Abstract
Rats were maintained on a daily schedule of water deprivation for 22 h, followed by 2 h of access to water and test solution. For one group, the test solution was 0.9% NaCl. For another group, the test solution was 24% sucrose. After rats’ intakes were stable, both groups were given placebos or doses of methadone. Methadone (0.5 and 1.0 mg/kg) increased intakes of both the salty and the sweet solutions. These data confirm that certain opioids increase intake of palatable ingesta and indicate that the prescription of methadone may have a side effect of unduly enhancing intake of certain foods.
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Bertino, M., Abelson, M. L., Marglin, S. H., Neuman, R., Burkhardt, C. A., & Reid, L. D. (in press). Small doses of morphine increase intake of and preference for salty solutions among rats. Pharmacology Biochemistry & Behavior.
Calcagnetti, D. J., & Reid, L. D. (1983). Morphine and acceptability of putative reinforcers. Pharmacology Biochemistry & Behavior, 18, 567–569.
Czirr, S. A., & Reid, L. D. (1986). Demonstrating morphine’s effects on sucrose-intake. Brain Research Bulletin, 17, 639–642.
Hubbell, C. L., Czirr, S. A., Hunter, G. A., Beaman, C. A., LeCann, N. C., & Reid, L. D. (1986). Consumption of ethanol solution is potentiated by morphine and attenuated by naloxone persistently across daily repeated administrations. Alcohol, 3, 39–54.
Hubbell, C. L., Czirr, S. A., & Reid, L. D. (1987). Persistence and specificity of small doses of morphine on intake of alcoholic beverages. Alcohol, 4, 149–156.
Mudar, P. J., LeCann, N. C., Czirr, S. A., Hubbell, C. L., & Reid, L. D. (1986). Methadone, pentobarbital, pimozide and ethanol-intake. Alcohol, 3, 303–308.
Myers, W. D., Ng, K. T., Marzuki, S., Myers, R. D., & Singer, G. (1984). Alteration of alcohol drinking in the rat by peripherally selfadministered acetaldehyde. Alcohol, 1, 229–236.
Reid, L. D. (1985). Endogenous opioid peptides and regulation of drinking and feeding. American Journal of Clinical Nutrition, 42, 1099–1132.
Reid, L. D., & Hunter, G. A. (1984). Morphine and naloxone modulate intake of ethanol. Alcohol, 1, 33–37.
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This research was supported, in part, by a grant from the National Institute on Alcohol Abuse and Alcoholism. We thank Jean Bestle and Betty Osganian for their help with the clerical tasks.
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Abelson, M.L., Reid, L.D. Methadone and intake of palatable fluids. Bull. Psychon. Soc. 26, 71–72 (1988). https://doi.org/10.3758/BF03334865
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DOI: https://doi.org/10.3758/BF03334865