : Richard Wagner, Tristan und Isolde -- L'ultimo rito : Richard Wagner, Parsifal -- Azzurre solitudini : Gustav Mahler, Terza sinfonia -- Universi sonori (...) : Gustav Mahler, Ottava sinfonia -- Orizzonti perduti : Gustav Mahler, Das Lied von der Erde -- Labirinti : Richard Strauss, Also sprach Zarathustra -- Cortei di ombre : Richard Strauss, Metamorphosen -- La terza via : Omaggio a Francesco d'Avalos. (shrink)

This article juxtaposes Anna Pawełczyńska’s writings with the works of Meir Dworzecki and Dov Levin. It will adopt a threefold analytical lens: first, using Pawełczyńska’s writings to reassess the conception of the early resistance that Dworzecki elaborated, second utilising Dworzecki’s viewpoint as a means to articulate Pawełczyńska’s perspective of Amidah, and then looking at Levin’s perspective on Pawełczyńska’s use of partisan testimony as a historical source. The main aims are to contribute to today’s debates on the Jewish resistance and the (...) relevance of partisanship in Holocaust historiography. The article also highlights some debates on the relationship between history and memory, as well as the necessity of rethinking Catholic-Jewish relations in Poland before and after the war. It presses for a new discussion of Dan Michman’s discourse of Jewish resistance, or Yehuda Bauer’s conceptualisation of it, and underscores the originality of Levin’s thought on memory as an essential tool for history. By way of a conclusion, the reader is invited to rethink the Polish World War II historiography and to read Rabbi Joseph Soloveitchik’s contribution about the blessings of the Amidah. (shrink)

The Enneagram opens a remarkable window into the truth about us, but simply diagnosing our number doesn't do justice to who we are. Transformation happens as we grow in awareness and learn how to apply Enneagram insights to the rhythms of our daily lives. Filled with exercises to engage, challenge, encourage, and sustain, this handbook will help us grow in greater awareness and lead us to spiritual and relational transformation.

This paper considers the early reception of Einstein's theory of relativity in the Arab world, with emphasis directed to its popularization. Educated Arabs generally had no contention with Einstein's political, religious or cultural background. On the contrary, they viewed him as the genius of the age and defended him against his critics.

A new theoretical approach to language has emerged in the past 10–15 years that allows linguistic observations about form–meaning pairings, known as ‘construc- tions’, to be stated directly. Constructionist approaches aim to account for the full range of facts about language, without assuming that a particular subset of the data is part of a privileged ‘core’. Researchers in this field argue that unusual constructions shed light on more general issues, and can illuminate what is required for a complete account of (...) language. (shrink)

In response to a global population with increasingly complex issues at the end of life, a movement in the U.S. has emerged incorporating doulas into end-of-life care. These end-of-life (EOL) doulas are not just focused on the quality of life, but also the quality of death. Like birth doulas, who provide support for pregnant patients and their families, EOL doulas help alleviate physical and mental discomfort in those who are dying. In this paper, we explore the role of EOL doulas (...) in improving the care of unrepresented patients, who lack decision-making capacity and have no surrogates or documents to guide their healthcare decisions. We argue that EOL doulas may help this traditionally underserved population experience a “good death” by answering several ethical and procedural challenges. As quasi-independent, non-medical members of the healthcare team, they provide a balancing, advocating voice on behalf of the patient, and may also help reduce inappropriate treatment, delays in care, and the overburdening of the public guardianship system. As such, attention should be given to formally defining their place within the healthcare infrastructure. Ultimately, we contend that EOL doulas are key to ensuring optimal, ethical care for unrepresented patient populations. (shrink)

In two experiments, participants had to choose between a sure and a risky option. The sure option was presented either in a gain or a loss frame. Need was defined as a minimum score the participants had to reach. Moreover, choices were made under two different time constraints and with three different levels of induced need to be reached within a fixed number of trials. The two experiments differed with respect to the specific amounts to win and the need levels. (...) The $$2 \times 2 \times 3$$2×2×3 design was a within-subject design. Data were evaluated on an overall and on a group level, the latter based on participants’ stated risk preference and on revealed preferences using cluster analysis across subjects. Overall, the results showed riskier behavior when the choice options were presented as losses as compared to gains and when the induced need was highest. Time limits enhanced the framing effect. (shrink)

The Eurotransplant Kidney Allocation System (ETKAS) emerged from the XCOMB model by Wujciak and Opelz (1993a,b), who applied computer simulation studies to create an allocation algorithm. The present study investigated how experts would allocate a donated organ to patients on the waiting list with respect to the five allocation factors proposed in the ETKAS (number of mismatches, mismatch probability, waiting time, distance, international exchange balance). The experts’ evaluations were compared to the ETKAS points as well as to factor weights established (...) in mandatory allocation guidelines which are based on the German law for organ allocation (Transplantationsgesetz). The investigation was carried out using a conjoint analysis. Overall, the results indicate a fairly high degree of agreement between the experts’ opinions and the existing allocation system ETKAS and even more so for the allocation guidelines, in particular, with respect to the factors Mismatches, Mismatch probability, and Waiting time. (shrink)

This book examines Latina/o college student leadership and leadership development in higher education. Lozano analyzes emerging frameworks, empirical research, leadership models, essays, and promising practices to provide insight into how Latina/o students experience and promote leadership in higher education.

This study aims at discussing Global Business Citizenship Experiments (GBCE) as adaptation and selection mechanisms in organizations. GBCE are processes used by companies operating abroad to deal with discrepancies between their own principles and values and local norms, or the lack of them. I argue that these processes lead to adaptation of the individual companies to their environment, and to the evolution of organizational forms in the population.