The prevention, treatment and management of disease are closely linked to how the causes of a particular disease are explained. For multi-factorial conditions, the causal explanations are inevitably complex and competing models may exist to explain the same condition. Selecting one particular causal explanation over another will carry practical and ethical consequences that are acutely relevant for health policy. In this paper our focus is two-fold; the different models of causal explanation that are put forward within current scientific literature for (...) the high and rising prevalence of the common complex conditions of coronary artery disease and type 2 diabetes mellitus ; and how these explanations are taken up within national health policy guidelines. We examine the causal explanations for these two conditions through a systematic database search of current scientific literature. By identifying different causal explanations we propose a three-tier taxonomy of the most prominent models of explanations: evolutionary, lifecourse, and lifestyle and environment. We elaborate this taxonomy with a micro-level thematic analysis to illustrate how some explanations are semantically and rhetorically foregrounded over others. We then investigate the uptake of the scientific causal explanations in health policy documents with regard to the prevention and management recommendations of current National Service Frameworks for CAD and T2D. Our findings indicate a lack of congruence between the complexity and frequent overlap of causal explanations evident in the scientific literature and the predominant focus on lifestyle recommendations found in the mainstream health policy documents. (shrink)

This essay identifies two legal lineages underlying the common heritage concept, and applies each to the human genome. The essay notes some advantages and disadvantages of each approach, and argues that patenting of human genes would be allowable under either approach.

In the opening years of the 21st century, it became fashionable to describe the human genome as belonging to the common heritage of humanity. The United Nations, in its Universal Declaration on the Human Genome and Human Rights, now identifies the human genome as part of the common heritage, as does the international Human Genome Organization and the Council of Europe. The common heritage concept has played a prominent role in arguments against patenting the human genome or portions thereof. This (...) essay considers whether the common heritage designation will advance the political and legal goals of its proponents. (shrink)

In 1966, a team made up of Brazilian and foreign scientists spent a week carefully recording the body temperature and other clinical signs and symptoms of 110 Tiriyó Indigenous people in their communities along the Brazil-Suriname border. Led by the Yale University virologist and immunologist Francis Black, the researchers faced an "epidemic" with a special profile, distinct from those most common in Indigenous populations, which usually resulted in widespread illness, the collapse of subsistence activities, hunger, and as a rule, elevated (...) mortality.Rather, what was happening with the Tiriyó was a planned event, controlled and carefully... (shrink)

This article focuses on the ethno-biological expedition to the Amazon headed by Ettore Biocca between November 1962 and July 1963. Biocca, a parasitologist by training, assembled a multidisciplinary team to carry out an ethno-biological study of Amazon natives. The expedition work covered the natives' customs, myths, chants, diseases and the hallucinogenic compounds and curare they used, and took into account plants and animals common to the Amazon environment. This article aims to contribute to the understanding of the 20th-century Western approach (...) to the Amazon people and its cultural importance. It sets out to show how Biocca's encyclopaedic work related to the centrality of Amazonia and its peoples in scientific and cultural debates on modernity and Western culture in the 1960s, and how it connects to Cold War anxieties about the disappearance of ‘uncorrupted’ peoples. (shrink)