Through an examination of the actual research strategies and assumptions underlying the Human Genome Project (HGP), it is argued that the epistemic basis of the initial model organism programs is not best understood as reasoning via causal analog models (CAMs). In order to answer a series of questions about what is being modeled and what claims about the models are warranted, a descriptive epistemological method is employed that uses historical techniques to develop detailed accounts which, in turn, help to reveal (...) forms of reasoning that are explicit, or more often implicit, in the practice of a particular field of scientific study. It is suggested that a more valid characterization of the reasoning structure at work here is a form of case-based reasoning. This conceptualization of the role of model organisms can guide our understanding and assessment of these research programs, their knowledge claims and progress, and their limitations, as well as how we educate the public about this type of biomedical research. (shrink)

Scientific models represent aspects of the empirical world. I explore to what extent this representational relationship, given the specific properties of models, can be analysed in terms of propositions to which truth or falsity can be attributed. For example, models frequently entail false propositions despite the fact that they are intended to say something "truthful" about phenomena. I argue that the representational relationship is constituted by model users "agreeing" on the function of a model, on the fit with data and (...) on the aspects of a phenomenon that are modelled. Model users weigh the propositions entailed by a model and from this decide which of these propositions are crucial to the acceptance and continued use of the model. Thus, models represent phenomena when certain propositions they entail are true, but this alone does not exhaust the representational relationship. Therefore, the constraints that produce the choice of the relevant propositions in a model must also be examined and their analysis contributes to understanding the relationship between models and phenomena. (shrink)

We propose that scientific representation is a special case of a more general notion of representation, and that the relatively well worked-out and plausible theories of the latter are directly applicable to the scien- tific special case. Construing scientific representation in this way makes the so-called “problem of scientific representation” look much less inter- esting than it has seemed to many, and suggests that some of the (hotly contested) debates in the literature are concerned with non-issues.

Several prominent philosophers of science, most notably Ron Giere, propose that scientific theories are collections of models and that models represent the objects of scientific study. Some, including Giere, argue that models represent in the same way that pictures represent. Aestheticians have brought the picturing relation under intense scrutiny and presented important arguments against the tenability of particular accounts of picturing. Many of these arguments from aesthetics can be used against accounts of representation in philosophy of science. I rely on (...) Dominic Lopes’ recent summary of arguments against various views of picturing and reformulate some of them to fit the philosophy of science context. My specific targets here are Giere and Steven French. I go on to argue that assuming all scientific models and images represent in the same way is not the best guide to understanding scientific practice. (shrink)

Models occupy a central role in the scientific endeavour. Among the many purposes they serve, representation is of great importance. Many models are representations of something else; they stand for, depict, or imitate a selected part of the external world (often referred to as target system, parent system, original, or prototype). Well-known examples include the model of the solar system, the billiard ball model of a gas, the Bohr model of the atom, the Gaussian-chain model of a polymer, the MIT (...) bag model of quark confinement, the Lorenz model of the atmosphere, the Lotka-Volterra model of the predator-prey interaction, or the hydraulic model of an economy, to mention just a few. All these models represent their target systems (or selected parts of them) in one way or another. (shrink)

There has recently been an increase in interest in the role of models in science, of which the Pavia workshop on model-based reasoning is a manifestation. One result of this increased attention has been a proliferation of views on what models are and how they are used in science. In this presentation I will develop a unified interpretation of the nature and role of models in science. Central to this interpretation is an understanding of the relationships between models and other (...) elements of an understanding of science, particularly theories, data, and analogy. My conclusion will be that models play a much larger role in science than even the most ardent enthusiasts for models have typically claimed. Modeling, on my view, is not at all ancillary to doing science, but central to constructing scientific accounts of the natural world. (shrink)

I argue for an intentional conception of representation in science that requires bringing scientific agents and their intentions into the picture. So the formula is: Agents (1) intend; (2) to use model, M; (3) to represent a part of the world, W; (4) for some purpose, P. This conception legitimates using similarity as the basic relationship between models and the world. Moreover, since just about anything can be used to represent anything else, there can be no unified ontology of models. (...) This whole approach is further supported by a brief exposition of some recent work in cognitive, or usage-based, linguistics. Finally, with all the above as background, I criticize the recently much discussed idea that claims involving scientific models are really fictions. (shrink)

Most recent philosophical thought about the scientific representation of the world has focused on dyadic relationships between language-like entities and the world, particularly the semantic relationships of reference and truth. Drawing inspiration from diverse sources, I argue that we should focus on the pragmatic activity of representing, so that the basic representational relationship has the form: Scientists use models to represent aspects of the world for specific purposes. Leaving aside the terms "law" and "theory," I distinguish principles, specific conditions, models, (...) hypotheses, and generalizations. I argue that scientists use designated similarities between models and aspects of the world to form both hypotheses and generalizations. (shrink)

A general account of modeling in physics is proposed. Modeling is shown to involve three components: denotation, demonstration, and interpretation. Elements of the physical world are denoted by elements of the model; the model possesses an internal dynamic that allows us to demonstrate theoretical conclusions; these in turn need to be interpreted if we are to make predictions. The DDI account can be readily extended in ways that correspond to different aspects of scientific practice.

Why do policies fail? How can we objectively choose the best policy from two (or more) competing alternatives? How can we create better policies? To answer these critical questions this book presents an innovative yet workable approach. Avoiding Policy Failure uses emerging metapolicy methodologies in case studies that compare successful policies with ones that have failed. Those studies investigate the systemic nature of each policy text to gain new insights into why policies fail. -/- In addition to providing intriguing directions (...) for research, this book also suggests a bold new standard for evaluating policies. While this method is broadly generalizable, specific examples are provided showing how to develop better Economic Policy, Military Policy, and Constitutional Organizations. This book shows scholars, researchers, and policy analysts how to develop more effective policies so that we may achieve our highest aspirations and avoid the horrendous failures of the past. (shrink)