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  1. William Goodwin (2008). Implementation and Innovation in Total Synthesis. Foundations of Chemistry 10 (3):177-186.
    This article investigates how understanding the theory of organic chemistry facilitates the total synthesis of organic compounds. After locating the philosophical significance of this question within the methodology or epistemology of applied science, I summarize the results of previous work on this issue—roughly that theoretical organic chemistry underwrites a sequence of heuristic policies that help to isolate plausible synthetic routes from the array of possibilities provided by structural or descriptive organic chemistry. While this prior account makes a solid start, it (...)
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  2. William Mark Goodwin (2009). Scientific Understanding and Synthetic Design. British Journal for the Philosophy of Science 60 (2):271-301.
    Next SectionOne of the indisputable signs of the progress made in organic chemistry over the last two hundred years is the increased ability of chemists to manipulate, control, and design chemical reactions. The technological expertise manifest in contemporary synthetic organic chemistry is, at least in part, due to developments in the theory of organic chemistry. By appealing to a notable chemist's attempts to articulate and codify the heuristics of synthetic design, this paper investigates how understanding theoretical organic chemistry facilitates progress (...)
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  3. Roald Hoffmann (2007). What Might Philosophy of Science Look Like If Chemists Built It? Synthese 155 (3):321 - 336.
    Had more philosophers of science come from chemistry, their thinking would have been different. I begin by looking at a typical chemical paper, in which making something is the leitmotif, and conjecture/refutation is pretty much irrelevant. What in fact might have been, might be, different? The realism of chemists is reinforced by their remarkable ability to transform matter; they buy into reductionism where it serves them, but make no real use of it. Incommensurability is taken without a blink, and actually (...)
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  4. George B. Kauffman & Laurie M. Kauffman (2004). Fred Basolo: From Coello to Inorganic Chemistry: A Lifetime of Reactions. [REVIEW] Foundations of Chemistry 6 (3):247-250.
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  5. Jeffry L. Ramsey (2004). Straining to Explain Strain and Synthesis. Foundations of Chemistry 6 (1):81-91.
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  6. Joachim Schummer (2006). Gestalt Switch in Molecular Image Perception: The Aesthetic Origin of Molecular Nanotechnology in Supramolecular Chemistry. [REVIEW] Foundations of Chemistry 8 (1):53-72.
    According to ‘standard histories’ of nanotechnology, the colorful pictures of atoms produced by scanning probe microscopists since the 1980s essentially inspired visions of molecular nanotechnology. In this paper, I provide an entirely different account that, nonetheless, refers to aesthetic inspiration, First, I argue that the basic idea of molecular nanotechnology, i.e., producing molecular devices, has been the goal of supramolecular chemistry that emerged earlier, without being called nanotechnology. Secondly, I argue that in supramolecular chemistry the production of molecular devices was (...)
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  7. Joachim Schummer (2004). Editorial: Substances Versus Reactions. Hyle 10 (1):3 - 4.
    Is chemistry primarily about things or about processes, about chemical substances or about chemical reactions? Is a chemical reaction defined by the change of certain substances, or are substances defined by their characteristic chemical reactions? What appears to be a play on words to the modern scientist, is actually one of the most fundamental ontological question since antiquity, prompted by the most radical change – the chemical change or the ‘coming-to-be and passing-away’ as Aristotle’s treatise on theoretical chemistry came to (...)
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  8. Ross L. Stein (2006). A Process Theory of Enzyme Catalytic Power – the Interplay of Science and Metaphysics. Foundations of Chemistry 8 (1):3-29.
    Enzymes are protein catalysts of extraordinary efficiency, capable of bringing about rate enhancements of their biochemical reactions that can approach factors of 1020. Theories of enzyme catalysis, which seek to explain the means by which enzymes effect catalytic transformation of the substrate molecules on which they work, have evolved over the past century from the “lock-and-key” model proposed by Emil Fischer in 1894 to models that explicitly rely on transition state theory to the most recent theories that strive to provide (...)
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  9. Kenneth B. Wiberg (2004). Strain, Structure, Stability and Reactivity. Foundations of Chemistry 6 (1):65-80.