It has recently been argued that reproductive genetic manipulation technologies like mitochondrial replacement and germline CRISPR modifications cannot be said to save anyone’s life because, counterfactually, no one would suffer more or die sooner absent the intervention. The present article argues that, on the contrary, reproductive genetic manipulations may be life-saving (and, from this, have therapeutic value) under an appropriate population health perspective. As such, popular reports of reproductive genetic manipulations potentially saving lives or preventing disease are not necessarily mistaken, (...) though such terminology still requires further empirical validation. (shrink)

This paper discusses what the so-called Priority View implies regarding possible people. It is argued that this view is plausible when applied to fixed populations, but that, when applied to the issue of possible people, it faces certain difficulties. If it is claimed that possible people fall within the scope of the Priority View, we are led to the repugnant conclusion at a faster pace than we are by, e.g., utilitarianism. And if it is claimed that possible people do not (...) fall within the scope of the Priority View, we shall have to combine this view with a different view in order to avoid certain counter-intuitive judgements. Such a combined view, however, leads to intransitivities. At the end of the paper, I discuss what these conclusions imply regarding both the Priority View and our moral obligations to possible people. (shrink)

The case in favor of gene therapy is quite simple. Gene therapy is likely to improve the health and well-being of some people that are among the worst off in society, namely patients with painful and life-threatening diseases. However, two types of objection have been raised.