Vidal’s (Found Sci, 2010 ) and Rottiers’s (Found Sci, 2010 ) commentaries on my (2010) paper raised a number of important issues about the possible future trajectory of evolution and its implications for humanity. My response emphasizes that despite the inherent uncertainty involved in extrapolating the trajectory of evolution into the far future, the possibilities it reveals nonetheless have significant strategic implications for what we do with our lives here and now, individually and collectively. One important implication is the replacement (...) of postmodern scepticism and relativism with an evolutionary grand narrative that can guide humanity to participate successfully in the future evolution of life in the universe. (shrink)