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  1. Epigenetics: ambiguities and implications.Karola Stotz & Paul Griffiths - 2016 - History and Philosophy of the Life Sciences 38 (4):1-20.
    Everyone has heard of ‘epigenetics’, but the term means different things to different researchers. Four important contemporary meanings are outlined in this paper. Epigenetics in its various senses has implications for development, heredity, and evolution, and also for medicine. Concerning development, it cements the vision of a reactive genome strongly coupled to its environment. Concerning heredity, both narrowly epigenetic and broader ‘exogenetic’ systems of inheritance play important roles in the construction of phenotypes. A thoroughly epigenetic model of development and evolution (...)
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  • The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?Reinhard Stöger - 2008 - Bioessays 30 (2):156-166.
    Obesity and type 2 diabetes arise from a set of complex gene–environment interactions. Explanations for the heritability of these syndromes and the environmental contribution to disease susceptibility are addressed by the “thrifty genotype” and the “thrifty phenotype” hypotheses. Here, the merits of both models are discussed and elements of them are used to synthesize a “thrifty epigenotype” hypothesis. I propose that: (1) metabolic thrift, the capacity for efficient acquisition, storage and use of energy, is an ancient, complex trait, (2) the (...)
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  • RNA as the substrate for epigenome‐environment interactions.John S. Mattick - 2010 - Bioessays 32 (7):548-552.
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  • The nurture of nature: Hereditary plasticity in evolution.Ehud Lamm & Eva Jablonka - 2008 - Philosophical Psychology 21 (3):305 – 319.
    The dichotomy between Nature and Nurture, which has been dismantled within the framework of development, remains embodied in the notions of plasticity and evolvability. We argue that plasticity and evolvability, like development and heredity, are neither dichotomous nor distinct: the very same mechanisms may be involved in both, and the research perspective chosen depends to a large extent on the type of problem being explored and the kinds of questions being asked. Epigenetic inheritance leads to transgenerationally extended plasticity, and developmentally-induced (...)
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  • Intervention, integration and translation in obesity research: Genetic, developmental and metaorganismal approaches.Maureen O'Malley & Karola Stotz - 2011 - Philosophy, Ethics, and Humanities in Medicine 6:2.
    Obesity is the focus of multiple lines of inquiry that have -- together and separately -- produced many deep insights into the physiology of weight gain and maintenance. We examine three such streams of research and show how they are oriented to obesity intervention through multilevel integrated approaches. The first research programme is concerned with the genetics and biochemistry of fat production, and it links metabolism, physiology, endocrinology and neurochemistry. The second account of obesity is developmental and draws together epigenetic (...)
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  • Intervention, integration and translation in obesity research: Genetic, developmental and metaorganismal approaches.Stotz Karola & A. O'Malley Maureen - 2011 - Philosophy, Ethics, and Humanities in Medicine 6 (1):2.
    Obesity is the focus of multiple lines of inquiry that have -- together and separately -- produced many deep insights into the physiology of weight gain and maintenance. We examine three such streams of research and show how they are oriented to obesity intervention through multilevel integrated approaches. The first research programme is concerned with the genetics and biochemistry of fat production, and it links metabolism, physiology, endocrinology and neurochemistry. The second account of obesity is developmental and draws together epigenetic (...)
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  • Bridging the gap: The developmental aspects of evolution.Eva Jablonka & Marion J. Lamb - 2007 - Behavioral and Brain Sciences 30 (4):378-389.
    The commentaries on Evolution in Four Dimensions reflect views ranging from total adherence to gene-centered neo-Darwinism, to the acceptance of non-genetic and Lamarckian processes in evolution. We maintain that genetic, epigenetic, behavioral, and cultural variations have all been significant, and that the developmental aspects of heredity and evolution are an important bridge that can unite seemingly conflicting research programs and different disciplines.
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