Philosophical analyses of scientific methodology have long understood intuition to be incompatible with a rule based reasoning that is often considered necessary for a rational scientific method. This paper seeks to challenge this contention by highlighting the indispensable role that intuition plays in the application of methodologies for scientific discovery. In particular, it seeks to outline a positive role for intuition and personal judgment in scientific discovery by exploring a comparison between the use of heuristic reasoning in scientific practice and (...) engineering design. While these discussions share many features, it will also be shown that the successful use of heuristics in engineering design is often considered to depend on a crucial factor that is markedly absent from accounts of the use of heuristics in scientific discovery; experienced judgment. In the final sections of this paper, I will compare attitudes to the role of computer analysis in scientific and engineering practices, with the aim of showing how the limitations of scientific discovery machines reveal the need for including intuition in philosophical accounts of heuristic reasoning in scientific discovery. (shrink)

In the same year, 1961, Peter D. Mitchell and Robert R.J.P. Williams both put forward hypotheses for the mechanism of oxidative phosphorylation in mitochondria and photophosphorylation in chloroplasts. Mitchell's proposal was ultimately adopted and became known as the chemiosmotic theory. Both hypotheses were based on protons and differed markedly from the then prevailing chemical theory originally proposed by E.C. Slater in 1953, which by 1961 was failing to account for a number of experimental observations. Immediately following the publication of Williams (...) 's hypothesis and before his own was published, Mitchell initiated a correspondence. Examination of the letters shows the development of a dispute based on the validity of the proposals, who should have priority and particularly whether Mitchell had drawn on Williams 's work without acknowledgement. We have concluded that Mitchell's proposals were original although it is evident that prior to the correspondence Williams had considered and rejected a proposition similar to Mitchell's theory. However, a major cause of the dispute was the difference in disciplinary backgrounds of Mitchell, a microbial biochemist and Williams, a chemist. (shrink)

In the same year, 1961, Peter D. Mitchell and Robert R.J.P. Williams both put forward hypotheses for the mechanism of oxidative phosphorylation in mitochondria and photophosphorylation in chloroplasts. Mitchell's proposal was ultimately adopted and became known as the chemiosmotic theory. Both hypotheses were based on protons and differed markedly from the then prevailing chemical theory originally proposed by E.C. Slater in 1953, which by 1961 was failing to account for a number of experimental observations. Immediately following the publication of Williams's (...) hypothesis and before his own was published, Mitchell initiated a correspondence. Examination of the letters shows the development of a dispute based on the validity of the proposals, who should have priority and particularly whether Mitchell had drawn on Williams's work without acknowledgement. We have concluded that Mitchell's proposals were original although it is evident that prior to the correspondence Williams had considered and rejected a proposition similar to Mitchell's theory. However, a major cause of the dispute was the difference in disciplinary backgrounds of Mitchell, a microbial biochemist and Williams, a chemist. (shrink)

In 1983, Dr. J. Robin Warren and Dr. Barry Marshall reported finding a new kind of bacteria in the stomachs of people with gastritis. Warren and Marshall were soon led to the hypothesis that peptic ulcers are generally caused, not by excess acidity or stress, but by a bacterial infection. Initially, this hypothesis was viewed as preposterous, and it is still somewhat controversial. In 1994, however, a U. S. National Institutes of Health Consensus Development Panel concluded that infection appears to (...) play an important contributory role in the pathogenesis of peptic ulcers, and recommended that antibiotics be used in their treatment. Peptic ulcers are common, affecting up to 10% of the population, and evidence has mounted that many ulcers can be cured by eradicating the bacteria responsible for them. (shrink)

Popper is well known for rejecting a logic of discovery, but he is only justified in rejecting the same type of logic of discovery that is denied by consequentialism. His own account of hypothesis generation, based on a natural selection analogy, involves an error-eliminative logic of discovery and the differences he admits between biological and conceptual evolution suggest an error-corrective logic of discovery. These types of logics of discovery are based on principles of plausibility that are used in the generation (...) as opposed to the preliminary evaluation of hypotheses. The normative relevance of these principles is grounded in the distinction between strategic and definitory rules. (shrink)

Popper is well known for rejecting a logic of discovery, but he is only justified in rejecting the same type of logic of discovery that is denied by consequentialism. His own account of hypothesis generation, based on a natural selection analogy, involves an error-eliminative logic of discovery and the differences he admits between biological and conceptual evolution suggest an error-corrective logic of discovery. These types of logics of discovery are based on principles of plausibility that are used in the generation (...) as opposed to the preliminary evaluation of hypotheses. The normative relevance of these principles is grounded in the distinction between strategic and definitory rules. (shrink)

The process of theory development in physics is a very complex one. The best scientists sometimes proceed on the basis of their physical intuition, ignoring serious conceptual or mathematical objections well known to them at the time.The results soon justify their actions: but the removal of these objections is often not possible for a very long time. Four examples are presented: Newton, Schrödinger, Dirac, Dyson. Some thoughts on this “unreasonableness≓ are offered.

This paper focuses on the question of whether DNA patents help or hinder scientific discovery and innovation. While DNA patents create a wide variety of possible benefits and harms for science and technology, the evidence we have at this point in time supports the conclusion that they will probably promote rather than hamper scientific discovery and innovation. However, since DNA patenting is a relatively recent phenomena and the biotechnology industry is in its infancy, we should continue to gather evidence about (...) the effects of DNA patenting on scientific innovation and discovery as well the economic, social, and legal conditions relating to intellectual property in biotechnology. We should give the free market, the courts, researchers, and patent offices a chance to settle issues related to innovation and discovery, before we seek legislative remedies, since new laws proposed at this point would lack adequate foresight and could do more harm than good. However, we should be open to new laws or regulations on DNA patents if they are required to in order to deal with some of the biases and limitations of the free market. (shrink)

This paper provides examples drawn from the author’s experience that support the conclusion that errors and deceptions in archival science are often not easily or quickly corrected. The difficulty in correcting errors and deceptions needs wider recognition if it is to be overcome. In addition, the paper discusses how subtle abuses introduce errors into the archival literature.

Modes-of-being figure centrally in Heidegger's masterwork Being and Time. Testimony to this is Heidegger's characterisation of two of his most celebrated enquiries—the Existential analytic and the Zeug analysis—as investigations into the respective modes-of-being of the entities concerned. Yet despite the importance of this concept, commentators disagree widely about what a mode-of-being is. In this paper, I systematically outline and defend a novel and exegetically grounded interpretation of this concept. Strongly opposed to Kantian readings, such as those advocated by Taylor Carman (...) and Cristina Lafont, I interpret a mode-of-being as a universal that defines a district —that is, a natural class of entities that ought to be conceptualised in a special way. As such, every mode-of-being plays an important metaphysical and epistemic role: serving both to unify a natural class of a high degree of generality and as the interpretandum of an act yielding the basic-concepts pertaining to the entities therein. In explicating and arguing for this interpretation, I attribute a characteristically Aristotelian philosophical position to the early Heidegger, encompassing both metaphysical and epistemological realism and a conceptualist theory of universals. (shrink)

According to structural realism, in mature science there is structural continuity along theoretical change. A major counterexample to this thesis is the transition from the Eightfold Way to the Standard Model in particle physics. Nevertheless, the notion of structure is significantly important in comprehending the theoretical picture of particle physics, where particles change and undergo transmutations, while the only thing which remains unchanged is the basic structure, i.e. the symmetry group which controls the transmutations. This kind of view agrees with (...) the paradigmatic case where the structure is an internal symmetry and the instantiations are the elementary particles. The metaphysical view which reflects this situation is a version of ontic structuralism. (shrink)

The way scientific discovery has been conceptualized has changed drastically in the last few decades: its relation to logic, inference, methods, and evolution has been deeply reloaded. The ‘philosophical matrix’ moulded by logical empiricism and analytical tradition has been challenged by the ‘friends of discovery’, who opened up the way to a rational investigation of discovery. This has produced not only new theories of discovery, but also new ways of practicing it in a rational and more systematic way. Ampliative rules, (...) methods, heuristic procedures and even a logic of discovery have been investigated, extracted, reconstructed and refined. The outcome is a ‘scientific discovery revolution’: not only a new way of looking at discovery, but also a construction of tools that can guide us to discover something new. This is a very important contribution of philosophy of science to science, as it puts the former in a position not only to interpret what scientists do, but also to provide and improve tools that they can employ in their activity. (shrink)

This paper examines the points of disagreement between Petrus Camper and J. W. von Goethe regarding the existence of the inter-maxillary bone in humans as the link between man and the rest of nature. This historical case illustrates the fundamental role of aesthetic judgements in scientific discovery. Thus, I shall show how the eighteenth century discovery of the inter-maxillary bone in humans was largely determined by aesthetic factors—specifically, those sets of assumptions and criteria implied in the aesthetic schemata of Camper (...) and Goethe. I argue that the relevance of scientifically ascertainable morphological properties that count as evidence for the existence of bona fide anatomical structures depend on the aesthetic schema adopted by the communities assessing the classification. At the same time, I propose and explain mechanisms by which aesthetic considerations might determine the acceptability of empirical claims about the world. Based on the reconstruction of the arguments of Camper and Goethe, I conclude that aesthetic considerations play a substantive role in both the generation and preliminary evaluation of scientific hypotheses. This paper suggests a complementary relation between the mediation of aesthetic criteria in theory choice and in scientific discovery in that while aesthetic considerations in theory choice lead to conservatism; in the context of discovery they often lead to innovation. (shrink)

In the last years there has been a great improvement in the development of computational methods for combinatorial chemistry applied to drug discovery. This approach to drug discovery is sometimes called a “rational way” to manage a well known phenomenon in chemistry: serendipity discoveries. Traditionally, serendipity discoveries are understood as accidental findings made when the discoverer is in quest for something else. This ‘traditional’ pattern of serendipity appears to be a good characterization of discoveries where “luck” plays a key role. (...) In this sense, some initial failures in combinatorial chemistry are frequently attributed to a naïf appropriation of a “serendipity model” for discovery (a “serendipity mistake”). In this paper we try to evaluate this statement by criticizing its foundations. It will be suggested that the notion of serendipity has different aspects and that the criticism to the first attempts could be understood as a “serendipity mistake.” We will suggest that “serendipity” strategies, a kind of blind search, can be seen sometimes as a “genuine part” of scientific practice. A discussion will ensue about how this characterization can give us a better understanding of some aspects of serendipity discoveries. (shrink)

This piece is a commentary on a precis of Maggie Boden's book "The creative mind" published in Behavioral and Brain Sciences.

It is often argued that while biases routinely influence the generation of scientific theories, a subsequent rational evaluation of such theories will ensure that biases do not affect which theories are ultimately accepted. Against this line of thought, this paper shows that the existence of certain kinds of biases at the generation-stage implies the existence of biases at the evaluation-stage. The key argumentative move is to recognize that a scientist who comes up with a new theory about some phenomena has (...) thereby gained an unusual type of evidence, viz. information about the space of theories that could be true of the phenomena. It follows that if there is bias in the generation of scientific theories in a given domain, then the rational evaluation of theories with reference to the total evidence in that domain will also be biased. (shrink)

‘Serendipity’ is a category used to describe discoveries in science that occur at the intersection of chance and wisdom. In this paper, I argue for understanding serendipity in science as an emergent property of scientific discovery, describing an oblique relationship between the outcome of a discovery process and the intentions that drove it forward. The recognition of serendipity is correlated with an acknowledgment of the limits of expectations about potential sources of knowledge. I provide an analysis of serendipity in science (...) as a defense of this definition and its implications, drawing from theoretical and empirical research on experiences of serendipity as they occur in science and elsewhere. I focus on three interrelated features of serendipity in science. First, there are variations of serendipity. The process of serendipitous discovery can be complex. Second, a valuable outcome must be obtained before reflection upon the significance of the unexpected observation or event in respect to that outcome can take place. Therefore, serendipity is retrospectively categorized. Third, the primacy of epistemic expectations is elucidated. Finally, I place this analysis within discussions in philosophy of science regarding the impact of interpersonal competition upon the number and significance of scientific discoveries. Thus, the analysis of serendipity offered in this paper contributes to discussions about the social-epistemological aspects of scientific discovery and has normative implications for the structure of epistemically effective scientific communities. (shrink)

What is the role of chance in scientific discovery? And, more to the point, if chance plays a key role in scientific discovery, what room is left for reason? These are grounding questions in the debates, for instance, over whether there is a distinction to be made between discovery and justification in science, and whether innate genius must play a role in discovery or if there exists some method that can be taught to anyone. While the role of chance has (...) been discussed throughout the history of science, it has resurfaced in recent debates over how science should be funded, and particularly in the field of biomedical research. The word serendipity, for example, has become increasingly... (shrink)

Predictivism asserts that novel confirmations carry special probative weight. Epistemic pluralism asserts that the judgments of agents (about, e.g., the probabilities of theories) carry epistemic import. In this paper, I propose a new theory of predictivism that is tailored to pluralistic evaluators of theories. I replace the orthodox notion of use-novelty with a notion of endorsement-novelty, and argue that the intuition that predictivism is true has two roots. I provide a detailed Bayesian rendering of this theory and argue that pluralistic (...) theory evaluation pervades scientific practice. I compare my account of predictivism with those of Maher and Worrall. Introduction Why construction is a red herring for pluralist evaluators The unvirtuous accommodator Virtuous endorsers and the two roots of predictivism The two roots in Bayesian terms: the priors and background beliefs of endorsers Who are the pluralist evaluators? Two contemporary theories of predictivism 7.1 Maher: Reliable methods of theory construction 7.2 Worrall: The confirmation of core ideas Conclusion. (shrink)

In the past 150 years there have been many attempts to draw parallels between cultural and biological evolution. Most of these attempts were flawed due to lack of knowledge and false ideas about evolution. In recent decades these shortcomings have been cleared away, thus triggering a renewed interest in the subject. This paper offers a critical survey of the main issues and arguments in that discussion. The paper starts with an explication of the Darwinian algorithm of evolution. It is argued (...) that this ‘formula’ is substrate-neutral, which means that biological evolution might not be the only Darwinian process. Other dynamic systems could evolve as well provided that certain conditions are met. In the case of human culture this seems to be the case. The paper then focuses on the notion of niche construction. It is argued that niche construction plays a crucial role in human evolution because it has altered the sources of natural selection and thus the path of evolution. Next two approaches to cultural evolution are discussed: sociobiology and memetics. I will argue that both approaches have flaws because they either underestimate the influence of culture or they stretch analogies too far. Finally two common objections against the idea of cultural evolution are addressed: Lamarckian inheritance and the issue of guided variation. I will argue that although cultural evolution differs from biological evolution in several respects, these discrepancies do not jeopardize the claim that cultural evolution is essentially Darwinian. (shrink)

ArgumentUsing a striking example from the history of applied psychology, the concept of accident proneness, this paper suggests that historians of science may still find viable the idea of simultaneous discovery or construction of a scientific idea. Accident proneness was discovered independently in Germany and in Britain during the period of World War I. Later on, in 1926, the idea was independently formulated and named in both countries. The evidence shows not only striking simultaneity but true novelty and commensurateness of (...) the two formulations that crystallized at the same time in parallel, but distinctly separate, settings. (shrink)

Carnap and Goodman developed methods of conceptual re-engineering known respectively as explication and reflective equilibrium. These methods aim at advancing theories by developing concepts that are simultaneously guided by pre-existing concepts and intended to replace these concepts. This paper shows that Carnap’s and Goodman’s methods are historically closely related, analyses their structural interconnections, and argues that there is great systematic potential in interpreting them as aspects of one method, which ultimately must be conceived as a component of theory development. The (...) main results are: an adequate method of conceptual re-engineering must focus not on individual concepts but on systems of concepts and theories; the linear structure of Carnapian explication must be replaced by a process of mutual adjustments as described by Goodman; Carnap’s condition of similarity can be analysed into two components, one securing a relation to the specific extensions of the pre-existing concepts, one regulating the transition to the new system of concepts; these two criteria of adequacy can be built into Goodman’s account of reflective equilibrium to ensure that the resulting concepts promote theoretical virtues while being sufficiently similar to the concepts we started out with. (shrink)

What is creativity? One new idea may be creative, whereas another is merely new: What's the difference? And how is creativity possible? These questions about human creativity can be answered, at least in outline, using computational concepts. There are two broad types of creativity, improbabilist and impossibilist. Improbabilist creativity involves novel combinations of familiar ideas. A deeper type involves METCS: the mapping, exploration, and transformation of conceptual spaces. It is impossibilist, in that ideas may be generated which – with respect (...) to the particular conceptual space concerned – could not have been generated before. The more clearly conceptual spaces can be defined, the better we can identify creative ideas. Defining conceptual spaces is done by musicologists, literary critics, and historians of art and science. Humanist studies, rich in intuitive subtleties, can be complemented by the comparative rigour of a computational approach. Computational modelling can help to define a space, and to show how it may be mapped, explored, and transformed. Impossibilist creativity can be thought of in “classical” Al terms, whereas connectionism illuminates improbabilist creativity. Most Al models of creativity can only explore spaces, not transform them, because they have no self-reflexive maps enabling them to change their own rules. A few, however, can do so. A scientific understanding of creativity does not destroy our wonder at it, nor does it make creative ideas predictable. Demystification does not imply dehumanization. (shrink)

During the second half of the last century, the importance of serendipitous events in scientific frameworks has been progressively recognized, fueling hard debates about their role, nature, and structure in philosophy and sociology of science. Alas, while discussing the relevance of the topic for the comprehension of the nature of scientific discovery, the philosophical literature has hardly paid attention to the cognitive significance of serendipity, accepting rather than examining some of its most specific features, such as its game-changing effect, the (...) unexpectedness of its occurrence, and its affinity with the concept of “luck”. Thus, in this paper we aim at analyzing these characteristics in the light of their cognitive implications in the recognition, performance, and possible stimulation of serendipitous events in relation to scientific discoveries. (shrink)

Scientific thought is generally characterized as methodical and rational. I would like to present here an opposing view which treats science as a non-systematic activity, where serendipity, tinkering and imitation, rather than so-called rational thought, characterizes it. All these kinds of acts, which are considered to be a-rational, are related to an evolutionary view of science. I will deal here with a version of evolutionary epistemology as applied to science. The combination of variation and competition for survival is analogous to (...) the elements of Darwinian evolution. I will give some examples for this phenomenon in science from historical cases and Examples for this phenomenon in science are illustrated by some historical cases, in particular by the evolution of theories of internal symmetries in particle physics. (shrink)