The now classical idea that programmed cell death contributes to a plethora of developmental processes still has lost nothing of its impact. It is, therefore, important to establish effective three-dimensional reconstruction as well as simulation techniques to decipher the exact patterns and functions of such apoptotic events. The present study focuses on the question whether and how apoptosis promotes neurulation-associated processes in the spinal cord of Tupaia belangeri. Our 3D reconstructions demonstrate that at least two craniocaudal waves of apoptosis consecutively (...) pass through the dorsal spinal cord. The first wave appears to be involved in neural fold fusion and/or in selection processes among premigratory neural crest cells. The second one seems to assist in establishing the dorsal signaling center known as the roof plate. In the hindbrain, in contrast, apoptosis among premigratory neural crest cells progresses craniocaudally but discontinuously, in a segment-specific manner. Unlike apoptosis in the spinal cord, these segment-specific apoptotic events, however, precede later ones that seemingly support neural fold fusion and/or postfusion remodeling. Arguing with Whitehead that biological patterns and rhythms differ in that biological rhythms depend “upon the differences involved in each exhibition of the pattern” we show that 3D reconstruction and simulation techniques can contribute to distinguish between patterns and rhythms of apoptosis. By deciphering novel patterns and rhythms of developmental apoptosis, our reconstructions help to reconcile seemingly inconsistent earlier findings in chick and mouse embryos, and to create rules for computer simulations. (shrink)

The mind-body problem is analyzed in a physicalist perspective. By combining the concepts of emergence and algorithmic information theory in a thought experiment employing a basic nonlinear process, it is argued that epistemically strongly emergent properties may develop in a physical system. A comparison with the significantly more complex neural network of the brain shows that also consciousness is epistemically emergent in a strong sense. Thus reductionist understanding of consciousness appears not possible; the mind-body problem does not have a reductionist (...) solution. The ontologically emergent character of consciousness is then identified from a combinatorial analysis relating to system limits set by quantum mechanics, implying that consciousness is fundamentally irreducible to low-level phenomena. In the perspective of a modified definition of free will, the character of the physical interactions of the brain's neural system is subsequently studied. As an ontologically open system, it is asserted that its future states are undeterminable in principle. We argue that this leads to freedom of the will. (shrink)

This paper is about time preferences, the phenomenon that the very same things are usually considered the less valuable the farther in the future they are obtained. The utilities of those things are discounted at a certain rate. The paper presents a novel normative argument for exponential discount rates, whatever their empirical adequacy. It proposes to take indexical utility seriously, i.e. utilities referring to indexical propositions (that speak of ‘I’, ‘now’, etc.) as opposed to non-indexical propositions. Economic focus is only (...) on the latter, while the former are neglected. The potential ignorance of when is now generates a difference between indexical and non-indexical utility that can be exploited for a novel argument in favour of exponential discount rates. (shrink)

The enduring problem of free will has defied resolution across centuries. There is reason to believe that novel factors must be integrated into the analysis to make progress. Within the current physicalist framework, these factors encompass emergence and information theory, in the context of constraints imposed by physical limits on the representation of information. Furthermore the common, but vague, characterization of free will as 'being able to act differently' is rephrased into an explicatum more suitable for formal analysis. It is (...) argued that the mind is an ontologically open system; a causal high-level system, the dynamics of which cannot be reduced to the states of its associated low-level neural systems, not even if it is rendered physically closed. A positive answer to the question of free will for conscious agents is subsequently outlined. (shrink)

The mind-body problem is analyzed in a physicalist perspective. By combining the concepts of emergence and algorithmic information theory in a thought experiment employing a basic nonlinear process, it is shown that epistemically strongly emergent properties may develop in a physical system. Turning to the significantly more complex neural network of the brain it is subsequently argued that consciousness is epistemically emergent. Thus reductionist understanding of consciousness appears not possible; the mind-body problem does not have a reductionist solution. The ontologically (...) emergent character of consciousness is then identified from a combinatorial analysis relating to universal limits set by quantum mechanics, implying that consciousness is fundamentally irreducible to low-level phenomena. (shrink)

The mind–body problem is analyzed in a physicalist perspective. By combining the concepts of emergence and algorithmic information theory in a thought experiment, employing a basic nonlinear process, it is shown that epistemologically emergent properties may develop in a physical system. Turning to the significantly more complex neural network of the brain it is subsequently argued that consciousness is epistemologically emergent. Thus reductionist understanding of consciousness appears not possible; the mind–body problem does not have a reductionist solution. The ontologically emergent (...) character of consciousness is then identified from a combinatorial analysis relating to universal limits set by quantum mechanics, implying that consciousness is fundamentally irreducible to low-level phenomena. (shrink)

Der Unterricht in Medizinethik soll Medizinstudierenden die Grundlagen dafür vermitteln, in ihrer zukünftigen ärztlichen Tätigkeit gute Entscheidungen treffen zu können. Im Rahmen einer Panelstudie wird derzeit die Entwicklung moralischer Positionen, medizinethischer Kenntnisse und Motivationen von Medizinstudierenden der Ludwig-Maximilians-Universität München über den Verlauf des Studiums untersucht. Für die Datenerhebung wurde ein Fragebogen entwickelt, der medizinethische Positionen und Kenntnisse sowie Motivationen erfasst. Im Wintersemester 2009/10 wurde die erste Querschnittsuntersuchung mit Studierenden im 1., 3. und 8. Semester sowie im Praktischen Jahr durchgeführt. Die (...) Mehrzahl der Befragten verfügte über einen geringen Kenntnisstand in verschiedenen Themenbereichen des Unterrichtsfachs GTE. Rechtliche Grundlagen und praktische Umsetzung von Therapiebegrenzungsmaßnahmen waren bis ins PJ-Semester vielen Studierenden nicht bekannt. Im Verlauf des Studiums veränderten sich die Motivationen weg von der Motivation, Menschen helfen zu wollen, hin zu Wissenserwerb und dem Ergreifen eines sicheren Berufs. Obwohl viele Befragte ein hohes Interesse an medizinethischen Fragestellungen und Unterricht im Bereich GTE angaben, zeigte sich kein nachhaltiger Zuwachs an medizinethischen Kenntnissen im Laufe des Studiums. In der Zusammenschau werfen die Ergebnisse die Frage auf, inwieweit verschiedene Ausbildungskonzepte Einfluss auf die individuelle ethische Entwicklung Medizinstudierender nehmen können. Eine Untersuchung dieser Fragestellung bleibt Gegenstand weitergehender Forschung. (shrink)

We propose an analysis of backward causation in terms of interventionism that can avoid several problems typically associated with backward causation. Its main advantage over other accounts is that it allows for reducing the problematic task of supporting backward causal claims to the unproblematic task of finding evidence for several ordinary forward directed causal hypotheses.

And this paper is an attempt to say precisely how, thus addressing a philosophical problem which is commonly taken to be a serious one. It does so, however, in quite an idiosyncratic way. It is based on the account of inductive schemes I have given in (1988) and (1990a) and on the conception of causation I have presented in (1980), (1983), and (1990b), and it intends to fill one of many gaps which have been left by these papers. Still, I (...) have tried to make this paper self-contained. Section 1 explains the philosophical question this paper is about; in more general terms it asks what might be meant by objectifying epistemic states or features of them and to which extent epistemic states can be objectified. The next sections introduce the basis I rely on with formal precision and some explanation; section 2 deals with induction and section 3 with causation. Within these confines, section 4 attempts to give an explication of the relevant sense of objectification and section 5 investigates the extent to which various features of epistemic states are objectifiable. The two most salient results are roughly that the relation "A is a reason for B" cannot be objectified at all and that the relation "A is a cause of B" can be objectified only under substantial, though reasonable restrictions. What has all of this to do with probability? A lot. The paper trades on a pervasive duality between probabilistic and deterministic epistemology, between a probabilistic representation of epistemic states together with a theory of probabilistic causation and another representation of epistemic states which I call deterministic because it lends itself, in a perfectly parallel fashion, to a theory of deterministic causation. Here I explicitly deal only with the deterministic side, but the duality should pave the way for further conclusions concerning objective probabilities and statistical laws. This outlook is briefly expanded in the final section 6. (shrink)

Concentrating upon applications that are most relevant to modern physics, this valuable book surveys variational principles and examines their relationship to dynamics and quantum theory. Stressing the history and theory of these mathematical concepts rather than the mechanics, the authors provide many insights into the development of quantum mechanics and present much hard-to-find material in a remarkably lucid, compact form. After summarizing the historical background from Pythagoras to Francis Bacon, Professors Yourgrau and Mandelstram cover Fermat's principle of least time, the (...) principle of least action of Maupertuis, development of this principle by Euler and Lagrange, and the equations of Lagrange and Hamilton. Equipped by this thorough preparation to treat variational principles in general, they proceed to derive Hamilton's principle, the Hamilton-Jacobi equation, and Hamilton's canonical equations. An investigation of electrodynamics in Hamiltonian form covers next, followed by a resume of variational principles in classical dynamics. The authors then launch into an analysis of their most significant topics: the relation between variational principles and wave mechanics, and the principles of Feynman and Schwinger in quantum mechanics. Two concluding chapters extend the discussion to hydrodynamics and natural philosophy. Professional physicists, mathematicians, and advanced students with a strong mathematical background will find this stimulating volume invaluable reading. Extremely popular in its hardcover edition, this volume will find even wider appreciation in its first fine inexpensive paperbound edition. (shrink)

Wolfgang Rudzio ist als Politikwissenschaftler bekannt, der eines der wichtigsten und erfolgreichsten Lehrbücher zur Politik in der Bundesrepublik Deutschland geschrieben hat. In seinen Erinnerungen gibt er uns einen spannenden Einblick in sein wissenschaftliches, politisches und privates Leben, seine Kindheit in Ostpreußen und seine Familie. Es waren Flucht, Nachkriegszeit, Studentenbewegung, eigenes linkes Polit-Engagement und die Herausforderung des Kommunismus, die das Leben des Autors prägten. Zeitweilig für bekannte Politiker wie Carlo Schmid und Hans Matthöfer arbeitend, entschied er sich nach Mathematik-Examen und (...) Promotion in Geschichte nicht für Politik, sondern Politikwissenschaft. Manche seiner Forschungen knüpften an Lebenserfahrungen an. (shrink)

Research Integrity (RI) is high on the agenda of both institutions and science policy. The European Union as well as national ministries of science have launched ambitious initiatives to combat misconduct and breaches of research integrity. Often, such initiatives entail attempts to regulate scientific behavior through guidelines that institutions and academic communities can use to more easily identify and deal with cases of misconduct. Rather than framing misconduct as a result of an information deficit, we instead conceptualize Questionable Research Practices (...) (QRPs) as attempts by researchers to reconcile epistemic and social forms of uncertainty in knowledge production. Drawing on previous literature, we define epistemic uncertainty as the inherent intellectual unpredictability of scientific inquiry, while social uncertainty arises from the human-made conditions for scientific work. Our core argument—developed on the basis of 30 focus group interviews with researchers across different fields and European countries—is that breaches of research integrity can be understood as attempts to loosen overly tight coupling between the two forms of uncertainty. Our analytical approach is not meant to relativize or excuse misconduct, but rather to offer a more fine-grained perspective on what exactly it is that researchers want to accomplish by engaging in it. Based on the analysis, we conclude by proposing some concrete ways in which institutions and academic communities could try to reconcile epistemic and social uncertainties on a more collective level, thereby reducing incentives for researchers to engage in misconduct. (shrink)

Seit seiner Jugend kritisierte Wolfgang Harich die Philosophie Nietzsches. In den funfziger Jahren verfestigte sich dann ein dezidiert marxistisches Nietzsche-Bild, das er Zeit seines Lebens verteidigte. Nietzsche war fur ihn der Wegbereiter, ja, Begrunder der faschistischen Ideologie. Indem Harich am sozialistischen und humanistischen Erbe des originaren Marxismus festhielt, loste er in den achtziger Jahren die Nietzsche-Debatte der DDR aus, die ihn im kulturellen und wissenschaftlichen Leben der DDR endgultig isolierte. Band 12 der Reihe prasentiert Harichs letztes grosses Werk, den (...) Dialog "Nietzsche und seine Bruder", sowie zahlreiche Dokumente, darunter auch Briefe an Erich Honecker, Willy Stoph, Kurt Hager oder Stephan Hermlin. (shrink)

Dieses Buch geht davon aus, dass eine moderne Hermeneutik als Theorie des Verstehens im begrifflichen Rahmen der gegenwärtigen Theorie des Geistes und der Semantik rekonstruiert werden sollte. Vor diesem theoretischen Hintergrund, der in einem eigenen Kapitel näher umrissen wird, soll die Geschichte der Hermeneutik neu gelesen werden. Dabei wird deutlich, dass diese Lesart vielfach neue historische Interpretationen zu entwickeln und die wichtigsten Stationen der Geschichte der Hermeneutik theoretisch auf neue Weise zu integrieren vermag. Über die hermeneutischen Positionen hinaus, die in (...) den bisherigen Gesamtdarstellungen auftauchen, werden auch Entwürfe diskutiert, die besonders unter geist-theoretischen Aspekten interessant sind, zum Beispiel die antike Hermeneutik, die Hermeneutik Max Webers, die Hermeneutik der logischen Empiristen und die naturalistische Hermeneutik. Vor allem aber wird belegt, dass die Geschichte der Hermeneutik teilweise zu großen Einsichten gelangt ist, an die eine moderne Hermeneutik anknüpfen kann. Das Buch wendet sich nicht nur an Spezialisten der Hermeneutik-Geschichte, sondern an alle Interessierten, denen das Schicksal der verstehenden Wissenschaften am Herzen liegt, und möchte ihnen eine Perspektive empfehlen, unter der sich der Status und die Autonomie der Geisteswissenschaften sowie ihr Bezug auf das Humane unter Heranziehung substantieller Theorien auf neue Weise würdigen lassen. (shrink)

Seit Ende der 40er Jahre setzte sich Wolfgang Harich intensiv mit naturwissenschaftlichen und anthropologischen Fragestellungen auseinander. Dabei ging er der Frage nach, ob der Marxismus eine eigenständige Lehre vom Menschen benötige. Um 1950 entstand dann der Kontakt zu Arnold Gehlen, die Brieffreundschaft der beiden hielt bis zum Tod Gehlens. Über alle weltanschaulichen Diskrepanzen hinweg korrespondierten sie über wissenschaftliche Fragen und in zunehmendem Maße auch über Privates. Der Band enthält nach drei einleitenden Aufsätzen und Manuskripten Harichs dessen erhaltene Briefe an (...) Arnold Gehlen. Außerdem werden seine weiteren Studien zur Anthropologie präsentiert. Abschließend wird dann sein Eintreten für Paul Alsberg vorgestellt. (shrink)

Alles dreht sich um Werte. Sie werden von Politikern herbeizitiert, gerne bekennt man sich zu ihnen? in der Konsumwelt, in der politischen Aktionskunst, beim Wohnen, beim Essen und im Fitnesskult. Wolfgang Ullrich nimmt die Karriere der Werte in verschiedenen Bereichen unter die Lupe. Seine These: Sich zu Werten zu bekennen ist so beliebt, weil es dem Selbstbewusstsein schmeichelt. Man darf sich dann moralisch gut und sogar kreativ fühlen. Ullrich untersucht, wie Werte im Einzelnen in Szene gesetzt werden. Aber er (...) fragt auch, wie sich gesellschaftspolitische Debatten unter diesen Vorzeichen entwickeln. (shrink)

Mind-body problemet analyseras i ett reduktionistiskt perspektiv. Genom att kombinera emergensbegreppet med algoritmisk informationsteori visas i ett tankeexperiment att ett starkt epistemiskt emergent system kan konstrueras utifrån en relativt enkel, ickelinjär process. En jämförelse med hjärnans avsevärt mer komplexa neurala nätverk visar att även medvetandet kan karakteriseras som starkt epistemiskt emergent. Därmed är reduktionistisk förståelse av medvetandet inte möjlig; mind-body problemet har alltså inte en reduktionistisk lösning. Medvetandets ontologiskt emergenta karaktär kan därefter konstateras utifrån en kombinatorisk analys; det är därmed (...) principiellt oreducerbart till lägre-nivå-fenomen. I perspektivet av en modifierad definition av fri vilja diskuteras den fysiska växelverkan som äger rum i hjärnans neurala system. Trots att enskilda neurala lägre-nivå-processer är deterministiska, kan globala processer visas vara icke- deterministiska i ontologisk mening. Vi argumenterar för att detta leder till viljans frihet. (shrink)

Wolfgang Greive würdigt in seinem Buch das Werk Wolfhart Pannenbergs (1928–2014) als einzigartige Denkleistung, die den christlichen Glauben in seinem Wahrheitsanspruch neu zur Geltung bringt. Dabei versteht er Pannenbergs Denken als Widerspruch zu postmodernen Auffassungen, in denen die Frage nach „Wahrheit“ als unproduktiv abgekanzelt. Die Wahrheitsfrage ist dann fruchtbar, wenn sie in ihrer radikalen Geschichtlichkeit bestimmt wird. Indem Pannenberg die grundlegenden Probleme von Philosophie und Theologie zueinander in Beziehung setzt, gibt er Antworten auf die großen Fragen der Menschheit: Woher (...) kommen wir? Wohin gehen wir? Wer sind wir? Worauf vertrauen wir? (shrink)

The Illusion of Control makes the case that people waste an inordinate amount of energy trying to control events and people that they have little or no control over.