The principle of clinical equipoise requires that, aside from certain exceptional cases, second generation treatments ought to be tested against standard therapy. In violation of this principle, placebo-controlled trials (PCTs) continue to be used extensively in the development and licensure of second-generation treatments. This practice is typically justified by appeal to methodological arguments that purport to demonstrate that active-controlled trials (ACTs) are methodologically flawed. Foremost among these arguments is the so called assay sensitivity argument. In this paper, I take a (...) closer look at this argument. Following Duhem, I argue that all trials, placebo-controlled or not, rely on external information for their meaningful interpretation. Pending non-circular empirical evidence that we can trust the findings of PCTs to a greater degree than the findings of ACTs, I conclude that the assay sensitivity argument fails to demonstrate that placebo-controlled trials are preferable, methodologically or otherwise, to active-controlled trials. Contrary to the intentions of its authors, the fundamental lesson taught by the assay sensitivity argument is Duhemian: the validity of all clinical trials depends on external information. (shrink)

Quine’s “New Foundations” (NF) was first presented in Quine [1937] and later on in Quine [1963]. Ernst Specker [1958, 1962], building upon a previous result of Ehrenfeucht and Mostowski [1956], showed that NF is consistent if and only if there is a model of the Theory of Negative (and positive) Types (TNT) with full extensionality that admits of a “shifting automorphism,” but the existence of a such a model remains an open problem.

This unique study brings together for the first time two of the most important philosophers of the twentieh century. Are the views of Wittgenstein and Quine on method and philosophy compatible or radically opposed? Does Wittgenstein's conception of language engender that of Quine, or threaten its philosophical foundations? An understanding of the similarities and differences between the thought of Wittgenstein and Quine is essential if we are to have a full picture of the landscape of recent and contemporary philosophy. This (...) collection of essays offers various and original ways in which to view their relationship. (shrink)

A Linguistic Analysis of Prior, Quine, and Searle on Propositional Attitudes, Martinich on Fictional Reference, Taglicht on the Active/Passive Mood Distinction in English, etc.

It is argued that the blind ascriptive role for the word true, its use, that is, in conjunction with descriptions of classes of sentences or with proper names of sentences (but not quote-names), is one which applies indiscriminately to sentences regardless of whether these are in languages we speak, can understand, or can translate into sentences that we do speak (and understand). Formal analogues of the ordinary word true as they arise in Tarskis seminal work, and in others, cannot replicate (...) this essential role of the ordinary word true. (shrink)

The ramifications are explored of taking physical theories to commit their advocates only to ‘physically real’ entities, where ‘physically real’ means ‘causally efficacious’ (e.g., actual particles moving through space, such as dust motes), the ‘physically significant’ (e.g., centers of mass), and the merely mathematical—despite the fact that, in ordinary physical theory, all three sorts of posits are quantified over. It's argued that when such theories are regimented, existential quantification, even when interpreted ‘objectually’ (that is, in terms of satisfaction via variables, (...) rather than by substitution-instances) need not imply any ontological commitments. (shrink)

Duhem's and Quine's holistic theses, when properly understood, allow methodologically responsible ways of resolving a conflict between a theoretical system and experience; they only deny the possibility of doing it in an epistemically persuasive way. By developing a "string" model of scientific tests I argue that the pattern of interaction between the elements of a theoretical system arising in response to multiple adverse data can be helpful in locating a "weak spot" in it. Combining this model with anti-holistic arguments of (...) Popper, Greenwood, and Lakatos significantly reinforces their joint power. (shrink)

I argue that Quine''s famous claim, any statement can be held true come what may, demands an interpretation that implies that the meanings of the expressions in the held-true statement change. The intended interpretation of this claim is not clear from its context, and so it is often misunderstood by philosophers (and is misleadingly taught to their students). I explain Fodor and Lepore''s (1992) view that the above interpretation would render Quine''s assertion entirely trivial and reply, on both textual and (...) philosophical grounds, that only this trivial reading is consistent with Quine''s famous denial of analyticity. I also explain briefly how the trivial reading lends support to meaning holism, which, regardless of one''s views of its consequences, is an important position in the philosophy of language and mind. (shrink)

This paper examines Quine’s web of belief metaphor and its role in his various responses to conventionalism. Distinguishing between two versions of conventionalism, one based on the under-determination of theory, the other associated with a linguistic account of necessary truth, I show how Quine plays the two versions of conventionalism against each other. Some of Quine’s reservations about conventionalism are traced back to his 1934 lectures on Carnap. Although these lectures appear to endorse Carnap’s conventionalism, in exposing Carnap’s failure to (...) provide an explanatory account of analytic truth, they in fact anticipate Quine’s later critique of conventionalism. I further argue that Quine eventually deconstructs both his own metaphor and the thesis of under-determination it serves to illustrate. This enables him to hold onto under-determination, but at the cost of depleting it of any real epistemic significance. Lastly, I explore the implications of this deconstruction for Quine’s indeterminacy of translation thesis. (shrink)

This is what many philosophers believe today about the analytic/synthetic distinction: In his classic early writings on analyticity -- in particular, in "Truth by Convention," "Two Dogmas of Empiricism," and "Carnap and Logical Truth" -- Quine showed that there can be no distinction between sentences that are true purely by virtue of their meaning and those that are not. In so doing, Quine devastated the philosophical programs that depend upon a notion of analyticity -- specifically, the linguistic theory of necessary (...) truth, and the analytic theory of a priori knowledge. (shrink)

Contemporary developments in economicmethodology have produced a vibrant agenda ofcompeting positions. These include, amongothers, constructivism, critical realism andrhetoric, with each contributing to the Realistvs. Pragmatism debate in the philosophies of thesocial sciences. A major development in theneo-pragmatist contribution to economicmethodology has been Quine's pragmatic assaulton the dogmas of empiricism, which are nowclearly acknowledged within contemporaryeconomic methodology. This assault isencapsulated in the celebrated Duhem-Quinethesis, which according to a number ofcontemporary leading philosophers of economics,poses a particularly serious methodologicalproblem for economics. This problem, (...) asreflected in Hausman's analysis, consists ofthe inability of economics to learn fromexperience, thereby subverting the capacity totest economic theories. In this paper wedispute this position. Our argument is basedon a combination of Quine's holism with VanFraassen's constructive empiricism, especiallythe latter's analysis of empirical adequacy andhis pragmatic approach to explanation. Theresulting reorientation of economic methodologyrestores the capacity of economics to learnfrom experience and reinstates the imperativeof developing alternatives to orthodoxtheorizing in economics. (shrink)

A book review from the Quine volume of The Cambridge Companions to Philosophy series.

Quine has famously put forward the indispensability argument to force belief in the existence of mathematical objects (such as classes) due to their indis- pensability to our best theories of the world (Quine 1960). Quine has also advocated the indeterminacy of reference argument, according to which ref- erence is dramatically indeterminate: given a language, there’s no unique reference relation for that language (see Quine 1969a). In this paper, I ar- gue that these two arguments are in conflict with each other. (...) Whereas the indispensability argument supports realism about mathematics, the indeter- minacy of reference argument, when applied to mathematics, provides a powerful strategy in support of mathematical anti-realism. I conclude the paper by indicating why the indeterminacy of reference phenomenon should be preferred over the considerations regarding indispensability. In the end, even the Quinean shouldn’t be a realist (platonist) about mathematics. (shrink)

The discovery of the note cards for Quine’s previously unpublished 1946 lecture on nominalism provides an obvious occasion for commenting on the differences between the issue of nominalism as Quine first publicized it to a wide philosophical audience and the issue of nominalism as debated among Quine’s successors today. Yet as I read and reread the text of Quine’s lecture, I found myself struck less by the differences between Quine’s position there and the positions of present-day writers than by differences (...) between Quine’s position there and the positions of Quine himself in later writings — and not his writings from many years later but his writings from the next few years, and especially one of his writings from the very next year, his notorious joint paper with Goodman. (shrink)

In this era when results of empirical scientific research are being appealed to all across philosophy, when we even find moral philosophers invoking the results of brain scans, many profess to practice "naturalized epistemology," or to be "epistemological naturalists." Such phrases derive from the title of a well-known essay by Quine,[1] but Paul Gregory's thesis in the work under review is that there is less connection than is usually assumed between Quine's variety of naturalized epistemology and what is today taken, (...) by opponents and proponents alike, to constitute epistemological naturalism. To put it bluntly, as Gregory does in the opening sentence of his introduction, Quine "has not been well understood." If there is less connection between the Quinian and other epistemological naturalisms than there has often been taken to be, on Gregory's account there is also much more connection between Quine's position on epistemology and his positions on other contentious issues. (shrink)

A discussion of Quine and Davidson, as interpreted and criticized in Scott Soames’ Philosophical Analysis in the Twentieth Century, Volume II.

Tracing the background of Davidson’s work in the positivists’ philosophical emigration of the 30’s and in Quine, Evnine’s “Introduction” offers a “map of the terrain to be covered” which stresses the “rationalistic” character of Davidson’s views on holism and rationality. Thus, “his main philosophical concerns ... language, the mental and action...are the ingredients of a philosophical anthropology.” In spite of Quinean roots, the view is that “Davidson has now wholly removed himself, philosophically speaking, from the empiricist tradition.” The result: a (...) “rationalism,...a genuine, non-empiricist philosophical vision.” Though appealing to those of a “rationalist” leaning, this theme seems to generalize Davidson’s criticisms of Quine’s behaviorism as a lapse from empiricism. Often, it arises from interpretive gloss just where the tough-minded reader seeks quotation. (shrink)

Quine's aim in this slim book is to "update, sum up and clarify variously intersecting views on cognitive meaning, objective referencce, and the grounds of knowledge." Only nine pages had previously appeared as the book came to print. It is based largely on unpublished lectures and informal discussions of the past ten years back to the Immanuel Kant Lectures given at Stanford in 1980. It does not, then duplicate Leonelli's Italian translation of hte Kant lectures, La Scienza E I Datti (...) di Senso, which appeared in 1987. (shrink)

The two dogmas are (i) belief in an analytic/synthetic distinction, and (ii) reductionism (every meaningful statement is equivalent to a statement about experience). I’ll focus on Quine’s most influential arguments against (i), especially construed as arguments against conceptual analysis and an apriori/aposteriori distinction.

The problematic features of Quine's set theories NF and ML are a result of his replacing the higher-order predicate logic of type theory by a first-order logic of membership, and can be resolved by returning to a second-order logic of predication with nominalized predicates as abstract singular terms. We adopt a modified Fregean position called conceptual realism in which the concepts (unsaturated cognitive structures) that predicates stand for are distinguished from the extensions (or intensions) that their nominalizations denote as singular (...) terms. We argue against Quine's view that predicate quantifiers can be given a referential interpretation only if the entities predicates stand for on such an interpretation are the same as the classes (assuming extensionality) that nominalized predicates denote as singular terms. Quine's alternative of giving predicate quantifiers only a substitutional interpretation is compared with a constructive version of conceptual realism, which with a logic of nominalized predicates is compared with Quine's description of conceptualism as a ramified theory of classes. We argue against Quine's implicit assumption that conceptualism cannot account for impredicative concept-formation and compare holistic conceptual realism with Quine's class Platonism. (shrink)

The Quine-Putnam indispensability argument urges us to place mathematical entities on the same ontological footing as (other) theoretical entities of empirical science. Recently this argument has attracted much criticism, and in this paper I address one criticism due to Elliott Sober. Sober argues that mathematical theories cannot share the empirical support accrued by our best scientific theories, since mathematical propositions are not being tested in the same way as the clearly empirical propositions of science. In this paper I defend the (...) Quine-Putnam argument against Sober's objections. (shrink)

In this paper I examine Quine''s indispensability argument, with particular emphasis on what is meant by ''indispensable''. I show that confirmation theory plays a crucial role in answering this question and that once indispensability is understood in this light, Quine''s argument is seen to be a serious stumbling block for any scientific realist wishing to maintain an anti-realist position with regard to mathematical entities.

Quine introduced a famous distinction between the ‘notional’ sense and the ‘relational’ sense of certain attitude verbs. The distinction is both intuitive and sound but is often conflated with another distinction Quine draws between ‘dyadic’ and ‘triadic’ (or higher degree) attitudes. I argue that this conflation is largely responsible for the mistaken view that Quine’s account of attitudes is undermined by the problem of the ‘exportation’ of singular terms within attitude contexts. Quine’s system is also supposed to suffer from the (...) problem of ‘suspended judgement with continued belief’. I argue that this criticism fails to take account of a crucial presupposition of Quine’s about the connection between thought and language. The aim of the paper is to defend the spirit of Quine’s account of attitudes by offering solutions to these two problems. (shrink)

Quine rejects Peirce's theory of truth because, among other things, its notion of a limit of a sequence of theories is defective in that the notion of a limit depends on that of nearer than which is defined for numbers but not for theories. This paper shows that the missing definition of nearer than applied to theories can be supplied from within Quine's own epistemology. The upshot is that either Quine's epistemology must be rejected or Peirce's pragmatic theory of truth (...) is partially vindicated. (shrink)

This paper is a reexamination of Two Dogmas in the light of Quine's ongoing debate with Carnap over analyticity. It shows, first, that analytic is a technical term within Carnap's epistemology. As such it is intelligible, and Carnap's position can meet Quine's objections. Second, it shows that the core of Quine's objection is that he (Quine) has an alternative epistemology to advance, one which appears to make no room for analyticity. Finally, the paper shows that Quine's alternative epistemology is itself (...) open to very serious objections. Quine is not thereby refuted, but neither can Carnap's analyticity be dismissed as dogma. (shrink)