Inhibition of Prepotent Motor Responses after Orbitofrontal Lesions is Associated with Hemodynamic Activation in the Parietal Lobe
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1
Oslo University Hospital – Rikshospitalet, Department of Neuropsychiatry and Psychosomatic Medicine, Norway
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2
University of Oslo, Department of Psychology, Norway
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3
Sunnaas Rehabilitation Hospital, Norway
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4
University of Lund, Department of Psychology, Sweden
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5
Oslo University Hospital – Rikshospitalet, Department of Radiology, Norway
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6
Oslo University Hospital – Rikshospitalet, Department of Neurosurgery, Norway
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7
University of California, Department of Psychology and Helen Wills Neuroscience Institute, United States
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8
Oslo University Hospital – Rikshospitalet, Intervention Center, Norway
Inhibition of prepotent responses is an important aspect of cognitive control. Patients with frontal lobe injury often show impaired inhibitory control at the behavioral level. We examined motor response suppression in patients with orbitofrontal lesions (N = 14) after resection of primary intracranial tumor or contusion due to traumatic brain injury. Behavioral and fMRI hemodynamic responses were recorded during a Stop-signal task where task difficulty was equated across participants. Thus, healthy controls (N = 15) and patients did not differ in the relative number of successful and failed inhibitions. Patients responded more slowly to Go signals, but there was no significant speed difference in failed inhibition trials. Successful versus unsuccessful inhibition engaged pre-supplementary cortex, middle (MFG) and inferior frontal gyri (IFG) in controls, whereas no significant activation foci were seen in the orbitofrontal group. The successful inhibition versus Go signal contrast showed IFG activation in controls only. Both groups had inferior parietal lobe (IPL) activation. Analysis of failed inhibition compared with Go trials revealed dorsomedial and bilateral IPL recruitment in controls, while patients had IPL activation only. The results indicate that a fronto-parietal network subserves response inhibition in healthy controls. Orbitofrontal lesions disrupted frontal lobe involvement in the task. The findings point toward a possible compensatory role for the parietal part of the control network.
Conference:
The 20th Annual Rotman Research Institute Conference, The frontal lobes, Toronto, Canada, 22 Mar - 26 Mar, 2010.
Presentation Type:
Poster Presentation
Topic:
Cognitive Neuroscience
Citation:
Endestad
T,
Funderud
I,
Løvstad
M,
Lindgren
M,
Engen
H,
Due-Tønnessen
P,
Meling
T,
Knight
RT,
Courivaud
F and
Solbakk
AK
(2010). Inhibition of Prepotent Motor Responses after Orbitofrontal Lesions is Associated with Hemodynamic Activation in the Parietal Lobe.
Conference Abstract:
The 20th Annual Rotman Research Institute Conference, The frontal lobes.
doi: 10.3389/conf.fnins.2010.14.00104
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Received:
29 Jun 2010;
Published Online:
29 Jun 2010.
*
Correspondence:
A. K Solbakk, Oslo University Hospital – Rikshospitalet, Department of Neuropsychiatry and Psychosomatic Medicine, Oslo, Norway, anne-kristin.solbakk@rikshospitalet.no