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Of molecules and men

Seattle,: University of Washington Press (1966)

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  1. The Evolution of Complexity.Mark Bedau - 2009 - In Barberousse Anouk, Morange M. & Pradeau T. (eds.), Mapping the Future of Biology. Boston Studies in the Philosophy of Science, vol 266. Springer.
  • Metaphysics, Function and the Engineering of Life: the Problem of Vitalism.Charles T. Wolfe, Bohang Chen & Cécilia Bognon-Küss - 2018 - Kairos 20 (1):113-140.
    Vitalism was long viewed as the most grotesque view in biological theory: appeals to a mysterious life-force, Romantic insistence on the autonomy of life, or worse, a metaphysics of an entirely living universe. In the early twentieth century, attempts were made to present a revised, lighter version that was not weighted down by revisionary metaphysics: “organicism”. And mainstream philosophers of science criticized Driesch and Bergson’s “neovitalism” as a too-strong ontological commitment to the existence of certain entities or “forces”, over and (...)
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  • Introduction: Vitalism without Metaphysics? Medical Vitalism in the Enlightenment.Charles T. Wolfe - 2008 - Science in Context 21 (4):461-463.
    my introduction to special issue of Science in Context on 18c vitalism.
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  • What is a Gene? From molecules to metaphysics.Holmes Rolston - 2006 - Theoretical Medicine and Bioethics 27 (6):471-497.
    Mendelian genes have become molecular genes, with increasing puzzlement about locating them, due to increasing complexity in genomic webworks. Genome science finds modular and conserved units of inheritance, identified as homologous genes. Such genes are cybernetic, transmitting information over generations; this too requires multi-leveled analysis, from DNA transcription to development and reproduction of the whole organism. Genes are conserved; genes are also dynamic and creative in evolutionary speciation—most remarkably producing humans capable of wondering about what genes are.
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  • “What is Dead May Not Die”: Locating Marginalized Concepts Among Ordinary Biologists.Erik L. Peterson & Crystal Hall - 2022 - Journal of the History of Biology 55 (2):219-251.
    Historians and biologists identify the debate between mechanists and vitalists over the nature of life itself with the arguments of Driesch, Loeb, and other prominent voices. But what if the conversation was broader and the consequences deeper for the field? Following the suspicions of Joseph Needham in the 1930s and Francis Crick in the 1960s, we deployed tools of the digital humanities to an old problem in the history of biology. We analyzed over 31,000 peer-reviewed scientific papers and learned that (...)
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  • The religion of a scientist: Explorations into reality (religio philosophi naturalis).Arthur Peacocke - 1994 - Zygon 29 (4):639-659.
    Sir Thomas Browne's reflection on the synthesis between his Christian religion and his practice as a medical doctor, made over three centuries ago, leads into reflections on the present relation between religion and science in the personal experience of the writer. An account is given of how the actual practice of scientific investigation led the author to theistic inferences and how the study of DNA provoked questions concerning reductionism and emergence. This evoked the need for a map of knowledge, and (...)
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  • The Return of the Organism as a Fundamental Explanatory Concept in Biology.Daniel J. Nicholson - 2014 - Philosophy Compass 9 (5):347-359.
    Although it may seem like a truism to assert that biology is the science that studies organisms, during the second half of the twentieth century the organism category disappeared from biological theory. Over the past decade, however, biology has begun to witness the return of the organism as a fundamental explanatory concept. There are three major causes: (a) the realization that the Modern Synthesis does not provide a fully satisfactory understanding of evolution; (b) the growing awareness of the limits of (...)
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  • Physical symbol systems.Allen Newell - 1980 - Cognitive Science 4 (2):135-83.
    On the occasion of a first conference on Cognitive Science, it seems appropriate to review the basis of common understanding between the various disciplines. In my estimate, the most fundamental contribution so far of artificial intelligence and computer science to the joint enterprise of cognitive science has been the notion of a physical symbol system, i.e., the concept of a broad class of systems capable of having and manipulating symbols, yet realizable in the physical universe. The notion of symbol so (...)
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  • A filosofia da ciência e a biologia.Sergio Hugo Menna - 2018 - Prometeus: Filosofia em Revista 11 (28).
    A Biologia é diferente de outras ciências naturais? Na Filosofia da ciência existe um longo e complexo debate sobre essa questão. O objetivo deste trabalho é apresentar os argumentos das principais interpretações rivais sobre esse assunto.
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  • Individuality and creativity: Is biology different?Kari Y. H. Lagerspetz - 1969 - Synthese 20 (2):254 - 260.
  • Secrets of God, nature, and life1.Evelyn Fox Keller - 1990 - History of the Human Sciences 3 (2):229-242.
  • Gene concepts and Genethics: Beyond exceptionalism.Péter Kakuk - 2008 - Science and Engineering Ethics 14 (3):357-375.
    The discursive explosion that was provoked by the new genetics could support the impression that the ethical and social problems posed by the new genetics are somehow exceptional in their very nature. According to this view we are faced with special ethical and social problems that create a challenge so fundamental that the special label of genethics is needless to justify. The historical account regarding the evolution of the gene concepts could serve us to highlight the limits of what we (...)
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  • Life and teleology.Israel Idalovichi - 1992 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 23 (1):85-103.
    A comprehensive definition of the phenomenon called "life" led to the addition of many dimensions to the natural sciences, and especially the conscious mental dimension. Historical attention is paid not only to those employing the natural philosophical paradigms, but also to evolutionary theories and to the Kantian teleological philosophy. The belief that science can solve the riddle of life is a category of purposal thinking. A revised version of critical teleology is essential for comprehension of life.
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  • Why the problem of reductionism in biology has implications for economics.Geoffrey M. Hodgson - 1993 - World Futures 37 (2):69-90.
    For several decades, economists have been preoccupied with an attempt to place their entire subject on the ‘sound microfoundations’ of general equilibrium theory, with its individualistic premises. However, this project has run into seemingly intractable problems. This essay examines underlying questions such as the appropriate building block of analysis and the structure of explanation in economics. The examination of biology is found to be instructive, due to debates concerning the limitations of reductionism within that discipline. The final part of the (...)
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  • Is Nature Enough? No.John F. Haught - 2003 - Zygon 38 (4):769-782.
    This essay is based on a lecture delivered at the 2002 IRAS Star Island conference, the theme of which was “Is Nature Enough? The Thirst for Transcendence.” I had been asked to represent the position of those who would answer No to the question. I thought it would stimulate discussion if I presented my side of the debate in a somewhat provocative manner rather than use a more ponderous approach that would argue each point in a meticulous and protracted fashion. (...)
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  • Information as metaphorical and allegorical construction: some methodological preludes.Mathias Gutmann & Benjamin Rathgeber - 2008 - Poiesis and Praxis 5 (3-4):211-232.
    Metaphors, allegories and other kinds of indirect speech-acts and catachretical phrases are usually considered to be the very opposite of scientific theories. An alternative can be identified in the constructivists’ approach, dealing with catachretical expressions as a starting point for the explication of scientific language games. The aim of this paper is to demonstrate such an alternative point of view, dealing with metaphorical applications of the term information within biological narratives.
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  • Ethical and political problems in third world biotechnology.Daniel J. Goldstein - 1989 - Journal of Agricultural and Environmental Ethics 2 (1):5-36.
    Third World countries are not pursuing scientific and technological policies leading to the development of strong biotechnological industries. Their leaders have been misled into believing that modern biotechnological industries can be built in the absence of strong, intellectually aggressive, and original scientific schools. Hence, they do not strive to reform their universities, which have weak commitments to research, and do not see the importance of having research hospitals able to generate excellent and relevant clinical investigation. These strategic gaps in scientific (...)
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  • Ethical and political problems in third world biotechnology.Daniel J. Goldstein - 1989 - Journal of Agricultural Ethics 2 (1):5-36.
    Third World countries are not pursuing scientific and technological policies leading to the development of strong biotechnological industries. Their leaders have been misled into believing that modern biotechnological industries can be built in the absence of strong, intellectually aggressive, and original scientific schools. Hence, they do not strive to reform their universities, which have weak commitments to research, and do not see the importance of having research hospitals able to generate excellent and relevant clinical investigation. These strategic gaps in scientific (...)
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  • Advocacy Science: Explaining the Term with Case Studies from Biotechnology.Ksenia Gerasimova - 2017 - Science and Engineering Ethics 24 (2):455-477.
    The paper discusses the use of term ‘advocacy science’ which is communication of science which goes beyond simple reporting of scientific findings, using the case study of biotechnology. It argues that advocacy science should be used to distinguish the engagement of modern civil society organizations to interpret scientific knowledge for their lobbying. It illustrates how this new communicative process has changed political discourse in science and general perception of the role of science in contemporary society.
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  • Cells as irreducible wholes: the failure of mechanism and the possibility of an organicist revival.Michael J. Denton, Govindasamy Kumaramanickavel & Michael Legge - 2013 - Biology and Philosophy 28 (1):31-52.
    According to vitalism, living organisms differ from machines and all other inanimate objects by being endowed with an indwelling immaterial directive agency, ‘vital force,’ or entelechy . While support for vitalism fell away in the late nineteenth century many biologists in the early twentieth century embraced a non vitalist philosophy variously termed organicism/holism/emergentism which aimed at replacing the actions of an immaterial spirit with what was seen as an equivalent but perfectly natural agency—the emergent autonomous activity of the whole organism. (...)
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  • Criticizing the Modern Synthesis: between Phenomenal Characteristics and Synthetic Principles.Bohang Chen, Joris Van Poucke & Gertrudis Van de Vijver - 2021 - Biosemiotics 14 (1):135-140.
    Starting from Denis Noble’s criticism on the modern synthesis, this article argues that the author’s presentation of the modern synthesis focusses too one-sidedly on the phenomenal characteristics of the living, whereby it is made easily suitable to his criticisms, but risks to remain trapped in a territory-struggle; this criticism lacks an explicit focus on logical matters, and more in particular on the synthetic principles required to situate the relevancy or irrelevancy of phenomenal characteristics beyond territory-struggles. A brief sketch of how (...)
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  • A non-metaphysical evaluation of vitalism in the early twentieth century.Bohang Chen - 2018 - History and Philosophy of the Life Sciences 40 (3):50.
    In biology the term “vitalism” is usually associated with Hans Driesch’s doctrine of the entelechy: entelechies were nonmaterial, bio-specific agents responsible for governing a few peculiar biological phenomena. Since vitalism defined as such violates metaphysical materialism, the received view refutes the doctrine of the entelechy as a metaphysical heresy. But in the early twentieth century, a different, non-metaphysical evaluation of vitalism was endorsed by some biologists and philosophers, which finally led to a logical refutation of the doctrine of the entelechy. (...)
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  • Biocomplexity: A pluralist research strategy is necessary for a mechanistic explanation of the "live" state.F. J. Bruggeman, H. V. Westerhoff & F. C. Boogerd - 2002 - Philosophical Psychology 15 (4):411 – 440.
    The biological sciences study (bio)complex living systems. Research directed at the mechanistic explanation of the "live" state truly requires a pluralist research program, i.e. BioComplexity research. The program should apply multiple intra-level and inter-level theories and methodologies. We substantiate this thesis with analysis of BioComplexity: metabolic and modular control analysis of metabolic pathways, emergence of oscillations, and the analysis of the functioning of glycolysis.
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  • Evolutionary anti-reductionism: Historical reflections. [REVIEW]John Beatty - 1990 - Biology and Philosophy 5 (2):199-210.
  • Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience.Christine Aicardi - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 55:83-95.
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  • An Ontic Account of Explanatory Reduction in Biology.Marie I. Kaiser - 2012 - Köln: Kölner Hochschulschriften.
    Convincing disputes about explanatory reductionism in the philosophy of biology require a clear and precise understanding of what a reductive explanation in biology is. The central aim of this book is to provide such an account by revealing the features that determine the reductive character of a biological explanation. Chapters I-IV provide the ground, on which I can then, in Chapter V, develop my own account of explanatory reduction in biology: Chapter I reveals the meta-philosophical assumptions that underlie my analysis (...)
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  • Holism and Reductionism in Biology and Ecology the Mutual Dependence of Higher and Lower Level Research Programmes.Rick C. Looijen - 2000 - Springer.
    Holism and reductionism are usually seen as opposite and mutually exclusive approaches to nature. Recently, some have come to see them as complementary rather than mutually exclusive. In this book I have argued that, even stronger, they should be seen as mutually dependent and co-operating research programmes. I have discussed holism and reductionism in biology in general and in ecology in particular. After an introductory chapter I have provided an overview of holistic and reductionistic positions in biology, and of the (...)
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  • A Conceptual Map of Scientism.Rik Peels - manuscript
    I argue that scientism in general is best understood as the thesis that the boundaries of the natural sciences should be expanded in order to include academic disciplines or realms of life that are widely considered not to belong to the realm of science. However, every adherent and critic of scientism should make clear which of the many varieties of scientism she adheres to or criticizes. In doing so, she should specify whether she is talking about (a) academic or universal (...)
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  • The Return of Vitalism: Canguilhem and French Biophilosophy in the 1960s.Charles T. Wolfe - manuscript
    The eminent French biologist and historian of biology, François Jacob, once notoriously declared “On n’interroge plus la vie dans les laboratoires”: laboratory research no longer inquires into the notion of ‘Life’. Nowadays, as David Hull puts it, “both scientists and philosophers take ontological reduction for granted… Organisms are ‘nothing but’ atoms, and that is that.” In the mid-twentieth century, from the immediate post-war period to the late 1960s, French philosophers of science such as Georges Canguilhem, Raymond Ruyer and Gilbert Simondon (...)
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  • Vitalism and Cognition in a Conscious Universe.Marco Masi - 2022 - Communicative and Integrative Biology 15 (1).
    According to the current scientific paradigm, what we call ‘life’, ‘mind’, and ‘consciousness’ are considered epiphenomenal occurrences, or emergent properties or functions of matter and energy. Science does not associate these with an inherent and distinct existence beyond a materialistic/energetic conception. ‘Life’ is a word pointing at cellular and multicellular processes forming organisms capable of specific functions and skills. ‘Mind’ is a cognitive ability emerging from a matrix of complex interactions of neuronal processes, while ‘consciousness’ is an even more elusive (...)
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  • From substantival to functional vitalism and beyond: animas, organisms and attitudes.Charles T. Wolfe - 2011 - Eidos: Revista de Filosofía de la Universidad Del Norte 14:212-235.
    I distinguish between ‘substantival’ and ‘functional’ forms of vitalism in the eighteenth century. Substantival vitalism presupposes the existence of a (substantive) vital force which either plays a causal role in the natural world as studied scientifically, or remains an immaterial, extra-causal entity. Functional vitalism tends to operate ‘post facto’, from the existence of living bodies to the search for explanatory models that will account for their uniquely ‘vital’ properties better than fully mechanistic models can. I discuss representative figures of the (...)
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  • Samostalnost znanosti o živome.Tonći Kokić - 2010 - Filozofska Istrazivanja 30 (1-2):211-229.
    Proturječnost stavova o položaju biologije unutar ili izvan područja znanosti može se podijeliti na nekoliko osnovnih pristupa. Prvi pristup smješta biologiju izvan znanstvenog područja zbog nedostatka univerzalnosti, nedostatka strogih generalizacija i nedostatka stroge kvantitativne strukture. Drugi pristup smatra biologiju znanošću koju treba svesti na fiziku. Treći pristup vidi značajne razlike između biologije s jedne, i fizike i kemije s druge strane, ali ipak tvrdi da je biologija prava znanost, no samostalna i s vlastitim pojmovnikom i metodologijom. Poredba načela prirodne znanosti (...)
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