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  1. What’s in a name? From “fluctuation fit” to “conformational selection”: rediscovery of a concept.Beáta G. Vértessy & Ferenc Orosz - 2021 - History and Philosophy of the Life Sciences 43 (3):1-21.
    Rediscoveries are not rare in biology. A recent example is the re-birth of the "fluctuation fit" concept developed by F. B. Straub and G. Szabolcsi in the sixties of the last century, under various names, the most popular of which is the "conformational selection". This theory offers an alternative to the "induced fit" concept by Koshland for the interpretation of the mechanism of protein—ligand interactions. A central question is whether the ligand induces a conformational change (as described by the induced (...)
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  • Conceptual Constructive Models and Abstraction-as-Aggregation.Sim-Hui Tee - 2021 - Philosophia 49 (2):819-837.
    Conceptual constructive models are a type of scientific model that can be used to construct or reshape the target phenomenon conceptually. Though it has received scant attention from the philosophers, it raises an intriguing issue of how a conceptual constructive model can construct the target phenomenon in a conceptual way. Proponents of the conception of conceptual constructive models are not being explicit about the application of the constructive force of a model in the target construction. It is far from clear (...)
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  • Computational Construction of the Reality: Abstraction and Exploration-Driven Strategies in Constructing Protein–Protein Interfaces.Sim-Hui Tee - 2019 - Axiomathes 29 (3):311-328.
    Computational modeling is one of the primary approaches to constructing protein–protein interfaces in the laboratory. The algorithm-driven computational protein design has been successfully applied to the construction of functional proteins with improved binding affinity and increased thermostability. It is intriguing how a computational protein modeling approach can construct and shape the reality of new functional proteins from scratch. I articulate an account of abstraction and exploration-driven strategies in this computational endeavor. I aim to show that how a computational modelling approach, (...)
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  • Constructing reality with models.Tee Sim-Hui - 2019 - Synthese 196 (11):4605-4622.
    Scientific models are used to predict and understand the target phenomena in the reality. The kind of epistemic relationship between the model and the reality is always regarded by most of the philosophers as a representational one. I argue that, complementary to this representational role, some of the scientific models have a constructive role to play in altering and reconstructing the reality in a physical way. I hold that the idealized model assumptions and elements bestow the constructive force of a (...)
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  • Generative Models.Sim-Hui Tee - 2020 - Erkenntnis 88 (1):23-41.
    Generative models have been proposed as a new type of non-representational scientific models recently. A generative model is characterized with the capacity of producing new models on the basis of the existing one. The current accounts do not explain sufficiently the mechanism of the generative capacity of a generative model. I attempt to accomplish this task in this paper. I outline two antecedent accounts of generative models. I point out that both types of generative models function to generate new homogenous (...)
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  • Understanding metaphorical understanding (literally).Michael T. Stuart & Daniel Wilkenfeld - 2022 - European Journal for Philosophy of Science 12 (3):1-20.
    Metaphors are found all throughout science: in published papers, working hypotheses, policy documents, lecture slides, grant proposals, and press releases. They serve different functions, but perhaps most striking is the way they enable understanding, of a theory, phenomenon, or idea. In this paper, we leverage recent advances on the nature of metaphor and the nature of understanding to explore how they accomplish this feat. We attempt to shift the focus away from the epistemic value of the content of metaphors, to (...)
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  • True Griceanism: Filling the Gaps in Callender and Cohen’s Account of Scientific Representation.Quentin Ruyant - 2021 - Philosophy of Science 88 (3):533-553.
    Callender and Cohen have proposed to apply a “Gricean strategy” to the constitution problem of scientific representation, taking inspiration from Grice’s reduction of linguistic meaning to mental states. They suggest that scientific representation can be reduced to stipulation by epistemic agents. This account has been criticised for not making a distinction between symbolic and epistemic representation and not taking into account the communal aspects of scientific representation. I argue that these criticisms would not apply if Grice’s actual strategy were properly (...)
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  • Emergence and interacting hierarchies in shock physics.Mark Pexton - 2016 - European Journal for Philosophy of Science 6 (1):91-122.
    It is argued that explanations of shock waves display explanatory emergence in two different ways. Firstly, the use of discontinuities to model jumps in flow variables is an example of “physics avoidance”. This is where microphysical details can be ignored in an abstract model thus allowing us access to modal information which cannot be attained in principle in any other way. Secondly, Whitham’s interleaving criterion for continuous shock structure is an example of the way different characteristic scales interact in shock (...)
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  • How dimensional analysis can explain.Mark Pexton - 2014 - Synthese 191 (10):2333-2351.
    Dimensional analysis can offer us explanations by allowing us to answer What-if–things-had-been-different? questions rather than in virtue of, say, unifying diverse phenomena, important as that is. Additionally, it is argued that dimensional analysis is a form of modelling as it involves several of the aspects crucial in modelling, such as misrepresenting aspects of a target system. By highlighting the continuities dimensional analysis has with forms of modelling we are able to describe more precisely what makes dimensional analysis explanatory and understand (...)
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  • Scientific understanding and felicitous legitimate falsehoods.Insa Lawler - 2021 - Synthese 198 (7):6859-6887.
    Science is replete with falsehoods that epistemically facilitate understanding by virtue of being the very falsehoods they are. In view of this puzzling fact, some have relaxed the truth requirement on understanding. I offer a factive view of understanding that fully accommodates the puzzling fact in four steps: (i) I argue that the question how these falsehoods are related to the phenomenon to be understood and the question how they figure into the content of understanding it are independent. (ii) I (...)
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  • Models as Relational Categories.Tommi Kokkonen - 2017 - Science & Education 26 (7-9):777-798.
    Model-based learning has an established position within science education. It has been found to enhance conceptual understanding and provide a way for engaging students in authentic scientific activity. Despite ample research, few studies have examined the cognitive processes regarding learning scientific concepts within MBL. On the other hand, recent research within cognitive science has examined the learning of so-called relational categories. Relational categories are categories whose membership is determined on the basis of the common relational structure. In this theoretical paper, (...)
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  • Science in a New Mode: Good Old (Theoretical) Science Versus Brave New (Commodified) Knowledge Production?Tarja Knuuttila - 2013 - Science & Education 22 (10):2443-2461.
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  • Epistemic artifacts and the modal dimension of modeling.Tarja Knuuttila - 2021 - European Journal for Philosophy of Science 11 (3):1-18.
    The epistemic value of models has traditionally been approached from a representational perspective. This paper argues that the artifactual approach evades the problem of accounting for representation and better accommodates the modal dimension of modeling. From an artifactual perspective, models are viewed as erotetic vehicles constrained by their construction and available representational tools. The modal dimension of modeling is approached through two case studies. The first portrays mathematical modeling in economics, while the other discusses the modeling practice of synthetic biology, (...)
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  • Taking model pursuit seriously.HyeJeong Han - 2023 - European Journal for Philosophy of Science 13 (2):1-24.
    This paper aims to develop an account of the pursuitworthiness of models based on a view of models as epistemic tools. This paper is motivated by the historical question of why, in the 1960s, when many scientists hardly found QSAR models attractive, some pharmaceutical scientists pursued Quantitative Structure–Activity Relationship (QSAR) models despite the lack of potential for theoretical development or empirical success. This paper addresses this question by focusing on how models perform their heuristic functions as epistemic tools rather than (...)
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  • Minimal approximations and Norton’s dome.Samuel C. Fletcher - 2019 - Synthese 196 (5):1749-1760.
    In this note, I apply Norton’s (Philos Sci 79(2):207–232, 2012) distinction between idealizations and approximations to argue that the epistemic and inferential advantages often taken to accrue to minimal models (Batterman in Br J Philos Sci 53:21–38, 2002) could apply equally to approximations, including “infinite” ones for which there is no consistent model. This shows that the strategy of capturing essential features through minimality extends beyond models, even though the techniques for justifying this extended strategy remain similar. As an application (...)
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  • The role of disciplinary perspectives in an epistemology of scientific models.Mieke Boon - 2020 - European Journal for Philosophy of Science 10 (3):1-34.
    The purpose of this article is to develop an epistemology of scientific models in scientific research practices, and to show that disciplinary perspectives have crucial role in such an epistemology. A transcendental approach is taken, aimed at explanations of the kinds of questions relevant to the intended epistemology, such as “How is it possible that models provide knowledge about aspects of reality?” The approach is also pragmatic in the sense that the questions and explanations must be adequate and relevant to (...)
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  • Epistemological and educational issues in teaching practice-oriented scientific research: roles for philosophers of science.Mieke Boon, Mariana Orozco & Kishore Sivakumar - 2022 - European Journal for Philosophy of Science 12 (1):1-23.
    The complex societal challenges of the twenty-first Century require scientific researchers and academically educated professionals capable of conducting scientific research in complex problem contexts. Our central claim is that educational approaches inspired by a traditional empiricist epistemology insufficiently foster the required deep conceptual understanding and higher-order thinking skills necessary for epistemic tasks in scientific research. Conversely, we argue that constructivist epistemologies provide better guidance to educational approaches to promote research skills. We also argue that teachers adopting a constructivist learning theory (...)
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  • Epistemology for interdisciplinary research – shifting philosophical paradigms of science.Mieke Boon & Sophie Van Baalen - 2018 - European Journal for Philosophy of Science 9 (1):16.
    In science policy, it is generally acknowledged that science-based problem-solving requires interdisciplinary research. For example, policy makers invest in funding programs such as Horizon 2020 that aim to stimulate interdisciplinary research. Yet the epistemological processes that lead to effective interdisciplinary research are poorly understood. This article aims at an epistemology for interdisciplinary research, in particular, IDR for solving ‘real-world’ problems. Focus is on the question why researchers experience cognitive and epistemic difficulties in conducting IDR. Based on a study of educational (...)
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  • Adjusting the model to adjust the world: constructive mechanisms in postwar general equilibrium theory.Ivan Boldyrev & Alexey Ushakov - 2016 - Journal of Economic Methodology 23 (1):38-56.
    Economic methodologists most often study the relations between models and reality while focusing on the issues of the model's epistemic relevance in terms of its relation to the ‘real world’ and representing the real world in a model. We complement the discussion by bringing the model's constructive mechanisms or self-implementing technologies in play. By this, we mean the elements of the economic model that are aimed at ‘implementing’ it by envisaging the ways to change the reality in order to bring (...)
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  • Logical anti‐exceptionalism meets the “logic‐as‐models” approach.Jonas R. Becker Arenhart - 2022 - Theoria 88 (6):1211-1227.
    Logical anti‐exceptionalism is the view that logic is not special, it is continuous with science. This continuity is typically understood in terms of the use of the abductive method in logical theory choice, with logical knowledge resulting from our choice of the theory best accounting for the data. In this paper, we argue for two related claims: (i) that this understanding of the continuity between logic and science faces considerable challenges; and (ii) that such challenges may be avoided by elaborating (...)
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  • Epistemology for interdisciplinary research – shifting philosophical paradigms of science.Sophie Baalen & Mieke Boon - 2018 - European Journal for Philosophy of Science 9 (1):1-28.
    In science policy, it is generally acknowledged that science-based problem-solving requires interdisciplinary research. For example, policy makers invest in funding programs such as Horizon 2020 that aim to stimulate interdisciplinary research. Yet the epistemological processes that lead to effective interdisciplinary research are poorly understood. This article aims at an epistemology for interdisciplinary research, in particular, IDR for solving ‘real-world’ problems. Focus is on the question why researchers experience cognitive and epistemic difficulties in conducting IDR. Based on a study of educational (...)
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  • Logical Relativism Through Logical Contexts.Jonas R. Becker Arenhart - 2021 - European Journal of Analytic Philosophy 17 (2):(A2)5-28.
    We advance an approach to logical contexts that grounds the claim that logic is a local matter: distinct contexts require distinct logics. The approach results from a concern about context individuation, and holds that a logic may be constitutive of a context or domain of application. We add a naturalistic component: distinct domains are more than mere technical curiosities; as intuitionistic mathematics testifies, some of the distinct forms of inference in different domains are actively pursued as legitimate fields of research (...)
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  • Iconically modeling a demolition process in the photobook Palast Der Republik.Letícia Alves Vitral & João Queiroz - 2018 - Semiotica 2018 (224):191-209.
    Palast der Republik, by the photographer Christoph Rokitta, is an independent photobook published in 2013 in Berlin. In the photobook different semiotic resources are coupled in order to iconically model the demolition of the homonymous building in Berlin. In opposition to the trivial notion of icon as sign that stands for its object in a relation of similarity, we analyze the photobook as an icon whose main feature is the possibility of discovering information about its object through its manipulation. This (...)
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  • Artworks as diagrams : Diagrammatic reasoning and the epistemic potential of art.Leticia Vitral - unknown
    This thesis is concerned with establishing a bridge between matters of aesthetics and epistemology, by investigating the mechanisms through which artworks allow agents to derive knowledge through the former’s manipulation. It is proposed that, in order to understand the epistemic potential of artworks, we need to approach them as diagrams, in the sense developed by Charles Peirce. The background upon which the arguments are developed are mainly those of American Pragmatism – with a special emphasis on primary literature from Charles (...)
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  • Pluralists about Pluralism? Versions of Explanatory Pluralism in Psychiatry.Jeroen Van Bouwel - 2014 - In M. C. Galavotti, D. Dieks, W. J. Gonzalez, S. Hartmann, Th Uebel & M. Weber (eds.), New Directions in Philosophy of Science (The Philosophy of Science in a European Perspective Series). Springer. pp. 105-119.
    In this contribution, I comment on Raffaella Campaner’s defense of explanatory pluralism in psychiatry (in this volume). In her paper, Campaner focuses primarily on explanatory pluralism in contrast to explanatory reductionism. Furthermore, she distinguishes between pluralists who consider pluralism to be a temporary state on the one hand and pluralists who consider it to be a persisting state on the other hand. I suggest that it would be helpful to distinguish more than those two versions of pluralism – different understandings (...)
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  • Models in Science and Engineering: Imagining, Designing and Evaluating Representations.Michael Poznic - 2017 - Dissertation, Delft University of Technology
    The central question of this thesis is how one can learn about particular targets by using models of those targets. A widespread assumption is that models have to be representative models in order to foster knowledge about targets. Thus the thesis begins by examining the concept of representation from an epistemic point of view and supports an account of representation that does not distinguish between representation simpliciter and adequate representation. Representation, understood in the sense of a representative model, is regarded (...)
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