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  1. Federico Abascal & Rafael Zardoya (2012). LRRC8 Proteins Share a Common Ancestor with Pannexins, and May Form Hexameric Channels Involved in Cell‐Cell Communication. Bioessays 34 (7):551-560.
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  2. Yousef H. Abdulla (2001). A Plausible Function of the Prion Protein: Conjectures and a Hypothesis. Bioessays 23 (5):456-462.
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  3. P. Abir-Am (2006). Molecular Biology and its Recent Historiography: A Transnational Quest for the 'Big Picture'. History of Science 44 (1):95-118.
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  4. Pninn Abir-Am (1985). Themes, Genres and Orders of Legitimation in the Consolidation of New Scientific Disciplines: Deconstructing the Historiography of Molecular Biology. History of Science 23:73-117.
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  5. E. E. Abola, A. Bairoch, W. C. Barker, S. Beck, H. da BensonBerman, G. Cameron, C. Cantor, S. Doubet & T. J. P. Hubbard (2000). Quality Control in Databanks for Molecular Biology. Bioessays 22 (11):1024-1034.
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  6. Aare Abroi & Julian Gough (2011). Are Viruses a Source of New Protein Folds for Organisms?–Virosphere Structure Space and Evolution. Bioessays 33 (8):626-635.
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  7. Douglas Allchin (2002). To Err and Win a Nobel Prize: Paul Boyer, ATP Synthase and the Emergence of Bioenergetics. [REVIEW] Journal of the History of Biology 35 (1):149 - 172.
    Paul Boyer shared a Nobel Prize in 1997 for his work on the mechanism of ATP synthase. His earlier work, though (which contributed indirectly to his triumph), included major errors, both experimental and theoretical. Two benchmark cases offer insight into how scientists err and how they deal with error. Boyer's work also parallels and illustrates the emergence of bioenergetics in the second half of the twentieth century, rivaling achievements in evolution and molecular biology.
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  8. Matthew T. Andrews (2007). Advances in Molecular Biology of Hibernation in Mammals. Bioessays 29 (5):431-440.
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  9. Armando Aranda Anzaldo (2007). Back to the Future: Aristotle and Molecular Biology. Ludus Vitalis 15 (28):195-198.
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  10. Stefan Artmann (2004). Four Principles of Evolutionary Pragmatics in Jacob's Philosophy of Modern Biology. Axiomathes 14 (4):381-395.
    The French molecular biologist François Jacob outlined a theory of evolution as tinkering. From a methodological point of view, his approach can be seen as a biologic specification of the relation between laws, describing coherently the dynamics of a system, and contingent boundary conditions on this dynamics. From a semiotic perspective, tinkering is a pragmatic concept well-known from the information-theoretic anthropology of Claude Lévi-Strauss. In idealized contrast to an engineer, the tinkerer has to accept the concrete restrictions on his material (...)
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  11. Sunny Y. Auyang, Scientific Convergence in the Birth of Molecular Biology.
    “I myself was forced to call myself a molecular biologist because when inquiring clergymen asked me what I did, I got tired of explaining that I was a mixture of crystallographer, biophysicist, biochemist, and geneticist.” Thus explained Francis Crick, who with James Watson discovered in 1953 the double helical structure of DNA, the genetic material..
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  12. Francisco J. Ayala (1979). Biological Evolution: Recent Advances Through Molecular Studies. In Vittorio Mathieu & Paolo Rossi (eds.), Scientific Culture in the Contemporary World. Scientia. 185.
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  13. Tudor Baetu (2012). Filling in the Mechanistic Details: Two-Variable Experiments as Tests for Constitutive Relevance. [REVIEW] European Journal for Philosophy of Science 2 (3):337-353.
    This paper provides an account of the experimental conditions required for establishing whether correlating or causally relevant factors are constitutive components of a mechanism connecting input (start) and output (finish) conditions. I argue that two-variable experiments, where both the initial conditions and a component postulated by the mechanism are simultaneously manipulated on an independent basis, are usually required in order to differentiate between correlating or causally relevant factors and constitutively relevant ones. Based on a typical research project molecular biology, a (...)
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  14. Tudor M. Baetu (2011). A Defense of Syntax-Based Gene Concepts in Postgenomics: Genes as Modular Subroutines in the Master Genomic Program. Philosophy of Science 78 (5):712-723.
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  15. Majid Bani-Yaghoub & David E. Amundsen (2008). Study and Simulation of Reaction–Diffusion Systems Affected by Interacting Signaling Pathways. Acta Biotheoretica 56 (4):315-328.
    Possible effects of interaction (cross-talk) between signaling pathways is studied in a system of Reaction–Diffusion (RD) equations. Furthermore, the relevance of spontaneous neurite symmetry breaking and Turing instability has been examined through numerical simulations. The interaction between Retinoic Acid (RA) and Notch signaling pathways is considered as a perturbation to RD system of axon-forming potential for N2a neuroblastoma cells. The present work suggests that large increases to the level of RA–Notch interaction can possibly have substantial impacts on neurite outgrowth and (...)
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  16. Ancha Baranova (2012). The More the Merrier: The Pannexin Family Just Got a New Branch (Comment on DOI 10.1002/Bies. 201100173). Bioessays 34 (7):530-531.
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  17. Marcello Barbieri (2003). The Organic Codes: An Introduction to Semantic Biology. Cambridge University Press.
    The genetic code appeared on Earth with the first cells. The codes of cultural evolution arrived almost four billion years later. These are the only codes that are recognized by modern biology. In this book, however, Marcello Barbieri explains that there are many more organic codes in nature, and their appearance not only took place throughout the history of life but marked the major steps of that history. A code establishes a correspondence between two independent 'worlds', and the codemaker is (...)
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  18. Nils Aall Barricelli (1956). A “Chromosomic” Recombination Theory for Multiplicity Reactivation in Phages. Acta Biotheoretica 11 (3-4):107-120.
    With the assumption of inactivation of small traits in bacteriophages “chromosomes” by ultraviolet irradiation the probability of multiplicity reactivation of irradiated phages is calculated. The result appears to be in agreement with the experimental results ofDulbecco.In the mathematical treatment of the problem a distinction is made between ordinary genes, with probability of inactivation negligible relative to the probability of inactivation of the whole phage, and a few vulnerable centers or genes whose probability of inactivation is not negligible. The hypothesis of (...)
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  19. Jordan Bartol (forthcoming). Biochemical Kinds. British Journal for the Philosophy of Science:axu046.
    Chemical kinds (e.g. gold) are generally treated as having timelessly fixed identities. Biological kinds (e.g. goldfinches) are generally treated as evolved and/or evolving entities. So what kind of kind is a biochemical kind? This paper defends the thesis that biochemical molecules are clustered chemical kinds, some of which–namely, evolutionarily conserved units–are also biological kinds.On this thesis, a number of difficulties that have recently occupied philosophers concerned with proteins and kinds are shown to be resolved or dissolved.
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  20. M. Bayram, J. P. Bennett & M. C. Dewar (1993). Using Computer Algebra to Determine Rate Constants in Biochemistry. Acta Biotheoretica 41 (1-2):53-62.
    In earlier work we have described how computer algebra may be used to derive composite rate laws for complete systems of equations, using the mathematical technique of Gröbner Bases (Bennett, Davenport and Sauro, 1988). Such composite rate laws may then be fitted to experimental data to yield estimates of kinetic parameters.Recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate aminotransferase (AAT) and malate dehydrogenase (MDH) (...)
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  21. Mary C. Beckerle (1997). Zyxin: Zinc Fingers at Sites of Cell Adhesion. Bioessays 19 (11):949-957.
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  22. David Berlinski (1972). Philosophical Aspects of Molecular Biology. Journal of Philosophy 64 (12):319-335.
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  23. Martin J. Bishop (1985). Software Club: Software for Molecular Biology. IV. Power Where It is Needed: Workstations and Networks. Bioessays 2 (5):218-221.
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  24. Martin J. Bishop (1984). Software Club: Software for Molecular Biology. II. Restriction Mapping and DNA Sequencing Programs. Bioessays 1 (2):75-77.
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  25. David Bloor (1993). Where the Truth Lies: Franz Moewus and the Origins of Molecular Biology. [REVIEW] British Journal for the History of Science 26 (2):260-263.
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  26. Ernest Borek (1967). Phage and the Origins of Molecular Biology J. Cairns G. S. Stent J. D. Watson. BioScience 17 (4):273-273.
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  27. Francisco Javier Serrano Bosquet (2009). Linus Pauling : Molecular Disease and the Oorigins [Sic] of Molecular Biology. In González Recio & José Luis (eds.), Philosophical Essays on Physics and Biology. G. Olms.
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  28. D. A. Brown (1999). Molecular Biology of the Neuron By RW Davis, BJ Morris (Eds). Bioessays 21:361-361.
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  29. Terence A. Brown & Keri A. Brown (1994). Ancient DNA: Using Molecular Biology to Explore the Past. Bioessays 16 (10):719-726.
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  30. Richard M. Burian (1996). "The Tools of the Discipline: Biochemists and Molecular Biologists": A Comment. Journal of the History of Biology 29 (3):451 - 462.
    This last result leads, rather naturally, to some concluding observations and a series of questions for further investigation. These case studies show that in all of the sites examined, the institutionalization of molecular biology as a “discipline” was primarily driven by the need to separate groups of practitioners with divergent but overlapping interests within the local context. Thus molecular biology was contingently separated from agricultural or medical biochemistry, virology, work on the physiology of nucleic acids, and so forth for contingent (...)
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  31. Werner Ceusters & Barry Smith (2010). Foundations for a Realist Ontology of Mental Disease. Journal of Biomedical Semantics 1 (10):1-23.
    While classifications of mental disorders have existed for over one hundred years, it still remains unspecified what terms such as 'mental disorder', 'disease' and 'illness' might actually denote. While ontologies have been called in aid to address this shortfall since the GALEN project of the early 1990s, most attempts thus far have sought to provide a formal description of the structure of some pre-existing terminology or classification, rather than of the corresponding structures and processes on the side of the patient. (...)
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  32. Rosine Chandebois (1980). Cell Sociology and the Problem of Automation in the Development of Pluricellular Animals. Acta Biotheoretica 29 (1):1-35.
    The principles of automation (automatism and programming) in the unfolding of spatio-temporal patterns during animal development are deduced from experimental data reconsidered from the point of view of cell sociology. The developmental programme in the egg is not part of the genetic information but a part of the cytoplasmic information. Throughout development cells store extra-cellular information released by their neighbours in the form of cytoplasmic information. Successive determinations cannot be considered as successive reprogrammings of cells: each one consists of a (...)
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  33. Rosine Chandebois (1977). Cell Sociology and the Problem of Position Effect: Pattern Formation, Origin and Role of Gradients. Acta Biotheoretica 26 (4):203-238.
    The control of pattern formation and the significance of gradients is reconsidered on the basis of the concept of cell sociology (which takes into account continuous exchange of information between cells and the possibility of autonomous progression in differentiation). Not all traits of a pattern are imposed by a single prepattern, which would be an organized molecular framework or a gradient. Patterns are unfolded in steps; these are readjustments of a cell population to intrinsic and extrinsic changes in cell activities. (...)
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  34. Rosine Chandebois (1976). Cell Sociology: A Way of Reconsidering the Current Concepts of Morphogenesis. Acta Biotheoretica 25 (2-3):71-102.
    Research in the field of planarian regeneration on the one hand, and a general survey of embryology on the other, throw doubt upon the reality of supra-cellular controls, which are still at the basis of all modern concepts of morphogenesis. The necessity of referring to such controls, which have never been convincingly demonstrated, is probably due to the fact that two aspects of cell behaviour have been underestimated: 1) the capacity of cells to change their individualities for a time independently (...)
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  35. Robert H. Chesney (1990). Molecular Biology in Brief. BioScience 40 (5):400-400.
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  36. Philip Cohen (1985). Hormones, Second Messengers and the Reversible Phosphorylation of Proteins: An Overview. Bioessays 2 (2):63-68.
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  37. Jeffrey P. Cohn (1987). The Molecular Biology of Aging. BioScience 37 (2):99-102.
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  38. Barry Commoner (1969). Is Biology a Molecular Science. In Marjorie Glicksman Grene (ed.), The Anatomy of Knowledge: Papers Presented to the Study Group on Foundations of Cultural Unity, Bowdoin College, 1965 and 1966. London, Routledge & K. Paul. 73.
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  39. Angela N. H. Creager (2010). The Paradox of the Phage Group: Essay Review. [REVIEW] Journal of the History of Biology 43 (1):183 - 193.
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  40. Angela N. H. Creager (2009). Phosphorus-32 in the Phage Group: Radioisotopes as Historical Tracers of Molecular Biology. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 40 (1):29-42.
    The recent historiography of molecular biology features key technologies, instruments and materials, which offer a different view of the field and its turning points than preceding intellectual and institutional histories. Radioisotopes, in this vein, became essential tools in postwar life science research, including molecular biology, and are here analyzed through their use in experiments on bacteriophage. Isotopes were especially well suited for studying the dynamics of chemical transformation over time, through metabolic pathways or life cycles. Scientists labeled phage with phosphorus-32 (...)
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  41. Lindley Darden & Michael Cook (1994). Reasoning Strategies in Molecular Biology: Abstractions, Scans and Anomalies. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:179 - 191.
    Molecular biologists use different kinds of reasoning strategies for different tasks, such as hypothesis formation, experimental design, and anomaly resolution. More specifically, the reasoning strategies discussed in this paper may be characterized as (1) abstraction-instantiation, in which an abstract skeletal model is instantiated to produce an experimental system; (2) the systematic scan, in which alternative hypotheses are systematically generated; and (3) modular anomaly resolution, in which components of a model are stated explicitly and methodically changed to generate alternative changes to (...)
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  42. Eric H. Davidson (1994). Molecular Biology of Embryonic Development: How Far Have We Come in the Last ten Years? Bioessays 16 (9):603-615.
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  43. Fordyce A. Davidson (2012). Is Cell Fusion Driven by Excitation?(Comment on DOI: 10.1002/Bies. 201100135). Bioessays 34 (4):258-258.
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  44. P. R. Day (1983). Molecular Biology for Entrepreneurs Discovery: The Search for DNA's Secrets Mahlon Hoagland. BioScience 33 (5):340-340.
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  45. Soraya de Chadarevian (1999). Mapping Development or How Molecular is Molecular Biology? History and Philosophy of the Life Sciences 22 (3):381-396.
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  46. Xavier de la Cruz, Sergio Lois, Sara Sánchez‐Molina & Marian A. Martínez‐Balbás (2005). Do Protein Motifs Read the Histone Code? Bioessays 27 (2):164-175.
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  47. Alexis De Tiège, Koen Tanghe, Johan Braeckman & Yves Van de Peer (2014). From DNA- to NA-Centrism and the Conditions for Gene-Centrism Revisited. Biology and Philosophy 29 (1):55-69.
    First the ‘Weismann barrier’ and later on Francis Crick’s ‘central dogma’ of molecular biology nourished the gene-centric paradigm of life, i.e., the conception of the gene/genome as a ‘central source’ from which hereditary specificity unidirectionally flows or radiates into cellular biochemistry and development. Today, due to advances in molecular genetics and epigenetics, such as the discovery of complex post-genomic and epigenetic processes in which genes are causally integrated, many theorists argue that a gene-centric conception of the organism has become problematic. (...)
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  48. Sasadhar De (1992). Short Note on the Mechanics in the Contact Behaviour of Cells. Acta Biotheoretica 40 (4):333-337.
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  49. B. Delord (1999). Attractors and Pathological Aspects in Excitable Cells. Acta Biotheoretica 47 (3-4):239-252.
    In this article, physiological and pathological forms of excitability are studied in a two-dimensional electrical model of excitable cell endowed with a generic inward persistent conductance. Bifurcation analysis of the model is performed as a function of the maximal inward persistent conductance, the input current, or the voltage dependency of the activation function. Several discharge modes are exhibited, including: (1) a basic mode that corresponds to a resting potential and production of action potential; (2) bistability between resting potential and self-sustained (...)
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  50. Michael J. Denton, Govindasamy Kumaramanickavel & Michael Legge (2013). Cells as Irreducible Wholes: The Failure of Mechanism and the Possibility of an Organicist Revival. Biology and Philosophy 28 (1):31-52.
    According to vitalism, living organisms differ from machines and all other inanimate objects by being endowed with an indwelling immaterial directive agency, ‘vital force,’ or entelechy . While support for vitalism fell away in the late nineteenth century many biologists in the early twentieth century embraced a non vitalist philosophy variously termed organicism/holism/emergentism which aimed at replacing the actions of an immaterial spirit with what was seen as an equivalent but perfectly natural agency—the emergent autonomous activity of the whole organism. (...)
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