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Theoretical sequelae of a chronic neglect and unawareness of prefrontotectal pathways in the human brain

Published online by Cambridge University Press:  01 May 2007

Francisco Barceló
Affiliation:
Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, 07122 Palma de Mallorca, Spain; f.barcelo@uib.eshttp://www.mcst.es/
Robert T. Knight
Affiliation:
Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720-1650. rtknight@berkeley.eduhttp://bic.berkeley.edu/knightlab/

Abstract

Attention research with prefrontal patients supports Merker's argument regarding the crucial role for the midbrain in higher cognition, through largely overlooked and misunderstood prefrontotectal connectivity. However, information theoretic analyses reveal that both exogenous (i.e., collicular) and endogenous (prefrontal) sources of information are responsible for large-scale context-sensitive brain dynamics, with prefrontal cortex being at the top of the hierarchy for cognitive control.

Type
Open Peer Commentary
Copyright
2007 Cambridge University Press

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