The complete sequencing of the genome of the fruit fly Drosophila melanogaster offers the prospect of detailed functional analysis of the extensive gene families in this genetic model organism. Comprehensive functional analysis of family members is facilitated by access to a robust, stable and inducible expression system in a fly cell line. Here we show how the Schneider S2 cell line, derived from the Drosophila embryo, provides such an expression system, with the bonus that radioligand binding studies, second messenger assays, (...) ion imaging, patch‐clamp electrophysiology and gene silencing can readily be applied. Drosophila is also ideal for the study of new control strategies for insect pests since the receptors and ion channels that many new animal health drugs and crop protection chemicals target can be expressed in this cell line. In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines. BioEssays 24:1066–1073, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

Throughout the scientific age it has been increasingly realised that the path to knowledge is through carefully-controlled experimentation. Medicine must never, however, treat human beings as objects, or as the means to achieving increased knowledge. Ultimately the goal of human evolution will be served by the willing collaboration of members of society in the advancement of knowledge through carefully planned experimentation. As of now, however, many safeguards must be built into the system to ensure that no exploitation occurs. Experimenters are (...) charged with the task of designing the most ingenious experiments, to give maximum information with a minimum of trauma and always to ensure the fully informed consent of the participants. This paper was read to a conference on human rights in relation to forensic science organised by Centro Internazionale di Richerche e Studi Penale e Penitanziari, in cooperation with UNESCO, held in Messina, Italy, in March 1980. (shrink)

The fourteen authors in this collection used phenomenology and hermeneutics to conduct deep inquiry into perplexing and wondrous events in their work and personal lives. These seasoned scholar-practitioners gained remarkable insight into areas such as health care and illness, organ donation, intercultural communications, high-performance teams, artistic production, jazz improvisation, and the integration of Tai Chi into education. All authors were transformed by phenomenology's expanded ways of seeing and being.

Paul Ricoeur and Jacques Derrida agree that translation is a tensive activity oscillating between the possible and the impossible with reference to the transposition of meaning among diverse systems of discourse. Both acknowledge that risk, alterity, and plurality accompany every attempt at paraphrasing language “in other words.” Consequently, their positions adhere to the traditional adage that “the translator is a traitor,” precisely because something is always lost in the semantic transfer. Yet, Derrida notes an important disagreement between their respective approaches (...) to translation and accuses Ricoeur of harboring a nostalgia for unitive meaning and of promoting the possibility of a transcendental signified that could produce a “pure” translation. In this essay, I critique Derrida’s interpretation of Ricoeur specifically by examining their individual interpretations of the Tower of Babel myth. I argue that Ricoeur’s theory of Babel as a non-punitive celebration of diversity and the open play of meaning “out-deconstructs” Derrida’s own notion of dissemination. (shrink)

We present Woodin's proof that if there exists a measurable Woodin cardinal δ, then there is a forcing extension satisfying all $\Sigma _{2}^{2}$ sentences ϕ such that CH + ϕ holds in a forcing extension of V by a partial order in V δ . We also use some of the techniques from this proof to show that if there exists a stationary limit of stationary limits of Woodin cardinals, then in a homogeneous forcing extension there is an elementary embedding (...) j: V → M with critical point $\omega _{1}^{V}$ such that M is countably closed in the forcing extension. (shrink)

Clambering down slippery rocks to a swimming hole. Ducking the plume of smoke from a barbecue grill. Wishing for a breeze in a too-small dome tent. Scanning the sky for rain from a postage-stamp backyard. It is in these small moments of action—and inaction—that Justin Kimball captures our everyday attempts to relax. Indeed, one might argue that the events depicted are everyday life. Kimball’s compelling photographs depict ordinary people—parents and teens, grandparents and kids—in landscapes of leisure. These are not the (...) exclusive resorts and white sand beaches of the affluent; rather, they are the parks, campgrounds, and fishing piers where most Americans vacation. They are natural landscapes—inviting, green, and sometimes beautiful—but at the same time they are imperfect—muddy, crowded, and partially paved. There is nothing idyllic about these vacation spots; indeed, Kimball’s photographs make clear that daily life can never be fully left behind. The people in his pictures, though momentarily transformed by cascading water or the shade of towering trees, remain enmeshed in ties of family and obligation, shadowed by thoughts of home. It is Kimball’s particular genius to isolate these moments between duty and pleasure. Where We Find Ourselves enables viewers to identify with—and participate in—this bittersweet aspect of American leisure and the ambiguous contemporary relationship between people and nature. (shrink)

Why is a Reformational philosophy needed in Africa? It is necessary, because something is missing in African Christianity. Most Western missionaries taught Africans a “broken” or dualistic worldview. This caused a divorce between traditional culture and their new Christian religion. The Christian faith was perceived as something remote, only concerned with a distant past and a far-away future . It could not become a reality in their everyday lives. It could not develop into an all-encompassing worldview and lifestyle. Because Reformational (...) philosophy advocates the Biblical, holistic approach of a comprehensive worldview, it is welcomed on our continent. It contains a healing and liberating message to our bleeding and lost continent. What Africans, however, neither want nor can afford, is an ivory tower philosophy, playing intellectual games; a philosophy which does not do or change anything. They want a philosophy which is a “marriage” between abstract ideas and the facts on the ground. They need a Christian philosophy with compassion that may even contribute to the alleviation of their poverty! (shrink)

Using a new model focused on four core capacities-intellectual complexity, social location, empathetic accountability, and motivated action--Teaching Civic Engagement explores the significance of religious studies in fostering a vibrant, just, and democratic civic order.In the first section of the book, contributors detail this theoretical model and offer an initial application to the sources and methods that already define much teaching in the disciplines of religious studies and theology. A second section offers chapters focused on specific strategies for teaching civic engagement (...) in religion classrooms, including traditional textual studies, reflective writing, community-based learning, field trips, media analysis, ethnographic methods, direct community engagement and a reflective practice of "ascetic withdrawal." The final section of the volume explores theoretical issues, including the delimitation of the "civic" as a category, connections between local and global in the civic project, the question of political advocacy in the classroom, and the role of normative commitments.Collectively these chapters illustrate the real possibility of connecting the scholarly study of religion with the societies in which we, our students, and our institutions exist. The contributing authors model new ways of engaging questions of civic belonging and social activism in the religion classroom, belying the stereotype of the ivory tower intellectual. (shrink)

This article explores humanism in the context of the Tower of Babel.

We show that Hechler’s forcings for adding a tower and for adding a mad family can be represented as finite support iterations of Mathias forcings with respect to filters and that these filters are $${\mathcal {B}}$$ B -Canjar for any countably directed unbounded family $${\mathcal {B}}$$ B of the ground model. In particular, they preserve the unboundedness of any unbounded scale of the ground model. Moreover, we show that $${\mathfrak {b}}=\omega _1$$ b = ω 1 in every extension by the (...) above forcing notions. (shrink)

Exploring the putative role of nature in human well-being has typically been operationalized and measured within a quantitative paradigm of research. However, such approaches are limited in the extent to which they can capture the full range of how natural experiences support well-being. The aim of the study was to explore personal experiences in nature and consider how they might be important to human health and well-being. Based on a descriptive phenomenological analysis of fifty descriptions of memorable moments in nature (...) from England, Indonesia, and Norway, our findings illustrate a common structure presented under three themes: 1. serenity that gives rise to a growing awareness of how the body is stimulated by the senses; 2. admiration and appreciation for the sensation of beauty; 3. an emerging sense of togetherness and deep emotional bonding. The findings are discussed using the concepts of ecological time and the ecological body, which foreground being in nature as constituted as an interdependent and dynamic human process. We conclude by understanding well-being in terms of human responsiveness to their surroundings and thus as rooted in the human condition. (shrink)

Originally published in 1910, this book attempts to describe knowledge from the point of view of a philosophical psychology. Wodehouse treats the text as a 'psychological preface to metaphysics', and splits her examination into three sections: knowledge as resulting from judgements in the actual world; the philosophical problem of fallible knowledge; and the question of imagination and 'the variousness of reality'. This book will be of value to anyone with an interest in Wodehouse's work or in the overlap of psychology (...) and philosophy. (shrink)

The New Evil Demon problem has been hotly debated since the case was introduced in the early 1980’s (e.g. Lehrer and Cohen 1983; Cohen 1984), and there seems to be recent increased interest in the topic. In a forthcoming collection of papers on the New Evil Demon problem (Dutant and Dorsch, forthcoming), at least two of the papers, both by prominent epistemologists, attempt to resist the problem by appealing to the distinction between justification and excuses. My primary aim here is (...) to critically evaluate this new excuse maneuver as a response to the New Evil Demon problem. -/- Their response attempts to give us reason to reject the idea that victims of the New Evil Demon have justification for believing as they do. I shall argue that this approach is ultimately unsuccessful, however much of value can be learned from these attempts. In particular, progress in the debate can be made by following those who advance the excuse maneuver and make explicit the connection between epistemic justification and epistemic norms. By doing so, the questions being debated are clarified, as is the methodology being used to attempt to answer them. (shrink)

There are various equivalent formulations of the Church-Turing thesis. A common one is that every effective computation can be carried out by a Turing machine. The Church-Turing thesis is often misunderstood, particularly in recent writing in the philosophy of mind.

Genetic analysis of Drosophil has provided evidence in support of two proposed evolutionary genetic mechanisms of aging: mutation accumulation and antagonistic pleiotropy. Both mechanisms result from the lack of natural selection acting on old organisms. Analyses of large numbers of flies have revealed that mortality rates do not continue to rise with age as previously thought, but plateau at advanced ages. This phenomenon has implications both for models and for definitions of aging, and may be explained by the evolutionary theories. (...) The physiological processes and genes most relevant to aging are being identified using Drosophila lines selected in the laboratory for postponed senescence. Oxidative stress and insufficient metabolic reserves/capacity may be particularly important factors in limiting the fruitfly lifespan. Genes which exhibit aging‐related changes in expression are now being identified. Transgenic flies are being used to analyze the mechanisms of such aging‐related gene expression, and to test the effects of specific genes on aging and aging‐related deterioration. (shrink)

Outsider mission workers with local church communities, such as with the agency Latin Link, can have a role in the promotion of church and community-based income generation projects as a poverty reduction strategy and as a way of healthy community involvement generally. This is likely to involve a process of healthy community decision-making, some generic business training for potential project leaders and workers, and a microfinance scheme run with established guidelines. In this way, outside initiative promotes community development rather than (...) imposing unsuitable solutions from the outside. (shrink)