Cat Wars is a dangerous book that declares war on all free-roaming cats. Filled with hyperbole and exaggerated statistics, the book argues that cats are a danger to humans, birds, and other free-living animals and should be eradicated from the landscape—a devastating, expensive, inhumane, and useless result. This review exposes the flaws in the authors’ analysis and ethical approach and redirects the dialogue toward an ethic that protects all animals. Compassionate conservationism promotes the use of nonlethal management strategies to protect (...) individual birds and other animals while compassionately reducing the number of free-roaming cats. (shrink)

Schaffner’s model of theory reduction has played an important role in philosophy of science and philosophy of biology. Here, the model is found to be problematic because of an internal tension. Indeed, standard antireductionist external criticisms concerning reduction functions and laws in biology do not provide a full picture of the limits of Schaffner’s model. However, despite the internal tension, his model usefully highlights the importance of regulative ideals associated with the search for derivational, and embedding, deductive relations (...) among mathematical structures in theoretical biology. A reconstructed Schaffnerian model could therefore shed light on mathematical theory development in the biological sciences and on the epistemology of mathematical practices more generally. *Received November 2006; revised March 2009. †To contact the author, please write to: Philosophy Department, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064; e‐mail: [email protected]. (shrink)

In this paper I consider Kenneth Schaffner''s(1998) rendition of ''''developmentalism'''' from the point of viewof bacteriophage biology. I argue that the fact that a viablephage can be produced from purified DNA and host cellularcomponents lends some support to the anti-developmentalist, ifthey first show that one can draw a principled distinctionbetween genetic and environmental effects. The existence ofhost-controlled phage host range restriction supports thedevelopmentalist''s insistence on the parity of DNA andenvironment. However, in the case of bacteriophage, thedevelopmentalist stands on less (...) firm ground than when organismswith nervous systems, such as Schaffner''s C. elegans, areconsidered. (shrink)

I claim that the Hodgkin‐Huxley (HH) current equations owe a great deal of their importance to their role in bringing results from experiments on squid giant action preparations to bear on the study of the action potential in other neurons in other in vitro and in vivo environments. I consider ideas from Weber and Craver about the role of Coulomb’s and other fundamental equations in explaining the action potential and in HH’s development of their equations. Also, I offer an embellishment (...) to Schaffner’s emergent unifier conception of the HH model. †To contact the author, please write to: Department of HPS, University of Pittsburgh, 1017 Cathedral of Learning, Pittsburgh, PA 15260; e‐mail: [email protected]. (shrink)

Kenneth Schaffner has argued that evolutionary theory, strictly understood, cannot support the functional ascriptions used in adaptational functional explanations. Although the causal ascription clause in these ascriptions is supported, the goal-ascription clause cannot be, since it imports anthropocentric features deriving from a vulgar understanding of evolutionary theory. I argue that an etiological interpretation of selectional explanations sanctions both the causal and goal-ascription clauses of functional ascriptions and provides a way to understand teleological explanation within evolutionary biology.

In their 2010 paper, Dizadji-Bahmani, Frigg, and Hartmann argue that the generalized version of the Nagel–Schaffner model that they have developed is the right one for intertheoretic reduction, i.e. the kind of reduction that involves theories with largely overlapping domains of application. Drawing on the GNS, DFH presented a Bayesian analysis of the confirmatory relation between the reducing theory and the reduced theory and argued that, post-reduction, evidence confirming the reducing theory also confirms the reduced theory and evidence confirming (...) the reduced theory also confirms the reducing theory, which meets the expectations one has about theories with largely overlapping domains. In this paper, I argue that the Bayesian analysis presented by DFH faces difficulties. In particular, I argue that the conditional probabilities that DFH introduce to model the bridge law entail consequences that run against the GNS. However, I also argue that, given slight modifications of the analysis that are in agreement with the GNS, one is able to account for these difficulties and, moreover, one is able to more rigorously analyse the confirmatory relation between the reducing and the reduced theory. (shrink)

Although Caenorhabditis elegans was chosen and modified to be an organism that would facilitate a reductionist program for neurogenetics, recent research has provided evidence for properties that are emergent from the neurons. While neurogenetic advances have been made using C. elegans which may be useful in explaining human neurobiology, there are severe limitations on C. elegans to explain any significant human behavior.

Philosophers of science have offered different accounts of what it means for one scientific theory to reduce to another. I propose a more or less friendly amendment to Kenneth Schaffner’s “General Reduction-Replacement” model of scientific unification. Schaffner interprets scientific unification broadly in terms of a continuum from theory reduction to theory replacement. As such, his account leaves no place on its continuum for type irreducible and irreplaceable theories. The same is true for other accounts that incorporate Schaffner's (...) continuum, for example, those developed by Paul Churchland, Clifford Hooker, and John Bickle. Yet I believe a more general account of scientific unification should include type irreducible and irreplaceable theories in an account of their partial reduction, specifically, when there is a reduction of their tokens. Thus I propose a “Reduction-Reception-Replacement” model wherein type irreducible and irreplaceable theories are accepted or received for the purpose of unifying domains of particulars. I also suggest a link between this kind of token reduction and mechanistic explanation. (shrink)

Kenneth C. Schaffner's paper is an important contribution to the literature on behavioral genetics and on genetics in general. Schaffner has a long record of injecting real molecular biology into philosophical discussions of genetics. His treatments of the reduction of Mendelian to molecular genetics first drew philosophical attention to the problems of detail that have fuelled both anti-reductionism and more sophisticated models of theory reduction. An injection of molecular detail into discussions of genetics is particularly necessary at the (...) present time, when so many philosophers seem happy to discuss the philosophical and ethical implications of molecular biology using gene concepts derived from evolutionary biology ). Schaffner has long advocated the view that the philosophy of biology should be more than the philosophy of evolution. This paper shows how radically a picture of gene action derived from molecular biology undercuts the popular picture associated with a more evolutionary view of genes as units of heredity or as ‘difference-makers’ mediated by the ‘black box’ of development. (shrink)

Various scientific theories stand in a reductive relation to each other. In a recent article, we have argued that a generalized version of the Nagel-Schaffner model (GNS) is the right account of this relation. In this article, we present a Bayesian analysis of how GNS impacts on confirmation. We formalize the relation between the reducing and the reduced theory before and after the reduction using Bayesian networks, and thereby show that, post-reduction, the two theories are confirmatory of each other. (...) We then ask when a purported reduction should be accepted on epistemic grounds. To do so, we compare the prior and posterior probabilities of the conjunction of both theories before and after the reduction and ask how well each is confirmed by the available evidence. (shrink)

Kendler and Schaffner have written an exemplary case study of the rise of the dopamine hypothesis and, if not its fall, at least its stagnation and transmutation. They bring out well both the state of the science and the opportunities offered by the theory to consider some famous philosophical theories of scientific progress. So well, in fact, have they done this, that I do not have a lot to say about it. I will just mention one or two points (...) that I found interesting, and then say a little about what looks to me like an omission from the story that the two Kens recount.One point they raise is the importance of competitor theories: now, there is supposed to be an old story about a quack who was apprehended during .. (shrink)

A conventional wisdom about the progress of physics holds that successive theories wholly encompass the domains of their predecessors through a process that is often called reduction. While certain influential accounts of inter-theory reduction in physics take reduction to require a single "global" derivation of one theory's laws from those of another, I show that global reductions are not available in all cases where the conventional wisdom requires reduction to hold. However, I argue that a weaker "local" form of reduction, (...) which defines reduction between theories in terms of a more fundamental notion of reduction between models of a single fixed system, is available in such cases and moreover suffices to uphold the conventional wisdom. To illustrate the sort of fixed-system, inter-model reduction that grounds inter-theoretic reduction on this picture, I specialize to a particular class of cases in which both models are dynamical systems. I show that reduction in these cases is underwritten by a mathematical relationship that follows the broad prescriptions of Nagel/Schaffner reduction, and support this claim with several examples. Moreover, I show that this broadly Nagelian analysis of inter-model reduction encompasses several cases that are sometimes cited as instances of the "physicist's" limit-based notion of reduction. (shrink)

In a recent paper, William K. Goosens objects to the arguments I set out some time ago attacking the logical empiricist analysis of reduction as applied to genetics. In these works I did not argue against the claim that Mendelian genetics was being reduced to molecular biology. Nor did I conclude, as Goosens asserts, that in the case of genetics, “reduction is insignificant”. To the contrary, I repeatedly stated that, “given our pre-analytic intuitions about reduction,” the reduction of Mendelian to (...) molecular genetics “is a case of reduction, a paradigm case”. And in agreement with Kenneth Schaffner I argued that reduction “in some very important, pre-analytic sense has taken place and is taking place in genetics”. The target of my objections to reduction in genetics was not “reduction” in some pre-analytic sense. Nor was it the various explications which have appeared since. Rather it was the notion of theory reduction set out a generation ago by such logical empiricists as Ernest Nagel, The particular version of this analysis which I chose to attack was that presented by Schaffner ; for Schaffner's later views, see his. I chose Schaffner's explication to attack because I thought it was the best of its kind and because it was the only defense of the logical empiricist analysis at the time which used genetics as one of its chief examples. Contrary to Goosens' assumption, in criticizing Schaffner's explication, I did not thereby “endorse” it. (shrink)

Scientism: The New Orthodoxy is a comprehensive philosophical overview of the question of scientism, discussing the place of science in the humanities and religion. Clarifying and defining the key terms in play in discussions of scientism, this collection identifies the dimensions that differentiate science from scientism. Leading scholars appraise the means available to science, covering the impact of the neurosciences and the new challenges it presents for the law and the self. Illustrating the effect of scientism on the humanities, Scientism: (...) The New Orthodoxy addresses what science is. This provocative collection is an important contribution to the humanities in the 21st century. Contributors include: Peter Hacker, Bastian van Fraassen, Kenneth Schaffner, Roger Scruton, James K.A. Smith, Richard Swinburne, Lawrence Principe and Richard Williams. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Psychiatric Comorbidity:More Than a Kuhnian AnomalyPeter Zachar (bio)Keywordscomorbidity, classification, epidemiology, differential diagnosis, personality disorderDr. Aragona's article in this issue of Philosophy, Psychiatry, & Psychology makes some important points regarding the relationship between comorbidity rates and the classification system currently used in psychiatry. Particularly persuasive is his claim that observed patterns of comorbidity are, in important respects, consequences of the structure of the classification system. I am not convinced, however, (...) that comorbidity is best conceptualized as an artifact of the taxonic structure of the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the International Classification of Diseases (ICD). Instead, I suggest that the use of dichotomies such as true versus artifactual should be used with caution when psychiatric classification is being discussed.In contrast with the artifact hypothesis, I argue that the phenomena covered by the term "comorbidity" are real, expectable features of the psychiatric domain. They are not the phlogiston and luminiferous ether of psychiatry. I am skeptical of the notion that high comorbidity rates as a whole can be understood as Kuhnian anomalies, or that there is a crisis, or that after a period of revolutionary science a new paradigm would eliminate these 'anomalies.' In short, high rates of comorbidity in psychiatry will not simply disappear once scientists develop a better nosological paradigm. High levels of comorbidity can, however, be both lowered and provided a better, evidence-based conceptual framework.Many Conditions, One OrganIn general medicine, comorbidity conventionally refers to the simultaneous occurrence of two independent disease processes or distinct clinical entities, such as heart disease and liver cancer (Feinstein, 1970; Jablensky 2004). The presence of one disease is supposed to affect the other in such a way that the co-occurrence of the two has implications for prognosis and treatment.Comorbidity in psychiatry is a broader concept, referring to a variety of conditions that overlap in multiple ways. The different kinds of overlap are amenable to detailed empirical analysis (e. g., Klein and Riso 1993; Neale and Kendler 1995). Depressive reactions to primary disorders, attention deficit symptoms associated with mania, panic attacks in the context of severe borderline personality disorder, substance abuse disorders among psychopaths, histrionic dynamics combined [End Page 13] with narcissistic personality traits, and emergent conditions such as schizoaffective disorder are all distinct types of comorbidity. The kinds of overlapping conditions just listed are sometimes termed psychiatric comorbidity. Also important is comorbidity between psychiatric disorders and general medical conditions as is studied in behavioral medicine and health psychology. The crisis, if there is one, is a crisis of comorbidities.The heart disease and liver cancer type of comorbidity as independent organ systems being affected is ruled out a priori in psychiatric comorbidity proper. In psychiatry, "psychopathological disease processes" can all be expected to affect a single organ, namely the brain or, more likely, affect the different systems that are tightly integrated in the brain. The tight integration can make putative comorbid psychiatric disorders difficult to disentangle.It is a widely held consensus that causes, not organ systems, are what matter in comorbidity. In this tradition, Dr. Aragona claims that in general medicine shared symptoms between two diseases (such as fever and fatigue) are not a problem because the diseases are differentiated with respect to etiology; in psychiatry, however, where syndromes are differentiated by a description of symptoms only, symptomatic overlap is a problem.Is descriptive psychopathology, therefore, a root cause of the "crisis of comorbidity" and should it be abandoned in favor of etiological classification? Unfortunately, forcing psychiatric nosology to conform to an etiological paradigm is unlikely to resolve the problem of psychiatric comorbidity. As noted, the problem is one of distinguishing between the different etiological disease processes that are affecting tightly integrated systems in the brain. The brain as a whole is a multilevel, dynamic, and open system, which has an ecology (Zachar 2000). As argued by Kendler (2005) and Schaffner (2002, 2008), it has not thus far, and may never be fully possible to segregate causes and their associated psychiatric disorders into parsimonious etiological packages. In the ecology of neuroscience, causes and effects tend to merge in a continuous series of common pathways.It would be foolish... (shrink)

Synchronic intertheoretic reductions are an important field of research in science. Arguably, the best model able to represent the main relations occurring in this kind of scientific reduction is the Nagelian account of reduction, a model further developed by Schaffner and nowadays known as the generalized version of the Nagel–Schaffner model. In their article, Dizadji-Bahmani, Frigg, and Hartmann specified the two main desiderata of a reduction á la GNS: confirmation and coherence. DFH first and, more rigorously, Tešic later (...) analyse the confirmatory relation between the reducing and the reduced theory in terms of Bayesian confirmation theory. The purpose of this article is to analyse and compare the degree of coherence between the two theories involved in the GNS before and after the reduction. For this reason, in the first section, I will be looking at the reduction of thermodynamics to statistical mechanics and use it as an example to describe the GNS. In the second section, I will introduce three coherence measures which will then be employed in the comparison. Finally, in the last two sections, I will compare the degrees of coherence between the reducing and the reduced theory before and after the reduction and use a few numerical examples to understand the relation between coherence and confirmation measures. (shrink)

Leuridan (2011) questions whether mechanisms can really replace laws at the heart of our thinking about science. In doing so, he enters a long-standing discussion about the relationship between the mech-anistic structures evident in the theories of contemporary biology and the laws of nature privileged especially in traditional empiricist traditions of the philosophy of science (see e.g. Wimsatt 1974; Bechtel and Abrahamsen 2005; Bogen 2005; Darden 2006; Glennan 1996; MDC 2000; Schaffner 1993; Tabery 2003; Weber 2005). In our view, (...) Leuridan misconstrues this discussion. His weak positive claim that mechanistic sciences appeal to generalizations is true but uninteresting. His stronger claim, that all causal claims require laws, is unsupported by his arguments. Though we proceed by criticizing Leuridan’s arguments, our greater purpose is to embellish his arguments in order to show how thinking about mechanisms enriches and transforms old philosophical debates about laws in biology and provides new insights into how generalizations afford prediction, explanation and control. (shrink)

It can be argued (cf. Dizadji‑Bahmani et al. 2010) that an increase in coherence is one goal that drives reductionist enterprises. Consequently, the question if or how well this goal is achieved can serve as an epistemic criterion for evaluating both a concrete case of a purported reduction and our model of reduction : what conditions on the model allow for an increase in coherence ? In order to answer this question, I provide an analysis of the relation between the (...) reduction and the coherence of two theories. The underlying model of reduction is a (generalised) Nagelian model (cf. Nagel 1970, Schaffner 1974, Dizadji‑Bahmani et al. 2010). For coherence, different measures have been put forward (e.g. Shogenji 1999, Olsson 2002, Fitelson 2003, Bovens & Hartmann 2003). However, since there are counterexamples to each proposed coherence measure, we should be careful that the analysis be sufficiently stable (in a sense to be specified). It will turn out that this can be done. (shrink)

The reductive strategies, such as the deductive-nomological (DN) model of explanation, or the Nagel–Schaffner reduction, have been perceived negatively ever since their first applications in historical inquiry. However, the role of the analysis of inter-theory relations, such as the preservation of success and retrospective rationality, has hardly ever received much attention from historians of science. In this paper, I am exploring the applicability of the analysis of inter-theory relations for the rational reconstruction of the development of science. I demonstrate (...) that the historiography of Anneliese Maier is a good example of a few reductive strategies at play in historical inquiry that do not submit to the same criticism that the synchronic reductive analysis of theories is submitted to. (shrink)

This multidisciplinary collection explores three key concepts underpinning psychiatry -- explanation, phenomenology, and nosology -- and their continuing relevance in an age of neuroimaging and genetic analysis. An introduction by Kenneth S. Kendler lays out the philosophical grounding of psychiatric practice. The first section addresses the concept of explanation, from the difficulties in describing complex behavior to the categorization of psychological and biological causality. In the second section, contributors discuss experience, including the complex and vexing issue of how self-agency and (...) free will affect mental health. The third and final section examines the organizational difficulties in psychiatric nosology and the instability of the existing diagnostic system. Each chapter has both an introduction by the editors and a concluding comment by another of the book's contributors. Contributors: John Campbell, Ph.D.; Thomas Fuchs, M.D., Ph.D.; Shaun Gallagher, Ph.D.; Kenneth S. Kendler, M.D.; Sandra D. Mitchell, Ph.D.; Dominic P. Murphy, Ph.D.; Josef Parnas, M.D., Dr.Med.Sci.; Louis A. Sass, Ph.D.; Kenneth F. Schaffner, M.D., Ph.D.; James F. Woodward, Ph.D.; Peter Zachar, Ph.D. (shrink)

Medicine has been a very fruitful source of significant issues for philosophy over the last 30 years. The vast majority of the issues discussed have been normative—they have been problems in morality and political philosophy that now make up the field called bioethics. However, biomedical science presents many other philosophical questions that have gotten relatively little attention, particularly topics in metaphysics, epistemology and philosophy of science. This volume focuses on problems in these areas as they surface in biomedical science. Important (...) changes in philosophy make biomedical science an especially interesting area of inquiry. Contemporary philosophy is largely naturalistic in approach—it takes philosophy to be constrained by the results of the natural sciences and able to contribute to the natural sciences as well. Exactly what those constraints and contributions should be is a matter of controversy. What is not controversial is that important questions in philosophy of science and metaphysics are raised by the practice of science. Physics, biology, and economics have all drawn extensive philosophical analysis, so much so that philosophical study of these areas have become specialized subdisciplines within philosophy of science. Philosophy of medicine approached from the perspective of philosophy of science—with important exceptions (Schaffner, 1993; Thagard, 2000)—has been relatively undeveloped. Nonetheless, medicine should have a central place in epistemological and metaphysical debates over science. It is unarguably the most practically important of the sciences. It also draws by the far the greatest resources and research efforts of any area in biology. Yet philosophy of biology has focused almost exclusively on evolutionary biology, leaving the vast enterprises of immunology, cancer biology, virology, clinical medicine, and so on unexplored. Naturalized philosophy has emphasized the important interplay of historical and sociological aspects of science with its philosophical interpretation. Biomedical science as a large scale social enterprise is a natural target for such approaches. Relatedly, within philosophy there has been a growing interest and appreciation for the connections between issues of value and issues of fact in science (Kincaid et al., 2007). Biomedical science is a paradigm instance where the two intersect. The upshot is that biomedical science is a potential rich area for philosophical investigation in areas outside biomedical ethics. This volume seeks to show that promise and to encourage its exploration. (shrink)

The contributions that the philosophy of medicine can make to both the philosophy of science and the practice of science have been obscured in recent years by an overemphasis on personalities rather than critical themes. Two themes have dominated general discussion within contemporary philosophy of science: methodological essentialism and dynamic gradualism. These themes are defined and considered in light of Kenneth Schaffner's argument that theories in biomedicine have a structure and logic unlike that found in theories of the natural (...) sciences. Schaffner's arguments are suggestive but not definitive as a refutation of methodological essentialism. I argue that a primary reason for differences in the logic and structure of theories in biomedicine is not, as some philosophers have suggested, a product of ontological differences, but rather a product of the practical and pragmatic concerns of scientific theorizing in many areas of science, such as medicine. Keywords: philosophy of medicine, philosophy of science, logic of medicine, medical theory, methodological essentialism, dynamic gradualism CiteULike Connotea Del.icio.us What's this? (shrink)

Taking as starting point Kuhn’s analysis of science textbooks and its application to Sinnott and Dunn’s (1925), it will be discussed the problem of the existence of laws in biology. In particular, it will be showed, in accordance with the proposals of Darden (1991) and Schaffner (1980, 1986, 1993), the relevance of the exemplars, diagrammatically or graphically represented, in the way in which is carried out the teaching and learning process of classical genetics, inasmuch as the information contained in (...) them, indispensable for the right development of that process, exceeds the information contained in the “laws” linguistically articulated and presented in the textbooks. However, it will be maintained that the information is implicit in the law that according to the structuralist concept of fundamental law and the reconstruction of genetics presented by Balzer & Dawe (1990), and later developed by Balzer & Lorenzano (1997) and Lorenzano (1995, 2000, 2002a) could be considered the fundamental law of classical genetics,the law of matching, clearly identified in this paper. (shrink)

We introduce a new model of reduction inspired by Kemeny and Oppenheim’s model [Kemeny & Oppenheim 1956] and argue that this model is operative in a “ruthlessly reductive” part of current neuroscience. Kemeny and Oppenheim’s model was quickly rejected in mid-20th-century philosophy of science and replaced by models developed by Ernest Nagel and Kenneth Schaffner [Nagel 1961], [Schaffner 1967]. We think that Kemeny and Oppenheim’s model was correctly rejected, given what a “theory of reduction” was supposed to account (...) for at that time. But their guiding insights about what constitutes scientific reduction—increases in explanatory scope and systematization—reflect actual practices of current reductionistic neuroscience. The key rehabilitative step to make their insights fit current scientific details is to restate them using resources from recent work on causal-mechanistic explanation. We begin with a scientific case study, drawn from the relatively new field of “molecular and cellular cognition”. It provides an explanation of the well-known Ebbinghaus spacing effect on learning and memory in terms of interactions between a transcriptional enhancer protein and its inhibiting phosphatase in neurons recruited into the memory trace. Next we briefly describe some popular models of reduction from mid-20th-century philosophy of science. We point out how these models fail to illuminate key features of our scientific case study. Finally we present our causal-mechanistically updated Kemeny and Oppenheim-inspired model and argue that it nicely accounts for the details of our scientific case study. We close with a remark that will hopefully undercut the surprise many may feel to learn that a long-rejected philosophical account of reduction actually is at work in one of the most prominent reductionistic endeavors in current science. (shrink)

A longstanding criticism of Ernest Nagel's model of reduction is that it fails to take theory change into account. This criticism builds on the received view that Nagelian reductions are incompatible with theory change. This article challenges the received view by showing that Nagel's model can easily accommodate theory change. Indeed, Nagel's model is essentially static as it only gives unchanging formal and nonformal conditions for reduction; in contrast, theory change belongs to the dynamic history of science; as a result, (...) the application of Nagel's model to scientific knowledge from different historical periods yields a series of Nagelian reductions of different degrees of reductive success. This Nagelian treatment of theory change is illustrated by considering the enterprise of reducing thermodynamics to statistical mechanics in the late nineteenth century. It is also contended that, in handling theory change Nagel's model has greater merits than subsequent models (exemplified by Kenneth Schaffner's general reduction-replacement model). This article concludes by suggesting that Nagel's model of reduction deals with theory change exactly in the same way as logical empiricism does with historicism. (shrink)

What is called “time travel” cinema is but one aspect in a tripartite series of interweaving modes of disjunctive narration which is also – simultaneously – a cinema of “many worlds” and “altered states”. Exploiting Gilles Deleuze's three syntheses of time, space, and consciousness from Difference and Repetition (1968) allows a conceptual development of these cinematic series through three popular Hollywood film cycles beginning with Planet of the Apes (Franklin J. Schaffner, 1968), The Terminator (James Cameron, 1984), and Back (...) to the Future (Robert Zemeckis, 1985). In so doing, film and philosophy are deployed as two series which together create inexhaustible atemporal, aspatial, and ahuman disjunctions, ungrounding everyday spatio-temporal identities, and affirming productive images of cinematic thought. (shrink)

La conception traditionnelle des théories scientifiques en philosophie de langue anglaise, qu’on appelle la « received view », et qui culmine au début des années 1960, posait de nombreux obstacles à une conception des théories scientifiques en biologie et en médecine. La conception sémantique des théories scientifiques qui lui succéda permit de lever ces obstacles, mais pas de différencier les théories en biologie expérimentale et en médecine. Le présent article met en évidence comment, en s’appuyant sur cette conception, Schaffner (...) établit la spécificité des théories biologiques et médicales par rapport aux théories physiques, comment Thompson établit que c’est le savoir biologique et non le savoir clinique qui, véritablement théorique, fonde le caractère proprement scientifique de la médecine, et enfin, comment Sadegh-Zadeh peut proposer à son tour des caractéristiques des théories médicales qui leur sont potentiellement spécifiques et les distinguent des théories biologiques. (shrink)

Throughout his career David Hull has sought to bring the philosophy of science into closer contact with science and especially with biological science (Hull 1969, 1997b). This effort has taken many forms. Sometimes it has meant ‘either explaining basic biology to philosophers or explaining basic philosophy to biologists’ (Hull 1996, p. 77). The first of these tasks, simple as it sounds, has been responsible for revolutionary changes. It is well known that traditional philosophy of science, modeled as it was on (...) theoretical physics, proved inadequate when philosophers turned their attention to biological science. Biological examples have driven major revisions of accounts of reduction (Hull 1974; Schaffner 1993, Ch. 9), laws of nature (Beatty et al. 1997), theories (Lloyd 1988) and natural kinds (Wilson 1999, Part III). Nor is explaining basic philosophy to biologists a task to be looked down upon. It is useful, not because philosophy has all the answers, but because scientists must think about how to do science, that is doing philosophy of science and scientists frequently reinvent philosophical views with known flaws. Early in his career Hull found biological systematists in the grip of a crude operationalism about scientific concepts and said so in the pages of Systematic Zoology (Hull 1968). For the next thirty years, as biologists debated the nature of species and the correct principles of classification, Hull added a philosophical note at the same congresses and in the same journals (Hull 1970, 1976, 1980, 1997a, 1999). (shrink)

I examine the branch of evolutionary epistemology which tries to account for the character of cognitive mechanisms in animals and humans by extending the biological theory of evolution to the neurophysiological substrates of cognition. Like Plotkin, I construe this branch as a struggling science, and attempt to characterize the sort of theory one might expect to find this truly interdisciplinary endeavor, an endeavor which encompasses not only evolutionary biology, cognitive psychology, and developmental neuroscience, but also and especially, the computational modeling (...) of artificial life programming; I suggest that extending Schaffner''s notion of interlevel theories to include both horizontal and vertical levels of abstraction best fits the theories currently being developed in cognitive science. Finally, I support this claim with examples drawn from computational modeling data using the genetic algorithm. (shrink)

Der Aufsatz lotet den zeitgenössischen Reduktionismus aus. Im ersten Teil wird in zentrale Stationen der wissenschaftstheoretischen Debatte um Theorien-Reduktion eingeleitet, wobei das Schaffner-Hooker-Modell und die Bedeutung von Näherungsbegriffen hervorgehoben werden. Der zweite Teil behandelt die multiple Realisierbarkeit als eines der nach wie vor zentralen anti-reduktionistischen Argumente. Die Analyse soll zeigen, dass es sich hierbei nicht um ein einheitliches Phänomen handelt, sondern dass sehr verschiedene Kategorien von Multirealisierbarkeit zu unterscheiden sind. In einem vereinfachten Slogan: multiple Realisierbarkeit ist ihrerseits multirealisiert. Der (...) Aufsatz entwickelt eine rohe Taxonomie von Typen multipler Realisierbarkeit und möglicher reduktionistischer Strategien, wobei genuine Fälle von Multirealisierbarkeit auf geteilte Eigenschaften zurückgeführt werden. Im letzten Teil wird die besondere Rolle von Näherungen im Zusammenhang mit der explanatorischen Spannung zwischen ontischem Reduktionismus und epistemischen Anti-Reduktionismus verdeutlicht. (shrink)

Recent years have witnessed an intensification of historical and philosophical research on the link between psychotropic drugs and psychiatric theories. For example, Kendler and Schaffner detailed how the dopamine hypothesis of schizophrenia was intimately linked to the dopamine theory of antipsychotic drug action. Here, a related case is explored: the use of antidepressants' neurochemical effects to speculate about the pathophysiology of depression.This rationale was central to American psychiatrist Schildkraut's landmark article on the catecholamine hypothesis of affective disorders. Accordingly, the (...) paper's hypothesis—that depressions may relate to decreased... (shrink)

Taking as starting point Kuhn’s analysis of science textbooks and its application to Sinnott and Dunn’s (1925), it will be discussed the problem of the existence of laws in biology. In particular, it will be showed, in accordance with the proposals of Darden (1991) and Schaffner (1980, 1986, 1993), the relevance of the exemplars, diagrammatically or graphically represented, in the way in which is carried out the teaching and learning process of classical genetics, inasmuch as the information contained in (...) them, indispensable for the right development of that process, exceeds the information contained in the “laws” linguistically articulated and presented in the textbooks. However, it will be maintained that the information is implicit in the law that according to the structuralist concept of fundamental law and the reconstruction of genetics presented by Balzer & Dawe (1990), and later developed by Balzer & Lorenzano (1997) and Lorenzano (1995, 2000, 2002a) could be considered the fundamental law of classical genetics,the law of matching, clearly identified in this paper. (shrink)

One important aspect of biological explanation is detailed causal modeling of particular phenomena in limited experimental background conditions. Recognising this allows one to appreciate that a sufficient condition for a reduction in biology is a molecular model of (1) only the demonstrated causal parameters of a biological model and (2) only within a replicable experimental background. These identities—which are ubiquitous in biology and form the basis of ruthless reductions (Bickle, Philosophy and neuroscience: a ruthlessly reductive account, 2003)—are criticised as merely (...) “local” (Sullivan, Synthese 167:511–539, 2009) or “fragmentary” (Schaffner, Synthese, 151(3):377–402, 2006). However, in an instructive case, a biological model is preserved in molecular terms, demonstrating a complex phenomenon that has been successfully reduced. (shrink)

It is easy to say that the analysis by Kendler and Schaffner of the status of the dopamine hypothesis of schizophrenia (DHS) is, at the very least, a scholarly read. It includes an exhaustive review of the DHS literature accompanied by a demanding critique. The authors' bar for hypothesis verification is high, and their conclusion is negative—that scientific support is insufficient to retain the hypothesis as such. They proceed to evaluate the reasons they see for both (1) the extensive (...) testing of the hypothesis extending over decades and (2) the failure of the field to falsify in a timely fashion. In a very interesting section, they review philosophical positions about how and in what context scientific advances .. (shrink)