While innovations in modern microscopy, spectroscopy, and nanoscopy techniques have made single molecule observation a standard in many laboratories, the actual design of meaningful fluorescence reporter systems now hinders major scientific breakthroughs. Even though the field of chemical biology is supercharging the fluorescence toolbox, surprisingly few strategies exist that make the transition from model systems to biologically relevant applications. At the same time, the number of microscopy techniques is growing dramatically. We explain our view on how the impact of modern (...) technologies is influenced not only by further hard‐ and software developments, but also by the availability and suitability of protein‐engineering tools. We identify how the largely independent research fields of chemical biology and fluorescence nanoscopy can influence each other to synergistically drive future technology that can visualize the localization, structure, and dynamics of molecular function without constraints. (shrink)

These CQ Sources were compiled by Bette Anton, Edward M. Spencer, Ann E. Mills, and Carlton Hegwood Jr.

Objective: Ethical guidelines are designed to ensure benefits, protection and respect of participants in clinical research. Clinical trials must now be registered on open-access databases and provide details on ethical considerations. This systematic survey aimed to determine the extent to which recently registered clinical trials report the use of standard of care and post-trial obligations in trial registries, and whether trial characteristics vary according to setting. Methods: We selected global randomized trials registered on http://www.clinicaltrials.gov and http://www.controlled-trials.com. We searched for intervention (...) trials of HIV/AIDS, malaria, and tuberculosis from 9 October 2004, the date of the most recent version of the Helsinki Declaration, to 10 April 2007. Results: We collected data from 312 trials. Fifty-eight percent (58%, 95% CI = 53 to 64) of trial protocols report informed consent. Fifty-eight percent (58%, 95% CI = 53 to 64) of trials report active controls. Almost no trials (1%, 95% CI = 0.5 to 3) mention post-trial provisions. Most trials measure surrogate outcomes. Twenty percent (20%, 95% CI = 16 to 25) of trials measure patient-important outcomes, such as death; and the odds that these outcomes are in a low income country are five times greater than for a developed country (odds ratio (OR) 5.03, 95% CI = 2.70 to 9.35, p = < 0.001). Pharmaceutical companies are involved in 28% (CI = 23 to 33) of trials and measure surrogate outcomes more often than nonpharmaceutical companies (OR 2.45, 95% CI = 1.18 to 5.09, p = 0.31). Conclusion: We found a large discrepancy in the quality of reporting and approaches used in trials in developing settings compared to wealthier settings. (shrink)

How should we live? What really exists? And how do we know for sure? In this lively and engaging study, Edward Craig argues that learning philosophy is merely a matter of broadening and deepening what most of us do already. But he also shows that philosophy is no mere intellectual pastime: thinkers such as Plato, the Buddhist sages, Descartes, Hobbes, Hume, Hegel, Darwin, Mill, and de Beauvoir responded to real needs and events—and many of their concerns shape our daily (...) lives. (shrink)

This study defines the relationship between humanism and liberalism by comparing the two Victorian figures who were most concerned with the preservation of humanistic values in a free and democratic society: Matthew Arnold and John Stuart Mill. The book sets apart Arnold and Mill from their contemporaries and points out their similarities to one another in discussions of their theories of history, poetry, their celebration of the contemplative life and their willingness to welcome democracy. At the same time it examines (...) the differences between the two men, which he uses to create a dialogue between humanism and liberalism on the question of how a high cultural ideal can be realized in democratic society. (shrink)

Until the time of Karl Marx and John Stuart Mill, philosophers generally held economics to be an integral element of moral philosophy. These days, the language of values—moral, aesthetic, and cognitive—dominates philosophic discourse, even though contemporary philosophers rarely hold economics to be integral to moral philosophy. Examining the thought of Friedrich Nietzsche and the art of Marcel Proust, Edward Andrew provides the first sustained critical analysis of values discourse, an analysis that deconstructs its content and its form.

Two unique aspects of spinoza's theory of freedom of expression are explored in depth-Its articulation of a positive liberty of expression, And the distinction it draws between pure expressive acts and speech intended as action. Spinoza's theory is then applied to cases where speech causes harm. His theory is explicitly distinguished from that of mill, And it is concluded that his theory, Although not without faults, Avoids several difficulties of other liberal theories.

The traditional view of tax holds that consumption taxes fail tax the yield to capital, whereas income taxes do, leading to John Stuart Mill's criticism of the income tax as a "double tax" on wealth that is saved. A better analytic understanding illustrates that there are two types of consumption taxes. A prepaid consumption or (equivalently) wage tax indeed ignores the yield to capital. But a consistent progressive postpaid consumption tax gets at such yield, at the individual level, when but (...) only when the returns to capital are used to elevate lifestyles in material terms. Such a tax allows "ordinary" savings that move around labor earnings, in constant dollar terms, to different periods of an individual's life, such as times of retirement or heightened medical or educational needs. Because a progressive postpaid consumption tax falls on the yield to capital at the right time-when its use at the individual level becomes manifest-all other taxes on capital, such as capital gains, gift and estate, and corporate income taxes, can and should be repealed, in the name of fairness. Footnotesa I thank the editors, my research assistants Alex Baskin and Nina Kang, and the other contributors to this volume for their helpful comments. (shrink)

The explosion of publications on race, gender, and minority cultures during recent decades was a natural reaction to the universalistic pretensions of Western philosophy, for which many of these issues were invisible. The theoretical articulation of these issues has substantially contributed to the transformation of philosophy. However, the side-effect of an overemphasis on difference is an underestimating of unity, which may lead to disintegration. The challenge to philosophical thought on race, gender, and culture is to reconcile the difference with commonality, (...) and diversity with unity. This essay explores the issues of cultural identity and intercultural relations and their interpretation in African-Caribbean thought. The first part of the essay surveys the current debate over multiculturalism, which promotes diversity but overlooks the interrelations of cultures, and the alternative ideas of interculturality or the dialogue of cultures. Thedissatisfaction with multiculturalism and postmodern relativism stimulated alternative approaches, such as “transculture” and “intercultural philosophy”. Mikhail Epstein criticizes relativism from the perspective of “critical universalism” and develops the concept of “transculture”. Raúl Fornet-Betancourt’s project of the intercultural transformation of philosophy asserts the cultural embedding of philosophical thinking and draws attention to the indigenous and African thought. The second half of the essay focuses on the ideas of identity and interculturality as they are expressed in African-Caribbean philosophy. This philosophy is viewed as a part of Africana philosophy. Various theoretical approaches to the issues of race and culture are examined: Charles Mills’ concept of “racial contract”, Lewis Gordon’s “Africana philosophy of existence”, and Paget Henry’s project of Africana philosophy, which combines the existentialphenomenological approach with analysis of the discursive formations in search for the identity of this philosophy. The analysis shows that in the evolution of African-Caribbean philosophy, as in Latin American and other “Third World philosophies”, the initial focus on the search for identity is followed by more interest in dialogical relationships with other philosophies as a condition for its own development. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

I propose a broad concept of happiness as an ultimate moral goal that is consistent with what reflective people desire and what people generally approve. Broad happiness includes many and various pleasures, a minimum of pain, a predominately active life and awareness of what can be attained. Besides these characteristics, which are found in Mill, I add that mental and physical faculties must be developed in accord with biological potential, people must be able to choose activities that exercise their developed (...) faculties and must be able to achieve many of the goals toward which their activities aim. This claim can be established by considering scientific data and analyzing what moralists usually approve. According to it, intellectual activities will be found to be the most important aspects of happiness.My concept will differ from Mill’s in that I reject the notion that happiness is synonymous with pleasure and the absence of pain, although both are part of happiness. Because Mill adopted this definition, his theory produced many anomalies. For example, in order to maintain that intellectual activities are morally superior, Mill was led to introduce qualities of pleasure. This maneuver is inconsistent with his empiricism. Moreover, the activities that are most approved from a moral point of view cannot be explained by the pleasure principle. The broad concept of happiness can account for the primacy of intellectual activities and those activities that are most often morally approved. (shrink)

I propose a broad concept of happiness as an ultimate moral goal that is consistent with what reflective people desire and what people generally approve. Broad happiness includes many and various pleasures, a minimum of pain, a predominately active life and awareness of what can be attained. Besides these characteristics, which are found in Mill, I add that mental and physical faculties must be developed in accord with biological potential, people must be able to choose activities that exercise their developed (...) faculties and must be able to achieve many of the goals toward which their activities aim. This claim can be established by considering scientific data and analyzing what moralists usually approve. According to it, intellectual activities will be found to be the most important aspects of happiness.My concept will differ from Mill’s in that I reject the notion that happiness is synonymous with pleasure and the absence of pain, although both are part of happiness. Because Mill adopted this definition, his theory produced many anomalies. For example, in order to maintain that intellectual activities are morally superior, Mill was led to introduce qualities of pleasure. This maneuver is inconsistent with his empiricism. Moreover, the activities that are most approved from a moral point of view cannot be explained by the pleasure principle. The broad concept of happiness can account for the primacy of intellectual activities and those activities that are most often morally approved. (shrink)

HAMILTON WORRIED THAT THERE WERE REPRESENTATIVE ELEMENTS\nIN REID'S EPISTEMOLOGY, WHILE J S MILL FLATLY CHARACTERIZED\nTHE SCOT AS A REPRESENTATIVE REALIST. I ARGUE THAT HAMILTON\nAND MILL WERE MISTAKEN AND THAT THEIR MISTAKES AROSE FROM\nAN INSUFFICIENT UNDERSTANDING AND APPRECIATION OF THE\nNATIVISTIC ELEMENTS OF THE UNDERSTANDING INTRODUCED BY\nREID; AND TO INSUFFICIENT AWARENESS OF REID'S\nCHARACTERIZATION OF PERCEPTION AS ACTIVE IN CONTRAST TO\nBRITISH EMPIRICIST RELIANCE ON A PASSIVELY GIVEN EPISTEMIC\nBASE. REID REJECTED EVERY VARIETY OF THE "MESSENGER"\nTHEORY.

Mill predicted that “[t]he Liberty is likely to survive longer than anything else that I have written … because the conjunction of [Harriet Taylor’s] mind with mine has rendered it a kind of philosophic text-book of a single truth, which the changes progressively taking place in modern society tend to bring out in ever greater relief.” Indeed, _On Liberty_ is one of the most influential books ever written, and remains a foundational document for the understanding of vital political, philosophical and (...) social issues. In addition to its many useful appendices, this new edition includes a chronology, bibliography, and a substantial introduction which outlines Mill’s life and works, and sets this central work of 1859 in the context of both his own intellectual development and of the play of ideas and political forces in Victorian society. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Strange Death of British IdealismEdward SkidelskyIIn 1958, the Oxford philosopher G. J. Warnock opened his survey of twentieth-century English philosophy with some disparaging comments on British Idealism. It was, he writes, "an exotic in the English scene, the product of a quite recent revolution in ways of thought due primarily to German influences." Analytic philosophy, by contrast, represents a return to the venerable lineage of British empiricism, as (...) Bertrand Russell "symbolically joins hands" with his godfather John Stuart Mill. "Hume and Berkley would have been sadly puzzled by the pages of Bradley, to say nothing of Hegel's. But either might have conversed quite naturally with Moore, and with Russell too, at least in his less technical moments."1All this is rhetoric rather than history. Russell can be called the inheritor of Mill only with respect to his political and social attitudes; his main philosophical endeavour—the establishment of mathematics on a priori foundations—ran diametrically opposed to Mill. And Hume and Berkley would have been just as sadly puzzled by Moore's analysis of language—an activity they both regarded as the defining vice of scholasticism—as by anything in Bradley.Warnock's error has proved remarkably persistent. Only recently, thanks largely to the work of Peter Hylton, has the anti-empiricist, Platonist character of Russell's early thought been properly appreciated.2 I do not intend, in what follows, to retrace these philosophical arguments. My question is historical. It concerns the role of national feeling, first in the demise of Idealism after the First World War, and later in the interpretation of that demise after the Second. With regard to first question, I argue that the rejection of Idealism in Britain was in no sense [End Page 41] a reassertion of national tradition. The opposite is closer to the truth; the change in philosophical fashion was primarily a consequence of a widespread revulsion against nationalism following World War I. That this was later misinterpreted owes largely—and this is my second claim—to the very different climate prevailing in Britain after World War II. If in the twenties the British reserved their scorn for "Prussian militarism," in the fifties everything associated with Germany, its philosophy included, was viewed as irredeemably tainted. Analytic philosophy tried to present itself as a home-grown product, with deep roots in the English empiricist tradition. This partly accounts for the change in style from the highly technical scientism of Russell and the logical positivists to the concern with "ordinary language" characteristic of post-war Oxford philosophy. The fact that most of analytic philosophy's continental exponents were forced by Hitler into British or American exile assisted in the process of its naturalisation. Within a decade, it was possible to regard "analytic" and "Anglo-Saxon" philosophy as synonyms.Warnock's mistake now becomes easier to understand. He has interpreted the early twentieth century in the light of the post-war period, coming to the conclusion that Moore and Russell's rejection of Idealism was a reassertion of English national tradition. He has condensed fifty years of history into a single moment. I intend in what follows to pull apart the stages that Warnock has concertinaed together, demonstrating that national feeling played a far more complex and contradictory role in the history of British philosophy.IIOn one point Warnock is correct: Idealism did not perish of refutation. "Metaphysical systems do not yield...," he writes, "to frontal attack. Their odd property of being demonstrable only, so to speak, from within confers on them also a high resistance to attack from outside.... Such systems are much more vulnerable to ennui than to disproof" (Warnock, pp. 10–11). The claim of Russell and Moore to have "refuted" Bradley is regarded with scepticism by most recent commentators. Idealism, they point out, rested on something more substantial than a mere failure of logic or common-sense, and was therefore not vulnerable to the kind of simple knock-down arguments advanced by Russell and Moore. The causes of its decline must be sought elsewhere, in the broader cultural and political tendencies of the age.Had Russell and Moore's arguments been truly knock-down... (shrink)

Rolling Stones guitarist Keith Richards has argued that rock and roll happens from the neck down. In this contribution to The Rolling Stones and Philosophy, edited by Luke Dick and George Reisch, I draw on neuroscience to argue that, in the parlance of John Stuart Mill, rock and roll is both a higher and a lower pleasure.

Formulations of Mill's principle of utility are examined, and it is shown that Mill did not recognize a moral obligation to maximize the good, as is often assumed. His was neither a maximizing act nor rule utilitarianism. It was a distinctive minimizing utilitarianism which morally obligates us only to abstain from inflicting harm, to prevent harm, to provide for others minimal essentials of well being (to which rights correspond), and to be occasionally charitable or benevolent.

Modern bioethics is clearly dominated by deontologists who believe that we have some way of identifying morally correct and incorrect acts or rules besides taking account of their consequences. Robert M. Veatch is one of the most outspoken of those numerous modern medical ethicists who agree in rejecting all forms of teleological, utilitarian, or consequentialist ethical theories. This paper examines his critique of utilitarianism and shows that the utilitarianism of John Stuart Mill is either not touched at all by his (...) critique or can be defended against it. This article argues that the dominant deontological majority is mistaken and that a utilitarian theory of moral action very much like Mill’s is precisely what is needed by modern medical ethics and by those medical practitioners who are resolved to practice medicine in a reasonable and morally acceptable manner. (shrink)

Jean Gagnier’s De vita, et rebus gestis Mohammedis was the first substantial biography of the Prophet Muhammad translated by a European author directly from an authentic Muslim source. Familiar to Edward Gibbon and Voltaire, Gagnier’s work significantly shaped European understandings of the origins of Islam well into the nineteenth century. Yet Gagnier’s scholarship has not been examined in any depth since it was closely read by his contemporaries. This article provides an analysis of Gagnier’s strategies and competencies as a (...) translator and reconstructs his attempt to exploit the Arabic manuscripts then available to an Oxford scholar. It argues that the case of Gagnier is a cautionary reminder that philological approaches to the study of the Muslim past did not necessarily occasion sympathy for Islam. Old prejudices continued to influence Gagnier’s decisions as a translator and were passed on in new forms to later readers. Moreover, aspects of the Muslim historiographical tradition discovered by Gagnier did not necessarily incline his readers to a more positive view of Islam. The increased accessibility of Islamic historical texts could just as easily serve the Christian polemicist as the Enlightened historian. (shrink)

Traditional hedonists like Epicurus, Bentham and Sidgwick were quantitative hedonists who assumed that pleasures and pains differ, not just from each other, but also from other pleasures and pains only in such quantitatively measurable ways as intensity, duration, and nearness or remoteness in time. They also differ with respect to their sources or causes. John Stuart Mill introduced an interesting and important complication into the modern theory of hedonism by insisting that pleasures also differ qualitatively as well as quantitatively. This (...) article thoroughly and critically examines Mill’s attempt to explain what qualitative differences might mean, and it proposes, defends, and extends a plausible theory of qualitative differences. (shrink)

Dr. Lacewing’s paper is a very interesting one. We agree in part, but only in part. Lacewing (2012) rejects the general thesis that “causal inferences must always be justified on the basis of Mill’s canons” (p. 199). I agree, but so does his target, Adolf Grünbaum, as we shall see in a moment. But first there is a question about Grünbaum’s alleged reliance on Mill’s Methods of Agreement and Difference. This interpretation may not make a difference to Lacewing’s arguments, but (...) it is worth correcting, given that some philosophers criticize both methods and yet their criticisms have no direct bearing on any of Grünbaum’s arguments. When Grünbaum speaks of “Millian methods,” he is not necessarily talking .. (shrink)

Contemporary Perspectives on the History of Philosophy was first published in 1983. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions. The authors of the 27 appears in Volume 8, Midwest Studies in Philosophy,have established reputations as historians of philosophy, but their vantage point, here, is from "contemporary perspectives" - they use contemporary analytic skills to examine problems and issues considered by past philosophers. The (...) papers, arranged in historical order, fall into six groups: ancient philosophy (the Pythagoreans, Plato, and Aristotle); the seventeenth-century rationalists (Descartes, Leibniz and Spinoza); the empiricists (Locke, Berkeley, and Hume); Kant; the nineteenth century (Hegel, Schopenhauer, and Mill); and, in conclusion, an essay on Wittgenstein's Tractatus and two broad, retrospective papers entitled "Old Analyses of the Physical World and new Philosophies of Language" and "Moral Crisis and the History of Ethics.". (shrink)

The latter half of nineteenth-century England was rife with the evolution question. As English imperialism also reached its pinnacle during this time, racial gradations and superiority of the white race in the newly formed human chain loomed large culturally. In 1849, Thomas Carlyle anonymously published his anti-emancipationist perspective in “The Occasional Discourse on the Negro Question,” followed by John Stuart Mill’s divergent response to him in 1850 titled, “The Negro Question.” In 1878, The Westminster Review also published a woman’s perspective, (...) “The Importance of Race and Its Bearing on the Negro Question” by Alice Bodington, which resembled the Carlyle essay in various ways. Although Mill’s essay was a direct attack on Carlyle’s explosive article and is overtly against Carlyle and Bodington’s ideas, this paper argues that an imperialist agenda underlies Mill’s views and in fact poses the same theories of Carlyle and Bodington. The paper first proceeds to interrogate Mill’s hegemonic subtext through a comparison of these three essays by situating them within the scientific discourse of the era, arguing that science, especially phrenology and evolution theories, didn’t exist in a vacuum, but was used to perpetrate the normative racial ideologies of the period. The paper also uses Edward Said’s theory of ‘Othering the Orient’ in Culture and Imperialism to show that while Mill seemingly diverges from Carlyle’s stance, this ‘othering’ is in fact present in all three writers’ works. (shrink)

Reissued here in its corrected second edition of 1864, this essay by John Stuart Mill argues for a utilitarian theory of morality. Originally printed as a series of three articles in Fraser's Magazine in 1861, the work sought to refine the 'greatest happiness' principle that had been championed by Jeremy Bentham, defending it from common criticisms, and offering a justification of its validity. Following Bentham, Mill holds that actions can be judged as right or wrong depending on whether they promote (...) happiness or 'the reverse of happiness'. Although attracted by Bentham's consequentialist framework based on empirical evidence rather than intuition, Mill separates happiness into 'higher' and 'lower' pleasures, arguing for a weighted system of measurement when making and judging decisions. Dissected and debated since its first appearance, the essay is Mill's key discussion on the topic and remains a fundamental text in the study of ethics. (shrink)

Virtually all the earlier critics — including Sidgwick and the Oxford Idealists — thought J. S. Mill’s arguments for qualities of pleasure and their ranking unacceptable. More recently there has been something of a reversal of this opinion, with commentators such as Skorupski, Donner, Berger and Wilson supporting Mill, and other writers, such as Edwards and Sprigge, arguing that qualitative hedonism is plausible. This paper reconsiders some of the arguments of F.H. Bradley and other earlier critics who dismissed Mill’s quantity-quality (...) distinction. (shrink)

This volume of The Subjection of Women provides a reliable text in an inexpensive edition, with explanatory notes but no additional editorial apparatus. -/- .

In this work, Mill reflects on the struggle between liberty and authority and defends the view that “the only purpose for which power can be rightfully exercised over any member of a civilized community, against his will, is to prevent harm to others.” He questions the justification for the limits of freedom of conscience and religion, freedom of speech, freedom of action, and the nature of liberalism itself. This new Broadview Edition demonstrates the ways in which Mill’s intellectual landscape differed (...) markedly from our own, while also drawing attention to the reasons why the work remains relevant and essential reading in the present day. Appendices include antecedents to Mill’s work, critical discussions by his contemporaries, and related writings by Mill. Please note: Broadview offers two separate editions of On Liberty. The Kahn edition is particularly relevant to readers who are interested in how the work is situated in the history of political philosophy, whereas the Alexander edition is recommended to those most interested in the work’s Victorian literary and social contexts. (shrink)

John Stuart Mill's Utilitarianism is one of the most important, controversial, and suggestive works of moral philosophy ever written. Mill defends the view that all human action should produce the greatest happiness overall, and that happiness itself is to be understood as consisting in "higher" and "lower" pleasures. This volume uses the 1871 edition of the text, the last to be published in Mill's lifetime. The text is preceded by a comprehensive introduction assessing Mill's philosophy and the alternatives to utilitarianism, (...) and discussing some of the specific issues Mill raises in Utilitarianism. (shrink)

A foundational text in modern empiricist method, published in 1843 by Victorian England's foremost philosopher of political and social life.